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All Journal HAYATI Journal of Biosciences Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya The Journal of Experimental Life Sciences (JELS) Biotropika Research Journal of Life Science Natural B Edu Geography Jurnal Pengembangan Teknologi Informasi dan Ilmu Komputer Jurnal Penelitian Pendidikan IPA (JPPIPA) Indonesian Journal of Cardiology Buletin Anatomi dan Fisiologi (Bulletin of Anatomy and Physiology) Care : Jurnal Ilmiah Ilmu Kesehatan Jurnal Jamu Indonesia Nusantara Science and Technology Proceedings Berkala Penelitian Hayati Makara Journal of Science Indonesian Journal of Jamu
Sri Widyarti
Biology Department, Faculty Of Mathematics And Natural Sciences Brawijaya University, Malang Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Other

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The Study of Combination Ethanol Extract of Averrhoa bilimbi L. and Momordica charantia L. on CD4+CD25+TGF-β+ Spleenocytes of Hyperglycemia Mice Amrulloh, Harits; Novinda, Bella; Sartika, Intan; Widyarti, Sri; Rifa'i, Muhaimin
The Journal of Experimental Life Science Vol. 10 No. 3 (2020)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jels.2020.010.03.05

Abstract

Diabetes mellitus is one of the four priority non-infectious diseases in the world. Plant-based medicine is an alternative treatment with few side effects. Star fruit (Averrhoa bilimbi L.) and bitter melon (Momordica charantia L.) are plants that have anti-hyperglycemic activity. Hyperglycemia produces Reactive Oxygen Species (ROS) that make the β-cells of the pancreas necrosis that decreasing insulin synthesis. The anti-inflammatory activity appears based on the relative levels of CD4+ and CD25+, which are TGF-β-producing regulatory T cells where TGF-β is a mediator that acts as an immunosuppressant. TGF-β would induce CD4 + T lymphocytes into T reg. The purpose of this study is to determine the profile of TGF-β on CD4+ and CD25+ spleenocytes on hyperglycemia mice after ABMC (Averrhoa bilimbi Momordica charantia mix) treatment. Mice were divided into 5 groups, non-diabetic (N), hyperglycemia (H), hyperglycemia with extract doses of 10 mg.kg-1 BW (P1), 40 mg.kg-1 BW (P2), and 160 mg.kg-1 BW (P3). Diabetic mice were obtained after a single injection dose of 145 mg.kg-1 BW streptozotocin (STZ). The result showed that ABMC can reduce blood sugar levels faster and able reduce the number of CD4+TGF-β+ cells in hyperglycemia mice. Keywords: Averrhoa bilimbi L., CD4+TGF-β+, CD25+TGF-β+, hyperglycemia, Momordica charantia L.
Oxyhydrogen Nanobubbles Suppress FoxP3 and Ki-67 Expression in a Wistar Rat Model of Hepatocellular Carcinoma Natasya Adiba Zahrah; Sri Widyarti; Dyah Kinasih Wuragil; Wibi Riawan; Olly Indrajani; Ahmad Lubab; Aditya Tri Hernowo; Sutiman Bambang Sumitro; Aulanni'am
Jurnal Penelitian Pendidikan IPA Vol 12 No 1 (2026)
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v12i1.13858

Abstract

HCC is difficult to treat due to its complex tumor microenvironment and the ineffectiveness of available therapies. Gas-based anticancer approaches are promising, but are hampered by instability and difficulties in targeted delivery. HHOnbs (containing hydrogen (H2), oxygen (O2), and low-dose hydrogen peroxide (H2O2) at the nanoscale) have been proposed to improve the stability and precision of gas-based therapies. This study aimed to investigate the effects of HHOnbs on the immunoregulatory marker FoxP3 and the proliferation marker Ki-67 in a Wistar rat model of HCC induced by diethylnitrosamine (DEN)/carbon tetrachloride (CCl4). The design used was a true experimental design. HHOnbs were administered intravenously. Liver tissue was assessed using immunohistochemistry to measure FoxP3 and Ki-67 expression. HHOnbs treatment significantly reduced FoxP3 and Ki-67 expression (p<0.05). FoxP3 is a marker of regulatory T cells (Tregs), which often inhibit antitumor immune responses. Its decrease indicates an increased immune response potential. Ki-67 is a marker of cell proliferation. Its decrease indicates the suppression of cancer cell growth. Further investigations are warranted to compare its efficacy with standard therapies, assess different treatment durations, and elucidate the underlying molecular signaling pathways.
Co-Authors A'liyatur Rosidah A.A. Ketut Agung Cahyawan W A’liyatur Rosyidah Aditya Tri Hernowo Ahmad Lubab Ahmad Soni Ahmad Soni Amandia Dewi Permana Shita Amrulloh, Harits Apik Budi Santoso Arief Azhary Aris Soewondo Aris Suwondo Aristyani, Sherry Askandar Tjokroprawiro Attabik Mukhammad Amrillah Aulanni'am Azzamuddin, Haidar Cholilia Abadiatul Masruroh Cholilia Abadiatul Masruroh Damayanti, Febriane Eka Daniar Kusumawati Dayu Nirwana Putri Dewi Parlina Ningrum Dian Siswanto Djanggan Sargowo Dyah Kinasih Wuragil Eko Puji Astuti Erly Nur Aisyah Estri Laras Arumingtyas Farida Rachmawati, Farida Fatinah, Arik Arubil Hafiedz Maulana Is Karima Karima, Is Khansa, Shafanony Khoirin Maghfiroh Linda Kartika Dewi Lulut Dwi Nurmamulyosari, Lulut Dwi M. Irsyad Nur Maftuch Maftuch Marji Marji Moch Sasmito Djati Mochammad Pratama Viadi Mohammad Mabrur Muhaimin Rifa&#039;i Muhaimin Rifa&#039;i Muhaimin Rifa&#039;i Muhaimin Rifa'i Muhaimin Rifai&#039;i Muhamad Aris Widodo Naqiyah A. Mulachelah Nashi Widodo Natasya Adiba Zahrah Noer Hasanah Novinda, Bella Nunung Harijati Nur Jannah Nur Permatasari Nur Permatasari Nuzulul Hikmah Olly Indrajani Puspitoputri, Alya H. Radita Intan Aisyah Pratiwi Rasjad Indra Retno Susilowati Retty Ratnawati Rifa'i, Muhaimin Rifa'i, Muhaimin Rifa’i, Muhaimin Rike Wahyuningroom Rike Wahyuningroom Ririn Rochmawati Rismawati, Ria Rizki Amalia Rochmatika, Lailiyavina Rodiyati Azrianingsih Rodiyati Azrianingsih Rosidah, A'liyatur Rosyidah, A’liyatur Sakti, Sefihara Paramitha Sapti Puspitarini Sari, Fikriya Novita Sartika, Intan Satuman Satuman Serafinah Indriyani Sherry Aristyani Siti Imama Khoiriyah Sofy Permana Soni, Ahmad Sri Rahayu SRI RAHAYU Sri Rahayu Sri Rahayu Sri Rahayu Sri Rahayu Suroso Suroso Sutiman B. Sumitro Sutiman B. Sumitro Sutiman B. Sumitro Sutiman B. Sumitro Sutiman Bambang Sumitro Suwondo, Aris Syahputra Wibowo Teguh Suprihatin Teguh Suprihatin Ulinnuha, Maria Wibi Riawan Widodo Widodo Yayu Tsamrotul Fuadah, Yayu Tsamrotul Yoga Dwi Jatmiko YOGA DWI JATMIKO Yuni Kilawati Zauhani Kusnul