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All Journal Jurnal Nalar Pendidikan Jurnal Ilmu Perpustakaan Sainteknol : Jurnal Sains dan Teknologi Majalah Obat Tradisional Transformatika: Jurnal Bahasa, Sastra, dan Pengajarannya Jurnal Surya Medika Majalah Farmaseutik HIKMAH : JURNAL PENDIDIKAN AGAMA ISLAM Jurnal Mandala Pharmacon Indonesia Jurnal FARMAKU (Farmasi Muhammadiyah Kuningan) JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan Jurnal Ilmiah Kesehatan Masyarakat : Media Komunikasi Komunitas Kesehatan Masyarakat Jurnal Kesehatan Tambusai Well Being JEBDEKER: Jurnal Ekonomi, Manajemen, Akuntansi, Bisnis Digital, Ekonomi Kreatif, Entrepreneur Center of Knowledge JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Medika Respati : Jurnal Ilmiah Kesehatan Kompeten: Jurnal Ilmiah Ekonomi dan Bisnis JRAP (Jurnal Riset Akuntansi dan Perpajakan) Jurnal Abdimas Jatibara Academic Hospital Journal Asian Journal of Management, Entrepreneurship and Social Science Indonesian Journal of Pharmacology and Therapy Jurnal Rekam Medic
Ika Puspita Sari
Biology Department, Faculty of Mathematics and Natural Sciences, Universitas Negeri Semarang
Religion Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Jurnal Surya Medika

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The Practice of Prolonging Meropenem Infusion: A Narrative Review of Literatures Over the Last Decade: The Practice of Prolonging Meropenem Infusion: A Narrative Review of Literatures Over the Last Decade Fauzi, Rifani; Widyati, Widyati; Sari, Ika Puspita
Jurnal Surya Medika (JSM) Vol. 10 No. 1 (2024): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v10i1.7162

Abstract

Background: The emergence of Antimicrobial Resistance (AMR) has forced clinicians and medical professionals to implement a strict Antimicrobial Stewardship policy. One of the pillar of Antimicrobial Stewardship is by optimizing the use of antibiotic agents. Beta-lactams demonstrate a time-dependent effect in combating bacteria. Since it is pharmacodynamically supported, a prolonged exposure via intravenous administration could be a feasible strategy to maximize the bactericidal effect. Meropenem, a beta-lactam antibiotic of carbapenems sub-class, also falls into the category above. However, there are questions to be answered regarding its stability, compatibility, safety, and clinical outcomes superiority compared to the standard intermittent infusion, before we can determine its effectiveness to be delivered as prolonged or extended infusion. Aims: This article would like to review literatures regarding the rationale behind the practice of prolonging meropenem infusion from the last decade. Method: For this narrative review we utilized articles extracted from Cochrane Library, ScienceDirect, and SageJournals databases from the last ten years. We also added complementary related articles from UpToDate®. Selected articles were limited to those published in english. Inclusion criteria specifically only including related articles to the practice of prolonging meropenem infusion on adult patients. A total of 18 articles were reviewed for the synthesis of this narrative review. Conclusion: Meropenem is eligible for prolonged infusion protocol since it is theoretically supported, adequate in stability, less concern for incompatibility, and potentially can provide better clinical outcomes compared to standard intermittent infusion.
Co-Authors A., Diki Aprianto Abdurrohman KM, M. Sa’id Amin Retnoningsih Anwar, Sumadi Lukman Ardha, Doglas Rama Bayu Arif Wijaya Arifin, Shokhibul Ariyanti, Irma Arwani, M. Atika Atika Azizah, Zulfi Bathari, Anggraini Citra Ryshang Batubara, Naufal Akbar Bayu Bakti Angga Santoso Candraningrat, I Dewa Agung Ayu Diva Darwito Dewi Latifatul Ilma Dewi, Aprilya Tunggo Dicky M. Rizal, Dicky M. Djoko Wahyono Dyawati, Nova Ediati Sasmito Eka, Anggri Endang Lukitaningsih Enni Suwarsi Rahayu Estriningsih, Endang Fairuza, Najwa Falihah, Atika Hanum Fauzi, Rifani Firda Ridhayani Firiyah, Erna Tsalatsatul Fita Rahmawati Fitriyah, Erna Tsalasatul Harahap, Amira Mufidah I Dewa Putu Pramantara Ibrahim, Muhammad Malik Irfan Muris Setiawan Karundeng, Glory Claudia Kurnia, Ita Lubis, Zulfahmi Mahardinata, Nur Azid MAULANA, AGUNG FIRMAN Maulidiyah, Vivin Nur Mazidah, Nurul Mecca Arfa, Mecca Muhammad Husaini Muhammad Nurul Huda Munadi, Windya Rizki Dwi Mustofa Mustofa Muvita Rina Wati Nabila, Lathifa Nafi’a, Fikrotul Ilman Nanang Munif Yasin Nurkhalika, Rachmi Nurul Huda Nurwulandari , Andini parakoso, gigih Pratama, Anton Purwaningtyastuti, Eni Rakhmawati, Fitria Ratna Ratna Riani, Susetya Lia Rizka Humardewayanti Asdie Roni, Faishol Rufaidah, Alfin Rumiyati, Rumiyati Sahid, Muhammad Novrizal Abdi Selamet, Ni Made Dwi Antika Simamora, Dian Mutiara Siti Rahayu Sulistyawati, Ety Diana Sulistyawaty, Ety Diana Taufik, Ganjar Titik Nuryastuti Tri Murti Andayani Utami, Tri Fitri Yana Wahyuddin, Munifah Widyati, Widyati Wiganata, Siken Agil Wijayana, Singgih Wiyatami, Monia Agni Yuni, Ika Yusmanisari, Eka Zahro, Indira Munifatus