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All Journal Nurse Media Journal of Nursing Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kesehatan Andalas The Indonesian Biomedical Journal Biomedical Journal of Indonesia Jurnal Ilmiah Universitas Batanghari Jambi Jurnal Keperawatan Silampari JURNAL KESEHATAN PERINTIS Journal of Midwifery Majalah Kedokteran Andalas Jurnal Kesehatan Majalah Patologi Indonesia Jurnal Biomedika Jurnal Ners Journal of Telenursing (JOTING) Bioscientia Medicina : Journal of Biomedicine and Translational Research Cermin Dunia Kedokteran Jurnal Ilmu Kesehatan Indonesia (JIKSI) Indonesian Journal of Cancer Jurnal Sains, Teknologi dan Kesehatan Media Penelitian dan Pengembangan Kesehatan Cermin Dunia Kedokteran Biodiversitas Journal of Biological Diversity
Wirsma Arif Harahap
Bagian Bedah Fakultas Kedokteran Universitas Andalas
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Determinants of Physical and Mental Health-related Quality of Life among Patients with Breast Cancer During COVID-19 Pandemic Jamil, Mohd; Merdawati, Leni; Krisdianto, Boby Febri; Khambri, Daan; Harahap, Wirsma Arif; Arifin, Hidayat
Nurse Media Journal of Nursing Vol 13, No 3 (2023): (December 2023)
Publisher : Department of Nursing, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/nmjn.v13i3.54738

Abstract

Background: The concern surrounding the physical and mental health-related quality of life (HRQoL) among patients with breast cancer emerged during COVID-19. However, there is a lack of sufficient studies that have specifically addressed this issue. It is crucial to emphasize the evaluation of this aspect as it significantly impacts the enhancement of future physical and mental HRQoL for these patients.Purpose: This study investigated the determinants of physical and mental HRQoL among patients with breast cancer during COVID-19.Methods: In a cross-sectional study conducted between September and October 2022, participation involved 260 patients diagnosed with breast cancer, selected through convenience sampling. Our observation focused on assessing the outcomes of physical and mental HRQoL using the Short Form (SF-12) questionnaire for data collection. Additionally, the data underwent analysis via binary logistic regression.Results: Respondents aged <50 years (p=0.010; aOR=2.08; 95% CI=1.18–3.67), unemployed (p=0.022; aOR=2.29; 95% CI=1.16–4.53), and had high depression (p=0.026; aOR=2.41; 95% CI=1.13–5.12) have a more likelihood to have low physical HRQoL. In addition, unemployed respondents (p=<0.001; aOR=4.15; 95% CI=2.14–8.04) and had high anxiety (p=0.004; aOR=2.71; 95% CI=1.38–5.33) have more likelihood to have low mental HRQoL.Conclusion: In this study, it was found that anxiety, depression, and unemployed respondents were associated with a higher likelihood of experiencing lower physical and mental HRQoL. Nurses and healthcare workers should prioritize addressing psychological issues such as anxiety and depression among breast cancer patients, emphasizing the necessity for interventions aimed at alleviating these concerns. 
Mutation of BRCA1/2 Gene in Premenopausal Triple-Negative Breast Cancer Patients in West Sumatera Harahap, Wirsma Arif; Khambri, Daan; Panigoro, Sonar Soni; Hafiz, Muhammad Zaki Abdul
Indonesian Journal of Cancer Vol 19, No 1 (2025): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i1.1255

Abstract

Background: The BRCA1/2 mutation rate was found to be higher in triple-negative breast cancer (TNBC) patients depending on young age, and the presence of a family history of breast cancer and ovarian cancer. Research on BRCA1/2 germline mutations that focused on premenopausal TNBC patients in Indonesia has never been carried out. The objective of this research is to determine the BRCA1/2 germline gene mutation status in premenopausal TNBC patients in West Sumatra.Methods: This is a descriptive study conducted at the Surgical Oncology Division of DR. M. Djamil Hospital, Padang from April to July 2023. This study included patients aged 50 years who were diagnosed with the TNBC subtype at Dr. M. Djamil Hospital, Padang from January 2016 to July 2023. Secondary data was collected through the patient’s medical records to observe the TNBC patient’s characteristics. A blood test of TNBC patients was carried out to determine germline mutation of BRCA1/2.Results: 22 patients with TNBC participated in the study. In this study, 4/22 (18.2%) had BRCA2 pathogenic mutations and no BRCA1 pathogenic mutation was found. All patients with BRCA2 pathogenic mutation have the same mutation characteristics, i.e exon 3, genetic variation (c.262_263delCT), amino acids (p.Leu88AlafsTer12), and type of mutation (Frameshift Deletion). Conclusions: TNBC patients in West Sumatra have BRCA2 pathogenic mutations with the same characteristics as the mutations
Serum Prolactine Levels and Prolactine Receptor Expression in Premenopausal Breast Cancer: A Potential Predictive Biomarker? Effif Syofra Tripriadi; Sinta Chaira Maulanisa; Nur Indrawati Lipoeto; Yanwirasti Yanwirasti; Fadil Oenzil; Wirsma Arif Harahap; Tania Nugrah Utami; Farah Mardhiyah
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.52299

Abstract

Introduction: Premenopausal breast cancer (PBC) is often more aggressive than postmenopausal cases, with prolactin playing a key role in tumor development. This study examines the relationship between serum prolactin levels, prolactin receptor (PRLR) expression, and clinicopathological features in PBC patients. Methods: This cross-sectional study was conducted from 2021 - 2022 at multiple hospitals in Pekanbaru, Indonesia. Thirty-five PBC patients and 35 healthy controls were included. Serum prolactin levels were measured using ELISA, and PRLR expression was assessed via IHC. Statistical analysis was performed using independent t-tests and correlation analysis (p < 0.05). Results: PBC patients had higher prolactin levels (51.96±80.40 ng/mL) than controls (20.83±15.74 ng/mL, p = 0.031). PRLR expression was detected in over 90% of tumors, with a significant correlation between prolactin levels and cancer stage (p = 0.035). Discussion: These findings suggest prolactin contributes to PBC progression, with higher levels linked to advanced stages, possibly through JAK2/STAT5 signaling. Conclusion: Serum prolactin levels and PRLR expression are associated with cancer stage, supporting their potential as biomarkers for early detection and disease progression. Further studies are needed for validation.
Validity and reliability test of the knowledge level questionnaire of cancer patients undergoing radiotherapy Hanum, Fathiya Juwita; Machmud, Rizanda; Gondhowiardjo, Soehartati; Khambri, Daan; Harahap, Wirsma Arif; Elliyanti, Aisyah; Firdawati, Firdawati; Semiarty, Rima
Media Penelitian dan Pengembangan Kesehatan Vol. 36 No. 1 (2026): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v36i1.3604

Abstract

Background: Radiotherapy is one of the main modalities in cancer treatment. The success of this therapy is strongly influenced by the knowledge of patients about the disease and radiotherapy. The researcher developed a questionnaire to measure the level of knowledge among cancer patients undergoing radiotherapy. Objective: This study aimed to assess the validity and reliability of a knowledge-level questionnaire for cancer patients receiving radiotherapy at Dr. M. Djamil General Hospital, Padang. Methods: This research employed a quantitative approach with a cross-sectional design. A total of 30 cancer patients undergoing radiotherapy were included as respondents using a consecutive sampling technique. The questionnaire instrument was developed by the researcher and consisted of 25 items covering five domains of knowledge: cancer, radiotherapy, side effects, self-care, and nutrition. Results: Validity testing was conducted using Pearson’s correlation analysis, while reliability was assessed using Cronbach’s Alpha. Out of the 25 items, 19 were statistically valid (p<0.05), with correlation coefficients (r) ranging from moderate to strong (0.470–0.745). The Cronbach’s Alpha value for the valid items was 0.904, indicating excellent reliability. Conclusion: The developed questionnaire was proven to be both valid and reliable for measuring the knowledge level of cancer patients undergoing radiotherapy. This instrument has the potential to be used in clinical practice and research to support more targeted educational interventions.
Association of Carcinoembryonic Antigen, Hemoglobin, and Neutrophil to Lymphocyte Ratio with Colorectal Cancer Histopathological Grade in West Sumatra, Indonesia Muhammad Zidane Innanda; Dwi Yulia; Avit Suchitra; Wirsma Arif Harahap; Rikarni Rikarni; Eka Nofita
Jurnal Kesehatan Vol 17 No 1 (2026): Jurnal Kesehatan
Publisher : Poltekkes Kemenkes Tanjung Karang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jk.v17i1.5584

Abstract

Colorectal cancer is a global health issue with a significant incidence and mortality rate. Identifying clinical characteristics using tumor biomarkers and hematological parameters is a crucial aspect in evaluating tumor cell differentiation grade. This study aims to determine the characteristics of Carcinoembryonic Antigen (CEA) levels, hemoglobin, and Neutrophil to Lymphocyte Ratio (NLR) values as indicators of histopathological differentiation grade in colorectal cancer patients. This was an observational, analytic study with a retrospective design, using medical record data from patients at Dr. M. Djamil General Hospital in Padang, from January 2023 to December 2024. A total of 154 patients meeting the inclusion and exclusion criteria were selected using a total sampling technique. Data were analyzed using statistical tests to assess the significance of the relationship between variables. The patient distribution showed a higher prevalence of females (55.8%), and more than half (62.3%) were aged 50 years or older. The histopathological profile was predominantly low grade (81.2%). Statistical test results showed a significant association between CEA levels and histopathological differentiation grade (p=0.017). However, no statistically significant association was found between hemoglobin levels (p=0.822) or NLR values (p=0.303) and histopathological differentiation grade. There is a potential association between CEA levels and histopathological differentiation grade, whereas hemoglobin levels and NLR values did not show a significant association. CEA levels can serve as a potential indicator in predicting tumor differentiation grade in colorectal cancer patients.
Data provision of PIK3CA gene diversity and recombinant plasmids preparation for control DNA in developing the trastuzumab predictive response diagnostic kit DESRIANI DESRIANI; BUGI RATNO BUDIARTO; WIRSMA ARIF HARAHAP; M. ALI WARISMAN; AUDREY VANIA CLARISSA OMPUSUNGGU; DINA ATHARIAH; FARIDA MIRNAWATI; IDA YUSSRIYANI; FUAD ALAHWANI; AHMAD RIZQI KURNIAWAN
Biodiversitas Journal of Biological Diversity Vol. 17 No. 2 (2016)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d170237

Abstract

Desriani, Budiarto BR, Harahap WA, Warisman MA,Ompusunggu AVC, Athariah D, Mirnawati F, Sriyani IY, Alahwani F, Kurniawan AR. 2016. Data provision of PIK3CA gene diversity and recombinant plasmids preparation for control DNA in developing the trastuzumab predictive response diagnostic kit. Biodiversitas 17: 647-652. HER-2 overexpression is well known as a poor prognostic factor for breast cancer patients. Targeted therapy can be carried out using monoclonal antibody named trastuzumab. Some reports have higlighted the core problem of HER2 positive-breast cancer resitance on trastuzumab due to incorrect in selecting HER2 status patient who will reciept the drug and the emergence of PIK3CA mutations especially in exon 9 and 20 which is the downstream of HER-2 pathway. In this study, data provision of PIK3CA gene and preparation of plasmid to support developing the trastuzumab predictive response diagnostic kits will be reported. Based on direct DNA sequencing result, two samples of 68 breast cancer patients exhibited mutation at exon 20 H1047R, while another three samples showed silent mutation (T1025T) at the same exon. On the other hand, careful strategy should be considered for exon 9 analysis, since we found that almost 68 samples sequenced none of them were exon 9 positive (pesudogene). Two prepared plasmids, pGEMT-easy PIK3CA exon 9 and 20 will be applied as control PIK3CA gene for qPCR SYBR green I-based PIK3CA genotyping, while pGEMT easy HER-2 will be applied as a reference gene for scoring HER-2 status. The standard curve equation of plasmid-cloned HER2 gene amplification was Y=-3,0472x + 46,465, R2= 0,99 with qPCR efficiency was 115%, respectively. Inconclusion, data provision and control DNA preparation of predicted factors for breast cancer patients who positively respond to trastuzumab are very fundamental important aspects for the development of trastuzumab response diagnostic kit which is based on Indonesian population genetics profile.
Co-Authors ., Azamris ., Oktahermoniza Afriwardi Afriwardi AHMAD RIZQI KURNIAWAN Aisyah Elliyanti Aisyah Ellyanti Ari Oktavenra Arifin, Hidayat Aswiyanti Asri AUDREY VANIA CLARISSA OMPUSUNGGU Avit Suchitra Avit Suchitra Azamris Azamris Bastian Nova Beni Indra, Beni Bethy Suryawathy Hernowo Bugi R Budiarto BUGI RATNO BUDIARTO Cicilia Artitin Daan Khambri Deddy Saputra Defrin Defrin Desriani Desriani DESRIANI DESRIANI Dessy Arisanty Desti Wahyuni Dewi Rusnita Diandra K., Puti Reno DINA ATHARIAH Dwi Yulia Edison Edison Effif Syofra Tripriadi Eka Nofita Erin Desweni Fadil Oenzil Farah Mardhiyah FARIDA MIRNAWATI Fathma Mardhotilla Ferry Sandra Firdawati Firdawati Fitra, Maisa FUAD ALAHWANI Hafiz, Muhammad Zaki Abdul Hanum, Fathiya Juwita Hasmiwati IDA YUSSRIYANI Irianiwati Widodo Ismiati Ismiati Jamil, Mohd Krisdianto, Boby Febri Kurniawan, Arif Rasyidi Leni Merdawati M. ALI WARISMAN Magdi Ayuza Maisa Fitra Martga Bella Rahimi Masnadi, Nice Rachmawati Muhammad Fadhil Muhammad Fadhil Muhammad Iqbal Muhammad Zidane Innanda Muthia Afdhelia Putri Anbiar Nailatul Fadhilah Nindrea, Ricvan Dana Nora, Sondang Nur Indrawati Lipoeto Oktahermoniza Oktahermoniza . Oktahermoniza Oktahermoniza Oktarina, Elvi Oktavenra, Ari Oktora, Meta Zulyati Pieri Kumaladewi Putri, Rizqy Nurfathonah Raden Mohamad Herdian Bhakti Ramadanus Ramadanus Ramadanus Ramadhan Karsono Richvan Dana Nindrea Ricvan Dana Nindrea Rikarni Rikarni Rima Semiarty Risna Meliyani Rizanda Machmud Rony Rustam Rony Rustam Rosfita Rasyid Rusnita, Dewi Rustam, Rony Rusydah Syarlina Salmiah Agus Selfi Renita Rusjdi Shinta Qorina Sinta Chaira Maulanisa Soehartati Gondhowiardjo Sofia Mubarika Sofia Mubarika Haryana Sonar Panigoro Sondang Nora Sondang Nora Suci Estetika Sari Suyuthie, Heldrian Dwinanda Tania Nugrah Utami Tofriza Tofriza Vashti Resti Putri Firdaus Yanwirasti - Yanwirasti - Yanwirasti Yanwirasti Yanwirasti Yanwirasti Yenda Hasnita Yevri Zulfiqar Yuniar Lestari Yuniar Lestari