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Dismilaritas Kadar Low Density Lipoprotein Kolesterol pada Pasien Dislipidemia dengan Metode Homogenous Formula Friedewald di RSUD Mardi Waluyo Kota Blitar: Dissimilarity of Low Density Lipoprotein Cholesterol Levels in Dyslipidemia Patients Using the Friedewald Homogenous Formula Method at Mardi Waluyo Regional Hospital, Blitar City Hartati Tuna; MM Riyaniarti Estri Wuryandari; Mely Purnadianti; Nita Damayanti; Vivien Dwi Purnamasari; Gerardin Ranind Kirana
Life Science Vol. 14 No. 2 (2025): November 2025
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/unnesjlifesci.v14.i2.17182

Abstract

Dyslipidemia is one of the primary risk factors for vascular disease, which can lead to an increase in the number of lipid profile tests. Low-density lipoprotein cholesterol (LDL-C) is one of the signs of dyslipidemia and can be examined using the direct method (homogeneous) or the Friedewald formula. This examination method has its own advantages and disadvantages. This study aims to determine the difference in LDL cholesterol levels using the direct method and the Friedewald formula in dyslipidemia sufferers at Mardi Waluyo Hospital, Blitar City. The research design carried out is a cumulative analytical research with a cross survey approach. This study was conducted on 40 patients who underwent lipid profile examinations at the Laboratory of Mardi Waluyo Hospital, Blitar City. Blood samples that are examined and included in the dyslipidemia criteria are then checked for LDL cholesterol levels with the Friedewald formula. Based on the results of the study, the results ofthe statistical analysis of the Independent test sample t-test with a meaningfulness level of 95% (α = 0.05) were obtained by the LDL t statistic result (1.706) < t table 2.02439. There was no significant difference in the results of the LDL cholesterol examination of the direct method and Friedewald formula in people with dyslipidemia, For this reason, further research is needed to determine LDL cholesterol levels, both in the extract and with the Friedewald formula, using the gold standard method for LDL cholesterol examination in accordance with the recommendations of the National Cholesterol Education Program (NCEP) is ultracentrifugation as a comparison of LDL cholesterol research
HUBUNGAN JUMLAH TROMBOSIT DENGAN JUMLAH PARASIT PADA PASIEN MALARIA DI RSUD BIAK Purnadianti, Mely; Prodyanatasari , Arshy; Prasetyani Putri , Mardiana; Agustina, Novia; Katrine Siahan, Elisabet
Judika (Jurnal Nusantara Medika) Vol 8 No 1 (2024): Volume 8 No 1 April 2024
Publisher : Universitas Nusantara PGRI Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29407/judika.v8i1.22553

Abstract

Malaria merupakan salah satu penyakit endemik yang disebabkan oleh Plasmodium sp, infeksi malaria mempengaruhi trombosit total dimana penurunan jumlah trombosit disebabkan oleh peningkatan proses penghancuran trombosit. Rata-rata penurunan jumlah trombosit sesuai dengan peningkatan jumlah parasit dalam darah pada malaria. Tingginya jumlah parasit dalam darah menyebabkan kerusakan trombosit dalam sirkulasi darah menjadi lebih signifikan sehingga penurunan jumlah trombosit semakin tinggi. RSUD Biak merupakan rumah sakit rujukan dengan jumlah kasus malaria terbanyak yang terdapat pada angka 653 pada tahun 2022. Tujuan penelitian ini adalah untuk mengetahui korelasi antara jumlah trombosit dengan jumlah parasit pada penderita malaria di RS Biak. Kajian ini menggunakan desain penelitian Cross Sectional Study. Teknik pengambilan sampel yang digunakan adalah Quota Sampling. Sampel yang digunakan sebanyak 48 orang. Analisis data penelitian ini menggunakan uji Spearman Rank. Hasil penelitian diperoleh 47 orang (98%) pasien malaria mengalami penurunan jumlah trombosit dan 1 orang (2%) pasien malaria dengan jumlah trombosit normal, kemudian mendapat hasil penelitian dengan jumlah kategori parasit rendah 3 orang (6%), sedang 27 orang (56%), tinggi 14 orang (29%), dan hiperparasitemia 4 orang (8%). Berdasarkan uji statistik diperoleh p-value p-value 0,000 (<0,05) dan koefisien korelasi -0,632. Hasil Kesimpulan dari penelitian ini terdapat hubungan yang kuat antara jumlah penurunan.
The Effect of Time on Blood Types of ABO Systems on Saliva Spots of Cigarette Butts for Forensic Identification Purnadianti, Mely; MAR, Mieke Sylvia; Yudianto, Ahmad
Folia Medica Indonesiana Vol. 54, No. 4
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The identification process is not only carried out on the body of a victim of a crime, but identification can also be carried out on the evidence evidence found at the crime scene. The timing of a crime case and the time interval for collecting evidence of a crime is an obstacle in the process of identifying blood saliva on cigarette butts. Saliva will dry within an hour and forty minutes at room temperature and with the influence of various other factors saliva will dry in less than three hours. The purpose of this study was to determine the effect of the duration of temperature exposure on the protein levels of cigarette saliva in order to help the identification process of forensic blood groups. The time series design was used in this study where 18 filter cigarette butts were collected from 6 individuals who were subjected to research with blood types A, B and AB then incubated 1.3 and 6 hours. Examination of protein content was carried out using trizol reagent with UV spectrophotometer reading. The data was processed using non-parametric T-test statistics. There was a decrease in salivary levels in a predetermined time of 1, 3 and 6 hours. Cigarette butt saliva protein levels can still be detected within 1, 3 and 6 hours so that they can be used to help identify the forensic blood group from cigarette butt saliva.
Occupational Safety Risk Analysis in Printing Area using JSA Sumaningrum, Ningsih Dewi; Mely Purnadianti
Jurnal Kesehatan dan Kedokteran Vol. 5 No. 1 (2026): Februari: Jurnal Kesehatan dan Kedokteran
Publisher : Asosiasi Dosen Muda Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56127/jukeke.v5i1.2466

Abstract

Printing workplaces involve diverse operational activities that may pose occupational safety and health (OSH) risks to workers. Objective: This study aims to identify potential hazards and assess occupational risk levels in a printing facility using the Job Safety Analysis (JSA) method, considering that printing, cutting, ink handling, and manual material handling activities may lead to work-related injuries and health disorders. Methodology: A descriptive observational approach was employed. Data were collected through direct workplace observations, interviews with workers and supervisors, and a review of work process documentation. The JSA procedure involved breaking down work activities into sequential steps, identifying hazards at each stage, and determining risk levels along with appropriate control measures. Findings: The results revealed exposure to mechanical, chemical, physical, and ergonomic hazards. Mechanical hazards were predominantly associated with printing and cutting machine operations, posing risks of hand injuries and crushing incidents. Chemical hazards were identified during ink handling activities, with potential health effects from skin contact and inhalation exposure. Ergonomic hazards were mainly observed during manual material handling tasks, increasing the risk of musculoskeletal disorders. Several identified hazards were classified as medium to high risk, indicating the need for prioritized preventive actions. Implications: The findings highlight the importance of implementing integrated OSH control measures, including engineering controls, administrative actions, consistent use of personal protective equipment, and the strengthening of workplace safety culture to reduce occupational risks in printing environments. Originality: This study provides a systematic, task-based hazard mapping of core printing processes using JSA, offering practical guidance for prioritizing risk control strategies in printing operations with medium to high risk levels.
EDUKASI DAMPAK MENGGUNAKAN GADGET PADA SISWA SEKOLAH DASAR Prodyanatasari, Arshy; Palupi Susilowati; Mely Purnadianti; Mardiana Prasetyani Putri; Hari Untarto Swandono; Krisnita Dwi Jayanti
Jurnal Pengabdian Masyarakat (Jupemas) Vol. 6 No. 1 (2025): Maret
Publisher : Universitas Bakti Tunas Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36465/jupemas.v6i1.1498

Abstract

Perkembangan teknologi telah membuat gadget menjadi bagian tak terpisahkan dari kehidupan siswa sekolah dasar, dengan 65% anak usia 6-12 tahun di Indonesia menggunakan gadget selama 3-5 jam per hari. Namun, penggunaan berlebihan dapat menimbulkan dampak negatif seperti gangguan kesehatan, kecanduan, dan penurunan performa akademik, sehingga diperlukan strategi untuk memastikan pemanfaatan gadget yang sehat dan bertanggung jawab. Kegiatan pengabdian masyarakat ini bertujuan untuk memberikan edukasi kepada siswa sekolah dasar mengenai dampak penggunaan gadget. Kegiatan ini dilaksanakan di SDN Bandar Lor 1 Kota Kediri pada 18 November 2024. Metode PkM adalah Participatory Action Research (PAR) dan populasi adalah siswa kelas 1-6 sebanyak 121 siswa dan sampel PkM adalah siswa kelas 4-6 sebanyak 73 siswa. Teknik pengumpulan data menggunakan lembar kuesioner dan Teknik analisis data menggunakan analisis statistis non parametrik Uji Wilcoxon karena data tidak terdistribusi normal. Pelaksanaan PkM dibagi menjadi empat tahapan, meliputi pretes, penyampaian materi edukasi, ice breaking, serta evaluasi melalui posttest. Hasil evaluasi menunjukkan adanya peningkatan pengetahuan siswa yang signifikan, terlihat dari perbandingan nilai pretest dan posttest yaitu sebesar 50.17 dan 97,17. Peningkatan ini menunjukkan bahwa kegiatan edukasi ini berhasil meningkatkan kesadaran siswa terhadap penggunaan gadget yang sehat dan bertanggung jawab. Kegiatan ini diharapkan dapat memberikan manfaat jangka panjang bagi siswa dalam mengelola penggunaan teknologi secara bijak dan menjadi model untuk pelaksanaan kegiatan serupa di masa mendatang.