Article Per Year (5 Year)
p-Index From 2020 - 2025
3.914
P-Index
This Author published in this journals
All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya Science and Technology Indonesia Majalah Kesehatan FKUB Ina Kidney JIMEK : Jurnal Ilmiah Mahasiswa Ekonomi Heart Science Journal CRJIM (Clinical and Research Journal in Internal Medicine) Jurnal Jeumpa Narra J Jurnal Klinik dan Riset Kesehatan Jurnal Penyakit Dalam Indonesia Jurnal Kesehatan Deka in Medicine
Nur Samsu
Brawijaya University, Dr. Saiful Anwar Hospital, Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

Published : 33 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Science and Technology Indonesia

 1 
Nanoparticle-Enhanced 3D-Connector Microfluidic Paper-Based Analytical Device (3D-µPADs) for Sensitive and Cost-Effective Detection of Albumin-Creatinine Ratio in Urine Sample Sabarudin, Akhmad; Fiddaroini, Saidun; Fahmi, Ahmad Luthfi; Roja’i, Abdul Munir; Salsabila, Isadora Evani; Aulanni’am; Srihardyastutie, Arie; Susanti, Hani; Samsu, Nur
Science and Technology Indonesia Vol. 10 No. 2 (2025): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.2.504-518

Abstract

Chronic kidney disease (CKD) is a global health challenge affecting over 800 million people worldwide. Early detection is crucial to prevent progression to end-stage renal disease (ESRD), where life-saving interventions like dialysis or transplantation are necessary. Among the markers for early kidney damage, the Albumin Creatinine Ratio (ACR) in urine is one of the most reliable. Conventional methods of ACR detection, such as LC/MS-MS and ELISA, are highly accurate but require expensive equipment and skilled personnel, limiting their accessibility, especially in resource-limited settings. To address this, we developed a 3D-connector microfluidic paperbased analytical device (3D-µPADs) enhanced with gold nanoparticles (AuNPs) for sensitive and low-cost ACR detection. The integration of AuNPs amplifies colorimetric signals, enhancing the visual distinction in albumin detection. Our 3D-µPADs werefabricated using chromatographic paper Whatman No. 1 with hydrophobic barriers created by solid wax printing, followed by reagent immobilization for albumin and creatinine detection. The colorimetric and distance responses, based on reactions with Bromocresol Green (BCG) and Chrome Azurol S-Palladium (CAS-Pd2+), were analyzed using ImageJ software to quantify albumin and creatinine levels. The 3D-µPADs exhibited optimal sensitivity and accuracy, with linear detection ranges for albumin and creatinine of 30–400 mg/g. Validation with human urine samples demonstrated an accuracy of 93.04%, suggesting that 3D-µPADs offer a promising alternative for early nephropathy detection. Our findings provide a cost-effective, accessible tool for CKD screening, potentially transforming diagnostics in low-resource environments.
Co-Authors ACHMAD RIFAI Achmad Rudijanto Akhmad Sabarudin Albaar, Thoha M. Arie Srihardyastutie asihanti rosita ferdiana Atma Gunawan Aulanni’am Aulya, Justika Usmadhani Baridwan, Fakhri Camoya Gersom Dela, Jamaludin A. Dewi, Ratih TK. Diana Lyrawati Didi Candradikusuma Dwinata, Michael Fachrureza, Mochamad Fahmi, Ahmad Luthfi Fajar, Jonny Karunia Farahdina, Farahdina Fatimatuz Zahroh, Fatimatuz Fiddaroini, Saidun Fredo Tamara, Fredo Friatna, Yudha Gandung Satriyono, Gandung Hani Susanti, Hani Heri Sutanto Huda, Fariz N. Ida Wahyuni Indiastari, Dewi Jack Roebijoso Jonny K. Fajar Kosasih, Angelia Kusuma, Yeziga Enggar Matondang, Asri Rizqi Mutia, Tari Ni Luh Tantri Niniek Budiarti B Novitasari, Adinda Dian Nurike S Mudjari, Nurike S Oktavia Rahayu Adianingsih Pratama, Satya Putra, Riyantono Putri, Irawati E. Rifa'i, Achmad Rizaliansyah, Ferdian Roja’i, Abdul Munir Rudy Salam, Rudy Salsabila, Isadora Evani Saraswati, Dara Sari, Fitria R. Susanto, Agung Suseno, Aryo Sutrisno, Muhammad A. Tidel, Caesar Tupamahu, Alvira R. Waafi, Affa Kiysa Wicaksono, Ramadi S. Wicaksono, Ramadi Satryo Winoto, Eden Wursito, Wursito Zuhri, Mohammad harisudin