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All Journal MEDIA KONSERVASI Jurnal Pengolahan Hasil Perikanan Indonesia International Journal of Artificial Intelligence Research JURNAL ILMIAH GEOMATIKA Marine Research in Indonesia Jurnal Riset Jakarta Jurnal Chart Datum CALL Jurnal Arastirma Jurnal PkM MIFTEK Jurnal Pengabdian Masyarakat dan Penelitian Thawalib Jurnal ASIK: Jurnal Administrasi, Bisnis, Ilmu Manajemen & Kependidikan Riwayat: Educational Journal of History and Humanities Jurnal Ilmiah Ekonomi, Manajemen dan Bisnis (EKMABIS) J-CEKI Journal Of Applied Multidisciplinary Studies (JAMS)
Muhammad Ramdhan
Balitbang - KP, Kementerian Kelautan dan Perikanan
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Environmental Science Languange, Linguistic, Communication & Media Mathematics Social Sciences Other

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Anti-breast cancer bioactive compounds and in-silico molecular prediction of Crassostrea angulata (Lamarck, 1819): Prediksi senyawa bioaktif antikanker payudara dan molekuler in-silico Crassostrea angulata (Lamarck, 1819) Kusumawati, Rr Puji Hastuti; Zamani, Neviaty Putri; Soedharma, Dedi; Nurjanah, Nurjanah; Arifin, Taslim; Yulius, Yulius; Samusamu, Andrias Steward; Akhwady, Rudhy; Ramdhan, Muhammad; Damanhuri, Harfiandri; Efendi, Eko; Mayaguezz, Henky; Muhaemin, Moh.
Jurnal Pengolahan Hasil Perikanan Indonesia Vol. 28 No. 1 (2025): Jurnal Pengolahan Hasil Perikanan Indonesia 28(1)
Publisher : Department of Aquatic Product Technology IPB University in collaboration with Masyarakat Pengolahan Hasil Perikanan Indonesia (MPHPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17844/jphpi.v28i1.57937

Abstract

Kanker payudara merupakan penyebab kematian kedua terbanyak di Indonesia. Bioprospeksi senyawa bioaktif dari organisme laut diharapkan dapat menjadi salah satu solusi pencegahan kanker payudara. Crassostrea angulata merupakan salah satu spesies tiram laut yang biasa dikonsumsi dan memiliki sejarah etnomedik di kalangan masyarakat Indonesia. Penelitian ini bertujuan untuk mengevaluasi potensi senyawa bioaktif antikanker dari ekstrak metanol C. angulata menggunakan analisis in-silico. Identifikasi senyawa aktif C. angulata menggunakan LC-HRMS melalui pendekatan molecular docking dengan mengombinasikan program-program KNApSAcK, CLC-Pred, SEA, STRING, PubChem, UniProt, PyMOL, PyRx, and PoseView. Hasil penelitian menunjukkan 12 senyawa aktif antikanker pada C. angulata, namun hanya 2 senyawa antikanker payudara (Flufenamic Acid, FA dan Hymenamide C, HC). Hasil molecular docking menunjukkan bahwa binding affinity yang kuat antara senyawa aktif Flufenamic Acid (FA) dengan protein target kanker payudara (CSF1R, PLK4, MKNK2, dan ABL1) dan senyawa Hymenamide C (HC) dengan protein target kanker payudara (GRB2 dan OXTR). Senyawa bioaktif FA menunjukkan nilai RMSD yang lebih rendah (mendekati 0Å) dengan ligan asli dari masing-masing protein target. FA memiliki potensi sebagai senyawa antikanker payudara yang lebih baik dari HC. Senyawa FA dan HC berpotensi sebagai penghambat protein target kanker payudara, namun masih memerlukan penelitian lebih lanjut terutama untuk penggunaan senyawa tersebut pada manusia.
TEACHERS' EXPERIENCES IN IMPLEMENTING THE INDEPENDENT CURRICULUM FOR STUDENTS WITH SPECIAL NEEDS AT MALIKA CENTER SPECIAL SCHOOL, WEST JAKARTA Ceilendra Saksana, Joned; Ramdhan, Muhammad; Muda Bota, Marselina
Journal Of Applied Multidisiplinary Studies Vol 1 No 2 (2025): Mei 2025
Publisher : Sekolah Tinggi Ilmu Ekonomi Ganesha

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Abstract

This study aims to understand teachers' experiences in implementing the Independent Curriculum (Kurikulum Merdeka) at Malika Center Special School (SLB) in West Jakarta, which serves students with various special needs. The originality of this research lies in its focus on the context of inclusive education with a new and flexible curriculum approach. A qualitative method was employed, with data collection techniques consisting of in-depth interviews and classroom observations. Empirical results show that teachers welcomed the Independent Curriculum due to its flexibility in adapting learning to individual student needs. This curriculum allows for a more personal and relevant approach; however, its implementation faces challenges such as limited adaptive resources, high teacher workload, and the need for intensive communication with parents. Strategies implemented include comprehensive assessment, collaboration with experts, and the development of adaptive materials based on students' actual needs. The implications of this study indicate the need for further support from schools and the government in the form of ongoing training, inclusive policies, and the provision of adequate resources to support the successful implementation of the Independent Curriculum in special schools. This research provides an important contribution to the development of inclusive education based on the national curriculum
THE INFLUENCE OF CURRICULUM RELEVANCE AND TEACHER COMPETENCE ON STUDENT SATISFACTION AT PKBM ANANDA BAIK ISLAMIC SCHOOL CIANJUR Ramdhan, Muhammad
JURNAL ASIK Vol 3 No 3 (2025): JURNAL ASIK: Jurnal Administrasi, Bisnis, Ilmu Manajemen, & Kependidikan
Publisher : BAIK Publishers

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59639/asik.v3i3.120

Abstract

This study aims to analyse the influence of curriculum relevance and teacher competence on student satisfaction at PKBM Ananda Baik Islamic School in Cianjur, Indonesia. Using a quantitative explanatory design, the research involved 50 students from Paket A (elementary equivalency), Paket B (junior high equivalency), and Paket C (senior high equivalency) in the 2025/2026 academic year, selected through accidental sampling. Data were collected using questionnaires measuring curriculum relevance, teacher competence, and student satisfaction, and were analysed through correlation tests, coefficients of determination, t-tests, and F-tests. The findings show that curriculum relevance has a significant effect on student satisfaction, with a correlation coefficient of ???? = 0.563 and ????2 = 0.317, while teacher competence also has a significant effect, with ???? = 0.621 and ????2 = 0.385. Simultaneously, curriculum relevance and teacher competence significantly influence student satisfaction, indicated by ???? = 0.656, ????2 = 0.431, and an F-value of 17.781 with a significance level of 0.000, suggesting that improvements in both variables jointly enhance student satisfaction at PKBM Ananda Baik Islamic School Cianjur.
Co-Authors Adhy Firdaus Adrianto, Dian Adventari, Tara Aep Saefullah Aida Heriati, Aida Akbar, Fikri Faisal Akmas, Nabila Andari, Sita Sri Andarista, Hilda Dian Assiddiqi, Hasbi Asyiri, Abdul Auliya, Naswa Damanhuri, Harfiandri DEDI SOEDHARMA Dini Purbani Effendy, Aidil Amin eko efendi ema, ema Ermawaty, Windy Erwin Hermawan Fakry, Hafidzh Fauziah, Asyifa Fujianti, Rista Ari Gunawan, Dino Guntor, Muhamad Haryono Haryono Hisyam, Nazhif Mochammad Ichsan Gaffar Ichsanuhaq, Gumilar Joned C. Saksana Joned Ceilendra Saksana Kusuma, Luh P A Savitri C Kusuma Kusumawati, Rr Puji Hastuti Lesmana Salim, Hadiwijaya Lusiani, Ripa Maftukhaturrizqoh, Olivia Mayaguezz, Henky Mochammad Imron Awalludin Moh. Muhaemin Muda Bota, Marselina Muhamad Ridwan Muhammad Ridwan Mulasih, Siti N. Nurjanah NEVIATY PUTRI ZAMANI Noviar, Ekky Ntoma, Ismail Adiyaksa Nugraha, Ilham Nurafifi, Sadam Alkayyis Nurbani, Muhammad Daffa Jati Nurhasanah, Ulfah OKY OXCYGENTRI Pagiling, Sarwan Purbowo, Andre Ramu Andika Rahman, Iwa Ali Rahmania, Rinny Rezeki, Pamella M Sri Rudhy Akhwady Ruswanda, Reza Sabina, Anninda Salim, Hadiwiijaya Lesmana Salim, Hadiwiijaya Lesmana Samusamu, Andrias Steward Setiyadi, Johar Setyawidati, Nur A.R. Siregar, Putera Abdilla Suandi, Imam Sudjatnika, Tenny SYAMSUL HIDAYAT Taslim Arifin Tito, Camellia Widodo S Pranowo Yulius Yulius Yulius, - Yulius, - Zainuddin, Zulkifli