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All Journal Jurnal Farmasi Sains dan Komunitas Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Journal Of Vocational Health Studies Jurnal SOLMA SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Ilmu Kefarmasian Indonesia Media Karya Kesehatan Jurnal Ilmiah Farmako Bahari Poltekita: Jurnal Pengabdian Masyarakat Jurnal Insan Farmasi Indonesia Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society
Faizah Min Fadhlillah
Department Of Pharmacy, Faculty Of Mathematics And Natural Sciences, Universitas Garut, Garut Regency, West Java, 44151, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Acute and Sub-Acute Oral Toxicity Assessment of Marchantia paleacea Bertol. Liverwort Herb Extract in Mice on Liver and Kidney Function Purkon, Dicki Bakhtiar; Nainggolan, Aurelya Veny Kurnia; Ningsih, Padmasari Diah Ayu Kumala; Kusmiyati, Mimin; Sudaryat, Yayat; Srinati, Ine; Fadhlillah, Faizah Min; Sufa, Hafizah Ilmi; Hotimah, Alni Khusnul
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008218

Abstract

Herbaceous liverwort Marchantia paleacea Bertol. has been known as a potential source that has bioactive compounds with various pharmacological benefits, such as: antimicroorganism, antifungal, antioxidant, immunomodulator, hepatoprotector, antipyretic, diuretic, cardiotonic, and vasorelactan. However, information regarding oral acute and sub-acute toxicity data from ethanol extracts of Marchantia paleacea Bertol. liverwort herb is still very limited. Therefore, this study aimed to evaluate the acute and sub-acute toxicity of liverwort herb ethanol extract in female mice of ddY strains. The acute toxicity test method was carried out by giving ethanol extract of the liverwort herb Marchantia paleacea Bertol. (EEMP) in single doses at doses of 250, 500, 1000, and 2000 mg/kg bw orally for 14 days, while sub-acute toxicity tests were performed by administering EEMP test extracts at doses of 125, 250, 500, 1000, and 2000 mg/kg bw orally for 28 days in accordance with testing standards from BPOM (2022), Thompson-Weil, and OECD. Parameters observed include clinical symptoms (including: mortality), profile of body weight changes, biochemical analysis of serum, and histopathological analysis of vital organs (liver and kidney). Results from acute toxicity testing showed that a single dose of EEMP at the tested level did not cause significant clinical symptoms and histopathological disorders, and there were no deaths in test animals classified as mild toxic substances based on BPOM criteria ( 2000 mg/kg bw). And sub-acute toxicity tests from the 125, 250, and 2000 mg/kg bw test groups revealed a significant increase in average SGOT levels compared to the normal control group on the 28th test day (p0.05) but still within the normal range. Most other test parameter profiles show no significant changes. Some of the observed changes, particularly in the biochemical and histological parameters of the organs that occur are assumed to be transient reaction effects and are not a sign of toxicity. These findings suggest the need for further study of the potential toxic effects of the liverwort herb Marchantia paleacea Bertol. This study provides important insights in the understanding of the potential uses of the liverwort herb Marchantia paleacea Bertol. as a product of herbal ingredients (nutraseutics, supplements, and traditional medicine), and reinforces the need to understand the potential toxicity risks associated with it. 
Peningkatan Perilaku Hidup Bersih dan Sehat (PHBS) Di Madrasah Tsanawiyah Persatuan Islam 99 Rancabango Melalui Workshop Pembuatan Sabun Najihudin, Aji; Auliasari, Nurul; Hindun, Siti; Rantika, Nopi; Amalia, Nur; Fadhlillah, Faizah Min
Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Vol 4, No 3 (2025)
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/phar.soc.v4i3.33782

Abstract

Perilaku hidup bersih dan sehat (PHBS) merupakan suatu praktik tentang perilaku seseorang dengan cara memperhatikan kebersihan, kesehatan, dan berperilaku sehat untuk meningkatkan derajat kesehatan. Tujuan dari kegiatan pengabdian kepada masyarakat ini adalah memberikan workshop kepada siswa dan guru Madrasah Tsanawih (MTS) Pesantren Persatuan Isalam (Persis) 99 Rancabango mengenai cara pembuatan sabun batang, sabun cuci tangan dan sabun cuci piring secara sederhana. Metode yang digunakan pada kegiatan ini yaitu melakukan pre-test mengenai mengenai perilaku hidup bersih dan sehat yang terkolerasi dengan berbagai aktivitas di pesantren, workshop pembuatan sabun batang, sabun cuci piring dan sabun cuci tangan oleh peserta kegiatan pengabdian, pemberian produk hasil workshop kepada peserta dan post-test. Selanjutnya dilakukan pengisian kuisioner tingkat kepuasan siswa dan guru terhadap kegiatan workshop, pemberian sertifikat, dan evaluasi. Kegiatan dilakukan pelatihan pembuatan produk kebersihan yang umum digunakan di rumah tangga, bahan dasar sabun yang digukan diantaranya adalah Natrium lauril sulfat, Natrim sulfat, amphitol, Natrium EDTA, pewarna, pewangi dan air. Dari kegiatan berlangung peserta mendapatkan pengalaman membuat dan mengolah produk pembersih sehingga dapat digunakan sebagai bagian produk dalam meningkatkan perilaku hidup bersih dan sehat  hasil evaluasi menunjukkan ada peningkatan pengetahuan siswa dan guru mengenai perilaku hidup bersih dan sehat yang dapat dilihat dari hasil evaluasi pre-test dan pos-test yaitu dari 82% menjadi 90% yang artinya adanya peningkatan sebesar 8%, dan untuk hasil kuesioner kepuasan siswa dan guru terhadap workshop pembuatan sabun yang diberikan yaitu menyatakan 99% siswa dan guru puas terhadap workshop yang diberikan.
Cost-effectiveness analysis of the use of antibiotics for typhoid fever inpatients in RSUD Bayu Asih Purwakarta Purkon, Dicki Bakhtiar; Agustin, Himeliya; Widyastiwi, Widyastiwi; Kusmiyati, Mimin; Fadhlillah, Faizah Min
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1679

Abstract

Typhoid fever is an infectious disease caused by Salmonella typhi, commonly treated with antibiotics to promote recovery and prevent complications. This study aimed to evaluate both the therapeutic effectiveness (clinical outcomes such as fever resolution and hospital stay duration) and the cost-effectiveness (economic efficiency of antibiotic use) in inpatients with typhoid fever at RSUD Bayu Asih Purwakarta (Bayu Asih District Hospital, Purwakarta) in 2023. A retrospective descriptive design was applied using 75 medical records from January to December 2023. Results showed that levofloxacin had the highest therapeutic effectiveness, reflected by the shortest hospitalization (3.5 days), whereas ceftriaxone was the most cost-effective, with an Average Cost-Effectiveness Ratio (ACER) of Rp. 194,858.78 per treatment. The Incremental Cost-Effectiveness Ratio (ICER) analysis indicated that the additional cost required for levofloxacin compared to ceftriaxone was disproportionate to the clinical benefit gained. In conclusion, while levofloxacin provides faster recovery, ceftriaxone remains the preferred option considering its superior cost-effectiveness. These findings emphasize the need to balance clinical outcomes and economic efficiency when determining antibiotic policies for typhoid management.
Pemberdayaan tukang jamu gendong kabupaten garut melalui penerapan CPOTB skala rumah tangga Kokom, Asep; Mariani, Ria; Amalia, Nur; Martiani, Isye; Fadhlillah, Faizah Min; Maharani, Raisha; Fajarwati, Neng Nabila
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 9, No 6 (2025): November (In Progress)
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v9i6.34259

Abstract

Abstrak Pengobatan tradisional telah menjadi bagian penting dari budaya Indonesia, dengan jamu sebagai salah satu warisan kesehatan yang masih dilestarikan hingga kini. Jamu gendong, yang diproduksi dan dipasarkan secara keliling oleh penjual, banyak dijumpai di Kabupaten Garut. Obat tradisional termasuk jamu gendong dalam proses pembuatannya harus memenuhi standar keamanan dan mutu produk sebagaimana diatur dalam Cara Pembuatan Obat Tradisional yang Baik (CPOTB). Kegiatan pengabdian kepada masyarakat ini bertujuan untuk memberdayakan penjual jamu gendong di Kabupaten Garut melalui penerapan CPOTB skala rumah tangga. Evaluasi pengetahuan dilakukan menggunakan pre-test dan post-test mencakup lima aspek CPOTB: pengertian dan tujuan, bahan baku, produksi, peralatan, dan higienitas personal. Hasil menunjukkan adanya peningkatan rata-rata pengetahuan peserta dari 87,5% sebelum peyuluhan menjadi 100% setelah penyuluhan. Peningkatan ini mencerminkan efektivitas kegiatan dalam meningkatkan pemahaman CPOTB. Namun, hasil diskusi mengungkapkan bahwa pemahaman tersebut belum sepenuhnya diimplementasikan dalam praktik produksi. Oleh karena itu, diperlukan pelatihan lanjutan berbasis praktik dan pendampingan berkelanjutan agar penerapan CPOTB dapat berjalan secara konsisten. Kata kunci: CPOTB; jamu gendong; Kabupaten Garut; mutu AbstractTraditional medicine has been an important part of Indonesian culture, with jamu as one of the health heritages that is still preserved today. Jamu gendong, which is produced and sold door-to-door by vendors, is widely found in Kabupaten Garut. Traditional medicines, including jamu gendong, must be produced in compliance with the safety and quality standards set out in the Good Traditional Medicine Manufacturing Practices (CPOTB). This community service activity aimed to empower jamu gendong vendors in Kabupaten Garut through the implementation of household-scale CPOTB. Knowledge evaluation was conducted using pre-test and post-test assessments covering five aspects of CPOTB: definition and objectives, raw materials, production, equipment, and personal hygiene. The results showed an increase in the participants’ average knowledge from 87.5% before the training to 100% after the training. This improvement reflects the effectiveness of the program in enhancing participants’ understanding of CPOTB. However, discussions revealed that this knowledge has not been fully implemented in production practices. Therefore, further practice-based training and continuous mentoring are needed to ensure the consistent application of CPOTB. Keywords: CPOTB; jamu gendong; Kabupaten Garut; quality
Co-Authors Afifah Rahmawati Agustin, Himeliya Ainun Nadhifah, Ainun Ansyirohanisa Ansyirohanisa Ansyirohanisa Ansyirohanisa Ardi Rustamsyah Ardi Rustamsyah Auliasari, Nurul Ayu Awaliyah Inayah Dani Sujana Dicki Bakhtiar Purkon Elvi Trinovani Elvi Trinovani, Elvi Fajarwati, Neng Nabila Farid Pedana Haerussana, Ayu Nala El Muna Hindun, Siti Hotimah, Alni Khusnul Imas Siti Nur Padilah Irvan Herdiana Khaira Arnella Kokom, Asep Lilis Febriyanti Maharani, Raisha Maigoda, Tonny Cortis Maria Immaculata Iwo Martiani, Isye Mimin Kusmiyati, Mimin Miranti, Mila Muhamad Zakiyuddin Abdul Aziz Muhammad Aqil Zaelani Nainggolan, Aurelya Veny Kurnia Najihudin, Aji Natasya Khairunnisa Nelly Selvatiany Ningsih, Padmasari Diah Ayu Kumala Nizella Syahla Nizella Syahla Nur Amalia Pambudi, Fatimah Ayu Putri Perdana, Farid Raden Aldizal Mahendra Rizkio Syamsudin RANTIKA, NOPI Ria Mariani Roseno, M.H. Siti Nuraeni Soemardji, Adreanus Andaja Srinati, Ine Sufa, Hafizah Ilmi Tanika Miatul Hadid Vindi Nur Amalia Wibowo, Diki Prayugo Windi Lestari Yayat Sudaryat Zahra Anggraeni Zahwa Ainunnisya Nur Aisyah