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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Jurnal Presipitasi : Media Komunikasi dan Pengembangan Teknik Lingkungan Pharmacology and Clinical Pharmacy Research Jurnal Mandala Pharmacon Indonesia Jurnal Ilmiah Medicamento Journal of Pharmaceutical and Health Research Jurnal Inkofar Jurnal Riset Farmasi Bandung Conference Series: Pharmacy Prosiding Seminar Hasil Penelitian dan Pengabdian Kepada Masyarakat Borneo Journal of Pharmacy Jurnal Sains dan Kesehatan
Vinda Maharani Patricia
Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Islam Bandung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Earth & Planetary Sciences Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Transportation

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Penetapan Kadar Flavonoid Total dan Pengujian Aktivitas Antioksidan Ekstrak Etanol 96% Biji Pepaya (Carica Papaya L.) Varietas Bangkok Pradini Shulistiya; Yani Lukmayani; Vinda Maharani Patricia
Jurnal Riset Farmasi Volume 5, No. 1, Juli 2025, Jurnal Riset Farmasi (JRF)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jrf.v5i1.6813

Abstract

Abstract. Bangkok papaya (Carica papaya L.) seeds contain flavonoid compounds that are thought to have antioxidant activity. This study aims to determine the total flavonoid content and determine the antioxidant activity of 96% ethanol extract of Bangkok papaya seeds. The extraction of Bangkok papaya seeds was done using the maceration method. Determination of total flavonoid content was done by colorimetric method using AlCl3 reagent with quercetin comparator and antioxidant activity testing was done by DPPH (2,2-diphenyl-1-picrylhydrazyl) method using vitamin C comparator. The results showed that the total flavonoid content was 192,80 mgQE/gr extract and the IC50 value of 96% ethanol extract of papaya seeds (Carica papaya L.) Bangkok variety was 2.374,79 ppm which is included in the category of very weak antioxidant activity. Abstrak. Biji pepaya (Carica papaya L.) varietas Bangkok mengandung senyawa flavonoid yang diduga memiliki aktivitas antioksidan. Penelitian ini bertujuan untuk menentukan kadar flavonoid total dan mengetahui aktivitas antioksidan dari ekstrak etanol 96% biji pepaya varietas Bangkok. Ekstraksi biji pepaya varietas Bangkok dilakukan dengan metode maserasi. Penetapan kadar flavonoid total dilakukan dengan metode kolorimetri menggunakan pereaksi AlCl3 dengan pembanding kuersetin dan pengujian aktivitas antioksidan dilakukan dengan metode DPPH (2,2-diphenyl-1-picrylhidrazil) menggunakan pembanding vitamin C. Dari hasil penelitian didapatkan kadar flavonoid total sebesar 192,80 mgQE/gr ekstrak dan nilai IC50 ekstrak etanol 96% biji pepaya (Carica papaya L.) varietas Bangkok sebesar 2.374,79 ppm yang termasuk dalam kategori aktivitas antioksidan sangat lemah.
Pengaruh Ekstraksi Terhadap Kadar Alkaloid Buah Mengkudu dan Penghambatan Enzim α-Amilase Sulistia Rahmawati; Kiki Mulkiya Yuliawati; Vinda Maharani Patricia
Jurnal Riset Farmasi Volume 5, No. 1, Juli 2025, Jurnal Riset Farmasi (JRF)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jrf.v5i1.6815

Abstract

Abstract. Noni fruit (Morinda citrifolia L.) is one of the plants used by ancient to prevent various diseases such as diabetes mellitus. The alkaloid compound group in noni fruit is known to be able to provide activity to reduce blood sugar levels so that it can prevent diabetes mellitus. This study aims to determine the total alkaloid content and the inhibition of α-amylase enzyme in noni fruit extracts on maceration method (EBMM) and reflux method (EBMR). Total alkaloid content of noni fruit extracts was measured using BCG (Bromocresol Green) method. The activity of reduce blood sugar levels was measured by inhibition α-amylase enzyme. The results showed that total alkaloid content in EBMM was 3,8271 mg RE/g, while in EBMR it was 3,6931 mg RE/g. The α-amylase enzyme inhibition of noni fruit extract was expressed based on IC50 value, The EBMM showing an IC50 value of 488.5 µg/mL and EBMR showing an IC50 value of 527.6 µg/mL. Based on this analysis, it was showed that there was no significant between EBMM and EBMR on total alkaloid content or inhibition of α-amylase enzyme. Abstrak. Buah mengkudu (Morinda citrifolia L.) merupakan salah satu tanaman yang digunakan masyarakat untuk mencegah berbagai penyakit salah satunya ialah diabetes mellitus. Golongan senyawa alkaloid pada buah mengkudu diketahui mampu memberikan aktivitas penurunan kadar gula darah sehingga dapat mencegah penyakit diabetes mellitus. Penelitian ini bertujuan untuk mengetahui kadar alkaloid total dan aktivitas penghambatan enzim α-amilase secara in-vitro pada ekstrak buah mengkudu yang diesktraksi dengan metode maserasi (EBMM) dan metode refluks (EBMR). Pengujian kadar alkaloid total pada ekstrak buah mengkudu dilakukan berdasarkan metode BCG (Bromocresol Green). Aktivitas penurunan kadar gula darah dilakukan dengan pengujian ekstrak buah mengkudu secara in-vitro berdasarkan metode penghambatan enzim α-amilase. Hasil Penelitian menunjukkan kadar alkaloid total pada EBMM sebesar 3,8271 mg RE/g dan kadar alkaloid total pada EBMR sebesar 3,6931 mg RE/g. Aktivitas penghambatan enzim α-amilase ekstrak buah mengkudu dinyatakan berdasarkan nilai IC50, Pada EBMM diperoleh nilai IC50 sebesar 488,5 µg/mL dan pada EBMR diperoleh nilai IC50 sebesar 527,6 µg/mL. Berdasarkan analisa tersebut dapat disimpulkan bahwa tidak ada tidak ada pengaruh signifikan antara EBMM dan EBMR terhadap kadar alkaloid total maupun aktivitas penghambatan enzim α-amilase.
Antioxidant Properties Of N-Hexane Extract From Tobacco Leaves (Nicotiana tabacum L.) Using 2,2-Diphenyl-1-Picrylhydrazil (DPPH) Method Patricia, Vinda Maharani; Az-zahra, Dhea Khairunnisa; Fakih, Taufik Muhammad; Suarantika, Farendina
Pharmacology and Clinical Pharmacy Research Vol 10, No 2 (2025)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v10i2.59372

Abstract

Tobacco (Nicotiana tabacum L.) is a commercial plant that often used for making cigarettes. In 2012, the government issued regulations for the diversification of tobacco products besides cigarettes. Some of these diversified tobacco products include organic pesticides, anesthetics, cosmetic ingredients, and biochar as an alternative to coal. Therefore, in order to further to diversification of tobacco product, this study aimed to determine the antioxidant activity from n-hexane extract from leaves using the Soxhlet extraction method. Antioxidant activity was assessed by the DPPH (2,2-diphenyl-1-picrylhydrazyl) method, while the total phenolic content was determined using the Folin-Ciocalteu method that allowed quantification of phenolic compounds in the extract, which possesses the role of antioxidant. The IC50 value obtained from the antioxidant activity assay of the n-hexane extract of tobacco leaves was 426.042 μg/mL, classified as very weak. Meanwhile, the total phenolic content was 51.93 mg GAE/g. These results suggest that the high total phenol content may have other potential activities that can be tested, such as antibacterial activity.
Pelatihan Pembuatan Liquid Smoke Dari Limbah Kelapa Untuk Mendukung Kemandirian Ekonomi Masyarakat Desa Cilentung Kabupaten Pandeglang Mukhoyyaroh, Qiswatun; Sutisna, Ade Jaya; Junaedi, Yusup; Nugraha, Nugraha; Patricia, Vinda Maharani; Alamsyah, Indra Fajar; Respati, Titik
Sehati Abdimas Vol 7 No 1 (2024): Prosiding Sehati Abdimas 2024
Publisher : PPPM POLTESA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47767/sehati_abdimas.v7i1.909

Abstract

ABSTRACT Pandeglang is recorded as the district with the highest poverty rate in Banten Province until 2023. This is in contrast to the potential of the resources owned by the region. The superior plantation commodity in the form of coconut is one of the best and most abundant commodities in Banten Province. The problem found in Cilentung Village, Pulosari District, Pandeglang Regency is that people sell coconuts in bulk to the city, then the coconut waste is returned to the village, causing environmental pollution and no innovation in diversification of coconut waste derivative products. The purpose of PkM is to train the community in making Liquid Smoke from coconut waste to support the economic independence of the people of Cilentung Village, Pandeglang Regency. The methods used to answer this problem are socialization of liquid smoke waste into Liquid Smoke, application of pyrolysis technology and coconut waste shredding machines, training in Making Liquid Smoke from Coconut Waste, mentoring and evaluation of activities.
Co-Authors Adinda Fitri Salsabila Agung Gunawan Akbar, Nabila Hadiah Alamsyah, Indra Fajar Amelia Ersa Renatha Athina Mardhatillah Az-zahra, Dhea Khairunnisa Bertha Rusdi Cahyaning Pertiwi Citra Mufidah Desma Nova Diana Deva Nissyarah Effendi Dhea Khairunnisa Az-zahra Dina Mulyanti Dwiratnasari Esti Rachmawati Sadiyah Esti Rachmawati Sadiyah Fakhrul Akbar Arrahim Farendina Suarantika Fauzia Ningrum Saputri Fauzia Ningrum Syaputri Gishela Bellania Hani Burhanudin Hanifa Rahma Herna Haryani Hilwati Hindersah Indra Topik Maulana Jihan Hana Fauziah Kenny Utami Prameswari Kiki Mulkiya Kiki Mulkiya Yuliawati Kiki Mulkiya Yuliawati Livi Kharisma Wibawa Livia Syafnir Livia Syafnir Livia Syafnir Livia Syafnir Medina Raudhatul Jannah Meytha Putri Dewanty Miftahadi, Machmuddin Fitra Mila Apriyani Mohamad Satori Muhammad Fadhil Safari Nabila Felisha Nadia Rahayu Nadia Nanda Aulia Rahma Nazwa Latiefah Firdaus Nugraha Nugraha Pradini Shulistiya Pupung Purnamasari Qiswatun Mukhoyyaroh Ratna Januarita Riza Hernawati Rodhiatul Jurdillah salma rahmawati Saputri, Fauzia Ningrum Satyawati Siti Hazar Sulistia Rahmawati Sutisna, Ade Jaya Suwendar Tasya Luthfiyyah Tasya Luthfiyyah Taufik Muhammad Fakih Thyazen Abdo Al - Hakimi Thyazen Alhakimi Titian Daru Asmara Tugon Titik Respati Tri Ayu Febrianti Wafiq Nur Azizah Yani Lukmayani Yani Lukmayani Yani Lukmayani Yuliani Ika Pratiwi Yusup Junaedi Zaina Alviona Pridesta