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All Journal CHEMPUBLISH JOURNAL JIP: Jurnal Ilmiah PGMI Jurnal Dakwah dan Komunikasi JEPA (Jurnal Ekonomi Pertanian dan Agribisnis) JURNAL EKSAKTA PENDIDIKAN (JEP) Jurnal Kolaboratif Sains Jurnal Literasiologi PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat SCAFFOLDING: Jurnal Pendidikan Islam dan Multikulturalisme Prosiding National Conference for Community Service Project Jurnal Manajemen Mandiri Saburai (JMMS) Jurnal Ilmiah Berkala: Sains dan Terapan Kimia JURNAL ILMU MANAJEMEN SABURAI (JIMS) Ekombis Sains: Jurnal Ekonomi, Keuangan dan Bisnis Jurnal Sosial dan Humanis Sains Jurnal Ilmiah Ilmu-Ilmu Peternakan Indonesian Journal of Multidisciplinary on Social and Technology Indonesian Journal of Innovation Multidisipliner Research Journal of International Multidisciplinary Research Jurnal Pengabdian UMKM Journal of Accounting Law Communication and Technology Celebes Journal of Community Services JURNAL REKAYASA KIMIA & LINGKUNGAN Indonesian Journal of Innovation Multidisipliner Research
Nelson Nelson
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Engineering Environmental Science Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Physics Public Health Social Sciences Other

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Journal : CHEMPUBLISH JOURNAL

 1 
Anticancer Activities of Seven Peronemins (A2, A3, B1, B2, B3, C1, and D1) from Peronema canescens Jack: A Prediction Studies Fikriansyah, Muhammad; Nelson, Nelson; Latief, Madyawati; Tarigan, Indra Lasmana
Chempublish Journal Vol. 7 No. 1 (2023): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v7i1.23726

Abstract

Cancer is one of the leading causes of human death. In 2019, it was reported that cancer was the second (22%) cause of death due to non-communicable diseases in the world's population. Research for alternative anticancer drugs is still being done, including anticancer from plants. One of the plants that have the potential to be developed as an anticancer alternative is the sungkai plant. Sungkai leaves contain many bioactive compounds, one of which is the clerodane-type diterpenoids, peronemins, A2 (1), A3 (2), B1 (3), B2 (4), B3 (5), C1 (6), and D1 (7). The aim of this study was to initial screen the potential of seven Peronemins compounds in Sungkai leaves extract as anticancer candidates. Initial screening was carried out by predicting in-silico anticancer activity of the seven compounds. Dihydrofolate reductase inhibitor (DHFR inhibitor) is one of the anticancer activity screening approaches. DHFR Inhibitor activity from perenomins derivatives with pIC50 values ​​of 0.785 (A2), respectively; 0.785 (A3); 0.799 (B2); 0.799 (B3); 0.799 (C1 and D1). In addition, from compounds 1,2,3,4,5 peronemin derivatives have potential anticancer activity through interaction with the target protein Voltage-gated potassium channel subunit while compounds 6, 7 also have biological activity potential anticancer on target protein Dihydrofolate reductase.
Isolasi Proses Bioaktif Ekstrak Metanol Daun Putat (Planchonia valida) sebagai Antioksidan Farid, Faizar; Br Sembiring, Vera Lorensya; Nelson, Nelson; Saputra, Muhammad Furqon Novryan; Putri, Silvi Ayudiah; Tarigan, Indra Lasmana; Latief, Madyawati
Chempublish Journal Vol. 6 No. 4 (2022): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v6i4.41634

Abstract

Putat leaves (Planchonia valida) are a plant that is traditionally used by people in the Tanjung Lanjut areas, Jambi as fresh vegetables, and as a traditional medicine to treat skin diseases and restore health. This identifies that the putat plant contains chemical compounds that have the potential to have antioxidant activity. Extraction was carried out using n-hexane and ethyl acetate solvents using multistage maceration. Next, phytochemical screening and antioxidant activity tests are carried out to obtain information about fractions that can potentially proceed to the isolation stage. In the maceration process, an extract percentage was obtained with a yield value of 1.39%. Next, isolation was carried out using vacuum liquid chromatography. The isolates obtained were then characterized using UV-Vis and FT-IR spectrophotometer instruments. The isolate obtained was in the form of a wet solid, and if seen through characterization, it belonged to the class of steroid compounds; it was suspected to be an ergosterol compound. Antioxidants are known to have the ability to inhibit and reduce the presence of free radicals in the human body. In this study, antioxidant activity was tested using the DPPH (2,2-diphenyl-1-picrihidazil) method on F1 isolates. The F1 isolate obtained was proven to have antioxidant activity with a value of 99.2265 ppm, which is classified in the strong antioxidant activity range.
Co-Authors Abdiyantoro, Restu Aksan, Aksan Amrullah Amrullah Andari, An An Andi Warisno Ang, Pendi Ansori, Afif Aprilson, Leonardo Arrohmatan, Arrohmatan Br Sembiring, Vera Lorensya Bunga, Yulita Karolina Christy, Christy Diah Riski Gusti Diana Sari, Novita Elina, Maria Elva Rahmi Fitri Faizar Farid Fergiawan, Fergiawan Fikriansyah, Muhammad Hadinata, Frans Hafizah, Tamama Henni Kusumastuti Hertanti, Hertanti Hesti Widi Astuti Idi Warsah Ikhsan, Adisyahfitri Evalina Imelda Aprilia Indra Lasmana Tarigan Intan Lestari Junaidi, Riskan Junaiedi, Ahmad Kazuo, Jeydhen Khairul Saleh Kho, Jensen Lies Kumara Dewi Madyawati Latief Maristiana Ayu Meikel, Meikel Mellina, Elvi Muhammad Hasan Muhammad Idris Muhammad Idris Muhammad Nasir Mustajada, Nafaisul Mustajadah, Nafaisul Naufal, Dzaki Ngadri, Ngadri Niar Azriya nuralang, nuralang Nurhadiansyah, Nurhadiansyah Nurmiati Nurmiati Putri Ramadhanti Putri, Silvi Ayudiah Rauf, Eka Ubaya Taruna Ria Gracia Sibarani Rita Erlinda Samudin, Mohammad Tofan Saputra, Muhammad Furqon Novryan Saputra, Roja Saputra, Yedi Irawan Sari, Novita Diana Sasora, Fajar Selviani, Rani Sri Rahmaningsih suhari, matson Sulpina, Musmuhediyanto, Susanto, Nindita Clourisa Amaris Swardana, Ryan Usman, Mursalin Wahid, Asdinar widodo, Rahmat Wiwik Damayanti, Wiwik Yeo, Sky Leonardo