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All Journal JURNAL GIZI INDONESIA Nurse Media Journal of Nursing UG Journal Journal of Nutrition College Forum Agribisnis Mutiara Medika: Jurnal Kedokteran dan Kesehatan The Indonesian Biomedical Journal ELT Forum: Journal of English Language Teaching Journal of Innovative Science Education Medica Hospitalia Jurnal Health Sains Jurnal Keperawatan Klinis dan Komunitas (Clinical and Community Nursing Journal) Neurona Seroja Husada: Jurnal Kesehatan Masyarakat Jurnal Info Kesehatan
Retnaningsih Retnaningsih
Departemen Ilmu Keluarga dan Konsumen Fakultas Ekologi Manusia Institut Pertanian Bogor
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Luaran Klinis dan Komplikasi Terapi Endovaskular pada Pasien Stroke Iskemik Akut dengan Trombolisis Intra-Arteri dan Trombektomi Mekanik pada Setting Penanganan Kritis Retnaningsih, Retnaningsih; Tugasworo, Dodik; Kurnianto, Aditya; Tri Rahayu, Fitriani
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 3 (2025): Vol 41 No 3 (2024): Volume 41, No 3 - Juni 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i3.774

Abstract

Introduction: Acute ischemic stroke (AIS) is a major cause of disability and death worldwide. Mechanical thrombectomy (MT) has become the standard endovascular therapy for AIS with large vessel occlusion, though incomplete reperfusion remains a concern. Intra-arterial thrombolysis (IA-T) has emerged as a potential adjunct therapy to enhance reperfusion. Aim: To evaluate clinical outcomes and complication rates between IA-T plus MT compared to MT alone in AIS patients treated in the ICU of Dr. Kariadi Hospital, Semarang. Methods: A total of 38 AIS patients with MCA occlusion who received endovascular reperfusion therapy were divided into two intervention groups: IA-T + TM (n=18) and TM alone (n=20). Outcomes according to Modified Rankin Scale (mRS) score and complication data were compared between groups. Results: Patients in both groups had similar baseline characteristics. A higher percentage of patients in the IA-T + MT group achieved favorable mRS scores (0–2) compared to the MT-only group (72.2% vs 65%), though the difference was not statistically significant (p=0.632). No significant differences in complication rates were found. Discussion: The combination of IA-T and MT showed a trend toward better functional outcomes without significantly increasing complications. This suggests potential benefit in selected cases. Keywords: ischemic stroke, intra-arterial thrombolysis, mechanical thrombectomy
Manajemen Syok Hipovolemia pada Pasien Fraktur Patologis Neck-Femur Suspek Metastasis dengan Hemiarthroplasty: Studi Kasus Retnaningsih, Retnaningsih; Triyanto, Arifin; Subekti, Tri
Jurnal Keperawatan Klinis dan Komunitas (Clinical and Community Nursing Journal) Vol 8, No 2 (2024)
Publisher : PSIK FKKMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jkkk.95734

Abstract

Background: Hemiarthroplasty in a pathological neck-femur fracture of suspected Metastatic Bone Disease (MBD) case, increases the risk of intraoperative bleeding and hypovolemic shock. Case studies related to this phenomenon are scarce.Objective: Describe the management of hypovolemic shock in pathological neck-femur fracture patient with MBD suspect which was followed by hemiarthroplasty action.Case Report: A 59-year-old woman experienced bleeding of 1,000-1,300 cc during surgery, causing shock with low blood pressure, tachycardia, and cold acral. Management of hypovolemic shock during surgery included fluid resuscitation, administration of vasopressors, blood transfusion, and administration of tranexamic acid.Outcome: Hypovolemic shock management course of action was include hemodynamic and coagulation management, with the collaboration of a team of nurses and doctors. The role of instrument, circular, and anesthesia nurses was crucial to maintain patient stability during surgery. After being given management intervention hypovolemic shock, the patient's response to resuscitation therapy was in a fast category so that the shock was quickly resolved and the operation could be continued until completion.Conclusion: Monitoring and rapid treatment of shock in pathological neck-femur fracture patient with MBD suspect which is followed by hemiarthroplasty action, including intraoperative bleeding, can prevent morbidity and mortality.INTISARILatar belakang:Hemiarthroplasty pada fraktur patologis neck-femur suspek Metastatic Bone Disease (MBD) meningkatkan risiko perdarahan intraoperatif dan syok hipovolemia. Studi kasus terkait hal ini masih jarang ditemukan. Tujuan: Mendeskripsikan tata laksana manajemen syok hipovolemia pada pasien fraktur patologis neck-femur suspek mengalami MBD untuk kemudian mendapatkan tindakan hemiarthroplasty.Laporan kasus: Wanita 59 tahun mengalami perdarahan 1.000-1.300 cc selama operasi, menyebabkan syok dengan tekanan darah rendah, takikardi, dan akral dingin. Manajemen syok hipovolemia selama operasi, meliputi resusitasi cairan, pemberian vasopressor, transfusi darah, dan pemberian asam traneksamat.Hasil:Tindakan manajemen syok hipovolemia meliputi manajemen hemodinamik dan koagulasi, dengan kolaborasi tim perawat dan dokter. Peran perawat instrumen, sirkuler, dan anestesi penting untuk menjaga stabilitas pasien selama operasi. Setelah diberikan intervensi manajemen syok hipovolemia, respons pasien terhadap terapi resusitasi termasuk katagori cepat, sehingga syok segera teratasi dan operasi dapat dilanjutkan sampai selesai.Simpulan:Monitoring dan penanganan syok secara cepat pada pasien fraktur patologis neck-femur yang dilakukan tindakan hemiarthroplasty dengan perdarahan intraoperatif dapat mencegah morbiditas dan mortalitas.  
The Injected Plasma of Myasthenia Gravis Patient with A Low T-reg Level Caused Clinical Myasthenic Syndromes in Swiss-Webster Mice Pasmanasari, Elta Diah; Purwaningsih, Erni Hernawati; Retnaningsih, Retnaningsih; Purba, Jan Sudir; Octaviana, Fitri
The Indonesian Biomedical Journal Vol 16, No 4 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i4.3086

Abstract

BACKGROUND: Myasthenia gravis (MG) is a rare autoimmune disease affecting neuromuscular junction involvement. The finding that T-reg level in MG patients was lower than that in normal persons leads to the idea that the primary pathology of the disease is T-reg dependent. The T-reg level of MG patients seems to be decreasing compared to that of normal persons. The study was conducted to observe the contribution of T-reg level in plasma injected into Swiss-Webster mice to develop clinically and pathologically myasthenic syndromes.METHODS: Swiss-Webster mice were grouped into three groups: the groups received plasma with normal, low, and high T-reg levels, respectively. The T-reg levels of the mice were measured with flow cytometry analysis and a human regulatory T-cell cocktail for T-cell surface cell marker. The motor function, interleukin (IL)-2, interferon (IFN)-γ, and thymus weight of mice were measured after the injection. Histopathological examination was performed to analyze mice’s muscles and thymus.RESULTS: The result identified that the motor function (2-week treatment group: p=0.021 and 3-week treatment group: p=0.032) and muscle width (p=0.014, p=0.032 and p≤0.001) were significantly lower in the low T-reg level plasma group compared to control and high T-reg level plasma groups. The thymus showed an increase in weight without an increase in the cortex-medulla ratio of the thymus, indicating hyperplasia. Both IL-2 and IFN-γ levels were lower in the low and high T-reg level groups compared with the control group, indicating the autoimmune process.CONCLUSION: Low T-reg level was associated with lower motor function, muscle width, increased thymus weight, as well as lower IL-2 and IFN-γ levels. T-reg level contributed to clinical myasthenic syndromes but not pathological findings. This research method is expected to be a basis for the development of animal models with Swiss-Webster mice.KEYWORDS: animal model, Myasthenia gravis, Swiss-Webster mice
Correlation between Language Screening Test and Frenchay Aphasia Screening Test for Aphasia Screening in Ischemic Stroke Febryanto, Dwi; Yudiatma, Muh. Firman; Widiawatie, Noni; Retnaningsih, Retnaningsih; Handayani, Fitria; Anggraini, Ria
JURNAL INFO KESEHATAN Vol 22 No 1 (2024): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol22.Iss1.991

Abstract

Aphasia is a communication disorder that occurs after brain damage. Delays in diagnosing aphasia can lead to depression, decrease quality of life, and raise hospital stays and costs. Ischemic stroke aphasia screening instruments have been widely developed but are still difficult to interpret.  Nowadays, the Language Screening Test (LAST) is reportedly quick, easy to understand, straightforward, and suitable for use by nurses. However, the LAST subtests are different from the Frenchay Aphasia Screening Test (FAST), which has been used in the past to evaluate aphasia. This study aims to determine the relationship between LAST and FAST in ischemic stroke aphasic patients for aphasia screening. The study used an analytic observational method with a cross-sectional approach. The population in this study were stroke patients at Tugurejo Semarang Hospital who had their CT Scan checked. The sample was taken using a purposive sampling technique. Bivariate data analysis with Spearman Rank Correlation test. We obtained 50 samples 19 male patients and 31 female patients with the highest age range of 51-60 years as many as 26 patients. The highest Education and profession is primary school and housewife. Patients who experienced aphasia with LAST and FAST scored as many as 27 and 29 people, while the rest not have aphasia. The Spearman's Rank test obtained p-values of 0,000 and < 0,05 respectively. Meanwhile, the correlation coefficients of LAST and FAST on aphasia were 0,678 and 0,678 respectively. There is a positive correlation between the LAST and FAST in ischemic stroke aphasic patients for aphasia screening. Nurses can use the LAST instrument to collect data and establish nursing diagnoses of verbal communication disorders.
Optimizing Brain-Computer Interfaces for Methampetamine Use Disorder through Quantitative Electroencephalography (QEEG) and Transcranial Doppler Analysis: Article Review Caroline, Maria; Syahrul, Syahrul; Tugasworo, Dodik; Retnaningsih, Retnaningsih; Juswanto, Gerard
Jurnal Health Sains Vol. 5 No. 9 (2024): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v5i9.1372

Abstract

A Brain-Computer Interface (BCI) is a system that allows a person to control external devices using only their brain activity. It works by translating brain signals into commands that can be understood by a computer. Several lines of evidence demonstrated the deleterious effect of methamphetamine (MA) on neurological and psychological functions. The use of amphetamines, such as MA, is associated with cerebrovascular complications such as cerebrovascular accidents (CVA) ,hemorrhage, hypoxic damage and vasculitis. Interestingly, while changes to cerebral blood flow (CBF) in response to acute amphetamine exposure have been reported. Transcranial Color Doppler (TCCD) is a non-invasive medical imaging technique that uses ultrasound waves to measure blood flow velocity in the major arteries of the brain, specifically within the circle of Willis. The research paper you referenced explores the use of TCCD as a potential measurement modality for BCIs. Quantitative electroencephalogram (qEEG) is a powerful tool for understanding brain function qEEG can reveal specific brain wave patterns associated with drug addiction, potentially providing insights into the neurobiological mechanisms underlying cravings, withdrawal symptoms, and relapse risk in Methamphetamine User Disorder (MUD). There is growing research interest in using Transcranial dopller as a measurement modality for BCIs.Here are some of the key considerations for using Transcranial doppler in BCIs: Mental Tasks, signal processing and classification, accuracy and reliability. Transcranial doppler provides information about blood flow in specific arteries but lacks detailed spatial information about brain activity. These patterns could vary depending on the type of drug, the severity of addiction, and individual differences. Transcranial doppler in measuring middle cerebral artery (MCA) blood flow velocity parameters (peak systolic velocity (PSV) and mean flow velocity (MFV)). qEEG can help researchers investigate the complex interplay between addiction and other brain disorders, like depression or anxiety. Characteristic qEEG in drugs addiction Increased Theta (4-8 Hz) and delta (1-4 Hz) brain waves are often associated with sleep and relaxation. However, research has shown that individuals with drug addiction may have increased theta and delta activity, particularly in the frontal and temporal regions of the brain. Altered Beta (13-30 Hz) brain waves are generally associated with wakefulness, alertness, and cognitive processing. Studies have observed both increases and decreases in beta activity in individuals with drug addiction, depending on the type of drug, the stage of addiction, and the specific brain regions being examined. The results of this research have important practical implications for building an diagnostic and functional assement with a better understanding of an using technology.
Co-Authors Afina, Siti Agung, Locoporta Aisy, Rihadatul Al Mutanafisa, Tasneem Amin Husni Andhitara, Yovita Andhitara, Yovita Andhitara Anjani, Gemala Ardhini, Rahmi Arifin Triyanto Asep Taryana Budisulistyo, Trianggoro Caroline, Maria Daynuri, Daynuri Diah Retno Wahyuningrum Dodik Tugasworo Dwi Febryanto Endang Gumbira Sa’id Erni Hernawati Purwaningsih, Erni Hernawati Fadila Ramadini Febriantina Dewi Firli Bramantyo, Dion Fitri Octaviana Fitria Handayani Hajijah, Rengganis Novyanti Hamdani, Faishol Hartono, Jimmy Eko Budi Jaeri, Santoso Jethro Budiman, Jethro Juswanto, Gerard Kurnianto, Aditya Kurnianto, Aditya Kurnianto Lia Yuliana Martha Irene Kartasurya Muh Firman Yudiatma Nana Rochana, Nana Nani Maharani Noni Widiawatie Nuraini Nuraini Pasmanasari, Elta Diah Priambada, Dody Purba, Jan Sudir Puspitawati, Arinta Putri, Ayulia Karisma Putri, Nadya Yona Eka Rahmawati, Dani Rahmayanti Rahmayanti RIA ANGGRAINI Saiful Ridlo Satrioaji, Hari Wahono Sofro, Muchlis AU Achsan Udji Suryadi Suryadi Suryawati, Herlina Syahrul Syahrul Tamad, Fatiha Sri Utami Tri Rahayu, Fitriani Tri Subekti Trisnaningtyas, Wenny Tsaniadi Prihastomo, Krisna Tugasworo, Dodik ` W.H, Nugrahaningsih Wahyuni, Ribut Nurul Tri Widaryanti, Widya Bella Yuridis, Melani Sukma