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All Journal Jurnal Teknologi Dan Industri Pangan Jurnal Ilmu Pertanian Zuriat Jurnal AGROTEKNOLOGI Jurnal Ilmu Dasar e-Journal Pustaka Kesehatan Berkala Ilmiah Pertanian BERKALA SAINSTEK Agrovigor: Jurnal Agroekoteknologi Indonesian Journal of Agricultural Science UNEJ e-Proceeding Jurnal Bioteknologi & Biosains Indonesia (JBBI) Journal of Livestock Science and Production Indonesian Journal of Chemistry Jurnal Bioindustri Jurnal Abdi Insani PAPUMA: Journal of Comunnity Services Journal of Bioindustry
Tri Agus Siswoyo
Program Studi Magister Bioteknologi, Universitas Jember, Jl. Kalimantan, Kampus Tegal Boto, Jember 68121, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Physics Veterinary

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Interleukin-6 as an Indicator for Acute Toxicity of DBL2β-PfEMP1 Recombinant protein as a Peptide-based Malaria Vaccine Candidate Sari, Leny Yulia Widia; Sulistyaningsih, Erma; Siswoyo, Tri Agus
Jurnal ILMU DASAR Vol 26 No 1 (2025)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/jid.v26i1.48709

Abstract

Malaria caused by Plasmodium spp is an important health problem, and vaccination could be essential for disease prevention. One potential protein candidate is the Duffy binding-like 2β (DBL2β)-Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1). The protein is responsible for malaria pathogenesis by mediating binding to intercellular adhesion molecule-1 (ICAM-1), a receptor on the host cells. This study aimed to investigate the acute toxicity of the DBL2β-PfEMP1 recombinant protein as a basis for developing a peptide-based malaria vaccine based on body weight and interleukin-6 (IL-6) concentration. The study used male and female Wistar rats, which were divided into treatment and control groups after two weeks of acclimatization. Rats in the treatment group were injected with 750 µg DBL2β-PfEMP1 recombinant protein, and the control group was injected with NaCl 0.9%. Any indications of clinical toxicity symptoms were closely monitored within 4 hours of injection up to 24 hours. Observations were conducted daily for 14 days and included body weight and toxicity symptoms such as rising fur, tremors, salivation, diarrhea, weakness, draping, excitability, twitching, and death. Blood was collected on days 5, 7, and 14 for IL-6 examination using the ELISA method. Rats were euthanized on day 14. Data were analyzed using an ANOVA test. There was no significant weight loss as well as weight gain and toxicity symptoms during 14 days after treatment in all groups. There was an increase IL-6 levels on day 14 in all groups. However, statistical analysis did not show a significant difference between the control and treatment groups (p>0.05). This study showed that the DBL2β-PfEMP1 recombinant protein has no acute toxicity in Wistar rats, implying its safety and potential as a peptide-based malaria vaccine.
Screening Fitokimia dan Studi Aktivitas Ekstrak Daun Sintok (Cinnamomum sintoc Bl.) Sebagai Antioksidan dan Antihiperlipidemia Kumalasari, Ardine; Handayani, Wuryanti; Siswoyo, Tri Agus
BERKALA SAINSTEK Vol 7 No 1 (2019)
Publisher : Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/bst.v7i1.9683

Abstract

Cinnamomum sintoc Bl. merupakan tanaman yang memiliki kandungan minyak atsiri di kulit batangnya yang digunakan untuk antioksidan, antihiperlipidemia dan lain-lain. Dari penelitian ini, senyawa metabolit sekunder dari daun sintok (kadar air 54,7%±0,69) diekstrak dengan metanol dan dianalisis dengan reagen spesifik. Daun sintok diekstraksi secara maserasi bertingkat dengan meningkatkan kepolaran pelarut, yaitu n-heksana, etil asetat, metanol. Uji antioksidan dan antihiperlipidemia dilakukan pada setiap ekstrak(HS, ES, MS) menggunakan standar asam galat equivalent. Total fenolik dan total flavonoid dihitung menggunakan kurva standar asam galat dan kuersetin, hasil total fenolik dari setiap ekstrak antara lain HS (39,23±2,79 mg AGE/g); ES (110,77±2,37 mg AGE/g); dan MS (283,63±3,96 mg AGE/g). Aktivitas antioksidan pada ekstrak ditentukan dengan kemampuan ekstrak untuk meredam DPPH sedangkan aktivitas antihiperlipidemia ekstrak ditentukan dengan kemampuan ekstrak untuk menghambat kinerja lipase. Potensi ekstrak daun sintok terhadap antioksidan cukup tinggi hanya untuk ekstrak MS, sedangkan potensi terhadap antihiperlipidemia untuk semua jenis ekstrak.
PELATIHAN AKLIMATISASI ANGGREK Dendrobium BAGI REMAJA MUSALA DARUL IMAN KECAMATAN SUMBERSARI JEMBER Restanto, Didik; Dewanti, Parawita; Handoyo, Tri; Soeparjono, Sigit; Hartatik, Sri; Slameto, Slameto; Siswoyo, Tri Agus; widjayanthi, Lenny; Avivi, Sholeh; Wulanjari, Distiana; Saleh, Azmi; Hazmi, Muhammad
PAPUMA: Journal of Community Services Vol. 2 No. 01 (2024): April 2024
Publisher : Program Studi Agronomi Fakultas Pertanian Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/papuma.v2i01.834

Abstract

The Dendrobium sp orchid is an orchid that is suitable for living in equatorial areas because it requires full light. Acclimatization is a very important stage for future orchid development. The aim of this service is to provide training to member of the Musala Darul Iman to understand orchid acclimatization techniques which can be used as equipment in orchid agribusiness. From the results of this trial, the audience's enthusiasm was obtained in listening to the lecture and practice, both in cultivation and agribusiness. Seedlings to be acclimatized should be healthy and perfect, good technique of transferring to a soft pot must be solid, watering was done after 7 days to give the root system the opportunity to develop well and required high levels of patience.
PENGARUH KONSENTRASI DAN WAKTU APLIKASI CaCl2 TERHADAP FISIKOKIMIA BUAH TOMAT (Lycopersicum esculentum Mill.) Lina Asri Wulandari; Tri Agus Siswoyo; Kacung Hariyono
JURNAL BIOINDUSTRI (JOURNAL OF BIOINDUSTRY) Jurnal Bioindustri: VOL. 2 NO. 1 (2019)
Publisher : Universitas Trilogi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31326/jbio.v2i1.481

Abstract

Tomato was classified as a climacteric fruit with a fast ripening period andthen followed by the increase of fruit softening. The inhibition of fruit softening was needed to maintain the quality and shelf life of the fruit. One of the way to inhibit the tomatoes softening was calcium application. However, the best concentration and timing of calcium application for tomato was still limited. The aimed of research was to determine the best combination of concentration and time of application of calcium chloride (CaCl2) to the physicochemical of tomato. Experiment was arranged in factorial completely randomized design (CRD) with two factors and three replications. First factor was concentration of CaCl2 which consisted of 5 levels (0 M; 0.3 M; 0.6 M; 0.9 M; 1.2 M), while the second factor was application time of CaCl2 (pre- and post-harvesting). The results showed that there was no interaction between concentration and application time of CaCl2 to the physicochemical of tomatoes. Treatment of CaCl2 1.2 M could increased fruit calcium content, inhibited weight loss and fruit softness, increased total titrated acid content, and inhibited the degradation of vitamin C. The application time of CaCl2 in pre- and post-harvest was not significantly different in term of physicochemical properties. Keywords: fruit softness, quality, weight loss, shelf life, vitamin C
SOSIALISASI DAN PENDAMPINGAN PEMBUATAN ENKAPSULASI PUPUK ORGANIK GRANULAR DARI LIMBAH KOTORAN SAPI MENGGUNAKAN BAKTERI RHIZOBIUM SPP. BAGI MASYARAKAT TANI DESA MAYANGAN, KECAMATAN GUMUKMAS, KABUPATEN JEMBER Soeparjono, Sigit; Khozin, Mohammad Nur; Putri, Widya Kristiyanti; Siswoyo, Tri Agus; Slameto, Slameto; Niagra, Risnanda Deva Martha; Ahnaf, Yusuf Dary
Jurnal Abdi Insani Vol 12 No 1 (2025): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v12i1.2246

Abstract

Peningkatan harga dan terbatasnya ketersediaan pupuk bersubsidi menyebabkan petani mencari alternatif pupuk yang lebih terjangkau dan tersedia untuk mendukung kesinambungan usaha budidaya pertanian. Salah satu pupuk yang sering digunakan masyarakat adalah pupuk organik yang berasal dari limbah kotoran hewan ternak sapi. Desa Mayangan, Kecamatan Gumukmas, Kabupaten Jember memiliki potensi limbah kotoran sapi yang melimpah dari usaha pertenakan yang di lakukan oleh masyarakat desa setempat. Sebagian besar para petani masih menggunakan cara konvensional sehingga membutuhkan waktu relatif lama. Pengabdian desa binaan Universitas Jember di Desa Mayangan ini bertujuan untuk membantu penyediaan pupuk organik bagi petani dan mempercepat waktu proses pembuatan pupuk dari limbah kotoran sapi dengan aplikasi teknologi enkapsulasi pupuk organik  granular. Diharapkan kegiatan pengabdian ini mampu mendukung program pertanian berkelanjutan dan ketahanan pangan. Adapun tahapan pengabdian yang direncanakan meliputi sosialisasi kegiatan dan edukasi, pendampingan pembuatan pupuk organik granular berbahan dasar limah kotoran sapi,  penerapan teknologi enkapsulasi, dan Focus Group Discussion (FGD). Program strategis sesuai RIP UNEJ yang diacu yaitu pengembangan dan penerapan teknologi unggulan tepat guna untuk mendukung peningkatan kesejahteraan masyarakat melalui program desa mitra unggulan. Hasil kegiatan pengabdian ini dapat disimpulkan bahwa dari 25 responden menunjukkan 100% peserta mengenal pupuk granula dari kompos kotoran sapi dan mengenal bakteri Rhizobium sp., serta 92% mampu membuat enkapsulasi pupuk dari limbah kotoran sapi dengan bakteri Rhizobium sp.
STUDI PENGELOLAAN SAMPAH TERPADU DI BANK SAMPAH BERSERI KOTA KEDIRI Widuri, Laily Ilman; Agustin, Vira Audita; Khozin, Mohammad Nur; Siswoyo, Tri Agus
PAPUMA: Journal of Community Services Vol. 3 No. 02 (2025): Agustus 2025
Publisher : Program Studi Agronomi Fakultas Pertanian Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/papuma.v3i02.6223

Abstract

Waste management in urban areas is a serious issue if it is not handled properly and with special attention to management activities. Properly managed waste can provide economic value if it is sorted and processed at the source. The Waste Bank “BERSERI” in Burengan Village, Kediri City, plays an important role in reducing the amount of waste in urban areas through a participatory approach to the community. This community service activity aimed to provide an overview of waste management activities at the Waste Bank and to outline the involvement of the community and relevant parties in supporting waste management activities at the Waste Bank “BERSERI” in Kediri City. The community service activities conducted by the Service Team included discussions and interviews during a visit to the BERSERI Waste Bank location. The results of the interviews indicated that the Waste Bank “BERSERI” has collected various types of inorganic waste through mechanisms including sorting, weighing, recording, and distributing the proceeds from waste sales to customers. The waste collected has also been recycled into valuable products, both from inorganic and organic waste. The existence of waste bank management heavily depends on active community participation and the roles of various parties, including the government, universities, and the private sector.   
Co-Authors A.A. Istri Ratnadewi AA Sudharmawan, AA Adrian Syawaluddin Siregar Adrian Syawaluddin Siregar Agustin, Vira Audita Ahnaf, Yusuf Dary Ali Santosa Anandini Aulia Safiera Aprila Iga Mufidah Arbi Bahtiar Boedi Iman Halanobis Azmi Saleh Bambang Kusmanadhi Bambang Sugiharto Bambang Sugiharto Bambang Sukowardojo Bambang Sukowardojo Budipratiwi Wisudyaningsih Budipratiwi Wisudyaningsih Djenal . Djenal Djenal Dwi Setyawan Endah Puspitasari Erfan Efendi Erma Sulistyaningsih Fariza Oktaviani Fitra Dea Wafa Frida Oktaningtias Widiarthi Harianti Novita Ika Oktavianawati Irma Novita Sari Jainur Rochman Kacung Hariyono Kartika Tari Azhar Khozin, Mohammad Nur Kumalasari, Ardine Kumalasari, Ardine Laily Ilman Widuri, Laily Ilman Lenny Widjayanthi Lina Asri Wulandari listya purnamasari Martiyas Pujirahayu Mohammad Ubaidillah Muhammad Hazmi Nabila Nur Aisyah Al Ayyubi Niagra, Risnanda Deva Martha Norry Eka Palupi Nur Fauziah Matra Nurul Pratiwi Parawita Dewanti Rahmawati Rahmawati Restanto, Didik Restanto, Didik Pudji Reza Septyan Pratama Sari, Leny Yulia Widia Sholeh Avivi Sigit Soeparjono Siswandono, Siswandono Sitompul, Novrida Yanti Slameto Slameto Sri Hartatik Tri Ardiyati TRI HANDOYO Ubaidillah, Mohammad Untung Murdiyanto Untung Murdiyanto Untung Murdiyanto Widya Kristiyanti Putri Wulanjari, Distiana Wuryanti Handayani Yagus Wijayanto Yeni Tri Puspitaningrum Yudi Wicaksono