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All Journal International Journal of Public Health Science (IJPHS) International Journal of Evaluation and Research in Education (IJERE) NURSCOPE: Jurnal Penelitian dan Pemikiran Ilmiah Keperawatan Nurse Media Journal of Nursing Jurnal Pendidikan Indonesia Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Jurnal NERS Transformasi: Jurnal Pengabdian Masyarakat Indonesian Journal of Tropical and Infectious Disease Jurnal Inovasi Pendidikan IPA Jurnal Penelitian Kesehatan Suara Forikes Jurnal Keperawatan Muhammadiyah Jurnal Ilmiah Kesehatan Media Husada Care : Jurnal Ilmiah Ilmu Kesehatan Aptisi Transactions on Technopreneurship (ATT) Community Service Journal of Indonesia Jurnal Ners Journal of Telenursing (JOTING) Critical Medical and Surgical Nursing Journal Attractive : Innovative Education Journal Jurnal Layanan Masyarakat (Journal of Public Service) Indonesian Journal of Community Health Nursing Indonesian Journal of Global Health research Babali Nursing Research Jurnal Pengabdian Masyarakat dalam Kesehatan Among : Jurnal Pengabdian Masyarakat Integrated Science Education Journal Jurnal Pengabdian kepada Masyarakat Pelita Abdi Masyarakat KESANS : International Journal of Health and Science Abimanyu: Journal of Community Engagement The Journal of Palembang Nursing Studies DUNIA KEPERAWATAN: JURNAL KEPERAWATAN DAN KESEHATAN Eduvest - Journal of Universal Studies E-Amal: Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Global Health Research Jurnal Penelitian Perawat Profesional
Ika Nur Pratiwi
Fakultas Keperawatan, Universitas Airlangga, Indonesia
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Androgen Receptor, Resistensi Terapi, dan Pendekatan Terapeutik Baru pada Kanker Prostat Winda Gusya; Farabilla Fredela; Sekar Arum Firdausi; Ika Nur Pratiwi
Jurnal Penelitian Perawat Profesional Vol. 7 No. 6 (2025): Desember 2025, Jurnal Penelitian Perawat Profesional
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/jppp.v7i6.1064

Abstract

Androgen receptor (AR) merupakan penggerak utama perkembangan kanker prostat dan tetap aktif meskipun kadar testosteron telah mencapai kondisi kastrasi. Resistensi terapi muncul melalui amplifikasi AR, mutasi ligand-binding domain (LBD), varian splice seperti AR-V7, bypass pathways (misalnya glucocorticoid receptor), serta aktivasi jalur non-AR seperti PI3K/AKT dan NF-κB. Tinjauan sistematis ini menganalisis mekanisme resistensi berbasis AR, peran jalur non-AR, serta efektivitas pendekatan terapeutik baru pada castration-resistant prostate cancer (CRPC). Systematic review dilakukan sesuai PRISMA 2020. PICO digunakan untuk merumuskan pertanyaan riset. Pencarian dilakukan pada PubMed, Scopus, Web of Science, dan Embase menggunakan kata kunci seperti “prostate cancer”, “castration-resistant prostate cancer”, “androgen receptor”, “AR-V7”, “antiandrogen resistance”, dan “novel AR-targeted therapy” dengan rentang publikasi 2015–2025. Screening dilakukan oleh dua reviewer independen. Kualitas studi dianalisis menggunakan RoB-2 dan Newcastle–Ottawa Scale. Dari 1.972 artikel yang teridentifikasi pada tahap awal, sebanyak 33 studi memenuhi kriteria inklusi dan disertakan dalam sintesis akhir. Lima tema utama ditemukan: (1) reaktivasi AR melalui amplifikasi, mutasi, dan AR-V7; (2) aktivasi jalur non-AR; (3) resistensi terhadap antiandrogen generasi baru; (4) terapi inovatif seperti PROTACs, AR-V7 degraders, N-terminal domain inhibitors, dan RNA interference; (5) pendekatan drug repurposing & strategi re-sensitisasi seperti Bipolar Androgen Therapy (BAT). Resistensi CRPC didorong oleh interaksi kompleks antara perubahan AR, jalur kompensasi non-AR, dan adaptasi epigenetik. Terapi multimodal berbasis biomarker menjadi arah masa depan pengelolaan CRPC.
THE The Effect of Telehealth-Based Self Management Interventions for Irritable Bowel Syndrome: A Systematic Rofiqa Dwi Febriyanti; Ika Nur Pratiwi; Fayza Eka Zhafirah; Wynne Faiza Rosada
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1167

Abstract

An Irritable Bowel Syndrome (IBS) is a dysfunctional bowel disorder characterized by such gastrointestinal symptoms as abdominal pain, defecation, constipation, and bloating. Consequently, the condition may worsen over time. A systematic evaluation of the effectiveness, mechanisms, and implementation aspects of telemedicine-based self-management strategies in adults with irritable bowel syndrome (IBS). This study used a quantitative method with a systematic review approach following the PRISMA 2020 guidelines. The search was conducted in various databases such as PubMed, Scopus, Web Of Science (WOS), Sciencedirect, and Proquest with a publication year range from 2020 to 2025. The Boolean search strategy was: “self-management” OR “self-care” “telehealth” AND ‘telemedicine’ “Irritable Bowel Syndrome OR intestinal disorder.” From the 1,074 articles found, after screening using inclusion and exclusion criteria, 20 articles were selected for further analysis using the JBI Critical Appraisal checklist. 20 articles that met the study criteria showed that the use of telehealth can improve self-management skills and reduce the number of inpatient cases. The highest level of effectiveness was achieved through collaboration between telehealth and interprofessional health services in food map management. Digital self-management through telehealth is effective and feasible as an adjunct to IBS management, with consistent evidence for CBT-based, nutritional, relaxation, and multimodal interventions despite methodological variations.  
Latihan Aerobic Exercise terhadap Kadar Glukosa Darah pada Penderita Diabetes Mellitus Tipe 2 Geladis Titanik; Andri Setiya Wahyudi; Ika Nur Pratiwi
Journal of Telenursing (JOTING) Vol. 8 No. 1 (2026): Journal of Telenursing (JOTING)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/3ezha928

Abstract

This study aims to analyze the effect of aerobic exercise on blood glucose levels in patients with type 2 diabetes mellitus. The research method used quantitative research with a quasi-experimental design with a pretest-posttest approach in the aerobic exercise group and the control group by measuring blood glucose levels including fasting blood glucose tests using a glucometer. The study showed that fasting blood glucose decreased on average from 155 ± 9.41 mg/dL to 144 ± 9.31 mg/dL (p < 0.001), with a range from 139–167 mg/dL to 127–155 mg/dL. These results indicate that aerobic exercise interventions can significantly lower blood glucose levels. Aerobic exercise has been shown to be effective in improving glycemic control and metabolic health in individuals with type 2 diabetes mellitus (T2DM). In conclusion, there is a significant effect of aerobic exercise on blood sugar levels in T2DM patients. Aerobic exercise significantly reduces fasting blood glucose levels in patients with Type 2 Diabetes Mellitus.  Keywords: Aerobic Exercise, Diabetes Mellitus, Blood Glucose Levels 
Co-Authors -, Maison Abu Bakar Abu Bakar Agostinha Soares AH Yusuf Ah Yusuf, Ah Albertina Dete Tabik Andi Safutra Suraya Andri Setiya Wahyudi Arifin, Hidayat Astalini Astalini Baiq Rista Ananta Pratiwi Betsytifani, Pahlevi Darmaji, Darmaji Dianis Wulan Sari Dianita, Eka Mei Doreen Phiri Dwi Agus Kurniawan Elsi Dwi Hapsari Ependi, Radias Eskarani Tri Pratiwi Evi Kartika Maharani Farabilla Fredela Farida, Novi Fayza Eka Zhafirah Gabriel Wanda Sinawang Geladis Titanik Herley Windo Setiawan Ika Yuni Widyawati Irawan, Arizka Dwi Ishomatul Faizah Joni Haryanto Kittisak Kumpeera Kurniawan, Dwi Agus Kurniawati, Ninuk Dian Kusnanto Kusnanto Lailatun Ni&#039;mah Lailatun Ni'mah Lailatun Ni'mah Lailatun Ni’mah Laily Hidayati Laura Navika Yamani Lee, Bih-O Lie Liana Fuadiati Lingga Curnia Dewi Lingga Curnia Dwi Maria Fatima Koa Merryana Adriani Muhammad Abi Zakaria Nihayati, Hanik Endang Nimah, Lailatun Nuring Pangastuti Nursalam Nursalam Nursalam, Nursalam Pahlevi Betsytifani Paramita, Fajrinandetya Pawanis, Zulfayandi Prabawati, Dita Dwi Oktav Pradanie, Retnayu Puspitasari, Tari Okta Putri, Malinda Kurnia Qona'ah, Arina Qonaah, Arina Qothrunnadaa, Azka R Endro Sulistyono Ramoo, Vimala Rista Fauzinigtyas Rista Fauziningtyas, Rista Rofiqa Dwi Febriyanti RR Dian Tristiana Santos Ximenes, Herminia dos Sari Tauhidiyah Sari, Purwanti Nurvita Sekar Arum Firdausi Siti Nur Qomariah Suharyono Suharyono Sukartini, Titin Sylvia Dwi Wahyuni Tintin Sukartini Sukartini, Tintin Sukartini Titanik, Geladis Tri Agustiningsih Wahyuni, Erna Dwi Wardani, Indrasari Winda Gusya Wynne Faiza Rosada Yahaya, Nor Aziyan Yulis Setiya Dewi