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EFEK ANALGETIK ANTIPIRETIK EKSTRAK ETANOL KULIT BUAH MANGGIS (Garcinia mangostana L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR Ika Puspitaningrum; Lia Kusmita; Wahyuning Setyani
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL.11 NO.1 JUNI 2014
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (331.084 KB) | DOI: 10.31942/jiffk.v11i1.1284

Abstract

ABSTRACT Antipyretic analgesic is a compound that can relieve pain and can reduce fever. One of the plants that has potential as antipyretic analgesic is mangosteen (Garcinia mangostana L.). Mangosteen peel contains flavonoids and alkaloids that may have an effect as an analgesic. In addition, flavonoids could inhibit prostaglandin that has antipyretic effect. This study aims to determine the antipyretic analgesic effect of ethanol extract of mangosteen peel and the effective dose.             Analgesic and antipyretic test using 25 male Wistar rats were divided 5 groups , I (negative control) CMC Na 0,5 % , II (positive control) paracetamol 50 mg/kg body weight, and III, IV and V suspension of the ethanol extract of the skin manggis 50; 100 and 200 mg/kg body weight. Pain stimuli by dipping a rat tail in the water temperature of 40° C for 10 seconds. Rat response to a painful stimulus done prior to treatment (normal response), and 30 minutes after treatment. While excitatory fever in rat by injection of 0.2 ml vaccine DPT are intramuscular. Rectal temperature of rat were measured before treatment (initial temperature), 60 minutes after the vaccine, as well as 30 minutes after treatment . Rat response to a painful stimulus and a rectal temperature of rat was analyzed using SPSS statistical release 16 .            The results showed that the ethanol extract of mangosteen peel can improve the rat response to pain stimulation and lower the temperature of the mice vaccinated fever DPT. The effective dose of ethanol extract of mangosteen peel as antipyretic analgesic is 50 mg / kg body weight.Keywords: mangosteen skin, analgesics, antipyretics
EFEK HIPOTRIGLISERIDEMIA TEPUNG UMBI KIMPUL (Xanthosoma violaceum Schott.) PADA TIKUS PUTIH JANTAN Yustisia Dian Advistasari; Etty Sulistyowati; Ika Puspitaningrum
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI & FARMASI KLINIK VOL. 13 NO. 1 JUNI 2016
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (363.812 KB) | DOI: 10.31942/jiffk.v13i1.1446

Abstract

ABSTRACT Triglycerides (triacylglycerols) is the major lipid compounds in body fat and food deposits. Hypertriglyceridemia is a disorder characterized by an  increase of triglyceridesconcentration  in the blood. Tuber purse known as  Umbi Kimpul(Xanthosomaviolaceum Schott.) is believed as a medicinal plant. This study aims to determine the effect of hipotrigliseridemiaof purse tuber flour and the effective dose. To determine the effect of hipotrigliseridemia of purse tuber flour, 30 white male Wistar rats were used and they were divided into 6 groups. Group I (normal control) was  fed a standard food, group II (negative control) was given suspension CMC Na 0,5%, group III (positive control) was given suspension gemfibrozil 54 mg / kgbody weight of mice, group IV, V and VI were given pursetuber flour wtih graded dose at 270, 540 and 1080 mg / kgbody weight of mice. The Induction of hypertriglyceridemia was  a mixture of standard rat food with 15% lard and 5% egg yolk of duck, as well as fructose 1.8 g / kg body weight of mice. The Induction was conducted for 50 days, unless  the normal control group. Blood triglyceride levels were measured on days 0, 51 and 58. The triglyceride levels were calculated their decline percentagebefore statistically tested using SPSS statistical release16. The results showed a significant difference in the negative control group CMCNa suspension with purse tuber flour suspension. It is concluded that  the purse tuber flour suspension has an effect of hipotrigliseridemia. The effective dose of pursetuber flour as hipotrigliseridemia is 270 mg / kg body weight of mice. Keywords  : flour tuber kimpul, hypotriglyceride, white male rats
Pelatihan Pembuatan Jamu Saritoga dan Penyuluhan Sistem Imun Pada Ibu PKK: Kusmita, Lia; Dwi Franyoto, Yuvianti; Mutmainah, Mutmainah; Puspitaningrum, Ika; Bagiana, I kadek
JURNAL INOVASI DAN PENGABDIAN MASYARAKAT INDONESIA Vol 3 No 2 (2024): April
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jipmi.v3i2.217

Abstract

Latar belakang: Jamu adalah sebutan untuk obat tradisional dari Indonesia. Jamu dibuat dari bahan alami dari tumbuhan seperti rimpang (akar-akaran), daun-daunan, kulit batang dan buah. Diperkirakan sekitar 70-80% populasi di negara berkembang memiliki ketergantungan pada obat tradisional. Secara umum jamu dianggap tidak beracun dan tidak menimbulkan efek samping. Khasiat jamu telah teruji oleh waktu, zaman dan sejarah, serta bukti empiris langsung pada manusia selama ratusan tahun. Tanaman obat keluarga atau yang lebih populer sebagai TOGA merupakan tanaman obat yang ditanam di lingkup lingkungan keluarga. Pada masa pandemi, terjadi tren peningkatan penggunaan obat tradisional untuk menjaga daya tahan tubuh. Berbagai pembuktian secara ilmiah tentang manfaat tanaman obat dalam hal menjaga daya tahan tubuh. Tujuan: Meningkatkan wawasan dan pengetahuan masyarakat mengenai TOGA serta manfaatnya, termasuk cara pengolahan dan pembuatan jamu Saritoga.. Metode: Pelaksanaan kegiatan dilakukan secara langsung melalui sosialisasi dan pelatihan langsung kepada kelompok masyarakat sasaran. Hasil: Masyarakat yang awalnya tidak memahami sistem imun jadi lebih paham. Hasil pretest nilai jawaban yang benar adalah 45% setelah dilakukan pelatihan dan penyuluhan nilai jawaban yang benar meningkat menjadi 85%. Kesimpulan: Pelatihan dan penyuluhan dapat meningkatkan pengetahuan perihal system imun dan ketrampilan pembuatan jamu Saritoga pada masyarakat. Kata kunci: pelatihan, penyuluhan, saritoga, sistem imun _____________________________________________________________________________________ Abstract Background: Jamu is the name for traditional medicine from Indonesia. Herbal medicine is made from natural plant ingredients such as rhizomes (roots), leaves, bark, and fruit. It is estimated that around 70-80% of the population in developing countries is dependent on traditional medicine. Herbal medicine is considered non-toxic and does not cause side effects. The efficacy of herbal medicine has been tested by time, time, and history, as well as direct empirical evidence on humans for hundreds of years. Family medicinal plants or TOGA are medicinal plants grown within the family environment. During the pandemic, there has been a trend of increasing the use of traditional medicine to maintain the body's immune system. The benefits of medicinal plants in keeping the body's immune system are scientific evidence. Objective: Increase public insight and knowledge regarding TOGA and its benefits, including how to process and make Saritoga herbal medicine. Method: Activities implementation is directly through direct outreach and training to target community groups. Result: People who initially did not understand the immune system became more understanding. The pretest result of the correct answer value was 45%. After training and counseling, the correct answer value increased to 85%. Conclusion: Training and counseling can increase knowledge about the immune system and skills in making Saratoga herbal medicine in the community. Keywords: training, counseling saritoga, immune system
PEMBUATAN TABLET DARI EKSTRAK ETANOL BUAH API-API (Avicennia marina) SEBAGAI ANTIDIABETES MELLITUS Munisih, Siti; Advistasari, Yustisia Dian; Puspitaningrum, Ika
Media Farmasi Indonesia Vol. 12 No. 2 (2017): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

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Abstract

ABSTRAKTanaman api-api (Avicennia marina) merupakan salah satu jenis vegetasi mangrove. Masyarakat biasa mengkonsumsi buah api-api sebagai obat anti diabetes mellitus. Ekstrak etanol buah Api-api telah terbukti secara ilmiah sebagai antidiabetes mellitus. Penelitian ini bertujuan untuk mengetahui karakteristik fisik sediaan tablet ekstrak etanol buah Api-api. Tablet tersebut dibuat sesuai dengan dosis efektif dari hasil penelitian antidiabetes mellitus yang sudah dilakukan yakni sebesar 1,26 mg/kgBB tikus atau setara 10 mg/50 kg BB manusia. Pembuatan tablet diawali dengan mengeringkan ekstrak etanol buah Api-api dengan Avicel, Sodium Starch Glukolat, dan laktosa hingga homogen. Masa granul dibuat dengan mengunakan PVP 5% lalu diayak dengan ayakan nomer mesh 18 dan 30.Granul yang lolos ayakan 18 dikeringkan dalam almari pengering selama 10 menit. Tablet dicetak dengan penambahan Mg stearat dengan bobot rata-rata tablet 150 mg. Tablet yang diperoleh diuji sifat fisik tablet meliputi uji keseragaam bobot, kekerasan, kerapuhan, dan uji waktu hancur. Data yang diperoleh dianalisis kemudian disimpulkan. Hasiluji tablet menunjukkan formula tablet ekstrak etanol buah Api-api mampu memenuhi syarat keseragaman bobot, kekerasan, kerapuhan dan waktu hancur.
EFEK ANALGETIK TEPUNG UMBI BIDARA UPAS (Merremia mammosa (Lour) Hall. F.) PADA MENCIT JANTAN Puspitaningrum, Ika; Kusmita, Lia
Media Farmasi Indonesia Vol. 9 No. 2 (2014): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

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Abstract

Abstract Analgesic is a compound that can reduce or eliminate pain without losing consciousness. Bidara upas (Merremia mammosa (Lour) Hall. F.) is one of the flora that part edible tubers and useful for the treatment of, among others, anti-inflammatory and analgesic. The content of flavonoids and alkaloids in the tubers bidara upas could be expected to have an effect as an analgesic. This study aims to determine the analgesic effect bidara upas tuber starch (BUTS) and starch tubers effective dose bidara upas as an analgesic. This study was an experimental study with random sampling technique (random sampling). Testing of analgesic effect (BUTS) using 25 male mice Swiss strain which is divided into 5 groups. Group I, II, and III as a dose of 1, 2 and 3 are a group (BUTS) giving a dose of 1,5; 3; and 6 g/kgBB, IV as a negative control group is a group of distilled water provision, as well as the positive control group V is a group of administration of paracetamol dose 91 mg/kgBB. All treatments are given orally. 5-minute intervals after treatment, all mice were given painful stimuli in the form of a sterile solution of glacial acetic acid 1% v / v with a dose of 300 mg/kgBB and observed stretching that arise every interval of 5 minutes for 60 minutes. Total cumulative stretching all treatment groups were analyzed statistically with SPSS 16 with a 95% confidence level. It also calculated percent analgesic power all treatment groups. The results obtained are significant differences between the groups with a negative control group tuber flour upas bidara three doses. This proves tuber flour bidara upas have analgesic effect. In addition, the results obtained are significant differences between the positive control group by group tuber flour upas bidara three doses. Tuber bidara upas starch total cumulative dose has smaller stretching and % power analgesic greater than the paracetamol group. Based on these results, the effective dose tuber flour bidara upas as analgesic of 1,5 g/kgBB of mice.
EFEK IMUNOMODULATOR EKSTRAK ETANOL DAUN SOM JAWA (Talinum triangulare (Jacq.) Willd) PADA MENCIT JANTAN GALUR SWISS Wulansari, Rina; Setya Palupi, Dwi Hadi; Puspitaningrum, Ika
Media Farmasi Indonesia Vol. 11 No. 1 (2016): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

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Abstract

SARIDaun som jawa memiliki beberapa senyawa bioaktif diantaranya flavonoid.Flavonoid dapat mempengaruhi sistem imunitas melalui aktivitasnya padamakrofag. Penelitian ini bertujuan untuk mengetahui efek imunomodulator dandosis efektif dari ekstrak etanol daun som jawa (Talinum triangulare (Jacq.)Willd) terhadap respon imun non spesifik dan respon imun spesifik pada mencitjantan galur Swiss. Hasil pengujian aktivitas fagositik hewan uji berturut-turutpada ekstrak etanol daun som jawa dosis 50, 100, dan 150 mg/kgBB sebesar1,15124; 1,14982; 1,38195. Aktivitas ekstrak etanol daun som jawa juga dapatmeningkatkan berat organ limfoid (hati, limpa, timus) secara bermakna (p< 0,05)dibanding kontrol negatif dan tidak berbeda bermakna dibanding kontrol positif(p> 0,05). Ekstrak etanol daun som jawa mampu mempengaruhi respon imunseluler secara bermakna (p< 0,05) dibanding kontrol negatif dan tidak berbedabermakna dibanding kontrol positif (p> 0,05) pada dosis 100, dan 150 mg/kgBB.Ekstrak etanol daun som jawa ketiga dosis mampu meningkatkan nilai titerantibodi primer dan sekunder. Ekstrak etanol daun som jawa mempunyai efekimunostimulan terhadap respon imun non spesifik dan respon imun spesifik.Dosis efektif dari ekstrak etanol daun som jawa ditetapkan sebesar 100 mg/kgBB.
Pembuatan Eco-Enzyme dan Pemanfaatannya untuk Gel Anti Nyamuk di Desa Ngrawan Kecamatan Getasan Kabupaten Semarang Setiawati, Maria Caecilia Nanny; Munisih, Siti; Soendoro, Aries K.; Mutmainah, Mutmainah; Haryanti, Sri; Bagiana, Kadek; Puspitaningrum, Ika; R, Ungsari; F, Yuvianti D
Jurnal Pengabdian Kesehatan Vol 6, No 3 (2023): Jurnal Pengabdian Kesehatan
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM) STIKES Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/jpk.v6i3.289

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Sampah organik banyak dihasilkan dari dapur rumah tangga. Penumpukan sampah organik, dapat mengganggu lingkungan dan masyarakat. Pemanfaatan sampah organik, sudah mulai banyak diupayakan. Salah satuinya adalah dengan cara membuat sampah organik, menjadi Eco Enzyme (EE). EE merupakan cairan berwarna coklat, hasil fermentasi gula merah, bahan organik dan air (1:3:10), yang didiamkan selama 90 hari. Tujuan Pengabdian masyarakat ini adalah mengajarkan pembuatan EE dan pemanfaatannya dengan membuat sediaan gel antinyamuk. Kegiatan pengabdian dilakukan di desa Ngrawan, kecamatan Getasan, Kabupaten Semarang. Rangkaian kegiatan diawali dengan brain storming pada perangkat desa dan aktivis Karang Taruna, dilanjutkan dengan edukasi tentang EE dan pelatihan membuat gel EE, yang diikuti oleh 20 orang ibu rumah tangga, yang mayoritas (70%) berada di usia produktif 18-35 th. Edukasi EE dapat dipahami oleh peserta Pengabdian, terbukti dengan adanya perbedaan yang signifikan antara hasil jawaban benar, sesudah pelatihan (post test) dan sebelum pelatihan (pre test), dengan signifikansi p 0,004.   Jawaban pretest yang semuanya benar, adalah pada soal bahwa Pembuatan EE dapat mengurangi sampah, karena peserta sudah diminta membawa sampah organik dari rumah masing-masing. Sedangkan jawaban yang paling banyak salah adalah pada soal Pembuatan EE dapat menggunakan Gula pasir, karena bahan yang tepat adalah Gula merah. .. Kesimpulan dari pelaksanaan pengabdian masyarakat ini, masyarakat Desa Ngrawan, Kabupaten Semarang sudah memahami penjelasan tentang Eco Enzyme dan manfaatnya. Masyarakat peserta pelatihan juga bisa memahami tehnologi sederhana pembuatan sediaan gel Eco Enzyme yang bisa dimanfaatkan sebagai gel antinyamuk. Disarankan perlunya digiatkan pengenalan tentang Eco Enzyme kepada masyarakat secara lebih luas, karena sangat banyak manfaatnya untuk kesehatan alam dan manusia
Leaf Extract Microencapsulation of Stevia rebaudiana Bert Using Inulin-Chitosan as Anti-Diabetes Diet Mutmainah Mutmainah; Yohanes Martono; Ika Puspitaningrum; Lia Kusmita
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 3 (2021): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i3.270

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Diabetes mellitus is a collection of symptoms that arise in someone who has increased blood glucose levels. The Stevia plant (Stevia rebaudiana Bert) contains a compound of diterpene glycosides as steviosida and rebaudiosida A. Purified extract of steviosida and rebaudiosida A is widely used as a sweetener for low calorie food and beverage products or as a sugar substitute for diabetics and has the effect of lowering blood sugar levels. This study aims to determine the antidiabetic effect of microencapsulated preparations of Stevia leaf extract (Stevia rebaudiana) with a combination of inulin chitosan encapsulation. Antidiabetic mellitus test was carried out in vivo using test animals of male white rats of Wistar strain. The inducing compound that can cause the condition of diabetes mellitus test animals is Aloxan with a dose of 150 mg / kg Body weight of rats. given intraperitoneally for one day, then the mice were allowed to stand for 3 days to reach a state of diabetes mellitus. Blood glucose levels of test animals were measured on days 1 (initial), 5 (induction) and 12 (treatment) to determine the initial blood glucose levels, after induction of alloxan and after administration of test compounds both CMC Na 0.5% , glibenclamide, and preparations microencapsulation of Stevia leaf extract at a dose of 100; 300; and 700 mg / kg body weight. The results were obtained after 7 days of treatment, it was seen that blood glucose levels in the CMC group remained high, while the Glibenclamid administration group, and the three dosages of microencapsulation preparations of Stevia leaf extract could reduce blood glucose levels. This can be seen from the statistical test that there is a significant difference (p
UJI AKTIVITAS GEL EKSTRAK ETANOL BUAH OKRA (Abelmoschus esculentus) TERHADAP PENYEMBUHAN LUKA BAKAR DERAJAT II KULIT PUNGGUNG KELINCI JANTAN GALUR NEW ZEALAND Abdurrahman, Arrum Fadlillah; Puspitaningrum, Ika; Sari, Wulan Kartika
CENDEKIA EKSAKTA Vol. 6 No. 1 (2021)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/ce.v6i1.4407

Abstract

Luka bakar (burn) merupakan cedera akibat paparan dengan sumber panas seperti listrik, zat kimia, atau radiasi. Tanaman yang terdapat senyawa fitokimia dengan aktivitasnya dalam penyembuhan luka bakar salah satunya adalah buah okra (Abelmoschus esculentus). Tujuan dari penelitian ini untuk mengetahui aktivitas penyembuhan luka bakar derajat II, dan konsentrasi efektif gel ekstrak etanol buah okra pada kulit punggung kelinci jantan galur New Zealand. Penelitian menggunakan 6 ekor kelinci jantan galur New Zealand, berumur 4 sampai 5 bulan dan berat badannya 2 sampai 3 kg. Masing-masing kelinci diberikan 5 kelompok perlakuan. Kelompok perlakuan F1, F2 dan F3 diolesi gel ekstrak etanol buah okra 5%, 10%, dan 20%, kelompok F4 diolesi basis gel karbopol 940 dan kelompok F5 diolesi gel Bioplacenton®. Setiap hari diamati secara makroskopis hingga diameter luka tertutup sempurna (d=0). Pengujian statistika menunjukkan adanya perbedaan signifikan antara K(-) dengan ketiga konsentrasi gel ekstrak etanol buah okra dalam pengujian pH, daya lekat, daya sebar dan viskositas, disimpulkan bahwa konsentrasi ekstrak etanol buah okra berpengaruh terhadap karakteristik gel. Gambaran makroskopis setelah pemberian gel ekstrak etanol buah okra F2 dan F3 menunjukkan adanya perbedaan tidak signifikan dibandingkan dengan K(+), menunjukkan bahwa konsentrasi 10% dan 20% merupakan konsentrasi efektif penyembuhan luka bakar. Kata kunci: buah okra (Abelmoschus esculentus), diameter luka, gel, luka bakar
Immunomodulatory Effect of Dioscorea esculenta L. on NF-κB, TLR-4, TNF-α, and IL-10 Expressions in LPS-stimulated RAW 264.7 Mouse Macrophages Puspitaningrum, Ika; Ikawati, Muthi; Fakhrudin, Nanang; Nurrochmad, Arief
The Indonesian Biomedical Journal Vol 17, No 3 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i3.3630

Abstract

BACKGROUND: Gene expressions of toll-like receptor 4 (TLR)-4, nuclear factor-kappaB (NF-κB), tumor necrosis factor (TNF)-α, and interleukin (IL)-10 are known to have roles in the inflammatory process and affect the regulation of the immune system. A preliminary study showed that Dioscorea esculenta L. tuber has immunomodulatory activity against macrophage phagocytosis activity and lymphocyte proliferation. However, the immunomodulatory activity of aqueous extract (AE), polysaccharide fraction (PF), and non-polysaccharide fraction (NPF) of D. esculenta L. tubers on these gene expressions have not been elucidated well. Therefore, this study was performed to determine its immunomodulatory activity by utilizing RAW 264.7 cell culture induced by lipopolysaccharide (LPS).METHODS: RAW 264.7 cells were stimulated with LPS at a concentration of 1 µg/mL for 30 minutes before incubation with non-toxic concentrations of AE, PF, NPF, positive control, and inulin at 25 and 50 µg/mL. TNF-α, IL-10, TLR-4, NF-κB, and β-actin expressions were evaluated using reverse transcription-polymerase chain reaction (RT-PCR) and were normalized with β-actin as an internal control. Triplicate experiments were performed throughout this study.RESULTS: Treatment with 25 µg/mL NPF significantly decreased the expression of NF-κB, TLR-4, and TNF-α (p<0.05). In contrast, treatment of 25 and 50 µg/mL PF significantly decreased the NF-κB expression (p<0.05). Moreover, only treatment with 50 µg/mL AE exhibited a significant increase in IL-10 expression (p<0.05).CONCLUSION: Treatment with D. esculenta L. tuber stimulated macrophage RAW 264.7 cells via NF-κB, TLR-4, TNF-α, and IL-10 expressions. NPF at 25 µg/mL has stronger immunomodulatory activity in reducing the expression of genes involved in the inflammatory process that plays a role in regulating the immune system.KEYWORDS: Dioscorea esculenta L., Immunomodulator, IL-10, NF-κB, TLR-4, TNF-α, RAW 264.7 cell