Garuda - Garba Rujukan Digital

p-Index From 2020 - 2025

2.737

P-Index

This Author published in this journals

All Journal Jurnal Sain Veteriner Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Cancer Chemoprevention Majalah Obat Tradisional Pharmascience JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas Farmasains : Jurnal Ilmiah Ilmu Kefarmasian PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) FITOFARMAKA: Jurnal Ilmiah Farmasi JFIOnline Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Insan Farmasi Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan JKKI : Jurnal Kedokteran dan Kesehatan Indonesia

Moch. Saiful Bachri

Fakultas Farmasi, Universitas Ahmad Dahlan Yogyakarta

Author-ID : 368642

Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences Veterinary Other

Published : 37 Documents Claim Missing Document

Claim Missing Document

Articles

1 2 3 4

PENGARUH EKSTRAK AKAR SENGGANI (Melastoma affine D.Don) TERHADAP MOTILITAS DAN JUMLAH SPERMA TIKUS Bachri, Moch. Saiful; Donatus, Imono Argo; Wahyuono, Subagus
Jurnal Farmasi Indonesia Vol 4, No 2 (2008)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v4i2.15

Spermatogenesis effect ofÂ ethanol extract senggani root (Melastoma affine D. Don) was proved. Furthermore, the extract was fractionated with ethyl acetate and was investigated toward spermatogenesis effect to explore natural productÂ as maleÂ contraception. The subject of this research were five groups of thirty two fertile male Wistar rat,. Four groups were treated with ethyl acetate fraction of senggani root in gradually 500; 250; 125; and 62,5 mg/kg body weight dose. The fifth group as negative control was treated by CMC Na 0,5 %. Every groups was treated by orally administration for twenty two days period of time, once a day. In twenty third day, the rats were killed then observed toward the motility, sperm count, and testis histopathology. Results of the research indicated that there were influence toward spermatogenesis effect from ethyl acetate fraction of senggani root, especially at sperm motility and sperm count. Decrease of sperm motility after treatment was compared with negative control group. The percentage of the sperm count decreased at 500; 250 mg/kg body weight dose from ethyl acetate fraction was 49,74 % and 48,21.This decreased probably were caused by seminiferous tubules necrotic. Â ABSTRAK Pemberian ekstrak etanol akar senggani (Melastoma affine D. Don) telah terbukti dapat menyebabkan berkurangnya jumlah dan motilitas sperma tikus. Berdasarkan hasil penelitian tersebut dilakukan fraksinasi ekstrak etanol akar senggani dengan etil asetat kemudian fraksi itu di uji cobakan pada tikus dengan tujuan untuk eksplorasi bahan alam yang dapat dipakai sebagai bahan kontrasepsi pria. Penelitian ini menggunakan 32 ekor tikus jantan fertil galur Wistar, umur 2,5-4 bulan dengan bobot 145-350 g dan dibagi menjadi 5 kelompok. Empat kelompok merupakan kelompok perlakuan fraksi etil asetat akar senggani dengan dosis 500; 250; 125; dan 62,5 mg/kgBB. Kelompok V merupakan kelompok kontrol negatif dengan perlakuan CMC Na 0,5 %. Semua kelompok diberi perlakuan secara per oral selama 22Â hari dengan frekuensi pemberian sekali sehari. Pada hari ke-23 tikus dikorbankan dan diamati motilitas, dan jumlah atau angka sperma. Dilakukan juga pengamatan histopatologi organ testis. Hasil penelitian menunjukkan ada pengaruh pemberian fraksi etil asetat akar senggani terhadap motilitas dan jumlah (angka) sperma. Motilitas sperma menjadi berkurang pada semua dosis perlakuan jika dibandingkan dengan kelompok kontrol. Penurunan motilitas sperma terbesar pada dosis 250 mg/kgBB. Jumlah sperma juga mengalami penurunan untuk semua dosis perlakuan. Persentase penurunan jumlah sperma terbesar pada dosis 500 ; 250 mg/kgBB sebesar 49,74 % , dan 48,21 %. Penurunan ini kemungkinan diakibatkan oleh rusaknya tubulus seminiferus testis yang mengalami nekrosis

PENGARUH PEMBERIAN SUBKRONIK EKSTRAK KELOPAK BUNGA ROSELLA (Hibiscus Sabdariffa L.) TERHADAP KADAR SGPT SGOT DAN ALP Nurkhasanah Nurkhasanah; Moch. Saiful Bachri; Nofa Risma Azis
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 13, No 2 (2016)
Publisher : Sanata Dharma University

Roselle (Hibiscus sabdariffa L.) has been known as traditional medicinal plants. It needed to evaluate the safety of roselle extract on long-term oral administration. The research aimed to determine the savety of ethanolic extract of roselle calyx. Subchronic toxicity study of ethanolic extract of roselle calyx had been carried out on 60 Sprague Dawleys (SD) rats for 28 days. The roselle extract was administered orally every day, with doses of 50,100 and 200 mg/kgBW. There are 2 satellite groups, kept for another 14 days after the treatment in order to detect a delayed occurrence of toxic effect. Satellite group was given extract 200 mg/kgBW for 28 days and followed aquadest treatment for 14 days. At the end of experiment the blood was collected for meansuring SGPT, SGOT and ALP activity. The result showed that treatment of roselle calyx extract had no significant changes in SGPT SGOT, ALP activity. The delayed effect was not also observed. The ethanolic extract of roselle calyx didnt show toxic effects on the liver on subchronic administration.

Gastroprotective effect of Canna edulis Ker. ethanolic extract in piroxicam-induced rats Dara Pranidya Tilarso; Moch. Saiful Bachri; Wahyu Widyaningsih
Pharmaciana Vol 11, No 1 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Medications derived from plants and pure natural ingredients have far lower side effects and risks than synthetic drugs. One side effect of piroxicam is irritation of the digestive tract. One of the therapeutic preventions to minimize peptic ulcers was utilizing Canna edulis Ker. This study aims to prove that ethanolic extract of Canna edulis Ker. can be used as an alternative to prevent piroxicam-induced peptic ulcers based on ulcer index parameters and the protection ratio. The rats were divided randomly into 6 groups consisting of 5 rats. The normal group was given food and water. The negative control group was given 0.5% CMC-Na. The extract groups were given various doses of ethanolic extract ofÂ Canna edulisÂ Ker. (50, 100, and 200 mg/kg BW). The positive control was given sucralfate at 360 mg/kg BW dose. Rats were treated orally for 14 days. One hour after the treatment on the 14th day, all groups except group I were orally administered with piroxicam dissolved in 0.5% CMC-Na at 1.8 mg/kg BW dose. Twenty-four hours later, animals were sacrificed, dissected, and their stomach organs were removed to analyze its number of ulcers. Ulcer observation was formed by giving a score and protection ratio. The mean ulcer index value was 0.33Â±0.58 for 50 mg/kg BW and 100 mg/kg BW ethanol extract treatment groups, while the 200 mg/kg BW group showed 0.67Â±0.58. The protection ratio was 83.33Â±28.87 in 50 mg/kg BW and 100 mg/kg BW treatment groups, while Â 66.67Â±28.87 was shown in the 200mg/kg BW group. Canna edulisÂ Ker. ethanolic extract has the gastroprotective ability by decreasing the index of gastric ulcers and increasing the protection ratio to the stomach of piroxicam-induced rats.

The gastroprotective effects of arrowroot tuber starch (Maranta arundinacea L.) on ethanol-induced gastric damages in rats Vella Lailli; Moch Saiful Bachri; Wahyu Widyaningsih
Pharmaciana Vol 10, No 1 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Empirically, arrowroot tubers (Maranta arundinacea L.) have been widely used in the treatment of gastric ulcers. They are known to contain carbohydrates and flavonoids that play a role in reducing inflammation. This study sought to identify the gastroprotective effects of arrowroot tuber starch (Maranta arundinacea L.) on the ulcer index, % protection ratio, and the histopathological image of Wistar rat models of gastric ulcers. The test animals were divided into six groups. Group I was given free access to food and water (normal control), while Group II was given ethanol without treatment (negative control). Groups III, IV, and V were treated with arrowroot tuber starch at the doses of 125, 250, and 500 mg/kg BW, respectively. Group VI was given sucralfate at the dose of 400 mg/kg BW (positive control). All treatments were administered orally for 14 days and followed by 24 hours of fasting. On Day 15, all groups, except for the normal control, were given 96% ethanol orally at the dose of 1 ml/200gr BW. After one hour, they were dissected, and their stomach was removed for further analyses. The results showed that the administrations of arrowroot tuber starch at 125, 250, and 500 mg/kg BW produced ulcer indices of 2, 1.25, and 1.5, respectively, smaller than the negative control (4.25), and % protection ratios higher than the positive control. The histopathological imaging showed that the stomach of rats receiving arrowroot tuber starch at 250 mg/kg BW presented no pathological changes. Based on these findings, the arrowroot tuber starch is proven to have the ability as a gastroprotective agent.

EFEK HEPATOPROTEKTIF SERBUK AKAR PASAK BUMI (Eurycoma longifolia Jack.) DILIHAT DARI AKTIVITAS SGPTSGOT TIKUS JANTAN YANG DIINDUKSI CCl4 Wirawan Adikusuma; Moch. Saiful Bachri
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

This study was designed to evaluate the hepatoprotective effect of the powder Eurycomalongifolia Jack. From the activity level of SGPT-SGOT on CCl4-induced in male rats. Twentyfive male rats (150-250 g) divide in to 5 groups. Group I treated with aquadest was kept asnormal, group II treated with a single dose of CCl4 (1 ml/ kg BW i.p), group III and IV weretreated with Eurycoma longifolia Jack. (100 mg/kg BW and 200 mg/kg BW p.o) respectivelyand CCl4 (1 ml/kg BW i.p), group V treated with a single dose of curcumin (100 mg/kg BWp.o) and CCl4 (1 ml/kg BW i.p). Blood was collected from vena porta for determination ofSGPT-SGOT. The study showed the activity level of SGPT from the rats was treated byEurycoma longifolia Jack. 100 mg/kg BW and 200 mg/kg BW, Curcumin, and control groupsare 150.0Â±5.099 U/L; 113.6Â±5.508 U/L; 60.5Â±2.887 U/L; and 129.0Â±6.055 U/L respectively. Mean while the activity level of SGOT from the rats was treated by Eurycoma longifolia Jack.100 mg/ kg BW and 200 mg/ kg BW, Curcumin, and control groups are 369.4Â±11.165;263.0Â±1.803; 194.5Â±7.448; and 451.5Â±16.759 U/L respectively. The Eurycoma longifoliaJack. powder and Curcumin significantly (p < 0.05) declines two enzymes (SGPT and SGOT)than control group. The results concluded that Eurycoma longifolia Jack. powder hashepatoprotective effect.

UJI TOKSISITAS AKUT EKSTRAK ETANOL KELOPAK ROSELLA (Hibiscus sabdariffa L.) PADA TIKUS Sprague Dawley Fita Sari; Nurkhasanah Nurkhasanah; Moch. Saiful Bachri
Majalah Obat Tradisional Vol 21, No 1 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Roselle (Hibiscus sabdariffa L.) was used as a traditional medicine because it has antioxidant activity. Traditional medicine used to treat a disease should consider the safety aspects through the toxicity tests. This study aims to determine the acute toxicity of the ethanolic extract from the calyx of Hibiscus sabdariffa L., activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and hepar histopathology in Sprague Dawley (SD) rats. Acute toxicity tests was done by orall administration of single dose ethanolic extract at dose 40, 200, 1000 and 5000 mg/kg BB. The test was observed during 14 days post treatment. The activity of AST, ALT and ALP were measured by specthrophotometer UV-Vis Diasys® method. The results showed that LD50 of ethanolic extract of calyx roselle was found at 850,90 mg/kg BW, the activity of AST, ALT, ALP did not different significantly in the treatment to be and control group (p <0.05) and histopathological data found structural change and tissue in hepar. Tthe delayed toxic effects until day 14 was also not found. These research found that ethanolic extract of calyx roselle was toxic SDrats.

Toxicity Study of Volatile Oil Boesenbergia pandurata (Roxb) Schlecht Rhizome to Larvacide of Aedes aegypti and GC-MS Profile Widyasari Putranti; Saiful Bachri
Majalah Obat Tradisional Vol 23, No 2 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Boesenbergia pandurata (Roxb) Schlecht has been recognized by society as traditional drug for a long time. The active constituent of this plants especially the volatile oil, which contains monoterpenes and sesquiterpenes. The use of Boesenbergia pandurata (Roxb) Schlecht rhizome which is a botanical insecticide shows higher safety because the molecule is easily broken down into harmless compounds against the environment. The aim of this research were to know about the activity of larvacide from the volatile oil of Boesenbergia pandurata (Roxb) Schlecht rhizome and also to analyze its chemical compounds using GC-MS. The volatile oil was isolated from Boesenbergia pandurata (Roxb) Schlecht with steam and water destillation method. The volatile oil in the aqueous ethanol 70 % v/v was made as the test solution for larvacide. The concentrations of the volatile oil of Boesenbergia pandurata (Roxb) Schlecht rhizomes used were 150 ppm; 201 ppm; 270 ppm; 362 ppm; 485 ppm; 650 ppm. Abate was used as positive control at concentration 0,001 ppm; 0,0025 ppm; 0,0065 ppm; 0,016 ppm; 0,04 ppm; 0,1 ppm while aqueous ethanol 70 % v/v was used as negative control. Each treatment were used 20 larvaes of Aedes aegypti and was observed during 24 hours. The data of died larvae were counted to estimate the values of LC50 with probit analysis method. The chemical compound of volatile oil of Boesenbergia pandurata (Roxb) Schlecht was analyzed by the GC-MS. The results of this research showed that the volatile oil of Boesenbergia pandurata (Roxb) Schlecht have clear-brass colour, bitter taste, typically aromatic, rendemen equal to (0,25 ± 0,011) % v/w and refractive index 1,4818. The value of LC50 for the volatile oil of Boesenbergia pandurata (Roxb) Schlecht rhizome is (407,06 ± 31,6985) ppm while abate equal to (0,0132 ± 0,0013) ppm. This matter indicates that abate more potent to larvae of Aedes aegypti. The result of analyze the component of the volatile oil of Boesenbergia pandurata (Roxb) Schlecht by the GC-MS obtained of 15 peak chromatogram and 6 peak which has identified showed the possibility the existence of champene, eucalyptol, ocimene, camphora, geraniol, methyl cinnamate.

Combination Effects of Moringa oleifera Leaf Ethanol Extract and Andrographis paniculata Herb on Blood Glucose Levels and Pancreas Histopathology of Diabetic Rats Induced by Streptozotocin Annisa Fatmawati; Moch. Saiful Bachri; Laela Hayu Nurani
Majalah Obat Tradisional Vol 24, No 2 (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Type 2 diabetes mellitus is a non-contagious disease, can damage the glucose metabolic system in the body, and is characterized by hyperglycemic conditions. Moringa leaves (Moringa oleifera) and Andrographis herbs (Andrographis paniculata) have been studied to have antihyperglycemic activity in diabetic rats. The purpose of this study was to determine the effect of the combination of Moringa leaf ethanol extract (MLEE) and ethanol extract of Andrographis herbs (AHEE) in streptozotocin-induced rats (45 mg/kgBW). The subjects consisted of 32 rats, divided into 8 groups (1 healthy group and 7 type 2 DM groups). The study was conducted for 4 weeks by measuring blood glucose levels in pre-treatment, day 0, 14 and 28 with a single MLEE treatment dose of 300 mg/kgBW, single AHEE 300 mg/kgBW, combination of MLEE and AHEE 150+150 mg/kgBW, 200+100 mg/kgBW, 100 + 200 mg/kgBW, and gliclazide 5 mg/kgBW orally. The results of measurement of fasting blood glucose levels on day 28 showed that administration of gliclazide 5 mg/kg BW, single dose MLEE and AHEE, as well as its combination, had significant differences (p<0.05) compared to the hyperglycemic control group. Pancreatic organ histopathology features in the extract dose group showed that there was a change in the repair of insula Langerhans compared to the hyperglycemic control group which showed necrotic damage due to streptozotocin induction. Combination administration has the same antihyperglycemic effect by single dose extract in diabetic rats within 28 days, which also restore weight loss to normal.

Comparative Effects of Yellow Root (Arcangelisia flava (L.) Merr.) Decoctions with Water and Brackish Water on Kidneys and Uterus in Wistar Rats Suwijiyo Pramono; Risqika Y.T. Paramidhita; Marini Marini; Moch. Saiful Bachri
Majalah Obat Tradisional Vol 25, No 2 (2020)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.55178

Yellow root (Arcangelisia flava (L.) Merr.) is a medicinal plant used traditionally in Borneo, Indonesia, for several diseases. Nevertheless, it contains berberine alkaloids that are considered harmful. Empirically, based on local wisdom people do not boil yellow roots with water but with brackish water. This study aimed to determine the effects of yellow root decoctions made using water and brackish water on blood biochemical and histopathological profile of kidneys and uterus in Wistar rats after subchronic treatment. Overall, 70 Wistar female rats were divided into seven groups of which three groups were given yellow root water decoctions and three groups were given yellow root brackish water decoctions with doses equivalent to 1.25 g/kg BW, 2.5 g/kg BW and 5 g/kg BW of dried yellow root, whereas the control group was only given Aquadest. After 28 days of treatments, blood samples were obtained for biochemical examination followed by a surgical examination to observe the histological features of the organs. The results revealed significant differences in the blood urea nitrogen (BUN) levels between group that was given water decoction of the yellow root and the control group. On the other hand, the groups that were given brackish water decoction revealed no significant changes, except at the highest dose. Furthermore, histopathological features of rats treated using all doses of the yellow root water decoctions revealed organ damage compared with the normal group, manifested as hemorrhage, degeneration, and necrosis of the kidneys, as well as epithelial damage and inflammatory infiltration of the uterus.

The Gastroprotective Activity of Ethanol Extract of Curcuma domestica Val. on Mice Induced Ethanol - HCl Fitri Rahmania Farikha; Moch. Saiful Bachri
Indonesian Journal of Cancer Chemoprevention Vol 7, No 3 (2016)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev7iss3pp74-78

Curcuma domestica Val. (CD) is one of plant used as traditional medicine in around the world. One of the benefit of CD is to treat peptic ulcers. The aim of preset study to prove that the ethanol extract of CD has gastroprotective activity. This study used 25 male mice were divided into 5 groups. Group I as a control group were given suspension of 0.5% Na-CMC, groups II, III, and IV were each given ethanol extract of CD suspense with 0.5% Na-CMC at a dose of 50 mg/kg; 100 mg/kg; 200 mg/kg respectively, and group V was given ranitidine 10 mg/kg. All groups were treated orally for 6 days, then fasted for 24 hours, on the seventh day all mice induced 3M HCl - ethanol 60% (1:1) 0.2 ml/25 gBW. One hour later, mice were sacrificed by cervical dislocation, then dissected and taken gastric. Then performed an ulcer scoring and the curative ratio is calculated later in the histopathologic test. Data were analyzed using Kolmogorov-Smirnov test and the Levene test and ANOVA followed by LSD test level of 95%. The results showed there was no significant difference between the control with dose 50 mg/kgBW (p>0.05) and showed significant difference between control with dose 100 mg/kgBW (p<0.05),dose of 200 mg/kgBW (p<0,05), and ranitidine 10 mg/kgBW (p<0.05). Curative ratio percentage dose of 100 mg/kgBW; 200 mg/kgBW, and ranitidine are 38.89%, 61.11% and 66.67 % respectively. The conclusion of this research, the ethanol extract of Curcuma domestica Val at the dose 100 mg/kgBW and 200 mg/kgBW showed have gastroprotective activity.Keywords: Gastroprotective, Curcuma domestica Val., ethanol-HCl, Gastric ulcer

Co-Authors -, Nova Anggreni Anak Agung Gede Sugianthara Anggreni, Nova Annisa Fatmawati Ardilla, Mita Baroroh, Faridah Cipta Khairunnisa Citra Ariani Edityaningrum, Citra Danang Prasetyaning Amukti Dandy Annas Muttaqien Dara Pranidya Tilarso Daru Estiningsih Daud, Intan Deni Firmansyah Desi Iswahyuni Dian Prasasti Fauziyyah, Khusna Fita Sari Fitri Rahmania Farikha Galuh Rista Putri Haafizah Dania Hestuning Winda Maharani, Hestuning Winda Humolungo, Dwi Tiva Widyanti Sidik Ichwan Ridwan Rais Imono Argo Donatus, Imono Argo Intan Dwi Rahmita Laela Hayu Nurani Ma'ruf, Muhammad Maghfirah, Rahmayani Maharani, Hestuning Winda Marini Marini Muhammad Ma'ruf Muhammad Reza Ramadhani Muhammad Yusron Maulana El-Yunusi Nadia Selvia Najini, Robby Nofa Risma Azis Nur Mahdi Nurkhasanah Nurkhasanah Nurkhasanah Nurkhasanah Risqika Y.T. Paramidhita Sapto Yuliani Sapto Yuliani Sapto Yuliani Sofina Rahmadita Sri Mulyaningsih Subagus Wahyuono Suci Kurniati Suwijiyo Pramono Syarif, Yaumi Musfirah Vella Lailli Damarwati Vivi Sofia Wahyu Widyaningsih Wahyu Widyaningsih Wahyu Widyaningsih Wahyu Widyaningsih Widyasari Putranti Wiki Yuli Anita Wirawan Adikusuma

Title

Found 37 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 37 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 37 Documents
Search