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All Journal International Journal of Public Health Science (IJPHS) BALI MEDICAL JOURNAL (BMJ) journal of internal medicine INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES E-Jurnal Medika Udayana Media Kesehatan Masyarakat Indonesia Universa Medicina Paediatrica Indonesiana CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Public Health and Preventive Medicine Archive Journal of Global Pharma Technology Biomedika
Ketut Tuti Parwati Merati
Department Of Internal Medicine Faculty Of Medicine University Udayana/RSUP Sanglah
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : Biomedika

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External Validation of AI-powered GeNose C19 to Diagnose Volatile Organic Compounds in COVID-19 Patients Tested at Udayana University Academic Hospital Purnamasidhi, Cokorda Agung Wahyu; Darwinata, Agus Eka; Utama, I Made Susila; Merati, Ketut Tuti Parwati; Harkitasari, Saktivi; Junior, Darren; Diksha, I Gusti Ngurah Ariestha Satya; Suteja, Richard Christian
Biomedika Vol 16, No 2 (2024): Biomedika Agustus 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v16i2.3940

Abstract

In search for potential alternatives to RT-PCR, Gadjah Mada University developed GeNose C19 which was deemed to have high sensitivity, specificity, PPV, and NPV. The objective of this study is to contribute to the development of GeNose C19 by means of external validation conducted in Udayana University Academic Hospital, Bali. This was a cross-sectional study conducted on adults above 17 years old. Demographic variables, symptoms, vaccination status, GeNose C19 results, and RT-PCR results were measured. We analyzed the sensitivity, specificity, PPV, and NPV using respective appropriate formulas and the impact of other variables gathered towards accuracy by means of Chi-squared test, Mann-Whitney U test and independent-samples T test. The results showed that the subjects included in this study were 50.8% female and had a mean (IQR) age of 23.0 (21.0-27.5) years old. Only three subjects (2.5%) showed COVID-19-related symptoms such as cough (1.7%), flu (0.8%), fever (0.8%), and headache (0.8%). GeNose C19 yields a sensitivity of 83.1%, a specificity of 73.6%, PPV of 79.4%, and NPV of 78.0%. There were no variables that significantly affect the accuracy of GeNose C19. Further study is still required to validate GeNose C19’s performance in different environmental conditions and multiple different races.
Co-Authors Abdul Azis Abdul Azis Agus Eka Darwinata Anak Agung Ayu Yuli Gayatri Artha Camellia Astiti, Cok Istri Sri Dharma Bagus Ngurah Putu Arhana Brad Otto Claire Ryan Cok Istri Sri Dharma Astiti Cokorda Agung Wahyu Purnamasidhi Dewa Gde Agung Budiyasa Dewa Nyoman Wirawan Dewa Nyoman Wirawan, Dewa Nyoman Dian, Ni Made Dewi Diksha, I Gusti Ngurah Ariestha Satya Dyah Kanya Wati Elizabeth Haryanti Gayatri, Anak Agung Ayu Yuli Gusni Rahma Handayani, Putu Novi Haruko Akatsu Haryadi Haryadi - I Dewa Made Sukrama I Gde Raka Widiana I Gusti Ayu Agung Elis Indira I Gusti Ngurah Kade Mahardika I K. Suata I Ketut Agus Somia I Made Bakta I Made Susila Utama I Nyoman Sutarsa I Wayan Gede Artawan Eka Putra I Wayan Gede Artawan Eka Putra, I Wayan Gede Artawan Eka I Wayan Putu Sutirta Yasa Ida Bagus Nyoman Putra Dwija Ida Bagus Putra Manuaba Irwanto Irwanto Junior, Darren Ketut Dewi Kumara Wati Ketut Espana Giri Ketut Espana Giri Ketut Ridana Wibawa Ketut Suryana Komang Agus Trisna Amijaya, Komang Agus Trisna Kumbara, Cokorde Istri Yuliandari Krisnawardani Made Yogi Oktavian Prasetia Made Yogi Oktavian Prasetia, Made Yogi Oktavian Mahardani, Putu Nandika Tungga Yudanti N. Sri Budiyanti Ni Made Dewi Dian Sukmawati Ni Made Sri Nopiyani Ni Wayan Sri Rahayuni Ni Wayan Winarti Nittaya Phanuphak, Nittaya Plamularsih Swandari Rahayuni, Ni Wayan Sri Rudi Wisaksana Saktivi Harkitasari, Saktivi Sawitri, Anak Agung Sagung Semadhi, Putu Gitanjani Mahadewi Shannon Turnbul Siahaan, Katrin Wilentina Stefanie Juergens Suteja, Richard Christian Utama, I Made Susila Utarini, Gusti Ayu Eka Yundari, Yundari