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Journal : Indonesian Journal of Pharmacology and Therapy

Clinically significant of drug-drug interactions among children: a review Ridhayani, Firda; Sari, Ika Puspita; Andayani, Tri Murti
Indonesian Journal of Pharmacology and Therapy Vol 5 No 3 (2024)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.9663

Abstract

Drug-drug interactions among children are a getting along concern in health care settings, specifically intensive care units, as sources of adverse drug events that may affect patient condition. Children admitted to pediatric intensive care unit are more prone to drug-drug interactions owing to the diseases and medications complexity. This condition could put the patient at high risk of harm, particularly with his critical condition, so need intense considerations from clinical practitioners to prevent adverse drug events caused by potential drug-drug interactions. This article’s review attempts to explore the important drug-drug interactions among children, including explaining the drug combination, mechanism, and related adverse drug events to help health practitioners recognize it earlier before prescribing the medication. This article’s review explored previous research results from PubMed and Google Scholar as literature resources and PRISMA flow chart as protocol for article selection process. A total of 9 articles discussed comprehensively about the type of drug combinations, mechanism of drug-drug interactions, and associated adverse drug events with significant drug-drug interactions that commonly occurred in children’s patient during the treatment. The drug-drug interaction including midazolam-phenobarbital, cannabidiol-clobazam, Paxlovid-tacrolimus, inhaled fluticasone propionate-lopinavir/ritonavir, rifampicin-warfarin, clofazimine-moxifloxacin, benzatropine-haloperidol, and enalapril-spironolactone. In conclusion, gaining a better understanding of drug-drug interactions among children will empower healthcare professionals to develop useful strategies to recognize, manage, and prevent various types of pharmacokinetic and pharmacodynamic interactions. Especially at different stages in terms of age, physiology, and complexity of the disease in children.
Papillary thyroid carcinoma post total thyroidectomy: a case report Darwito; Ardha, Doglas Rama Bayu; Sari, Ika Puspita; Ridhayani, Firda
Indonesian Journal of Pharmacology and Therapy Vol 4 No 2 (2023)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.6980

Abstract

Thyroid malignancies are considered rare but it is the most common type of endocrine malignancy that increase rapidly over the past decades. Specifically, papillary thyroid carcinoma (PTC) in the pyramidal lobe is extremely rare. Herein, we described a case of recurrence case of PTC in the pyramidal lobe post total thyroidectomy with category VI T2N1M1 (Bethesda classification) with right neck lymph nodes metastasis at once and attempt to determine both clinical presentation and therapeutical strategies to overcome this case to diminish the possibility of tumor recurrence and optimize therapeutic outcomes for PTC recurrence. It was reported a 28 yo female with a diagnosis of PTC from the pyramidal lobe post-total thyroidectomy procedure. A definite diagnosis of PTC is important to understand the patient's condition and as a consideration to decide the appropriate procedure to cure it. The management of PTC with total thyroidectomy followed by removing the possible root source of recurrent PTC, such as the pyramidal lobe, is mandatory to minimize the residual thyroid tissue that dan influenced PTC recurrent. Even though almost all PTC has an excellent prognosis, periodic follow-up after surgery, and patients’ adherence to their medication are still required.
Co-Authors A., Diki Aprianto Abdurrohman KM, M. Sa’id Amin Retnoningsih Anwar, Sumadi Lukman Ardha, Doglas Rama Bayu Arif Wijaya Arifin, Shokhibul Ariyanti, Irma Arwani, M. Atika Atika Azizah, Zulfi Bathari, Anggraini Citra Ryshang Batubara, Naufal Akbar Bayu Bakti Angga Santoso Candraningrat, I Dewa Agung Ayu Diva Darwito Dewi Latifatul Ilma Dewi, Aprilya Tunggo Dicky M. Rizal, Dicky M. Djoko Wahyono Dyawati, Nova Ediati Sasmito Eka, Anggri Endang Lukitaningsih Enni Suwarsi Rahayu Estriningsih, Endang Fairuza, Najwa Falihah, Atika Hanum Fauzi, Rifani Firda Ridhayani Firiyah, Erna Tsalatsatul Fita Rahmawati Fitriyah, Erna Tsalasatul Harahap, Amira Mufidah I Dewa Putu Pramantara Ibrahim, Muhammad Malik Irfan Muris Setiawan Karundeng, Glory Claudia Kurnia, Ita Lubis, Zulfahmi Mahardinata, Nur Azid MAULANA, AGUNG FIRMAN Maulidiyah, Vivin Nur Mazidah, Nurul Mecca Arfa, Mecca Muhammad Husaini Muhammad Nurul Huda Munadi, Windya Rizki Dwi Mustofa Mustofa Muvita Rina Wati Nabila, Lathifa Nafi’a, Fikrotul Ilman Nanang Munif Yasin Nurkhalika, Rachmi Nurul Huda Nurwulandari , Andini parakoso, gigih Pratama, Anton Purwaningtyastuti, Eni Rakhmawati, Fitria Ratna Ratna Riani, Susetya Lia Rizka Humardewayanti Asdie Roni, Faishol Rufaidah, Alfin Rumiyati, Rumiyati Sahid, Muhammad Novrizal Abdi Selamet, Ni Made Dwi Antika Simamora, Dian Mutiara Siti Rahayu Sulistyawati, Ety Diana Sulistyawaty, Ety Diana Taufik, Ganjar Titik Nuryastuti Tri Murti Andayani Utami, Tri Fitri Yana Wahyuddin, Munifah Widyati, Widyati Wiganata, Siken Agil Wijayana, Singgih Wiyatami, Monia Agni Yuni, Ika Yusmanisari, Eka Zahro, Indira Munifatus