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Anti-breast cancer bioactive compounds and in-silico molecular prediction of Crassostrea angulata (Lamarck, 1819): Prediksi senyawa bioaktif antikanker payudara dan molekuler in-silico Crassostrea angulata (Lamarck, 1819) Kusumawati, Rr Puji Hastuti; Zamani, Neviaty Putri; Soedharma, Dedi; Nurjanah, Nurjanah; Arifin, Taslim; Yulius, Yulius; Samusamu, Andrias Steward; Akhwady, Rudhy; Ramdhan, Muhammad; Damanhuri, Harfiandri; Efendi, Eko; Mayaguezz, Henky; Muhaemin, Moh.
Jurnal Pengolahan Hasil Perikanan Indonesia Vol. 28 No. 1 (2025): Jurnal Pengolahan Hasil Perikanan Indonesia 28(1)
Publisher : Department of Aquatic Product Technology IPB University in collaboration with Masyarakat Pengolahan Hasil Perikanan Indonesia (MPHPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17844/jphpi.v28i1.57937

Abstract

Kanker payudara merupakan penyebab kematian kedua terbanyak di Indonesia. Bioprospeksi senyawa bioaktif dari organisme laut diharapkan dapat menjadi salah satu solusi pencegahan kanker payudara. Crassostrea angulata merupakan salah satu spesies tiram laut yang biasa dikonsumsi dan memiliki sejarah etnomedik di kalangan masyarakat Indonesia. Penelitian ini bertujuan untuk mengevaluasi potensi senyawa bioaktif antikanker dari ekstrak metanol C. angulata menggunakan analisis in-silico. Identifikasi senyawa aktif C. angulata menggunakan LC-HRMS melalui pendekatan molecular docking dengan mengombinasikan program-program KNApSAcK, CLC-Pred, SEA, STRING, PubChem, UniProt, PyMOL, PyRx, and PoseView. Hasil penelitian menunjukkan 12 senyawa aktif antikanker pada C. angulata, namun hanya 2 senyawa antikanker payudara (Flufenamic Acid, FA dan Hymenamide C, HC). Hasil molecular docking menunjukkan bahwa binding affinity yang kuat antara senyawa aktif Flufenamic Acid (FA) dengan protein target kanker payudara (CSF1R, PLK4, MKNK2, dan ABL1) dan senyawa Hymenamide C (HC) dengan protein target kanker payudara (GRB2 dan OXTR). Senyawa bioaktif FA menunjukkan nilai RMSD yang lebih rendah (mendekati 0Å) dengan ligan asli dari masing-masing protein target. FA memiliki potensi sebagai senyawa antikanker payudara yang lebih baik dari HC. Senyawa FA dan HC berpotensi sebagai penghambat protein target kanker payudara, namun masih memerlukan penelitian lebih lanjut terutama untuk penggunaan senyawa tersebut pada manusia.
TEACHERS' EXPERIENCES IN IMPLEMENTING THE INDEPENDENT CURRICULUM FOR STUDENTS WITH SPECIAL NEEDS AT MALIKA CENTER SPECIAL SCHOOL, WEST JAKARTA Ceilendra Saksana, Joned; Ramdhan, Muhammad; Muda Bota, Marselina
Journal Of Applied Multidisiplinary Studies Vol 1 No 2 (2025): Mei 2025
Publisher : Sekolah Tinggi Ilmu Ekonomi Ganesha

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Abstract

This study aims to understand teachers' experiences in implementing the Independent Curriculum (Kurikulum Merdeka) at Malika Center Special School (SLB) in West Jakarta, which serves students with various special needs. The originality of this research lies in its focus on the context of inclusive education with a new and flexible curriculum approach. A qualitative method was employed, with data collection techniques consisting of in-depth interviews and classroom observations. Empirical results show that teachers welcomed the Independent Curriculum due to its flexibility in adapting learning to individual student needs. This curriculum allows for a more personal and relevant approach; however, its implementation faces challenges such as limited adaptive resources, high teacher workload, and the need for intensive communication with parents. Strategies implemented include comprehensive assessment, collaboration with experts, and the development of adaptive materials based on students' actual needs. The implications of this study indicate the need for further support from schools and the government in the form of ongoing training, inclusive policies, and the provision of adequate resources to support the successful implementation of the Independent Curriculum in special schools. This research provides an important contribution to the development of inclusive education based on the national curriculum
THE INFLUENCE OF CURRICULUM RELEVANCE AND TEACHER COMPETENCE ON STUDENT SATISFACTION AT PKBM ANANDA BAIK ISLAMIC SCHOOL CIANJUR Ramdhan, Muhammad
JURNAL ASIK Vol 3 No 3 (2025): JURNAL ASIK: Jurnal Administrasi, Bisnis, Ilmu Manajemen, & Kependidikan
Publisher : BAIK Publishers

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59639/asik.v3i3.120

Abstract

This study aims to analyse the influence of curriculum relevance and teacher competence on student satisfaction at PKBM Ananda Baik Islamic School in Cianjur, Indonesia. Using a quantitative explanatory design, the research involved 50 students from Paket A (elementary equivalency), Paket B (junior high equivalency), and Paket C (senior high equivalency) in the 2025/2026 academic year, selected through accidental sampling. Data were collected using questionnaires measuring curriculum relevance, teacher competence, and student satisfaction, and were analysed through correlation tests, coefficients of determination, t-tests, and F-tests. The findings show that curriculum relevance has a significant effect on student satisfaction, with a correlation coefficient of ???? = 0.563 and ????2 = 0.317, while teacher competence also has a significant effect, with ???? = 0.621 and ????2 = 0.385. Simultaneously, curriculum relevance and teacher competence significantly influence student satisfaction, indicated by ???? = 0.656, ????2 = 0.431, and an F-value of 17.781 with a significance level of 0.000, suggesting that improvements in both variables jointly enhance student satisfaction at PKBM Ananda Baik Islamic School Cianjur.
Penerapan Prinsip Keadilan dalam Pembagian Risiko Kontrak Proyek Oil And Gas Ramdhan, Muhammad; Samian, Samian
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v11i1.63573

Abstract

Oil and gas projects are characterized by high technical complexity, large capital investment, and significant risk exposure, including technical, cost and time, health and safety (HSE), environmental, commercial, and regulatory risks. Contract design in oil and gas projects—particularly EPC/EPCI contracts and Production Sharing Contracts (PSC)—often raises issues of fairness in risk allocation between project owners and contractors. Imbalanced risk allocation practices tend to increase bid prices, trigger claims, and lead to contractual disputes. This article analyzes the application of fairness principles in risk allocation for oil and gas project contracts using a qualitative–normative approach through literature review and doctrinal analysis. The study integrates project risk allocation concepts, theories of fairness in contract law, and international standard practices such as FIDIC 2017 and knock-for-knock clauses. The findings indicate that fairness in risk allocation can be operationalized through criteria of control, capability, risk–reward symmetry, procedural transparency, and systemic impact. This article proposes a Fairness-Oriented Risk Allocation Framework (FORAF) as a conceptual approach to evaluate and design fairer risk allocation in oil and gas contracts. The framework is expected to reduce dispute potential and enhance the sustainability and performance of oil and gas projects, particularly in developing countries such as Indonesia.