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All Journal HAYATI Journal of Biosciences Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Pengajaran MIPA Jurnal Pendidikan Indonesia Formica Education Online Journal of Mathematical and Fundamental Sciences Jurnal Pendidikan Biologi Indonesia Jurnal Penelitian dan Pembelajaran IPA Science and Technology Indonesia Jurnal Penelitian Pendidikan IPA (JPPIPA) Pedagonal : Jurnal Ilmiah Pendidikan Bioscientist : Jurnal Ilmiah Biologi These proceedings represent the work of researchers participating in The International Conference on Elementary Education (ICEE) which is being hosted by the Elementary Education Study Programme School of Postgraduate Studies, Universitas Pendidikan Proceeding Biology Education Conference Makara Journal of Science Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) Applied Environmental Science Asian Journal of Toxicology, Environmental, and Occupational Health Jurnal Bisnis Kehutanan dan Lingkungan Jurnal Inovasi Pangan dan Gizi Jurnal Pendidikan MIPA Sasambo: Jurnal Abdimas (Journal of Community Service)
Didik Priyandoko
Universitas Pendidikan Indonesia
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Makara Journal of Science

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Phytochemical Analysis, Antioxidant Activity, and Cytotoxic Effects of Physalis angulata and Moringa oleifera Leaf Extracts on Cancer and Normal Cells In Vitro Priyandoko, Didik; Widowati, Wahyu; Sholihah, Ika Adhani; Zahira, Nurul Zahra; Bangun, Adityana Arta; Kusdianti, Kusdianti; Hernawati, Hernawati; Surakusumah, Wahyu; Juansah, Rahadian Deden
Makara Journal of Science Vol. 29, No. 1
Publisher : UI Scholars Hub

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Abstract

Physalis angulata and Moringa oleifera have long been the key ingredients of traditional medicine. This study aimed to obtain the metabolite profiles of the ethanolic leaf extracts of P. angulata (ELP) and M. oleifera (ELM), evaluate their antioxidant activity, and assess their toxicity against normal and cancer cells. The leaves were sourced from Balittro, West Java. The extraction used 70% ethanol and continued for 3 days. The metabolites were identified using Gas Chromatography-Mass Spectrometry (GC-MS), antioxidant activity was ascertained via the DPPH assay, and cytotoxicity was evaluated employing the PrestoBlue assay. GC-MS identified 23 compounds in ELP and 15 in ELM. The DPPH assay showed that ELM, ELP, or their combination exhibited marked antioxidant activity, with inhibition ranging from 50% to 90%. The toxicity assay against MCF-7 cancer cells demonstrated that ELP at 1,500 µg/mL and ELM at 1,200 µg/mL induced cytotoxicity. The ELP + ELM formulation exhibited stronger cytotoxic effects than the positive control. In contrast, ELM or ELP did not induce toxicity in normal CV-1 cells and, stimulated viability com-pared to the control. Thus, the phytochemical contents of ELM and ELP exhibited enhanced antioxidant activity, in-duced toxicity in cancer cells, and were safe for normal cells.
Co-Authors Adi Rahmat Agustin, Dhini Ahmad Faried Alexandro, Garry Alyasa, Rahadian Rasyid Anisa Noor Aulia Annaba, Aziz Any Aryani Azis, Rizal Azmi, Haibah Azzania Fibriani Bangun, Adityana Arta Dadang Machmudin Deocaris, Custer C. Diah - Kusumawaty Diah Puspitasari Dina Karina Islami Dzikrina, Hanina Eka Yudha Rahman Eliya Mei Sisri Faidah, Siti Tahany Rifa Fauziyah, Lathifah Zahra Febblina Daryanes Fitriani Nurpratiwi Susanto Fransisca Sudargo Gina Angelina Hadiprasetyo, Dhanar Septyawan Handayanie, Yunni Hanna Sari Widya Kusuma Harry Murti Hernawati Hernawati Hodijah, Siti Romlah Noer Janitra, Fikrah Jeffrey ., Jeffrey Juansah, Rahadian Deden Kartika Kaul, Sunil C. Kusdianti Kusdianti Kusdianti Leonita, Lastri Mamat Arohman Mrs Sariwulan Diana Muzakki, Naufal Ahmad Nainggolan, Ita Margaretha Nashi Widodo Naufal Ahmad Muzakki Naufal Ahmad Muzakki Naufal Ahmad Muzakki Nia Kania Nia Nurdiani Norine, Jennifer Nurul Faridah, Nurul Nuryani Rustaman Putri Yunitha Wardiny Qlintang, Sandy Rahmat, Adi RAHMAT, DENI Rahmi, Annisa Salsyabila Rizal Rizal S. Saefudin Sa'diatul Fuadiyah Sabrina, Adilah Hafizha Nur Saefudin Saefudin Sajidah, Salmaa Nabiilah Santoso, Fadhila Zahra Sari, Prima Mutia Sholihah, Ika Adhani Sholihah, Uswatun Siti Sriyati Suhara, Nur Fajriyah Surtikanti Hertien Koosbandiah, Surtikanti Sylva Sagita Teresa Liliana Wargasetia Topik Hidayat Triharsiwi, Dwi Nur TRINA EKAWATI TALLEI Try Kurniawan Vinna Kurniawati Sugiaman, Vinna Kurniawati Wadhwa, Renu Wahyu Surakusumah Wahyu Widowati WAHYU WIDOWATI Wahyudin, Wahyudin Wawan Setiawan Wawan Setiawan Yayan Sanjaya Yunita, Shella Yusuf Hilmi Adisendjaja Zahira, Nurul Zahra Zahra, Cheryl Dwi Nur