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Journal : West Science Nature and Technology

Plant-Based Natural Resource Management Strategies Using Fruits for Cholesterol Regulation Damayanti, Ida Ayu Manik; Wulansari, Nadya Treesna; Megayanti, Sri Dewi
West Science Nature and Technology Vol. 3 No. 04 (2025): West Science Nature and Technology
Publisher : Westscience Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58812/wsnt.v3i04.2630

Abstract

Cardiovascular diseases remain a leading cause of global mortality, with hypercholesterolemia representing a major modifiable risk factor. Growing interest has emerged in plant-based strategies, particularly fruit utilization, as sustainable approaches for cholesterol regulation. This study aimed to systematically review the pharmacological mechanisms of fruit-derived secondary metabolites involved in cholesterol lowering and to explore their relevance within plant-based natural resource management. A systematic literature review was conducted following PRISMA guidelines using ScienceDirect, PubMed, and Google Scholar databases. Evidence from in vivo and in vitro studies demonstrates that various fruits including Gedong Gincu mango, sweet orange, red dragon fruit, buni fruit, Rosa roxburghii, pineapple, Synsepalum dulcificum, mulberry, and Hiyung cayenne pepper contain bioactive secondary metabolites such as flavonoids, phenolics, anthocyanins, carotenoids, triterpenoids, alkaloids, saponins, dietary fiber, and antioxidant enzymes. These compounds exert cholesterol-lowering effects through multiple pharmacological pathways, including inhibition of cholesterol synthesis and absorption, enhancement of bile acid excretion, modulation of lipid metabolism–related gene expression, and reduction of oxidative stress and inflammation. Several fruit-based interventions showed significant reductions in total cholesterol and LDL levels, with some demonstrating efficacy comparable to conventional hypolipidemic agents. These findings highlight the potential of fruit-based natural resources as functional, sustainable, and scientifically supported strategies for cholesterol regulation and cardiovascular disease prevention.
Co-Authors A.A. Ayu Yuliati Darmini AA Istri Mas Padmiswari AAA Yuliati Darmini Abdul Haris Apriani, Ni Luh Putu Yudi Aristadewi, Ida Ayu Mas Arka, I Gede Widhi Artha, I Wayan Oktapratama Artsanthia, Jintana Darmini, A. A. A. Yuliati Deani, Ni Wayan Deni Redita, I Komang Dewi, Ni Putu Ayu Ratna Handi Partiwi, Putu I GEDE PUTU DARMA SUYASA I Ketut Swarjana I Wayan Remiasa Ida Ayu Manik Damayanti Ida Bagus Separsa Kusuma Inge Ruth Suantika Inge Ruth Suantika Israfil, Israfil Juliani, Made Kadek Buja Harditya Kadek Nuryanto Kusuma, I Made Jaya Maha Putra, I Nyoman Arya Maria, Riri Mas Aristadewi, Ida Ayu Megawati, Putu Vera Nadya Treesna Wulansari Ni Kadek Ayu Purnamawati Ni Komang Kresniari Ni Luh Putu Inca Buntari Agustini Ni Made Ayu Sukma Widyandari Ni Made Candra Citra Sari Ni Made Utari Dewi Ni Putu Kamaryati Ni Putu Riza Kurnia Indriana Ni Wayan Desi Bintari Ni Wayan Kesari Dharmapatni Ni Wayan Sukma Antari Ns. Putu Inge Suantika, S.Kep.,M.Kep Nur Halimah Nyoman Eta Risnawati Pangruating Diyu, Ida Ayu Ningrat Putra, I Komang Ardidhana Nugraha Putu Indrayoni Putu Inge Ruth Suantika Salvadila, Ni Kadek Ayu Septiyola Sanjana, I Wayan Sanjana, I Wayan Edi Sarah Kartika Wulandari Sari, Ni Made Candr Citra Sastrawan, I Ketut Wisma Sastrawati, Desak Kadek Satriani, Ni Luh Adi Sekardiani, Ni Luh Putu Suantika, S.Kep.,M.Kep, Ns. Putu Inge Suweca, I Gede Trisna, Made Oktaviani Bulan Wahyunadi, Ni Made Dewi Wangi, Ni Luh Putu Ayu Puspita Wardana, Dewa Gede Wisnu Widyas Pranata, Gst. Kade Adi Yudi Apriani, Ni Luh Putu Yuli Yulia Yusniawati, Yustina Ni Putu