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Journal : Academic Hospital Journal

A Narrative Review: Augmented Renal Clearance and Its Effect on Drug Therapy Selamet, Ni Made Dwi Antika; Sari, Ika Puspita; Andayani, Tri Murti
Academic Hospital Journal Vol 7, No 2 (2025)
Publisher : Rumah Sakit Akademik Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ahj.v7i2.105634

Abstract

Background: Augmented renal clearance (ARC) is a common condition in critically ill patients, particularly in intensive care units, characterized by enhanced renal elimination. The accelerated elimination of drugs can significantly impact therapeutic efficacy, potentially resulting in suboptimal treatment outcomes. This review aims to provide a comprehensive overview of drugs impacted by ARC, offering a better understanding of the impact of ARC on drug therapy.Method: A narrative review was conducted to explore previous studies from Scopus, PubMed, and ScienceDirect. PRISMA flow chart was used to guide the article selection process.Result:  A total of 14 articles were comprehensively reviewed and discussed regarding drugs affected by ARC, the impact of ARC on the pharmacokinetic/pharmacodynamic properties of drugs, and their clinical outcomes. Classes of drugs affected by ARC include beta-lactam antibiotics, glycopeptide antibiotics, anticoagulants, and anticonvulsants.Conclusion: Antibiotics are the most frequently reported drugs to be impacted by ARC, followed by anticoagulants and anticonvulsants. The impact of ARC on anticoagulants is inconsistent. ARC reduces free drug concentration, requires a higher dose to achieve the therapeutic target, and is associated with a higher risk of treatment failure. However, no significant differences were found in clinical response and mortality compared to non-ARC.
Co-Authors A., Diki Aprianto Abdurrohman KM, M. Sa’id Amin Retnoningsih Anwar, Sumadi Lukman Ardha, Doglas Rama Bayu Arif Wijaya Arifin, Shokhibul Ariyanti, Irma Arwani, M. Atika Atika Azizah, Zulfi Bathari, Anggraini Citra Ryshang Batubara, Naufal Akbar Bayu Bakti Angga Santoso Candraningrat, I Dewa Agung Ayu Diva Darwito Dewi Latifatul Ilma Dewi, Aprilya Tunggo Dicky M. Rizal, Dicky M. Djoko Wahyono Dyawati, Nova Ediati Sasmito Eka, Anggri Endang Lukitaningsih Enni Suwarsi Rahayu Estriningsih, Endang Fairuza, Najwa Falihah, Atika Hanum Fauzi, Rifani Firda Ridhayani Firiyah, Erna Tsalatsatul Fita Rahmawati Fitriyah, Erna Tsalasatul Harahap, Amira Mufidah I Dewa Putu Pramantara Ibrahim, Muhammad Malik Irfan Muris Setiawan Karundeng, Glory Claudia Kurnia, Ita Lubis, Zulfahmi Mahardinata, Nur Azid MAULANA, AGUNG FIRMAN Maulidiyah, Vivin Nur Mazidah, Nurul Mecca Arfa, Mecca Muhammad Husaini Muhammad Nurul Huda Munadi, Windya Rizki Dwi Mustofa Mustofa Muvita Rina Wati Nabila, Lathifa Nafi’a, Fikrotul Ilman Nanang Munif Yasin Nurkhalika, Rachmi Nurul Huda Nurwulandari , Andini parakoso, gigih Pratama, Anton Purwaningtyastuti, Eni Rakhmawati, Fitria Ratna Ratna Riani, Susetya Lia Rizka Humardewayanti Asdie Roni, Faishol Rufaidah, Alfin Rumiyati, Rumiyati Sahid, Muhammad Novrizal Abdi Selamet, Ni Made Dwi Antika Simamora, Dian Mutiara Siti Rahayu Sulistyawati, Ety Diana Sulistyawaty, Ety Diana Taufik, Ganjar Titik Nuryastuti Tri Murti Andayani Utami, Tri Fitri Yana Wahyuddin, Munifah Widyati, Widyati Wiganata, Siken Agil Wijayana, Singgih Wiyatami, Monia Agni Yuni, Ika Yusmanisari, Eka Zahro, Indira Munifatus