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All Journal International Journal of Integrated Health Sciences Medical Journal of Indonesia Jurnal Epidemiologi Kesehatan Indonesia The Indonesian Journal of Infectious Diseases Jurnal Respirologi Indonesia Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia SURABAYA PHYSICAL MEDICINE AND REHABILITATION JOURNAL Respiratory Science Narra J Malang Respiratory Journal Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Jurnal Ilmu Kesehatan Masyarakat Ophthalmologica Indonesiana Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Erlina Burhan
Departemen Pulmonologi Dan Kedokteran Respirasi Fakultas Kedokteran Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Long COVID: Diagnosis and Treatment of Respiratory Syndrome in Post COVID-19 Conditions Erlina Burhan
Jurnal Respirologi Indonesia Vol 42, No 3 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i3.279

Abstract

The ongoing COVID-19 pandemic has given rise to another medical burden that came from the symptoms experienced by patients after acute infection with SARS-CoV-2, a condition often called as Long COVID. As the number of COVID-19 cases remain rising, various studies and scientific researches are being conducted to understand more about Long COVID, and findings have consistently shown increased burden due to Long COVID that needs more attention from the clinical world. This article review collects various sources regarding the diagnosis and management of respiratory syndrome in post-COVID-19 conditions. Long COVID, currently referred to as a post-COVID-19 condition, consists of symptom(s) that occurs in individuals with a history of probable or confirmed SARS-CoV-2 infection, with symptoms lasting at least two months and cannot be explained by any alternative diagnosis. Symptoms that occur are very diverse from various organ systems, including the respiratory system. Knowledge regarding the possible symptoms as well as a thorough evaluation is needed to identify and diagnose post-COVID-19 conditions, and multidisciplinary management through a tiered system may help reach more cases of post-COVID-19 conditions. The treatment for post-COVID-19 conditions needs to be adjusted to the patient's condition, and the administration of pharmacological therapy such as steroids, bronchodilators, and mucolytics/antioxidants has to be based on clinical symptoms and radiological abnormalities.
Mesenchymal Stem Cells Role in COVID-19 Myocardial Injury Triya Damayanti; Mega Juliana; Yasmina Hanifah; Erlina Burhan; Putri Suci Ramadhany
Jurnal Respirologi Indonesia Vol 42, No 4 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i4.192

Abstract

Coronavirus Disease-19 (COVID-19) has become a global pandemic that affected the lives of billion individuals. The clinical spectrum of the disease varies from asymptomatic form to severe manifestation in term of acute respiratory distress syndrome (ARDS), shock and septic shock and multiple organ dysfunction syndrome (MODS). Clinical studies have also reported an association between COVID-19 and cardiovascular manifestation, such as myocardial injury, arrhythmias, acute coronary syndrome (ACS) and thromboembolism. Myocardial injury has been reported frequently and is associated with high mortality. The currently approved strategies for COVID-19 are supportive rather than curative treatment. Cell-based approaches, primarily using mesenchymal stem cell (MSC) has demonstrated safety and possible efficacy as an adjuvant therapy in COVID-19 patient. Mesenchymal stem cells have shown important role in the therapy of cardiovascular disease due to their prominent features including their ability to differentiate into cardiovascular cells, immunomodulatory properties, antifibrotic activity and ability to undergo neovasculogenic.
Coronavirus yang Meresahkan Dunia Erlina Burhan
Majalah Kedokteran Indonesia Vol 70 No 2 (2020): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.70.2-2020-170

Abstract

Di penghujung tahun 2019, laporan pemerintah China membuat publik ibuat penasaran dan tim ahli sibuk meneliti. Tepat tanggal 31 Desember 2019, China melaporkan kejadian luar biasa, kasus pneumonia misterius yang belum diketahui penyebabnya, tepatnya di Kota Wuhan, Provinsi Hubei.1 Berdasarkan penelitian terhadap 41 pasien pertama kasus diduga terkait atau terpapar dengan satu pasar hewan di Wuhan, China.
Myocard Injury in COVID-19 Patients After Application Of Umbilical Cord Mesenchymal Stem Cell (UC-MSC) as Adjuvant Therapy in Persahabatan Hospital Mega Juliana; Triya Damayanti; Yasmina Hanifah; Erlina Burhan
Respiratory Science Vol. 3 No. 3 (2023): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v3i3.89

Abstract

Background: Myocardial injury was a frequent cardiovascular manifestation of COVID-19 and associated with high mortality.  Cell-based approaches, primarily using mesenchymal stem cell (MSC) has demonstrated safety and possible efficacy as adjuvant therapy in COVID-19 patients. This study aims to evaluate myocardial injury in patients with moderate-severe and critically ill COVID-19 after the application of umbilical cord mesenchymal stem cell (UC-MSC) as adjuvant therapy in Persahabatan hospital. Method: This is a retrospective and prospective cohort study. A total of 28 subjects were allocated to 13 subjects in the control and 15 subjects in the experimental group. Subjects were given the standard treatment and UC-MSC or placebo. Myocardial injury is defined by an increase of troponin I >26 pg/ml. The biomarkers of troponin I, NT-proBNP and CRP was examined periodically. Cardiac pump evaluated by EF and TAPSE from echocardiography examination before and after UC-MSC application. The evaluation of myocardial injury, biomarkers, cardiac pump and 15-day mortality were observed between the two groups. Results: The incidence of myocardial injury was 28,6% of total subjects. Subjects with worsening myocardial injury were higher in the control group (6 subjects) than the experimental group (4 subjects) although not statistically significant. The difference in biomarkers (troponin I, NT- pro-BNP and CRP), cardiac pump function (EF and TAPSE) and 15-day mortality between two groups were not statistically significant. There was a trend of decreasing troponin I, NT-proBNP and CRP in the experimental group. Conclusion: UC-MSC application can be an option as adjuvant therapy in improving myocardial injury of moderate-severe and critically ill COVID-19 patients.
Changes in Pattern and Multifocal Electroretinogram in Tuberculosis Patient with Ethambutol Therapy Syntia Nusanti; Budiman Bintang Prakoso; Muhamad Sidik; Erlina Burhan; Aria Kekalih
Majalah Oftalmologi Indonesia Vol 48 No 1 (2022): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v48i1.100315

Abstract

Introduction: Tuberculosis (TB) is a world health problem, especially in Indonesia as the third biggest country for new emerging TB patients. Ethambutol is one of the standard therapies to treat TB patients in Indonesia. Ethambutol has a side effect called ethambutol optic neuropathy which is hard to diagnose due to normal fundus appearance in most cases and therefore often detected late. Early detection is necessary so that permanent damage can be prevented. Examination pattern electroretinography (pERG) and multifocal electroretinography (mfERG) have the advantage to detect and confirm ocular toxicity by ethambutol after the clinical problem had emerged. It is not yet known neither pERG nor mfERG could detect any changes to detect ethambutol ocular toxicity before the clinical problem emerged. Methods: This study was a prospective clinical trial with 40 eyes samples and analyzed with paired t and Wilcoxon tests. The ocular examination was conducted using the Snellen chart, HRR Richmond Plates, Pelli Robson, pERG, and mfERG in tuberculosis category 1 patient with 2 months follow-up. Result: Visual acuity, color, and contrast sensitivity were normal in all patients for 2 months follow-up period. In pERG examination, the mean implicit time wave P50 was shortened by -1.27± 4.71 mS (p=0.049), and the mean amplitude wave N95 was reduced by -0.93± 4.49 ?V (p=0.038). Both were statistically significant. In the mfERG examination, we did not find any statistically significant changes in both wave N1 and P1. Conclusion: Changes in pattern ERG presented earlier compared to mfERG after ethambutol therapy for 2 months.
Chronic Obstructive Pulmonary Disease Exacerbation Complicated with Pneumonia and Lung Cancer: An Evidence-based Case Report of Erdosteine Role in the Management of Complex COPD Ahmad Fadhil Ilham; Muhammad Ilham Dhiya Rakasiwi; Ris Raihan Felim; Ahmad Arfan; Erlina Burhan
Malang Respiratory Journal Vol. 6 No. 2 (2024): September 2024
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mrj.2024.006.02.05

Abstract

Background: Acute exacerbations of chronic obstructive pulmonary disease (COPD) are strongly associated with poor health status and morbidity. Erdosteine is a mucolytic agent that also has anti-inflammatory, antioxidant and antibacterial effects. This case report aims to evaluate the role of erdosteine in the prevention and treatment of acute exacerbations of complex COPD case. Case: A 73-year-old male arrived at the emergency department with an increased difficulty in breathing that had deteriorated over the previous 5 days, and had a history of heavy smoking for more than 40 years. Following a thorough examination, he was diagnosed with acute exacerbation of COPD (Anthonisen criteria type 2) in clinical group E, pneumonia, along with stage IIIA right lung tumor (T4N1Mx), and received erdosteine inhalation as part of his treatment. Discussion: A comprehensive search of journal databases (PubMed, EMBASE, CENTRAL, EBSCO Medline, Scopus, and ProQuest) was conducted using specific keywords, critical appraisal based on the Oxford Center for Evidence-Based Medicine. Article selection resulted in 1 systematic review article for the prevention of acute exacerbations and 1 systematic review article for the management of acute exacerbations of COPD. In patients with stable COPD, administration of erdosteine in the standard COPD regimen significantly reduced the risk of exacerbations (RR=0.65; p=0.01), while in patients with acute exacerbations of COPD, erdosteine increased treatment success (OR=3.2; p<0.0001). Conclusion: Erdosteine may serve as a therapeutic choice for COPD patients in preventing or managing acute exacerbations.
ASCORBIC ACID SUPPLEMENTATION FOR ADJUNCTIVE TREATMENT OF PULMONARY TUBERCULOSIS: REVIEW OF LABORATORY RESEARCH AND CLINICAL TRIALS IN INDONESIA Rakasiwi, Muhammad Ilham Dhiya; Taufik, Muhammad; Aristyo, Kevin; Wandawa, Azlina D; Burhan, Erlina; Kurniawan, Gerry; Ferian, Muhammad Farel
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 10 No. 2 (2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v10i2.1110

Abstract

Background: Tuberculosis (TB) is a highly lethal global disease caused by Mycobacterium tuberculosis (Mtb), which has affected approximately a quarter of the world's population. Ascorbic acid is acknowledged for its strong antioxidant properties, its ability to modulate the immune system, and its effectiveness against Mtb infections. Method: Literature search based on specific keywords following the PICO (Patient, Intervention, Comparison, Outcome) research question was carried out on Pubmed, Scopus and Google Scholar databases, as well as Garuda for clinical research in Indonesia. The flow of the literature search followed PRISMA and risk of bias analysis using the Rob2 tool. Discussion: Laboratory studies have shown that ascorbic acid, whether given by itself or in conjunction with standard anti-TB medications, can decrease the quantity of Mtb colony-forming units (CFU). Similar outcomes were witnessed in experiments conducted with mice. The administration of ascorbic acid to mice infected with Mtb also led to a reduction in lung tissue damage. Clinical trials carried out in Indonesia demonstrated that the addition of ascorbic acid resulted in a greater sputum conversion rate in comparison to patients who did not receive this supplementation. Conclusion: Ascorbic acid exhibits several clinical attributes that prove beneficial in the management of TB.
Family Support Pattern for Treatment Adherence Among Tuberculosis Patients in Deli Serdang Regency : A Qualitative Study Gurusinga, Rahmad; Afrizal, Afrizal; Bachtiar, Adang; Firdawati, Firdawati; Machmud, Rizanda; Burhan, Erlina; Jendrius, Jendrius; Semiarty, Rima
Jurnal Ilmu Kesehatan Masyarakat Vol. 15 No. 2 (2024): Jurnal Ilmu Kesehatan Masyarakat (JIKM)
Publisher : Association of Public Health Scholars based in Faculty of Public Health, Sriwijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26553/jikm.2024.15.2.220-233

Abstract

In Indonesia, 50% of tuberculosis (TB) treatments are discontinued prematurely. The success of TB treatment depends on patient adherence to completing the treatment. Family support is crucial in enhancing TB patient adherence, particularly regarding emotional and appreciation support. This study aims to explore the complexity of family support to TB patient adherence in Deli Serdang Regency, North Sumatra Province, Indonesia. This qualitative study employed participatory observation and in-depth interviews with TB patients and their family members. The research was conducted from February to April 2024 in Deli Serdang Regency, North Sumatra, Indonesia. Informants included 10 TB patients and 16 family members, selected purposively based on data from the public health center and the TB Program Holder. The researcher was the primary instrument of the study, focusing on two dimensions of family support: emotional and appreciation. Data validity was checked through credibility testing, including triangulation. The study findings indicate that family emotional support is reflected in expressions of empathy and caring. Sadness is evident from family members’ tears upon learning that a relative tested positive for TB. Family support is shown by accompanying TB patients to the health center and reminding them to take treatment. Appreciation support is demonstrated by valuing the patient’s treatment process. Family members encourage and motivate the patient to adhere to the treatment. Emotional and appreciation support from family plays a significant role in TB patient adherence to treatment. Families can significantly contribute to the success of TB treatment by demonstrating empathy, caring, and appreciation for the patient.
Physical Medicine and Rehabilitation Approach of Elderly with Atypical COVID-19 Symptoms Widjanantie, Siti Chandra; Burhan, Erlina; Susanto, Agus Dwi
Surabaya Physical Medicine and Rehabilitation Journal Vol. 6 No. 2 (2024): SPMRJ, AUGUST 2024
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/spmrj.v6i2.51713

Abstract

COVID-19 has affected the older population disproportionately. These patients are prone to have more severe COVID-19. Clinical manifestation of COVID-19 in the geriatric can be atypical and differs from the younger population. We report an 80-year-old male with atypical presentation of COVID-19. In this case report, we describe a COVID-19 patient with anorexia and gastrointestinal symptoms. We also describe the multidisciplinary aspect of physical medicine and rehabilitation management of the patient. Clinical manifestations in geriatric with COVID-19 can be atypical. Symptoms experienced may include anorexia and gastrointestinal tract symptoms. A multidisciplinary approach is needed to manage more seniors with COVID-19 and maximize their functional abilities.
Risk factors for viral hepatitis in pulmonary tuberculosis patients undergoing treatment: A systematic review and meta-analysis Ilham, Ahmad F.; Andini, Salsabila R.; Afladhia, Hanna L.; Rakasiwi, Muhammad ID.; Burhan, Erlina
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1242

Abstract

Liver injury in tuberculosis patients, associated with noncompliance with treatment, is further exacerbated by viral hepatitis, which not only directly harms the liver but also increases susceptibility to drug-induced liver injury. The aim of this study was to analyze the associated risk factors for viral hepatitis in tuberculosis patients. This systematic review and meta-analysis adhere to the PRISMA 2020 statement, and the protocol has been registered with PROSPERO (CRD42023477241). Screening and selection of articles were carried out according to predetermined inclusion and exclusion criteria, utilizing four databases: Embase, Medline, Scopus, and ProQuest. Baseline characteristics and patient-related risk factors from each included study were extracted, followed by a meta-analysis of factors that potentially had significance, with the heterogeneities also being analyzed. Of the 21 included studies out of 6,415 identified records, 12 potential risk factors for hepatitis B and 15 for hepatitis C were subjected to meta-analysis. Some key risk factors included for hepatitis B and C were HIV infection (OR: 3.42; 95%CI: 2.19–5.34 and OR: 6.99; 95%CI: 5.09–9.61, respectively), smoking (OR: 1.55; 95%CI: 1.19–2.02 and OR: 3.06; 95%CI: 1.63–5.75, respectively) and alcohol consumption (OR: 2.38; 95%CI: 1.06–5.37 and OR: 4.32; 95%CI: 2.76–6.78, respectively). Furthermore, meta-analysis indicated that other significant risk factors for hepatitis B and/or C include injecting and non-injecting drug use, multiple sexual partners, tattooing, ear-nose piercing, blood transfusion, dental interventions, homelessness, incarceration, living with prisoners, sexually transmitted diseases, and diabetes mellitus. In conclusion, patients with tuberculosis who have risk factors such as smoking, HIV, or alcohol consumption should be screened for hepatitis B and C to prevent liver injury.
Co-Authors - Afrizal A. M. Jayusman Adang Bachtiar Afladhia, Hanna L. Agus Dwi Susanto Agustin, Heidy Ahmad Arfan Ahmad Fadhil Ilham Akbar, Fadhian Andini, Salsabila R. Aniwidyaningsih, Wahju Anna Rozaliyani Anwar Jusuf Anwar Jusuf Aria Kekalih Arief Riadi Arifin Arifin Nawas Arifin Nawas Arifin, Arief Riadi Aristyo, Kevin Ary Indriana Savitri Asri C. Adisasmita Azzumar, Farchan Bahtiar Husain Bambang Dwi Hasto Baskoro, Hario Budhi Antariksa Budi Prasetyo Budi Prasetyo Budiman Bintang Prakoso Dewi Yennita Sari Diah Handayani Dwi Rendra Hadi Eddy Suratman Felim, Ris Raihan Ferian, Muhammad Farel Findra Setianingrum Firdawati, Firdawati Gustya, Gita Fajri Hario Baskoro Hasto, Bambang Dwi Henie Widowati Hera Afidjati Husain, Bahtiar Ibrahim Nur Insan Putra Darmawan Ilham, Ahmad F. Ilham, Ahmad Fadhil Isbaniah, Fathiyah Jaka Pradipta Jendrius Jendrius Kurniawan, Gerry Mega Juliana Mega Juliana Mirza Purwitasari Mohamad Fahmi Alatas Muhamad Sidik Muhammad Alkaff Muhammad Ikhsan Mokoagow Muhammad Ilham Dhiya Rakasiwi MUHAMMAD TAUFIK Nalapraya , Widhy Yudistira Noorwati Sutandyo Nugraha, Darrin Ananda Priyanti Z. Soepandi Priyanti ZS Putra, Andika Chandra Putri Suci Ramadhany Rahmad Gurusinga Rakasiwi, Muhammad ID. Rakasiwi, Muhammad Ilham Dhiya Rima Semiarty Ririen Razika Ramdhani Ris Raihan Felim Rita Rogayah Rizanda Machmud Samoedro, Erlang Sari, Adistya Sariasih Arumdati Satria Pratama Satria Pratama Satria Pratama Savitri, Ary Indriana Soehardiman, Dicky Syntia Nusanti Taufik, Feni Fitriani Tika Dwi Tama Triya Damayanti Triya Damayanti Tugas Ratmono Tugas Ratmono, Tugas Wandawa, Azlina D Widjanantie, Siti Chandra Yasmina Hanifah Yasmina Hanifah Zaini, Jamal