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In silico Pharmacokinetic and Toxicity Prediction of Compounds from Andrographis paniculata (Burm.f.) Nees. Izatunnafis, Izatunnafis; Murti, Yosi Bayu; Ari Sudarmanto, Bambang Sulistyo
Journal of Food and Pharmaceutical Sciences Vol 11, No 2 (2023): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.7436

Many compounds have been isolated from Andrographis paniculata (Burm. f.) Nees (AP). In drug discovery and development, plant secondary metabolites are popular as resources for drug candidates. A high-quality drug candidate should not only be effective against the therapeutic target, but it should also be safe and have good pharmacokinetic features. This study aimed to predict the pharmacokinetic features and toxicity potencies of 46 compounds from AP using the pKCSM online tool. According to pKCSM prediction, among the forty-six compounds from AP, compound 1 (14-Deoxy-11,12-didehydroandrographolide), compound 2 (14-Deoxyandrographolide), and compound 39 ((-)-beta-Sitosterol) have good pharmacokinetic features and do not have potencies to be mutagenic and hepatotoxic agents. The lethal dosage values (LD50) of compounds 1, 2, and 39, are 1935, 2053, and 2424 (mol/kg), respectively. However, further research is still needed to confirm these predictions.

Profiling Rosmarinic Acid and Sinensetin Content of Orthosiphon aristatus. from Three Different Locations with Variety Ethanol Concentration Ramadhani, Novia Putri; Murti, Yosi Bayu; Gani, Andayana Puspitasari
Journal of Food and Pharmaceutical Sciences Vol 12, No 2 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.13625

Orthosiphon aristatus is a well-known medicinal plant acknowledged for its therapeutic effect in treating urinary tract diseases, hypertension, diabetes mellitus, and arthritis. It is widely used as an ingredient in herbal medicine and distributed throughout the world, including China, Europe and Indonesia. Sinensetin are normally used as chemical marker to evaluate and control the quality of O. aristatus. However, in 2021, the European Medicines Agency changed the marker to rosmarinic acid. In order to determine the levels of rosmarinic acid and sinensetin in O. aristatus as well as the correlation between the two compounds, this study used high-performance liquid chromatography (HPLC) with a UV detector to analyze O. aristatus extract from three distinct locations with four different ethanol concentrations (96%, 75%, 50%, and 25%). Results showed that higher levels of rosmarinic acid was obtained in extractions using binary. Meanwhile, higher sinensetin content in O. aristatus were obtained by 96% ethanol (Klaten) and hydro-ethanol (Sleman, Bantul). In addition, this study discovered that the sinensetin levels had an inverse correlation with rosmarinic acid levels. It can be concluded that the rosmarinic acid and sinensetin contents are influenced by growing locations and ethanol concentrations.

Profiling Rosmarinic Acid and Sinensetin Content of Orthosiphon aristatus. from Three Different Locations with Variety Ethanol Concentration Ramadhani, Novia Putri; Murti, Yosi Bayu; Gani, Andayana Puspitasari
Journal of Food and Pharmaceutical Sciences Vol 12, No 2 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.13625

Orthosiphon aristatus is a well-known medicinal plant acknowledged for its therapeutic effect in treating urinary tract diseases, hypertension, diabetes mellitus, and arthritis. It is widely used as an ingredient in herbal medicine and distributed throughout the world, including China, Europe and Indonesia. Sinensetin are normally used as chemical marker to evaluate and control the quality of O. aristatus. However, in 2021, the European Medicines Agency changed the marker to rosmarinic acid. In order to determine the levels of rosmarinic acid and sinensetin in O. aristatus as well as the correlation between the two compounds, this study used high-performance liquid chromatography (HPLC) with a UV detector to analyze O. aristatus extract from three distinct locations with four different ethanol concentrations (96%, 75%, 50%, and 25%). Results showed that higher levels of rosmarinic acid was obtained in extractions using binary. Meanwhile, higher sinensetin content in O. aristatus were obtained by 96% ethanol (Klaten) and hydro-ethanol (Sleman, Bantul). In addition, this study discovered that the sinensetin levels had an inverse correlation with rosmarinic acid levels. It can be concluded that the rosmarinic acid and sinensetin contents are influenced by growing locations and ethanol concentrations.

Efektivitas Ozon Untuk Dekontaminasi Simplisia Temu Mangga Terhadap Cemaran Mikroba Di Pasar Beringharjo Rahmawati, Arini Nur Yunia Puspitaningrum; Purwantini, Indah; Murti, Yosi Bayu
Majalah Farmaseutik Vol 21, No 1 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v21i1.92668

Temu mangga (Curcuma mangga) merupakan tanaman obat Indonesia yang memiliki banyak manfaat kesehatan. Namun, simplisia temu mangga sering tercemar mikroba selama proses penanganan dan penyimpanan yang akan berpengaruh terhadap mutu dan keamanannya. Salah satu metode yang sedang dikembangkan untuk dekontaminasi mikroba adalah penggunaan ozon dan telah terbukti efektif dalam mengurangi mikroba pada berbagai jenis bahan pangan. Tujuan penelitian ini adalah untuk melihat efektifitas ozon dalam proses dekontaminasi simplisia temu mangga. Sampel temu mangga diambil dari Pasar Beringharjo dan diozonasi dengan dosis 10 g/h. Proses dekontaminasi ozon dilakukan pada rentang waktu 0-120 menit Perhitungan cemaran mikroba dilakukan dengan menghitung Angka Lempeng Total (ALT) dan Angka Kapang Kamir (AKK) sesuai persyaratan BPOM. Hasil penelitian menunjukkan bahwa ozon efektif dalam mengurangi jumlah mikroba pada temu mangga. Tanpa perlakuan ozon, ALT pada sampel mencapai 1,5 x 105 koloni/g. Setelah perlakuan ozon, ALT menurun menjadi 0,1-1 x 105 koloni/g. Selain itu, pada simplisia temu mangga setelah dilakukan ozonasi selama 30 menit tidak terdapat kapang dan kamir.

Pemetaan Saintifik terhadap Potensi Tanaman Brassicaceae sebagai Anti-inflamasi: Analisis Bibliometrik Periode Tahun 2003−2024 Tivanie, Riza Ayu; Murti, Yosi Bayu; Illian, Didi Nurhadi; Nugroho, Agung Endro
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.871

The Brassicaceae family is recognized for its antioxidant and anti-inflammatory properties. Due to its widespread distribution, it serves as a prominent source of bioactive phytochemicals, attracting considerable research interest. Brassicaceae plants contain several secondary metabolites, including glucosinolates, which are precursors to bioactive compounds like isothiocyanates (e.g., sulforaphane) that have demonstrated anti-inflammatory effects. This study aims to investigate keywords, countries, number of publications, institutions, authors, and journals related to Brassicaceae plants as anti-inflammatory agents during the period 2003–2024 using a comprehensive bibliometric analysis method. Information was collected using the Scopus database, followed by data analysis using the Biblioshiny R Package and VOSviewer. A total of 760 articles meeting the inclusion criteria were analyzed. The results indicate that 2023 saw the largest increase in research publications, with China emerging as the leading contributor, while the USA had the highest citation count. The International Journal of Molecular Sciences was identified as the most popular publishing journal. Kyung Hee University was designated as the most productive institution, with Li Y as the author with the highest contribution. Bibliometric data also highlighted several therapeutic target molecules, including cytokines, nitric oxide, cyclooxygenase-2, and Nrf2, which play crucial roles in the action mechanisms of signature metabolites from Brassicaceae plants, including sulforaphane, isothiocyanates, glucosinolates, and flavonoids, for therapeutic purposes as anti-inflammatory, antioxidant, antimicrobial, and chemopreventive agents. These findings highlight the significant potential of Brassicaceae medicinal plants for various therapeutic mechanisms and provide recommendations for future research in the pharmacy field.

Aktivitas Penghambatan enzim Dipeptidyl Peptidase 4 (DPP-4) dari ekstrak dan seskuiterpen lakton yang Diisolasi dari Daun Yacon (Smallanthus sonchifolius) Tamhid, Hady Anshory; Hertiani, Triana; Murti, Yosi Bayu; Murwanti, Retno
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 6, ISSUE 2, October 2025
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/EKSAKTA.vol6.iss2.art2

The Sesquiterpene lactones, enhydrin and uvedalin, are the chemotype and subtype compounds of the yacon leaf. They are known to have anti-diabetic activity, but their mechanisms are not clear. One of the mechanisms of anti-diabetic agents is to inhibit the activity of the dipeptidyl peptidase 4 enzyme (DPP-4). The research aimed to determine the inhibition of the extract, enhydrin, and uvedalin isolated from the yacon leaf against the DPP-4 enzyme activity. Yakon leaves were extracted using 70% ethanol by the maceration method. Enhydrin and uvedalin were obtained from previous research. The inhibitory activity of the DPP-4 enzyme was then determined by the fluorescence assay method using a multi-well plate reader. Sitagliptin was used as standard inhibitor of DPP-4 enzyme. The ethanol extract of yacon leaves inhibits the DPP-4 enzyme with an IC50 of 856.9 ppm. The percentage inhibition of the DPP-4 enzyme by the enhydrin and uvedalin at a concentration of 250 ppm was 2.37 and 35.16%, respectively. The inhibitory potency of the pure isolated compounds was not substantially greater than that of the crude extract itself. This led us to the conclusion that the overall contribution of enhydrin and uvedalin to the extract's DPP-4 inhibitory activity is actually modest, suggesting the presence of other active compounds within the extract. However, it may provide a new approach to the treatment of type 2 diabetes.

In silico Pharmacokinetic and Toxicity Prediction of Compounds from Andrographis paniculata (Burm.f.) Nees. Izatunnafis, Izatunnafis; Murti, Yosi Bayu; Ari Sudarmanto, Bambang Sulistyo
Journal of Food and Pharmaceutical Sciences Vol 11, No 2 (2023): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.7436

Many compounds have been isolated from Andrographis paniculata (Burm. f.) Nees (AP). In drug discovery and development, plant secondary metabolites are popular as resources for drug candidates. A high-quality drug candidate should not only be effective against the therapeutic target, but it should also be safe and have good pharmacokinetic features. This study aimed to predict the pharmacokinetic features and toxicity potencies of 46 compounds from AP using the pKCSM online tool. According to pKCSM prediction, among the forty-six compounds from AP, compound 1 (14-Deoxy-11,12-didehydroandrographolide), compound 2 (14-Deoxyandrographolide), and compound 39 ((-)-beta-Sitosterol) have good pharmacokinetic features and do not have potencies to be mutagenic and hepatotoxic agents. The lethal dosage values (LD50) of compounds 1, 2, and 39, are 1935, 2053, and 2424 (mol/kg), respectively. However, further research is still needed to confirm these predictions.

Mallotus repandus (Rottler) Müll.Arg. sebagai Obat Tradisional oleh Masyarakat Kota Kupang, Nusa Tenggara Timur Loe, Wahyuni Ester; Murti, Yosi Bayu; Purwantini, Indah
Majalah Farmaseutik Vol 22, No 2 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v22i2.111128

Mallotus repandus adalah tumbuhan yang masuk dalam famili Euphorbiaceae dengan berbagai aktivitas farmakologi. Oleh masyarakat Kota Kupang, tumbuhan ini sering disebut sebagai “pohon daun rote” yang digunakan sebagai obat tradisional secara turun-temurun hingga saat ini. Dokumentasi pengetahuan tradisional diperlukan sebagai upaya pelestarian kearifan lokal untuk mencegah hilangnya informasi yang hanya diwariskan secara lisan. Penelitian ini bertujuan untuk mendokumentasikan pengetahuan tradisional terkait penggunaan M. repandus dan identifikasi potensinya sebagai obat tradisional yang sudah digunakan secara turun temurun. Penelitian dilakukan melalui wawancara dengan metode snowball sampling pada 14 warga lokal di tiga lokasi di wilayah Kota Kupang. Hasil penelitian menunjukkan masyarakat lebih memanfaatkan bagian akar M. repandus yang dimanfaatkan untuk membantu mengatasi sakit kepala, pusing, lemas, lelah, sesak nafas, gangguan penglihatan, serta untuk mempercepat pemulihan ibu pasca melahirkan. Tumbuhan ini memiliki akar yang bercabang sehingga pengambilan bagian akar tidak menyebabkan kematian tumbuhan. Dari 14 responden semuanya berpendapat jika tumbuhan ini lebih dikenal untuk dikonsumsi pada ibu pasca melahirkan.

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