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Journal : Jurnal Kesehatan

Narrative Literature Review on MC4R rs17782313 Gene-Nutrient Interaction and Obesity Risk Yocku, Monica H.S. Otline; Pramono, Adriyan
Jurnal Kesehatan Vol 16 No 1 (2025): Jurnal Kesehatan
Publisher : Poltekkes Kemenkes Tanjung Karang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jk.v16i1.4893

Abstract

The Melanocortin 4 Receptor (MC4R) gene plays a critical role in appetite regulation and energy balance. The single nucleotide polymorphism (SNP) rs17782313, located near the MC4R gene, has been widely associated with an increased risk of obesity, primarily through its influence on appetite control and energy homeostasis. Understanding how this genetic variant interacts with dietary intake can offer valuable insights into the pathophysiology of obesity and inform personalized nutritional strategies. This study aims to investigate the role of SNP rs17782313 in dietary factors and obesity risk, with a particular focus on the underlying molecular mechanisms. A narrative literature review was conducted, synthesizing findings from molecular, genetic, and epidemiological studies. The review highlights how rs17782313 may influence MC4R function and how macronutrient intake, particularly carbohydrates, proteins, and fats, modulates this effect. Evidence suggests that nutritional factors can affect gene expression or interact directly with the MC4R pathway, influencing energy intake, metabolic responses, and body weight regulation. Observational studies in various populations confirm the global relevance of these gene-diet interactions. The findings highlight the need for an integrative approach that combines genetics and nutrition to develop individualized interventions for obesity prevention and treatment. Understanding these interactions may contribute to more effective management of obesity and related metabolic disorders by tailoring dietary recommendations to genetic profiles.
Co-Authors A.Savitri, Rachmania Afida Soucha Towil, Afida Soucha Ahmad Syauqy Ainun Anindita Rahadyani Aisya Maulida, Aisya Amanda Umihani, Amanda Anang M Legowo Andri C Kumoro Anggraeni, Neni Anggriany, Nissa Ani Margawati Anjani, Gemala Antika, Karinda Kennia Armelinda, Nyoman Putri Ari Aryanti Setyaningsih Ayu Rahadiyanti Bagoes Widjanarko Binar Panunggal Deny Yudi Fitranti Dewi Marfu’ah Kurniawati Diana N Afifah Diana Nur Afifah, Diana Nur Djuara P Lubis Dwi Astuti Farikha, Dwi Astuti Dwiningsih Dwiningsih Endang Mahati Endang Mahati Endang Sri Lestari Etika R Noer Etika Ratna Noer Faizah Fulyani Fauzia, Ria Febriandina, Kharisma Dwi Fika Noviandini Putri Sari Fillah Fithra Dieny Finta Wahdania Fitra Aprilindo Sase Fitri Wulandari Fitriyono Ayustaningwarno Fulyani, Faizah Galuh Hardaningsih Gisi Sari Bestari Hardhono Susanto Hardhono Susanto Hartanti Sandi Wijayanti Hertanto Wahyu Subagio Karimah, Asma Kura, Stefyne Sonya Yohana Kusmiyati Tjahjono Latifah Rachmawati Latifatul Khoir Hidayati Lilis Endang Wijayanti, Lilis Endang Liska Widiyastuti, Liska M Mexitalia Magfirah, Ariel Mahabatillah, Desty Mambaya, Helvi Desi Maria Mexitalia MARTHA ARDIARIA Mattarahmawati, Siti Andhini Maulana, Reza Achmad Mohammad Sulchan Mohammad Zen Rahfiludin MS Anam Muflihatul Muniroh Muflihatul Muniroh Mukarromah, Tsamaroh Azzah Muniroh, Muflihatul Mursid Tri Susilo Nawai, Fatmayanti Neni Anggraheni, Neni Niken Puruhita Ninik Rustanti Novita Kurnia Sari Nur Ahmad Habibi Nur Aini, Fadhilah Nurahmatika, Prisma Nurmasari Widyastuti Nursari, Elia Nawang Nuryanto Nuryanto Permatasari, Mayang Januarti Putri, Sylvia Rahmi Rahmawati, Eka Rina Regie Febriansyah, Regie Rina Pratiwi Rinta Amalia Safitri, Ulan Seno, Khristophorus Heri Nugroho Hario Shauma, Claradhita Ayu Siti Fatimah Muis Sylvia Rahmi Putri Untari Wardana, Ruliansyah Kusuma Widya Ayu Wulandari Yocku, Monica H.S. Otline Yuswo Supatmo