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All Journal Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Journal of Tropical Biodiversity and Biotechnology Paediatrica Indonesiana Jurnal Sinergitas PkM & CSR Medicinus : Jurnal Kedokteran FaST : Jurnal Sains dan Teknologi J-HESTECH (Journal Of Health Educational Science And Technology) Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute Unnes Journal of Public Health
Juandy Jo
Universitas Pelita Harapan
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Profile of Anti-Diphtheria Toxoid Immunoglobulin G among Pre-School Children in the Senen District, Jakarta, Indonesia Santi, Theresia; Jo, Juandy; Prayitno, Ari; Munasir, Zakiudin; Hegar, Badriul
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 7 No. - (2023): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v7i-.189

Abstract

Background: Diphtheria is a re-emerging disease in Indonesia that can be prevented by vaccination. This study evaluates the anti-diphtheria toxoid immunoglobulin G levels among healthy children aged 6 – 7 years old who had not received the second booster immunization for Diphtheria, Tetanus, and Pertussis (DTP) commonly administered at 5 – 7 years old. Methods: This cross-sectional study was conducted in the Senen district of Jakarta, Indonesia. All subjects had been vaccinated with three doses of immunization for DTP during the first year of life, and subsequently classified into a group of children who received the first booster immunization of DTP at 18 – 24 months old and who had not received it yet. Antibody against Diphtheria toxoids within the sera samples was assessed by commercial Anti-Diphtheria toxoid IgG Enzyme-Linked Immunosorbent Assay and classified in four groups: no protection (< 0.01 IU/ml), uncertain (0.01 – 0.09 IU/ml), full protection (0.10 – 1 IU/ml) and long-term protection (>1 IU/ml). Results: Eighty-nine children were included in this study; only 71 subjects (79.7%) had received the first DTP booster at 18–24 months old. The specific humoral immunity against diphtheria was observed among 57 children (64%). Notably, among the 89 subjects, only two subjects not receiving the first DTP booster still had antibody protection for diphtheria (p=0.001, OR 27.5, 95% CI: 5.71 – 132.42). Conclusion: The first diphtheria booster vaccination at 18 – 24 months old is crucial to protect pre-school children against diphtheria.
Co-Authors Abigail Christy, Suawa Natania Adhiwijaya, Ruben Patrick Advelina Hubertha Fanggidae Anasthasia Nathania Widjaja Andareas, Pangeran Ari Prayitno, Ari Ariela Samantha Aruan, Maroloan Badriul Hegar Basrowi, Ray Wagiu Budi Setiabudiawan Celeste Abigail Thanos Chelsea Valeria Simamora Christy, Suawa Natania Abigail Daniel Elia Firmansyah Dela Rosa Dilantika, Charisma Ernestine Arianditha Pranasti Febriani, Enjelia Feronia Reni Cyrena Santoso Firmansyah, Daniel Elia Friska Dewi Sari Hutauruk Harahap, Alida Roswita Irawan, Michella Ivo Novita Sah Bandar Jevon Lesmana Kandou, Abigail Sabrina Kartjito, Melissa Stephanie Kristin Marbun Kristin Talia Marbun Lesmana, Jevon Aaron Litanto, Vivian Marbun, Kristin Talia Margaretha Lodwinia Maroloan Aruan Octaviana, Cindy Pangeran Andareas Pongajow, Billy Yosua Costantin Putri, Angela Clarita Putri, Nathania Calista Reinhard Pinontoan Retno Asti Werdhani Ruben Patrick Adhiwijaya Samantha, Ariela Sanjaya, Astia Sara Thalia Subroto Satya Nugroho Satya Nugroho Simamora, Chelsea Valeria Sitorus, Nova Soentoro, Samuel E Soewono, Effendi Sophiano, Theophilus Soputro, Veronica Tammy Sri Rezeki S. Hadinegoro, Sri Rezeki S. Suawa Natania Abigail Christy Subroto, Sara Thalia Sugata, Marcelia Surapsari, Juwalita Suryadi, Jennifer Claudia Tan Tjie Jan, Tan Tjie Thanos, Celeste Abigail Thenoch, Adrian Samuel Theodora, Gisella Theresia Santi, Theresia Timothy, Michael Tjhajadi, Jennifer Patricia Victor, Hans Vidian, Valerie Vivian Litanto Watumbara, Medista Lisa Widjaja, Anasthasia Nathania Wijaya, Accoladea Yap, Cecilia Aileen Zakiudin Munasir