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All Journal Jurnal Farmasi Klinik Indonesia Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Panrita Abdi - Jurnal Pengabdian pada Masyarakat Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Respirologi Indonesia Jurnal farmasi UIN Alauddin Makassar Narra J Journal of Experimental and Clinical Pharmacy (JECP) Jurnal Ilmiah Kesehatan (JIKA) Borneo Journal of Pharmacy
Elly Wahyudin
Department Of Pharmacy, Faculty Of Pharmacy, Universitas Hasanuddin, Makassar
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Assessing health-related quality of life in schizophrenia patients using EQ-5D-5L index: Insights from patients and caregivers A. Prasetiyo, Nugraha; Wahyudin, Elly; Setiawan, Iman; Sanusi, Mayamariska; Purba, Fredrick D.; Arifin, Bustanul; Alkaff, Sylmina D.
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1314

Abstract

Schizophrenia is a prevalent mental health disorder often marked by relapses, significantly affecting the health-related quality of life (HRQoL) of both patients and their families. The aim of this study was to compare the EuroQol 5-Dimension 5-level (EQ-5D-5L) responses of schizophrenia patients and their caregivers. Using an observational cross-sectional design, HRQoL was assessed among schizophrenia patients and their family caregivers recruited from a provincial referral hospital. Sociodemographic (age, sex, education, marital status, income) and clinical variables (diagnosis, treatment duration, comorbidities) were analyzed alongside HRQoL using structured interviews, medical record reviews, and the EQ-5D-5L instrument (self-report by patients and proxy-reported by family caregivers). Statistical analyses included chi-square tests for associations, Wilcoxon tests for patient-family caregiver comparisons, and multivariate modeling of HRQoL determinants. A total of 526 participants (263 patients and 263 accompanying family caregivers) were included. Significant differences were observed between patients and family caregivers in two domains: pain/discomfort and anxiety/depression. Also, the agreement between patients' and family caregivers’ reports showed good results. A substantial agreement was observed between patient-reported and family caregiver-assessed HRQoL, as indicated by a Cohen’s Kappa value of 0.8. This result suggests a strong level of consistency between the two assessments, supporting the potential use of family caregivers as reliable proxies for evaluating patient HRQoL when self-reports are unavailable or unreliable. In the self-care domain, mobility, and daily activities, patient and caregiver assessments show high agreement. In conclusion, the closeness between patients and caregivers significantly influences patients' HRQoL, providing critical insights for evaluating treatment effectiveness in schizophrenia cases. While discrepancies exist between patient and caregiver assessments, these interactions are particularly impactful in subjective domains like pain/discomfort and anxiety/depression, but not for other domains that are visible.
Stigma and health-related quality of life (HRQoL) among people with multidrug-resistant tuberculosis (MDR-TB): A cross-sectional study in Indonesia Arifin, Bustanul; Sarwadan, Muhamad G.; Wahyudin, Elly; Sarifah, Latifah M.; Fuady, Ahmad; Purba, Fredrick D.; Alkaff, Sylmina D.; Ardiansyah, Akhmad; Madolangan, Jamaluddin
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1317

Abstract

Stigma often accompanies people with multidrug-resistant tuberculosis (MDR-TB) and potentially affects their health-related quality of life (HRQoL). The aim of this study was to investigate the stigma faced by patients with MDR-TB, both from the patients' and community's perspective, and its relationship with HRQoL. Data was gathered at the provincial hospital in Makassar, South Sulawesi, Indonesia. The instrument employed in this research was the Indonesian version of the tuberculosis (TB) stigma instrument to assess MDR-TB stigma from the patient and community perspectives. The patient perspective represents how individuals with TB perceive and experience stigma, including the fear of disclosure, isolation, and guilt (feeling responsible for the burden on their family or their own risky behaviors). Meanwhile, the community perspective reflects how individuals with TB perceive societal attitudes towards them, such as social distancing, avoidance, and reluctance to interact. HRQoL was measured using the European quality of life-5 dimensions-5 level version (EQ-5D-5L) instrument. Notably, the evaluation of anxiety and depression is centered on the fifth dimension of the EQ-5D-5L instrument. A total of 210 patients with MDR-TB were included in the study, all of whom reported experiencing stigma. Most participants perceived stigma at a moderate level, with 76% from the patient perspective and 71% from the community perspective. The average EQ-5D-5L index score was 0.72 (95% confidence interval (95%CI): 0.68–0.76). Measurements from both perspectives show similar scores. There is a substantial negative association between the level of stigma and HRQoL, both from the patient's perspective (R2=-0.33; F=102.52; p<0.001) and the community's (R2=-0.32; F=96.76; p<0.001). The study highlights that the stigma of MDR-TB significantly affects the HRQoL from the patient and community perspective.
Cardioprotective of Ethanol Extract of Black Turmeric (Curcuma Caesia Roxb) on Doxorubicin Induced Rats Pratiwi, Nadya; Wahyudin, Elly; Cangara, Muhammad Husni
Jurnal Ilmiah Kesehatan (JIKA) Vol. 6 No. 2 (2024): Volume 6 Nomor 2 Agustus 2024
Publisher : Sarana Ilmu Indonesia (salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v6i2.496

Abstract

Discovery of black turmeric's anti-radical, anti-inflammatory properties and ability to inhibit the growth of tumor cells. This study aimed to evaluate the cardioprotective effects and identity the effect of black turmeric (Curcuma caesia Roxb) ethanol extract in preventing cardiac damage in mice induced by doxorubicin. The experimental design employed is a pre-post test control group design. The study used male Wistar rats weighing between 150-200 grams, divided into 6 groups, with each group consisting of 4 rats. The first group, serving as the normal group, was only provided with food and water. The second group received Na-CMC as a negative control, while the third group was given Vitamin E as a positive control. The fourth, fifth, and sixth groups were administered suspensions of black turmeric extract at doses of 100, 300, and 500 mg/kg BW, respectively. The rats were induced with doxorubicin at a dose of 5 mg/kg BW once a week for 3weeks. On the final day of treatment, the rats were fasted for 18 hours, anesthetized, and blood samples were taken for analysis. The rats were also secured on a surgical board. Following induction, CKMB and LDH levels were measured again, and histopathological observations were conducted. The results showed CKMB levels indicated significant differences between groups with p<0,05 (0,025), while LDH levels did not show significant differences with p-value>0,05 (0,225). Histopathological examination of the heart revealed improvements in function and structure in the group IV.
Effects of Active Hexose Correlated Compound (AHCC®) on Clinical and Laboratory Response of Pulmonary Tuberculosis Patients Madolangan, Jamaluddin; Yusuf, Irawan; Wahyudin, Elly; Djaharuddin, Irawaty
Jurnal Respirologi Indonesia Vol 45 No 4 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i4.820

Abstract

Backgrounds: Active hexose correlated compound (AHCC), an α-glucan extracted from Lentinula edodes, is known for its immunomodulatory properties. It is suspected that the strong nutrients contained in AHCC are very safe and without side effects, including in tuberculosis patients. This study evaluated the effect of AHCC on clinical and hematologic responses in pulmonary tuberculosis (TB) patients Methods: A double-blind randomized controlled trial was conducted involving 60 pulmonary TB patients receiving standard anti-TB therapy. Participants were randomly assigned to receive either AHCC (3 g/day) or a placebo for six months. Clinical and laboratory parameters were assessed before and after treatment. Results: Patients in the AHCC group showed greater improvement in clinical symptoms (reduced cough, improved appetite, and weight gain) and significant enhancement of hematological and immunological markers compared with placebo (P<0.05). AHCC supplementation significantly increased CD4⁺ and CD8⁺ lymphocyte counts, suggesting improved immune recovery and modulation of host defense against Mycobacterium tuberculosis infection. Conclusion: AHCC supplementation alongside standard anti-TB therapy improves clinical outcomes and immune responses in patients with pulmonary tuberculosis.
Integrative Analysis of the Pharmacological Activities of Lumbricus rubellus: Evidence from Preclinical and Clinical Research Hardiana, Iyan; Wahyudin, Elly; Aswad, Muhammad; Agustina, Rina
Borneo Journal of Pharmacy Vol. 8 No. 4 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i4.8741

Abstract

Lumbricus rubellus, commonly known as the red earthworm, has long been used in traditional medicine and contains diverse bioactive compounds with therapeutic potential. However, comprehensive and systematic evaluation of its pharmacological mechanisms remains limited. This review systematically analyzes the pharmacological activities of L. rubellus based on in vivo and clinical trial evidence to provide an integrated scientific understanding of its therapeutic potential. A systematic literature search was performed in PubMed, ScienceDirect, Wiley Online Library, Cochrane Library, and Google Scholar for studies published between 2013 and 2022. The review followed PRISMA 2020 guidelines, applying the PICOS framework for eligibility determination. Study quality was assessed using the ARRIVE checklist for in vivo studies and the JADAD scale for clinical trials. Twelve studies met the inclusion criteria, comprising nine in vivo and three clinical trials. Lumbricus rubellus demonstrated multiple pharmacological effects, including fibrinolytic, antibacterial, hepatoprotective, neuroprotective, and anticancer activities. These effects are mainly attributed to proteins such as lumbrokinase and coelomic fluid metabolites that exhibit antithrombotic, anti-inflammatory, and cytoprotective actions. This review highlights strong evidence supporting the diverse pharmacological activities of L. rubellus and its potential as a natural source for developing novel therapeutic agents. Further standardized clinical investigations are required to confirm its efficacy and safety.
Co-Authors . Lukman . Mufidah . Subehan A. Prasetiyo, Nugraha Ahmad Fuady Aisyah Fatmawaty Aliyah Aliyah Alkaff, Sylmina D. Amin, Irnawati H. Andi Anggriani Ardiansyah, Akhmad Arif Santoso Asniar Pascayantri Bahar, Muhammad A. Bapulo, Nurdewi N. Bustanul Arifin Cangara, Husni Chaeratunnisa, Rizkya Dewita Fatiah Djaharuddin, Irawaty Dwi Leboe Ermina Pakki Fatmawati Fatmawati Firzan Nainu Gatot S Lawrence Gatot S. Lawrence Gemini Alam Habibie Habibie Hakim, Azima Hardiana, Iyan Hardiyanti, Widya Hasteti Husni - Herlina Rante Herlina Rante Iman Setiawan Inda Pratiwi Indriani Indriani Irawan Yusuf Ismail Ismail Isriany Ismail Jumriani Tammas Kasim, Hasyim Khairuddin - Latada, Nadila P. Latifah Rahman Latifah Rahman M Natsir Djide M Rusdi M. Natsir Djide Madolangan, Jamaluddin Mae Sri Hartati Wahyuningsih Marianti A Manggau Massi, Muhammad N. Mirianti A. Manggau, Mirianti A. Mudjahid, Mukarram Mufidah Mufidah Muh. Akbar Bahar Muhammad Aswad Munawarah Munawarah Munawwaroh, Makiyatul Nasruddin AM Niamuzisilawati, Eva Nurhikma A Pieter, Nova Audrey Luetta Pratama, Muhammad R. Pratiwi, Nadya Purba, Fredrick D. Putri, Tenri ZAD. Rina Agustina Risfah Yulianty Risfah Yulianty Risfah Yulianty Rosany tayeb Sanusi, Mayamariska Sarifah, Latifah M. Sartini Sartini Sarwadan, Muhamad G. Sri Yolandari Sumarheni Sumarheni Sunarti Syamsu Nur, Syamsu Tadjuddin Naid Tuti Handayani Zainal Umar, Abdul H. Utami, Ikrimah N. Veni Hadju Yayuk S. Rahayu Yulia Yusrini Djabir Yusnita Rifai Yuyun Sulitiani Zhulhajsyirah Zhulhajsyirah