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All Journal Majalah Kedokteran Bandung Althea Medical Journal Global Medical and Health Communication Jurnal Media Gizi Indonesia (MGI) Molecular and Cellular Biomedical Sciences (MCBS) AcTion: Aceh Nutrition Journal Jurnal Gizi Klinik Indonesia Jurnal Pendidikan dan Pelayanan Kebidanan Indonesia (Indonesian Journal of Education and Midwifery Care) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Jurnal Health Sains Jurnal Ilmu Faal Olahraga Indonesia Penelitian Gizi dan Makanan (The Journal of Nutrition and Food Research)

Gaga Irawan Nugraha

Fakultas Kedokteran Universitas Padjadjaran

Author-ID : 332775

Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

Published : 28 Documents Claim Missing Document

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A Literature Review on the Relationship between Iron and Zinc Levels in Diabetes Mellitus and the Effects of Their Supplementation Sefti Atletika Asiani; Gaga Irawan Nugraha; Sunarjati Sudigdoadi
Budapest International Research and Critics Institute (BIRCI-Journal): Humanities and Social Sciences Vol 4, No 3 (2021): Budapest International Research and Critics Institute August
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birci.v4i3.2495

This study aims to review the relationship between iron and zinc in diabetes mellitus and the effects of iron and zinc supplementation on changes in blood glucose levels. The results showed that diabetes mellitus was associated with low zinc levels and high levels of iron in body serum, as well as low iron levels in diabetes mellitus with iron deficiency anemia. Zinc supplementation in diabetes mellitus and iron in diabetes mellitus with iron deficiency anemia can reduce levels of fasting blood glucose and hemoglobin A1c. Nutritional therapy with zinc and iron supplements can decrease blood glucose levels with results that are influenced by dosage and period of supplementation. Screening for iron deficiency anemia needs to be done in diagnosing diabetes mellitus and implementing nutritional therapy with biomarkers of blood sugar levels in serum.

Hubungan pengetahuan, sikap, perilaku dan karakteristik ibu tentang ASI eksklusif terhadap status gizi bayi Seni Rahayu; Henni Djuhaeni; Gaga Irawan Nugraha; Gurid Eko Mulyo
AcTion: Aceh Nutrition Journal Vol 4, No 1 (2019): AcTion Vol 4 No 1 Tahun 2019
Publisher : Jurusan Gizi Politeknik Kesehatan Kemenkes Aceh

Exclusive breastfeeding is very beneficial for babies. The impact is not given exclusive breastfeeding could be increased morbidity and mortality, nutritional problems, impaired child growth, loss generation, increase the burden of family and state expenditures for the expenditure of formula milk and much more. The purpose of this study was to analyze the relationship of knowledge, attitudes, behaviors and characteristics of mothers towards exclusive breastfeeding with infant nutritional status. This study used a quantitative method with analytic observational design with a case control.. The study was conducted by 110 mothers who had babies aged 6-12 months in the Cibangkong Bandung village. It was consisting of 55 mothers who had babies with nutritional problems and 55 mothers who had babies with normal nutritional status. Data retrieval used a questionnaire. Assessment of nutritional status used the standard WHO child growth standards. The sample was taken by simple random sampling technique. Data analysis using logistic regression test. The results of the analysis showed that there was a relationship between knowledge (p= 0,006), and exclusive breastfeeding behavior (p= 0,013) with the nutritional status of the baby. In addition, maternal characteristics had an effect of 4,3 times to age and parity in the nutritional status of infants. By knowing the relationship between knowledge factors, attitudes, behaviors and characteristics of mothers with infant nutritional status, it is expected to have leverage to improve the nutritional status of infants. ASI eksklusif sangat bermanfaat bagi bayi, dampak yang dapat terjadi apabila bayi tidak diberikan ASI eksklusif adalah meningkatnya angka kesakitan dan kematian bayi, masalah gizi, gangguan tumbuh kembang anak, terjadinya loss generation, meningkatkan beban pengeluaran keluarga serta negara untuk pengeluaran susu formula dan masih banyak lagi. Tujuan penelitian untuk menganalisis hubungan pengetahuan, sikap, perilaku dan karakteristik Ibu terhadap pemberian ASI eksklusif dengan status gizi bayi. Penelitian menggunakan metode kuantitatif dengan desain observasional secara kasus kontrol. Penelitian dilakukan 110 ibu yang memiliki bayi usia 6-12 bulan di kelurahan Cibangkong Bandung yang terdiri dari 55 ibu yang memiliki bayi dengan masalah gizi dan 55 ibu yang memiliki bayi dengan status gizi normal. Pengambilan data menggunakan kuesioner. Penilaian status gizi menggunakan standar WHO child growth standards. Sampel diambil dengan teknik simple random sampling. Analisis data menggunakan Uji Regresi logistik. Hasil menunjukkan bahwa terdapat hubungan antara pengetahuan (p= 0,006), dan perilaku pemberian ASI eksklusif (p=0,013) dengan status gizi bayi. Selain itu, karakteristik ibu yaitu umur dan paritas berpengaruh sebesar 4,3 kali dalam status gizi bayi. Dengan diketahuinya hubungan faktor pegetahuan, sikap, perilaku dan karakteristik ibu dengan status gizi bayi, diharapkan mempunyai daya ungkit terhadap peningkatan status gizi bayi.

Effect of ZN Suplementation on Blood Glucose Levels and Insulin Resistance in Diabetes Mellitus Sefti Atletika Asiani; Gaga Irawan Nugraha; Sunarjati Sudigdoadi
Jurnal Health Sains Vol. 2 No. 11 (2021): Jurnal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v2i11.337

Diabetes mellitus (DM) is a metabolic disorder characterized by high levels of glucose in the blood. Micromineral levels are related to the mechanism of glucose homeostasis. The abnormal zinc levels can be risk factors for DM. Improvement of micro-mineral levels can improve blood sugar levels. This study aimed to review the effects of zinc supplementation on blood glucose levels and insulin resistance. This study showed that DM was associated with low zinc levels in body serum. Zinc supplementation reduced fasting blood glucose, hemoglobin A1c levels, and insulin resistance in rat model DM and human researchs. It occurs in many types of Zn supplements. Differences in results may be due to differences in the characteristics of the subjects, doses, and periods of administration. Zn can be used for nutritional therapy in DM by considering the dose and period of supplementation, and patient characteristics to get optimal results

Status gizi, asupan energi, dan serat sebagai faktor risiko kardiometabolik pada remaja pendek Siti Nur Fatimah; Ambrosius Purba; Kusnandi Rusmil; Gaga Irawan Nugraha
Jurnal Gizi Klinik Indonesia Vol 13, No 1 (2016): Juli
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.22682

Background: Prevalence of stunted adolescents is important because related with the cardiometabolic risk factor. Control of risk factors reduces the comorbidity including body mass index (BMI) control. Improvement of environmental factors such as energy and fiber intake contribute to reducing disease risk. Objective: This study aimed to analyze the relationship of a stunted adolescent with BMI, energy and fiber intake. Method: This study used cross-sectional design. The subject consisted of early adolescents with 10 to 14 years old in Jatinangor district, West Java. Determination of short stature and BMI refers to the WHO Growth Chart 2005. Data collection by the measure of height, weight, BMI calculation, and interviewed food intake by 3x24 hour food recall and analyzed with Nutrisurvey program. Statistical analysis by Mann-Whitney U test. Results: A total of 212 participants (106 stunted and 106 non-stunted) were enrolled. The proportion of stunted girls is 58 (54,9%) and stunted boys 48 (45,1%). Average of BMI in stunted is 17,15 (2,59) kg/m2 and 18,38 (3,33) kg/m2 in non-stunted, energy intake is 1.488,83 (513,52)kcal in stunted and 1.704,32 (663,49) in non-stunted, fiber intake is 4,36 (1,18) g in stunted and 4,53 (2,15) g in non stunted. There are significant differences in all variables between stunted and non-stunted with a p value for BMI 0,017, in energy intake 0,034 and fiber intake 0,032. BMI showed the correlation with disease risk. including cardiometabolic diseases in stunting. Energy intake and low fiber in growth age increase the risk of cardiometabolic diseases because in stunting have a low metabolic adaptation in protein synthesis and fat oxidation. Conclusion: The study shows there is a difference between BMI, energy intake and fiber in the stunted adolescent and non-stunted adolescent. Further research needs to analyze another risk fctor and intervention to improve nutrition status and metabolic condition.

Peran Penerapan Model Pembelajaran Asuhan Persalinan Kala III dan IV Terintegrasi Terhadap Motivasi dan Kompetensi Mahasiswa Serta Kepuasan Pasien Pada Praktik Klinik Kebidanan Lasiyati Yuswo Yani; Gaga Irawan Nugraha; Firman Fuad Wirakusumah; Farid Husin; Ishak Abdulhak; Vita Murniati Tarawan; Oki Suwarsa
Jurnal Pendidikan dan Pelayanan Kebidanan Indonesia (Indonesian Journal of Education and Midwifery Care Vol 2, No 4 (2015): Desember
Publisher : Program Studi Magister Kebidanan FK UNPAD

Model pembelajaran asuhan kebidanan saat ini belum menjawab kebutuhan masyarakat, sehingga diperlukan model pembelajaran alternatif dalam rangka memenuhi kebutuhan masyarakat dalam hal komptensi bidan. Model pembelajaran terintegrasi merupakan model pembelajaran yang sistematis dan komprehensif sehingga tujuan penerapan model ini meningkatkan motivasi dan kompetensi mahasiswa dalam praktik klinik kebidanan pada akhirnya diharapkan akan menimbulkan kepuasan pasien pada layanan yang diberikan mahasiswa pada praktik klinik kebidanan. Metode penelitian analitik dengan rancangan penelitian quasy experiment dengan pre test post test design. Pengambilan sampel dilakukan dengan cara total populasi dengan subjek penelitian mahasiswa DIII Kebidanan Universitas Sebelas Maret (UNS) Surakarta semester IV dengan jumlah 37 mahasiswa dan ibu postpartum yang persalinan kala III dan IV nya ditolong oleh mahasiswa. Analisis uji Wilcoxon untuk menilai perbedaan motivasi dan kompetensi (pengetahuan, sikap dan keterampilan) mahasiswa sebelum dan sesudah penerapan model pembelajaran. Uji Rank Spearman untuk mengetahui korelasi antara motivasi dan kompetensi (pengetahuan, sikap dan keterampilan) dengan kepuasan pasien, serta Uji regresi linier untuk menganalisis peran kompetensi (pengetehuan, sikap dan keterampilan) terhadap kepuasan pasien. Hasil penelitian motivasi dan kompetensi meningkat setelah penerapan (p<0,05), dengan peningkatan 45,06% motivasi dan kompetensi, 45,06% pada aspek pengetahuan, 42,06% pada aspek sikap, 53,83% pada aspek keterampilan. Motivasi tidak berkorelasi terhadap kompetensi dengan p>0,05. Kompetensi (pengetahuan, sikap dan keterampilan) berkorelasi terhadap kepuasan p<0,05 pasien dengan variabel sikap mempunyai korelasi cukup erat terhadap kepuasan dengan nilai koefisien korelasi sebesar 0,687 pada r² 47,2%. Simpulan dalam penelitian ini adalah penerapan model pembelajaran asuhan persalinan kala III dan IV meningkatkan motivasi dan kompetensi (pengetahuan, sikap dan keterampilan) mahasiswa. Motivasi tidak berkorelasi terhadap kompetensi mahasiswa, hal ini dapat disebabkan oleh faktor mahasiswa, lingkungan keluarga, dan lingkungan pembelajaran. Kompetensi berperan terhadap kepuasan pasien pada asuhan yang diberikan mahasiswa pada praktik klinik kebidanan. Kompetensi yang paling berperan terhadap kepuasan pasien terletak pada aspek sikap.

The Effect of Mixed-Fruit Juice on Uterine Contractions and Cervical Dilatation During the First Stage of Delivery Martasari, Bellia Loranthifolia; Cahyadi, Wisnu; Nugraha, Gaga Irawan; Husin, Farid; Susiarno, Hadi; Hidayat, Yudi Mulyana; Satari, Mieke Hemiawati
Global Medical & Health Communication (GMHC) Vol 7, No 1 (2019)
Publisher : Universitas Islam Bandung

Energy imbalance in delivery can inhibit the action of glycolytic enzymes and interfere with chemical reactions in muscle cells. These nuisances may interfere with uterine contractions that obstruct cervical dilatation. Therefore, mothers require a nutritional alternative which is practical, generates energy quickly and supplies glucose needed for uterine contractions. These can be fulfilled with a mixed-fruit juice beverage. Mixed-fruit juice consists of fruits, Tunisian dates, honey, and red beans. This study aims to analyze the effect of the mixed-fruit extract on uterine contraction and cervical dilatation during the first stage of delivery. This study used a randomized controlled trial design. The target population was all the mothers who would give birth in Bandung city in March−April 2017. The samples of this study were the gravida <4 who would give birth at the Pelayanan Obstetri Neonatal Emergensi Dasar/PONED (Basic Emergency Obstetric and Neonatal Care/BEONC) Puskesmas (Public Health Center) Ibrahim Ajie, Puter, Garuda, Pagarsih, and Padasuka, consisting of 30 subjects as the treatment group and other 30 subjects as the control group. Uterine contractions and cervical dilatation were measured clinically and recorded on partograph. The analysis of data was done using the chi-square test, independent t test, and Mann-Whitney test. The results showed that there was the effect of mix-juice on the frequency, the duration and the intensity of uterine contractions and cervical dilatation with p value<0.05 and relative risk (RR) values respectively of 1.3, 3.3, 2.6, 1.7. In conclusion, consuming mixed-fruit juice during the first stage of delivery give a significant impact on the progress of uterine contractions and cervical dilatation.PENGARUH PEMBERIAN MINUMAN MIX JUICE TERHADAP KONTRAKSI UTERUS DAN PEMBUKAAN SERVIKS SELAMA KALA I PERSALINANKetidakseimbangan energi saat persalinan dapat menghambat kerja enzim glikolitik dan mengganggu reaksi kimia dalam sel otot sehingga dapat menghambat kontraksi otot dan pembukaan serviks. Perlu alternatif nutrisi ibu bersalin yang praktis, cepat menghasilkan energi, dan memberikan asupan glukosa yang dibutuhkan untuk kontraksi uterus dalam bentuk minuman mix juice. Mix juice ini mengandung buah-buahan, kurma tunisia, madu, dan kacang merah. Penelitian ini bertujuan menganalisis pengaruh pemberian minuman mix juice terhadap kontraksi uterus dan pembukaan serviks selama kala I persalinan. Penelitian ini menggunakan desain randomized controlled trial. Populasi target adalah semua ibu yang akan melahirkan di Kota Bandung pada bulan Maret−April 2017. Sampel dalam penelitian ini adalah gravida <4 yang akan melahirkan di Puskesmas Pelayanan Obstetri Neonatus Emergensi Dasar (PONED) Ibrahim Ajie, Puter, Garuda, Pagarsih, dan Padasuka, yaitu 30 subjek pada kelompok perlakuan dan 30 subjek pada kelompok kontrol. Kontraksi uterus dan pembukaan serviks diukur secara klinis dan dicatat pada partograf. Analisis data menggunakan uji chi-kuadrat, uji t independen, dan Uji Mann-Whitney. Hasil penelitian didapatkan pengaruh pemberian minuman mix juice terhadap frekuensi, lama dan intensitas kontraksi uterus, serta pembukaan serviks dengan nilai p<0,05 dan nilai RR masing-masing sebesar 1,3; 3,3; 2,6; 1,7. Simpulan, pemberian minuman mix juice selama kala I persalinan berpengaruh terhadap kemajuan kontraksi uterus dan pembukaan serviks.

The μDrop Method Enhances Melanin Content Measurement in the in vitro Melanogenesis Model Using B16F10 Cell Line Yuliarni, Dinda; Kamilah, Mutiara Mila; Nugraha, Gaga Irawan; Faridah, Lia; Bashari, Muhammad Hasan; Ekawardhani, Savira
Molecular and Cellular Biomedical Sciences Vol 9, No 1 (2025)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v9i1.527

Background: The B16F10 cell line is a cell frequently used in melanin content assays. However, reports on cell models using B16F10 are limited, particularly as the robust model cell in the Indonesian cosmetics industry. We found measuring melanin content using microplate spectrophotometry to be challenging, so this research was conducted to develop a method using μDrop spectrophotometry.Materials and methods: In this in vitro study, the B16F10 melanoma cell line was cultured in Roswell Park Memorial Institute (RPMI) medium containing 5% fetal bovine serum (FBS). The cells were categorized into control, stimulated, and treated groups. Melanogenesis stimulation was achieved using 1μM α-melanocyte-stimulating hormone (α-MSH), while inhibition using 800 μg/ml kojic acid. After treatment, the cells were incubated for 48 hours. Their melanin content was then measured using an ELISA reader with a μDrop method and compared with the microplate method. Statistical analysis used a one-way ANOVA test with Turkey’s Post Hoc analysis.Results: The μDrop method increased the melanin signal into the linear range of machine readings, while the signals from the microplate method fell far below this range. The B16F10 melanoma cell lines stimulated by α-MSH exhibited increased melanin production compared with the control group, while kojic acid treatment significantly reduced (p<0.05) melanin content in the stimulated group.Conclusion: The μDrop method significantly outperformed the microplate method in measuring melanin content within melanogenesis cell models, offering enhanced accuracy and particularly excelling at quantifying low content of melanin. Keywords: μDrop, microplate, melanin, melanogenesis, B16F10 cell line, RPMI

HUBUNGAN PENGUKURAN LEMAK SUBKUTAN DENGAN INDEKS MASSA TUBUH PADA LAKI-LAKI USIA LANJUT Siti Nur Fatimah; Leva B Akbar; Ambrosius Purba; Vita Murniati Tarawan; Gaga Irawan Nugraha; Putri Tessa Radhiyanti; Titing Nurhayati
Penelitian Gizi dan Makanan (The Journal of Nutrition and Food Research) Vol. 40 No. 1 (2017)
Publisher : Persagi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/pgm.v40i1.6295.

Degenerative diseases are associated with obesity. Body mass index (BMI) measurement is a way to measure disease risk,howeverfat mass more explain metabolic conditions associated with degenerative diseases. Research shows consistent relation between these two parameters with diseases risk. This study aims to determine the association of fat mass by skinfold thickness measurement with BMI. The study design was observational with cross-sectional approach. This research was done at the UniversitasPadjadjaran in 2015. The number of subjects were 96 men with the inclusion criteria over 50 years, exclusion criteria have abnormal posture and edema. Statistical analysis used Spearman rank correlation test and a simple linear regression. Characteristics of age 67.98 (SD: 9.81) years, height 1.61 (SD: 0.61) m, weight 66.67 (SD: 10.74) kg, BMI: 26.28 (SD 3,55) kg / m2, body fat: 30.98 percent. The distribution of nutritional status category: underweight 2 percent, normoweight 11.9 percent, overweight 27.27 percent, obese 58.4 percent. Fat mass category: normal category 41.6 percent and overfat 58.4 percent. Correlation between fat mass with age of 0.094 percent, with heights 0.14 percent and with a BMI 0.55 percent. Simple linier regression analysis shows the equation: percent fat mass = 2,757 + 0.089. This equation means every increase of 1 BMI will increase the fat mass percent by (2.757 + 1*0.089)2. The implications of this equation show that BMI can predict fat mass in elderly men based on subcutaneous fat thicknessmeasurements. Penyakit degeneratif berhubungan dengan faktor risiko obesitas. Pengukuran indeks massa tubuh (IMT) merupakan cara untuk mengukur risiko penyakit, tetapi massa lemak dapat menggambarkan kondisi metabolik yang berhubungan dengan penyakit degeneratif. Penelitian menunjukkan hubungan konsisten antara kedua parameter ini dengan risiko penyakit. Penelitian ini bertujuan untuk mengetahui hubungan antara massa lemak berdasarkan pengukuran tebal lemak subkutan dengan IMT. Disain penelitian adalah observasional dengan pendekatan potong lintang. Penelitian dilakukan di kampus Universitas Padjadjaran tahun 2015. Jumlah subjek 96 laki-laki dengan kriteria inklusi di atas 50 tahun, kriteria ekslusi memiliki postur tubuh tidak normal dan edema. Variabel bebas adalah umur, tinggi badan dan IMT, variabel tergantung adalah massa lemak. Analisis statistik menggunakan uji korelasi Spearman rank dan uji regresi linier sederhana.Karakteristik usia 67,98(SD: 9,81) tahun, tinggi badan 1,61(SD : 0,61) m, berat badan 66,67 (SD : 10,74) kg, IMT: 26,28 (SD : 3,55) kg/m2, lemak tubuh: 30,98 persen.Sebaran kategori status giziterdiri dari berat badan kurang 2 persen, normal 11,9 persen, berat badan lebih 27,27 persen, obesitas 58,4 persen. Kategori massa lemak terdiri dari kategori normal 41,6 persen dan lebih 58,4 persen. Korelasi antara massa lemak dengan usia0,094 persen, dengan tinggi badan 0,14 persen dan dengan IMT 0,55 persen. Analisis regresi linier menghasilkan persamaan: persen massa lemak = 2,757 + 0.089 (IMT). Persamaan ini mempunyai arti setiap peningkatan 1 IMT akan meningkatkan persen massa lemak sebesar (2,757 + 1*0,089)2. Implikasi persamaan ini memperlihatkan IMT dapat memprediksi massa lemak pada laki-laki lanjut usia berdasarkan pengukuran tebal lemak subkutan.

Co-Authors - Yusnita, - Achadiyani Ambrosius Purba Ambrosius Purba Ambrosius Purba Armijn Firman Armijn Firman, Armijn Bashari, Muhammad Hasan Budi Setiabudiawan Cafrina, Gabriella Dany Hilmanto Dewi, Ni Wayan Eka Rahayu Dida Akhmad Gurnida Dida Akhmad Gurnida Dwi Agustian Elissa Evanti Widjaja Farid Husin Farid Husin Firman Fuad Wirakusumah Gabriella Cafrina Gloria Kartika Gurid PE Mulyo Henni Djuhaeni Hikmat Permana Husin, Farid I Made Jawi Irma Ruslina Defi Kamilah, Mutiara Mila Kartika, Gloria Kasmanto, Hendro Kavita Arumugam Kavita Arumugam, Kavita Kusnandi Rusmil Kusnandi Rusmil Lasiyati Yuswo Yani Leva B Akbar Lia Faridah Lisda Amalia Lola Ilona Lukman Pura Lynna Lidyana Lynna Lidyana Martasari, Bellia Loranthifolia Mieke Hemiawati Satari Mieke Hemiawati Satari Monita Sugianto Oki Suwarsa Putri Tessa Radhiyanti Rachmat Soelaeman Rezah Andriani Ria Bandiara Rudi Supriyadi Savira Ekawardhani Sefti Atletika Asiani Sefti Atletika Asiani Seni Rahayu Setiawan Setiawan Siti Nur Fatimah Siti Nur Fatimah Siti Nur Fatimah Sri Hartini K. S. Kariadi Stephanus Kristianto Witono Sudigdo Adi Sunarjati Sudidgo Adi Sunarjati Sudigdoadi Sunarjati Sudigdoadi Sunarjati Sudigdoadi Susiarno, Hadi Tiara Aulia Maisyarah Tiara Aulia Maisyarah Titing Nurhayati Vita Murniati Tarawan Vita Murniati Tarawan Vitriana Vitriana Yenni Zuhairini Yesi Herawati Yudi Mulyana Hidayat Yuliarni, Dinda Zulmansyah , Zulmansyah

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