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All Journal International Journal of Integrated Health Sciences Medical Journal of Indonesia Jurnal Epidemiologi Kesehatan Indonesia The Indonesian Journal of Infectious Diseases Jurnal Respirologi Indonesia Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia SURABAYA PHYSICAL MEDICINE AND REHABILITATION JOURNAL Respiratory Science Narra J Malang Respiratory Journal Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Jurnal Ilmu Kesehatan Masyarakat Ophthalmologica Indonesiana Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Erlina Burhan
Departemen Pulmonologi Dan Kedokteran Respirasi Fakultas Kedokteran Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Differential White Blood Cell Count and COVID-19 Hospital Length of Stay: A Post-hoc Analysis Gustya, Gita Fajri; Nugraha, Darrin Ananda; Rakasiwi, Muhammad Ilham Dhiya; Azzumar, Farchan; Burhan, Erlina
International Journal of Integrated Health Sciences Vol 12, No 2 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v12.n2.3915

Abstract

Objective: To explore the association between differential white blood cell count and hospital length of stay (LOS) in COVID-19 patients.Methods: This study is a post-hoc analysis of two prospective cohort studies involving hospitalized COVID-19 patients who received standard therapy, including antiviral and supportive treatments at Persahabatan Hospital, Jakarta, Indonesia, during the Delta and Omicron dominant pandemic periods. Baseline differential white blood cell count before initiation of therapy were documented. LOS was categorized as ≤10 days and >10 days.Result: Data from 463 subjects were included with most subjects were males (62.2%) with a median age of 54 (14–93) years. The average LOS for subjects was 12.7 (12.1–13.4) days. Bivariate tests showed that lymphocytes, neutrophils, monocytes, neutrophil-lymphocyte ratio (NLR), and neutrophil-monocyte ratio (NMR) had significant association (p <0.05) to LOS. Logistic regression showed that higher monocyte counts were associated with shorter LOS (adjusted OR 0.89; 95% CI 0.840 - 0.943; p < 0.001). ROC curve showed that higher monocyte counts (>8.35 × 10^3/µL) at admission may predict shorter hospitalization (<10 days).Conclusion: Monocyte count may serve as a potential marker for length of stay in COVID-19 patients, offering key insights for optimizing patient management and resource allocation.
Non-Genetic Risk Factors for First-Line Anti-Tuberculosis Drug-Induced Liver Injury in Active Pulmonary Tuberculosis Patients: A Systematic Review and Meta-Analysis Ilham, Ahmad Fadhil; Felim, Ris Raihan; Akbar, Fadhian; Burhan, Erlina
Jurnal Respirologi Indonesia Vol 45 No 3 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i3.693

Abstract

Background: Tuberculosis is still one of the leading causes of poor health and death worldwide. Drug-induced liver injury (DILI) is an important and serious side effect of anti-tuberculosis treatment and can cause non-adherence of patients to the treatment. To reduce the possibility of patients developing DILI, the risk factors must be identified. Methods: This systematic review was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 statement. Inclusion and exclusion criteria were used to screen and filter the articles that were obtained from literature searching performed through several journal databases. The extracted data were analyzed qualitatively and quantitatively. The quality of each study was also assessed using the modified Newcastle Ottawa Scale (NOS). The protocol for this systematic review has been registered with PROSPERO CRD42022384892. Results: The results showed that, of the 13 studies analyzed qualitatively, 11 studies with a total of 4,920 patients were selected for quantitative analysis. The factors analyzed and the results were female gender (OR=1.10; 95% CI=0.72-1.67; P=0.65), age over 40 years (OR=1.60; 95% CI=1.04-2.46; P=0.03), body mass index less than 18.5 kg/m2 (OR=0.96; 95% CI=0.52-1.79; P=0.9), active smoking (OR=0.71; 95% CI=0.34-1.49; P=0.36), frequent alcohol intake (OR=1.44; 95% CI=0.61-3.42; P=0.41), hepatitis B (OR=3.42; 95% CI=1.72-6.79; P<0.001]), and hepatitis C (OR=12.87; 95% CI=6.67-24.86; P<0.00001]). Conclusion: In conclusion, the evidence from this review suggests that older age, hepatitis B, and hepatitis C are significant risk factors thought to increase the incidence of DILI in active pulmonary tuberculosis patients taking first-line anti-tuberculosis regimens.
Epidemiological and Clinical Features of COVID-19 Patients at National Emergency Hospital Wisma Atlet Kemayoran, Jakarta, Indonesia Susanto, Agus Dwi; Rozaliyani, Anna; Prasetyo, Budi; Agustin, Heidy; Baskoro, Hario; Arifin, Arief Riadi; Pratama, Satria; Zaini, Jamal; Hasto, Bambang Dwi; Ratmono, Tugas; Savitri, Ary Indriana; Samoedro, Erlang; Husain, Bahtiar; Nawas, Arifin; Burhan, Erlina
Kesmas Vol. 16, No. 5
Publisher : UI Scholars Hub

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Abstract

The emergency hospital is intended to prevent transmission of COVID-19 in the community by isolating patients without symptoms, with mild or moderate symptoms. This study evaluated the clinical characteristics and outcomes of COVID-19 patients who were admitted to this facility. This retrospective study re-viewed data of patients treated at the National Emergency Hospital Wisma Atlet Kemayoran in Jakarta, Indonesia, from March 23 to April 30, 2020. Patient characteristics (clinical symptoms, laboratory test results, Chest X-Ray, SARS-CoV-2 immunoserology, and RT-PCR results from nasopharyngeal/ oropharyngeal preparations) were compared between severity groups. There were 413 COVID-19 cases analyzed, of which 190 (46%) were asymptomatic, 93 (22.5%) were mild, and 130 (31.5%) were moderate cases. Most asymptomatic cases were male, with young age, and without comorbidity. Mild cases were dominated by female and young patients, while most moderate cases were male and older patients. The number of patients with comorbidities was higher in mild and mod-erate cases. The patient’s overall outcome was good and did not differ based on the severity of symptoms. Despite the many challenges, patients with moderate symptoms can be safely treated in the emergency hospital.
Co-Authors - Afrizal A. M. Jayusman Adang Bachtiar Afladhia, Hanna L. Agus Dwi Susanto Agustin, Heidy Ahmad Arfan Ahmad Fadhil Ilham Akbar, Fadhian Andini, Salsabila R. Aniwidyaningsih, Wahju Anna Rozaliyani Anwar Jusuf Anwar Jusuf Aria Kekalih Arief Riadi Arifin Arifin Nawas Arifin Nawas Arifin, Arief Riadi Aristyo, Kevin Ary Indriana Savitri Asri C. Adisasmita Azzumar, Farchan Bahtiar Husain Bambang Dwi Hasto Baskoro, Hario Budhi Antariksa Budi Prasetyo Budi Prasetyo Budiman Bintang Prakoso Dewi Yennita Sari Diah Handayani Dwi Rendra Hadi Eddy Suratman Felim, Ris Raihan Ferian, Muhammad Farel Findra Setianingrum Firdawati, Firdawati Gustya, Gita Fajri Hario Baskoro Hasto, Bambang Dwi Henie Widowati Hera Afidjati Husain, Bahtiar Ibrahim Nur Insan Putra Darmawan Ilham, Ahmad F. Ilham, Ahmad Fadhil Isbaniah, Fathiyah Jaka Pradipta Jendrius Jendrius Kurniawan, Gerry Mega Juliana Mega Juliana Mirza Purwitasari Mohamad Fahmi Alatas Muhamad Sidik Muhammad Alkaff Muhammad Ikhsan Mokoagow Muhammad Ilham Dhiya Rakasiwi MUHAMMAD TAUFIK Nalapraya , Widhy Yudistira Noorwati Sutandyo Nugraha, Darrin Ananda Priyanti Z. Soepandi Priyanti ZS Putra, Andika Chandra Putri Suci Ramadhany Rahmad Gurusinga Rakasiwi, Muhammad ID. Rakasiwi, Muhammad Ilham Dhiya Rima Semiarty Ririen Razika Ramdhani Ris Raihan Felim Rita Rogayah Rizanda Machmud Samoedro, Erlang Sari, Adistya Sariasih Arumdati Satria Pratama Satria Pratama Satria Pratama Savitri, Ary Indriana Soehardiman, Dicky Syntia Nusanti Taufik, Feni Fitriani Tika Dwi Tama Triya Damayanti Triya Damayanti Tugas Ratmono Tugas Ratmono, Tugas Wandawa, Azlina D Widjanantie, Siti Chandra Yasmina Hanifah Yasmina Hanifah Zaini, Jamal