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All Journal JURNAL GIZI INDONESIA Nurse Media Journal of Nursing UG Journal Journal of Nutrition College Forum Agribisnis Journal of Consumer Science Mutiara Medika: Jurnal Kedokteran dan Kesehatan ELT Forum: Journal of English Language Teaching Journal of Consumer Sciences Journal of Innovative Science Education Medica Hospitalia Jurnal Health Sains Neurona Seroja Husada: Jurnal Kesehatan Masyarakat
Retnaningsih Retnaningsih
Departemen Ilmu Keluarga dan Konsumen Fakultas Ekologi Manusia Institut Pertanian Bogor
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Serial Case: Infarct Stroke In Covid 19 Patients Retnaningsih, Retnaningsih; Tamad, Fatiha Sri Utami; Tugasworo, Dodik; Andhitara, Yovita; Ardhini, Rahmi; Kurnianto, Aditya
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 1 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i1.744

Abstract

Introduction: SARS-CoV-2 has been reported to cause various neurological symptoms including stroke. SARS-CoV-2 infection causes the release of cytokines, proinflammatory chemokines, immune system activation, coagulopathy, endothelium, vasculitis, hypoxia, renin-angiotensin system imbalance, and cardiovascular complications, all of which can contribute to stroke. Purpose: Describe the incidence of stroke with different conditions in COVID 19 Cases: There were two cases of stroke infarct in a COVID-19 patient who was admitted to our hospital. Both were treated with a diagnosis of stroke infarct with previous COVID-19 symptoms, the results of laboratory examinations revealed an increase in inflammatory markers in both patients and had been given appropriate treatment according to each patient's condition. But at the end of the treatment one patient died and the other patient went home with clinical improvement. Discussion: The incidence of stroke infarct in this case is thought to be due to several factors, namely the presence of comorbidities in the patient, microvascular thrombus due to the formation of neutrophil extracellular traps (NET), activation of complement which causes thrombogenesis and vasculopathy, formation of antiphospholipid antibodies so that protein c is reduced, the formation of microparticles causes platelet hyperactivation. and increased tissue factor (TF) resulting in hypercoagulation. Adequate therapy in controlling inflammation due to COVID 19 has shown clinical improvement in stroke infarct patients. Conclusion: There are 2 cases of stroke infarction in patients with covid 19 who have comorbidities. The first case with COVID advanced stages experienced a worsening of the condition despite being given appropriate therapy. The second case with COVID middle stages experienced an improvement in the condition after the viral inflammatory factors were controlled and the comorbidity was well controlled.
Apolipoprotein E Polymorphism and Carotid Intima Medial Thickness Progression in Post Ischemic Stroke Patient: Apolipoprotein E Polymorphism and Carotid Intima Medial Thickness Progression in Post Ischemic Stroke Patient Kurnianto, Aditya; Retnaningsih, Retnaningsih; Tugasworo, Dodik; Andhitara, Yovita; Ardhini, Rahmi; Budiman, Jethro
Medica Hospitalia : Journal of Clinical Medicine Vol. 9 No. 2 (2022): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (362.471 KB) | DOI: 10.36408/mhjcm.v9i2.750

Abstract

Background : Apolipoprotein E (APOE) gene is believed to associate with cholesterol level, a risk factor of ischemic stroke. CIMT (carotid intima-media thickness) can be used to determine the degree of atherosclerosis. Increased CIMT may predict ischemic stroke recurrence. This study aimed to determine association between increased CIMT in post ischemic stroke patients and APOE genotype. Methods : This was an epidemiological prospective study involving 71 post ischemic stroke patients (1 month from onset), admitted from 2012 to 2013. CIMT was examined with carotid duplex ultrasound at 1st, 6th, and 12nd month after stroke onset. APOE gene polymorphism was examined using HRM (high-resolution melting) which is a simple method, accurate, and sensitive for genotyping. Results : We found 5 APOE gene variation categories, i.e. E2E3, E2E4, E3E3, E3E4, and E4E4. The most common allele was E3 and genotype groups E3E3 was the majority of the population. E2E4 allele had the highest CIMT level among others, in the 1st month, 6th month, and 12nd month after stroke, with no association with hypertension, diabetes, and hypercholesterolemia. E3E3 allele was most often associated with hypertension, diabetes mellitus, dyslipidemia, and hyperhomocysteinemia. Conclusion : The results showed that APOE genotype E2E4 may independently constitute risk factor for atherosclerosis progression (CIMT) in post ischemic stroke patients. While the E3E3 genotype was often associated with hypertension, diabetes mellitus, dyslipidemia, and hyperhomocysteinemia. Our results suggest that APOE E4 was not an important risk factor for carotid atherosclerosis in post ischemic stroke patient.
Analisis Variasi Genetik Gen Angiotensinogen M235T pada Penderita Stroke Iskemik di Rumah Sakit Umum Pusat Dr. Kariadi, Semarang secara Polymerase Chain Reaction Restriction Fragment Length Polimorfism (PCR- RFLP) Tugasworo, Dodik; Retnaningsih, Retnaningsih; Kurnianto, Aditya; Suryadi, Suryadi; Rahmawati, Dani; Rahmayanti, Rahmayanti; Budiman, Jethro
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 1 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i1.833

Abstract

Background: Stroke is the leading cause of death and disability in the world. The incidence of ischemic stroke is influenced by genetic factors, environmental factors and their interactions. Genetic variation of the Angiotensinogen (AGT) M235T gene is associated with hypertension and diabetes mellitus, which are risk factors for stroke. Objective: To examine the genetic variation of the Angiotensinogen M235T gene in patients with Ischemic Stroke treated at Dr. Kariadi General hospital, Semarang. Method: The subjects of the study were 72 ischemic stroke patients who were treated at the outpatient clinic of the Neurology Department Dr. Kariadi Semarang in January - December 2013. DNA extraction of research subjects was performed at the CEBIOR laboratory, Diponegoro National Hospital from January to March 2020. Amplification was performed with Polymerase Chain Reaction (PCR). Digestion of PCR products was using Restriction Fragment Length Polymorphism (RFLP) method. Results: Out of 72 samples, the AGT M235T CT were found in 37 samples (51.4%), the AGT M235T TT gene was found in 35 samples (48.6%) and no samples showed the AGT M235T CC. Conclusion: There are 3 types of genetic variants of the AGT M235T gene, including the AGT M235T CT, the AGT M235T TT and the AGT M235T CC. Among the three types of variants, the variant of the AGT M235T CT gene is the most common variant found in ischemic stroke patients treated at the Dr. Kariadi General Hospital Semarang.
The Wistar Rat Parietal Lobe Cell And Pain Perception Changes After Frequent Of Mobile Phone Electromagnetic Wave Expose Tamad, Fatiha Sri Utami; Budisulistyo, Trianggoro; Husni, Amin; Retnaningsih, Retnaningsih; Suryawati, Herlina; Suryadi, Suryadi
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 2 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i2.884

Abstract

Background: The increasing number of mobile phone users raises concerns about the effects. Mobile phone electromagnetic wave radiation harms pain perception due to granular cell changes in the cerebral parietal cortex. Objective: To determine the effect of exposure to electromagnetic waves mobile phone on pain perception due to changes in the granular cells of the cerebral parietal cortex Wistar rats. Methods: Experimental research using randomized posttest with control group design. Samples were 28 rats divided into 4 groups. The control group was not exposed, the treatment group was exposed to 2100 MHz electromagnetic waves for 2 hours/day with a distance of 3 cm for 15 days in treatment group 1, for 30 days in treatment group 2, and 45 days in treatment group 3. Measurement of pain onset using the hot method. Changes in pain threshold were taken from the difference in pain onset after exposure to before exposure. Granular cell changes in the cerebral parietal cortex were assessed from the total score with the provisions of normal cells (sumx0), hydropic degenerated cells (sumx1), and necrotic cells (sumx2). Results: The longer the exposure to mobile phones, the higher the pain threshold and the cerebral parietal cortex granular cell damage score. There was a significant difference in pain threshold and changes in cerebral parietal cortex granular cells between groups (p=0.000). There was a significant relationship between changes in the parietal cerebral cortex granular cells and pain threshold in Wistar rats exposed to electromagnetic waves (p=0.000). Conclusion: Exposure to mobile phone electromagnetic waves affects pain perception due to changes in the granular cells of the cerebral parietal cortex in wistar rats.
Correlation between Blood Vitamin D Levels and Lipid Profiles in Post-Ischemic Stroke Patients Jaeri, Santoso; Retnaningsih, Retnaningsih; Husni, Amin; Maharani, Nani; Anjani, Gemala
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 24, No 2 (2024): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v24i2.22202

Abstract

Dyslipidemia and vitamin D deficiency are the predisposing factors for stroke. It is also established that vitamin D contributes to cholesterol metabolisms. Unfortunately, there is no evidence regarding the correlation between blood vitamin D levels and lipid profiles in patients with post-ischemic stroke. Herewith, the authors determine the correlation between blood vitamin D levels and lipid profiles among patients with post-ischemic stroke. A cross-sectional approach among 40 patients with post-ischemic stroke was obtained consecutively. Demographic characteristics, as well as the history of other diseases and 24 24-hour recall diet, were recorded. Then, the measurement of blood vitamin D levels and lipid profiles, such as total, LDL, HDL cholesterol, and triglyceride levels, were performed. Their correlations were determined using the Spearman correlation test. Among 40 subjects, no significant correlation was revealed between blood vitamin D levels and the serum total, LDL, HDL cholesterol, and triglycerides levels (p=0.898, 0.560, 0.361, and 0.622 respectively, and r=0.021, -0.095, 0.080, and 0.080 respectively). To summarize, there is no significant correlation between blood vitamin D levels and all lipid profiles in patients with post-ischemic stroke.
CORRELATION OF TNF-ALFA INFLAMMATION BIOMARKER LEVELS WITH THE INDONESIAN VERSION OF MONTREAL COGNITIVE ASSESSMENT (MOCA-INA) SCORES IN LAKUNAR ISCHEMIC STROKE PATIENTS Hamdani, Faishol; Hartono, Jimmy Eko Budi; Tugasworo, Dodik; Retnaningsih, Retnaningsih; Suryawati, Herlina; Puspitawati, Arinta
Seroja Husada: Jurnal Kesehatan Masyarakat Vol. 1 No. 5 (2024): Seroja Husada: Jurnal Kesehatan Masyarakat
Publisher : Seroja Husada: Jurnal Kesehatan Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Tumor Necrosis Factor-Alpha (TNF-α) is a pro-inflammatory cytokine that is responsible for modulation the immune system. TNF-α is another important mediator involved in stroke pathophysiology. Cerebral small vessel disease (CSVD) is a major cause of lacunar ischemic stroke. In stroke there is an increase in TNF-α levels where post-stroke neuroanatomic damage can cause cognitive impairment. Objective: Proving the relationship between TNF-α serum levels on the day 3 of onset and the Moca Ina score on the day 7 of onset, day 30, and the difference in MoCa-INA scores and analyzing the relationship of risk factors cognitive function in lacunar ischemic stroke patients. Methods: An analytical observational study with a prospective cohort approach. Subjects were first-time lacunar ischemic stroke with blood sampling on the day 3 of onset to evaluate TNF-α levels. Cognitive function was examined by the MoCa-INA score which was evaluated on day 7 and day 30. Eta correlation test to connect TNF-α levels with MoCa-INA scores. Bivariate and multivariate analyzes used between the MoCa-INA score and other confounding factors. Results: There was a strong correlation between TNF-α levels on day 3 of onset and MoCA-INA on day 7 (ƞ= 0.972), a very strong correlation was found between TNF-α levels on day 3 of onset and MoCA-INA on day 30 (ƞ= 1,000), and there was a strong correlation between TNF-α levels on day 3 of onset and the difference between MoCA-INA (ƞ=0.905). there is a confounding variable diabetes mellitus that affects the 7th day of MoCA-INA. In the sub-analysis study, the mean serum TNF-α level on cognitive impairment on day 30 was higher than on day 7 with the most dominant domains being visuospatial and executive. Conclusion: There is a strong relationship between serum TNF-α levels and MoCa-INA scores in lacunar ischemic stroke patients, and there is one confounding variable of diabetes mellitus that affects the MoCa-INA score on the 7th day of examination.
Optimizing Brain-Computer Interfaces for Methampetamine Use Disorder through Quantitative Electroencephalography (QEEG) and Transcranial Doppler Analysis: Article Review Caroline, Maria; Syahrul, Syahrul; Tugasworo, Dodik; Retnaningsih, Retnaningsih; Juswanto, Gerard
Jurnal Health Sains Vol. 5 No. 9 (2024): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v5i9.1372

Abstract

A Brain-Computer Interface (BCI) is a system that allows a person to control external devices using only their brain activity. It works by translating brain signals into commands that can be understood by a computer. Several lines of evidence demonstrated the deleterious effect of methamphetamine (MA) on neurological and psychological functions. The use of amphetamines, such as MA, is associated with cerebrovascular complications such as cerebrovascular accidents (CVA) ,hemorrhage, hypoxic damage and vasculitis. Interestingly, while changes to cerebral blood flow (CBF) in response to acute amphetamine exposure have been reported. Transcranial Color Doppler (TCCD) is a non-invasive medical imaging technique that uses ultrasound waves to measure blood flow velocity in the major arteries of the brain, specifically within the circle of Willis. The research paper you referenced explores the use of TCCD as a potential measurement modality for BCIs. Quantitative electroencephalogram (qEEG) is a powerful tool for understanding brain function qEEG can reveal specific brain wave patterns associated with drug addiction, potentially providing insights into the neurobiological mechanisms underlying cravings, withdrawal symptoms, and relapse risk in Methamphetamine User Disorder (MUD). There is growing research interest in using Transcranial dopller as a measurement modality for BCIs.Here are some of the key considerations for using Transcranial doppler in BCIs: Mental Tasks, signal processing and classification, accuracy and reliability. Transcranial doppler provides information about blood flow in specific arteries but lacks detailed spatial information about brain activity. These patterns could vary depending on the type of drug, the severity of addiction, and individual differences. Transcranial doppler in measuring middle cerebral artery (MCA) blood flow velocity parameters (peak systolic velocity (PSV) and mean flow velocity (MFV)). qEEG can help researchers investigate the complex interplay between addiction and other brain disorders, like depression or anxiety. Characteristic qEEG in drugs addiction Increased Theta (4-8 Hz) and delta (1-4 Hz) brain waves are often associated with sleep and relaxation. However, research has shown that individuals with drug addiction may have increased theta and delta activity, particularly in the frontal and temporal regions of the brain. Altered Beta (13-30 Hz) brain waves are generally associated with wakefulness, alertness, and cognitive processing. Studies have observed both increases and decreases in beta activity in individuals with drug addiction, depending on the type of drug, the stage of addiction, and the specific brain regions being examined. The results of this research have important practical implications for building an diagnostic and functional assement with a better understanding of an using technology.
The Role of Motivation and Reference Group on Functional Food Consumption Behavior Retnaningsih, Retnaningsih; Junedi, Rahmat
Journal of Consumer Sciences Vol. 9 No. 3 (2024): Journal of Consumer Sciences
Publisher : Department of Family and Consumer Sciences, Faculty of Human Ecology, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jcs.9.3.409-427

Abstract

The advancement of food science and technology has encouraged the development of functional foods in Indonesia. This study aimed to examine the influence of motivation and reference groups on functional food consumption behavior. This cross-sectional research involved 204 active students of IPB University who were selected using the simple random sampling technique. The data were analyzed using descriptive and inferential data analysis. The linear regression tests revealed that pocket money, reference groups, and motivation positively affected the frequency of functional food consumption. In addition, motivation had a significant positive effect on the number of types of functional foods consumed. The results showed that students' motivation to consume functional foods was low. In light of these findings, the government should actively promote the consumption of functional foods by regulating the prices of functional food sources in the market. Universities and industry producers must collaborate to conduct extensive outreach and education to effectively disseminate information about functional foods.
Luaran Klinis dan Komplikasi Terapi Endovaskular pada Pasien Stroke Iskemik Akut dengan Trombolisis Intra-Arteri dan Trombektomi Mekanik pada Setting Penanganan Kritis Retnaningsih, Retnaningsih; Tugasworo, Dodik; Kurnianto, Aditya; Tri Rahayu, Fitriani
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 3 (2025): Vol 41 No 3 (2024): Volume 41, No 3 - Juni 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i3.774

Abstract

Introduction: Acute ischemic stroke (AIS) is a major cause of disability and death worldwide. Mechanical thrombectomy (MT) has become the standard endovascular therapy for AIS with large vessel occlusion, though incomplete reperfusion remains a concern. Intra-arterial thrombolysis (IA-T) has emerged as a potential adjunct therapy to enhance reperfusion. Aim: To evaluate clinical outcomes and complication rates between IA-T plus MT compared to MT alone in AIS patients treated in the ICU of Dr. Kariadi Hospital, Semarang. Methods: A total of 38 AIS patients with MCA occlusion who received endovascular reperfusion therapy were divided into two intervention groups: IA-T + TM (n=18) and TM alone (n=20). Outcomes according to Modified Rankin Scale (mRS) score and complication data were compared between groups. Results: Patients in both groups had similar baseline characteristics. A higher percentage of patients in the IA-T + MT group achieved favorable mRS scores (0–2) compared to the MT-only group (72.2% vs 65%), though the difference was not statistically significant (p=0.632). No significant differences in complication rates were found. Discussion: The combination of IA-T and MT showed a trend toward better functional outcomes without significantly increasing complications. This suggests potential benefit in selected cases. Keywords: ischemic stroke, intra-arterial thrombolysis, mechanical thrombectomy
The Influence of Risk Perception, Smoking Fatwa Knowledge, and Smoking Behavior on the Intention to Quit Smoking in Adolescents Tyas, Ayuning; Retnaningsih, Retnaningsih
Journal of Consumer Sciences Vol. 10 No. 2 (2025): Journal of Consumer Sciences
Publisher : Department of Family and Consumer Sciences, Faculty of Human Ecology, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jcs.10.2.394-414

Abstract

Background: The percentage of adolescent smokers is increasing; however, survey results indicate that many adolescent smokers express a desire to quit. Purpose: This study aims to analyze the effects of risk perception, smoking fatwa knowledge, and smoking behavior on the intention to quit smoking. Method: This cross-sectional study involved 100 Muslim adolescents aged 13-18 years who had actively smoked within the past three months. Risk perception was measured across five dimensions: functional, financial, physical, psychological, and social. Knowledge of the smoking fatwa refers to the fatwa issued by the Indonesian Ulema Council (MUI). Findings: The results showed that the highest perceived risk was functional risk, while the lowest was social risk. Only 32% of participants were aware of the fatwa issued by the MUI. On average, participants smoked 6.3 cigarettes per day, and 81% were classified as light daily smokers. Knowledge of the fatwa and the number of cigarettes smoked daily did not affect the intention to quit smoking. Perceived social risk had a positive effect on smoking cessation intention. Conclusions: Based on the results of the study, the factors influencing adolescents' intention to quit smoking include age, father's age, father's education, father's smoking status, social perceptions, and smoking-related expenditure. Research implications: The findings suggest the need for a holistic approach that targets adolescents at the individual, family, and community levels. Preventive, curative, repressive, and persuasive strategies are essential to promote smoking cessation intentions and reduce smoking behavior among adolescents.
Co-Authors Afina, Siti Agung, Locoporta Aisy, Rihadatul Al Mutanafisa, Tasneem Amin Husni Andhitara, Yovita Andhitara, Yovita Andhitara Anjani, Gemala Ardhini, Rahmi Asep Taryana Budisulistyo, Trianggoro Caroline, Maria Daynuri, Daynuri Diah Retno Wahyuningrum Dodik Tugasworo Dwi Febryanto Endang Gumbira Sa’id Fadila Ramadini Febriantina Dewi Firli Bramantyo, Dion Fitria Handayani Hajijah, Rengganis Novyanti Hamdani, Faishol Hartono, Jimmy Eko Budi Jaeri, Santoso Jethro Budiman, Jethro Junedi, Rahmat Juswanto, Gerard Kurnianto, Aditya Kurnianto, Aditya Kurnianto Martha Irene Kartasurya Nana Rochana, Nana Nani Maharani Noni Widiawatie Nuraini Nuraini Priambada, Dody Puspitawati, Arinta Putri, Ayulia Karisma Putri, Nadya Yona Eka Rahmawati, Dani Rahmayanti Rahmayanti RIA ANGGRAINI Saiful Ridlo Satrioaji, Hari Wahono Sofro, Muchlis AU Achsan Udji Suryadi Suryadi Suryawati, Herlina Syahrul Syahrul Tamad, Fatiha Sri Utami Tri Rahayu, Fitriani Trisnaningtyas, Wenny Tsaniadi Prihastomo, Krisna Tugasworo, Dodik ` Tyas, Ayuning W.H, Nugrahaningsih Widaryanti, Widya Bella Yudiatma, Muh. Firman Yuridis, Melani Sukma