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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Pengabdian UntukMu NegeRI JSFK (Jurnal Sains Farmasi & Klinis) JURNAL PHOTON Jurnal Pengabdian Magister Pendidikan IPA JURNAL FARMASIMED (JFM) Jurnal Farmasi Indonesia AS-SHIHA: JURNAL KESEHATAN Journal Of Pharmacy
Hari, Dewi Gulyla
Department Of Pharmacy, Faculty Of Health And Natural Sceiences, Universitas Muhammadiyah Riau
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary

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Determination of Total Flavonoid Levels Of Cinnamon Leaf Infusion (Cinnamomum burmanni (Nees & T.Nees) Blume.) Using UV-Vis Spectrofotometry Lovena, Tri Nova; Dewi Gulyla Hari; Encik Juliansyah Arief
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/x2vajr20

Abstract

Background: Cinnamon leaves (Cinnamomum burmanni (Nees & T.Nees) Blume.) are natural plants used as traditional medicine because they have secondary metabolite compounds, namely flavonoids, tannins, saponins, alkaloids, and triterpenoids. Objective: This study aims to determine the total flavonoid compound levels found in cinnamon leaves (Cinnamomum burmanni (Nees & T.Nees) Blume.). Methods:The extraction method used is the infusa method using aquadest solvent. Qualitative analysis used phytochemical screening and quantitative analysis used is by UV Vis Spectrophotometry with standard comparison using quercetin. Results: For parametric data analysis using One Way Annova analysis. The results of phytochemical screening examination of cinnamon leaves (Cinnamomum burmanni (Nees & T.Nees) Blume.) are positive for flavonoid compounds with the total flavonoid compound content using the UV-Vis Spectrophotometry method is 0.5691 mgQE/g, and the results of parametric data analysis using One Way Annova analysis show a significant value of flavonoid content of 1.000> 0.05. This indicates that the flavonoid levels in the sample are relatively stable and homogeneous, so the treatments applied did not result in significant variation. This may suggest that the treatment factors in the study did not significantly affect the amount of flavonoids contained in the cinnamon leaf extract. Thus, the detected flavonoid content is likely more influenced by the natural characteristics of the plant rather than by the treatments tested. Conclusion: The cinnamon leaf (Cinnamomum burmanii) showed a positive result for the presence of flavonoid compounds.
Determination of Flavonoid Content of Ethanol Extract of Yellow Pumpkin Leaves (Cucurbita moschata Dulchesne ) Using Uv-Vis Spectrophotometry Dewi Gulyla Hari; Tri Nova Lovena; Ummul Khairiah
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/3rps7m67

Abstract

Background: Flavonoids are one of the most abundant groups of secondary metabolite compounds found in plant tissues. Pumpkin leaves (Cucurbita moschata Dulchesne ) can generally be used as antidiabetic, analgesic, nephroprotective and anticancer for stomach pain, jaundice, skin infections, lowering cholesterol, and blood sugar levels, and contain flavonoid compounds. Purpose: to determine the levels of flavonoid compounds contained in 70% ethanol extract of pumpkin leaves (Cucurbita moschata Dulchesne ). Methods: using the UV-Vis spectrophotometry method and to determine the flavonoid content from the results of phytochemical screening in the ethanol extract of pumpkin leaves. Pumpkin leaf extract was obtained through maceration techniques with 70% ethanol as the solvent. Results: The study showed that there was flavonoid content in pumpkin leaves, which was orange in color and the results of the study determined the flavonoid levels using UV-Vis spectrophotometry at a wavelength of 428 nm. om the resultsobtained from the measurement of the standard curve of quarcetin, it can be concluded that the higher the concentration used, the higher the absorbance value obtained and it can be seen that the results obtained total flavonoid content in the 70% ethanol extract sample of pumpkin leaves is 7.2672 mgQE/g.  Conclusion: There is a flavonoid compound content contained in pumpkin leaves.
Detection of Gene E6 HPV 18 With Real Time PCR (Polymerase Chain Reaction) Using Isolated Samples of Uterine Cancer Patients in Riau Province Hari, Dewi Gulyla
As-Shiha: Jurnal Kesehatan Vol. 1 No. 2 (2021): As-Shiha: Jurnal Kesehatan
Publisher : Fakultas MIPA dan Kesehatan, Universitas Muhammadiyah Riau

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Abstract

One indication that there has been malignancy in cervical lesions due to exposure to high-risk hpv types such as HPV 16 and 18 is the detection of oncogene DNA in the cervical tissue of cancer patients. The oncogenes are the E6 and E7 genes. Previous research data showed evidence that the prognosis of HPV 18 is more massive than that of other high-risk HPV types such as HPV 16. Thus, the effort to detect the E6 gene from biopsy samples of patients suspected of cervical cancer is the right and effective step in order to establish an accurate diagnosis of cervical cancer itself, especially caused by HPV 18.
Uji Aktivitas Antiinflamasi Ekstrak Etil Asetat Daun Tumbuhan Akar Kaik-Kaik (Uncaria cordata (Lour.) Merr) pada Tikus Putih (Rattus norvegicus) Jantan Noveri Rahmawati; Gulyla Hari, Dewi; Nurbaiti; Rahmawati, Ayu; Nursyafni; Indriani, Lusi; Lovena, Tri Nova; Arif, Muhammad; Hendri Sandi, Nofri
As-Shiha: Jurnal Kesehatan Vol. 3 No. 1 (2023): As-Shiha: Jurnal Kesehatan
Publisher : Fakultas MIPA dan Kesehatan, Universitas Muhammadiyah Riau

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Abstract

Antiinflammatory activity of ethyl acetate extracts of the leaves of plant Akar Kaik-kaik Uncaria cordata (Lour.) Merr on white male rats. This research examined the quality of crude drugs and extracts ethyl acetate. It is intended to obtain raw materials which can ultimately ensure uniform pharmacologic effect. Antiinflammatory activity of the ethyl acetate extract were tested using the method of paw edema against white male rats. The research were 15 rats mile which divided into 5 groups. Negative control (Na CMC 1%), positive control (Na diklofenak dose 4,5 mg/kgBB) and extract group ethyl acetat with the dose 100, 200 and 400 mg/kgBB given orally. The volume measurement after subcutaneous injection caragen 1% performed with one hour interval for 5 hours assessing with pletysmometer and calculated the inhibition persen. The result of this study showed that the quality of crude drugs and extract ethyl acetate meet the specified requirements Indonesian Herbal Pharmacopoeia. Ethyl acetate extract has significant anti-inflammatory effects to the negative control at doses of 200 and 400 mg/kgBB while against the positive control did not differ significantly white male rats.
Uji Aktivitas Ekstrak Etanol Daun Mimba (Azadirachta Indica A. Juss) Terhadap Bakteri Staphylococcus Aureus Lovena, Tri Nova; Gulyla Hari, Dewi
As-Shiha: Jurnal Kesehatan Vol. 3 No. 2 (2023): As-Shiha: Jurnal Kesehatan
Publisher : Fakultas MIPA dan Kesehatan, Universitas Muhammadiyah Riau

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Abstract

Infectious disease is a disease caused by microorganisms which is the body's response due to immune stimulation. One of the herbal ingredients used as a therapeutic agent is neem (Azadirachta indica A.Juss). This study aims to determine the content of secondary metabolites, minimum inhibitory concentration (MIC) and antibacterial activity found in n-hexane and ethanol extracts of neem leaves to Staphylococcus aureus bacteria. The extraction method used is the maceration method, the MIC method used is the liquid dilution method and the antibacterial activity test uses the disc diffusion method. The results of the phytochemical screening showed that the simplicia, n-hexane and ethanol extract of neem leaves positively contained flavonoids, saponins, tannins, steroids/triterpenoids. The MIC test results on the ethanol extract was obtained at a concentration of 6.25%. The ethanol extract with a concentration of 7% has weak activity at a concentration of 14% and 21% has moderate activity.
17-2 Analisis Perbandingan Biaya Riil dan Tarif Ina-Cbg’s pada Pasien Rawat Jalan Onkologi dengan Terapi Morfin Sulfat (Mst) di RSUD Arifin Achmad Provinsi Riau Meirita, Efilia; Endri, Novtafia; Hari, Dewi Gulyla; Lifiani, Rialita
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 17 No. 2 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

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Abstract

Health service financing through the INA-CBG's (Indonesia Case-Based Groups) system aims for efficiency and transparency in the National Health Insurance (JKN) system. However, in practice, there are often discrepancies between INA-CBG's rates and the real costs incurred by health facilities, especially in oncology patients with Morphine Sulfate (MST) therapy. This study aims to analyze the comparison of real costs and INA-CBG's tariffs for oncology outpatients with morphine sulfate therapy (MST) at RSUD Arifin Achmad Riau Province. This study used descriptive observational research method with retrospective data collection obtained from medical records of oncology outpatients who received Morphine Sulfate (MST) therapy 10 mg and 15 mg tablets during the period January-March 2024. The data were analyzed by comparing the real costs incurred by the hospital with the rates paid by BPJS through the INA-CBG's system and the Mann-Whitney U test was performed. The results of the analysis showed that there was a significant difference between real costs and INA-CBG's tariffs. The average real cost of drugs (MST) was higher than the INA-CBG's tariff. The real cost of drugs that exceeded the INA-CBG's tariff amounted to 481 people, with a total cost difference (loss) of IDR 218,155,324. There was a difference between real costs and INA-CBG's rates (p = .047) and INA-CBG's rates (p = .113).
Implementasi Pemanfaatan Teh Bunga Telang (Clitoria Ternatea) Sebagai Solusi Herbal Dalam Manajemen Hipertensi Dan Gula Darah Nurdin, Khazanah Nurain; Sari Rahmadhani; Nurdina Putri; Rahmi Amini; Hartini, Putri Tri; Dewi Gulyla Hari
Jurnal Pengabdian Magister Pendidikan IPA Vol 9 No 1 (2026): Januari - Maret 2026
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpmpi.v9i1.14244

Abstract

This community service program aimed to enhance community knowledge and skills in utilizing butterfly pea flower tea (Clitoria ternatea) as a supportive herbal approach for hypertension management and blood glucose control. The activity was conducted using an educational and applicative approach through the delivery of health-related materials and a demonstration of the proper and hygienic preparation of butterfly pea flower tea for the target community. The implementation method comprised preparation, execution, and evaluation stages, with improvements in participants’ knowledge assessed through pre-test and post-test questionnaires, as well as observations of participant engagement throughout the activity. The results indicated an increase in community understanding regarding the benefits, processing methods, and consumption of butterfly pea flower tea as a complementary therapy. Overall, this program contributed positively to community empowerment through the utilization of safe, affordable, and locally available herbal plants, with potential benefits in supporting the prevention and management of non-communicable diseases, particularly hypertension and blood glucose disorders.
Co-Authors Akmal Djamaan Amini, Rahmi Andani Eka Putra Arabella Natasya Arfiandi Arfiandi Ayu Rahmawati AYU RAHMAWATI Ayu Rahmawati Densi Selpia Sopianti Densi Selpia Sopianti Encik Juliansyah Arief Hartini, Putri Tri Hendri Sandi, Nofri Herli, Muhammad Azhari Indriani, Lusi Lifiani, Rialita Lusi Indriani M. Azhari Herli Saptadi Putra Marlina . Meirita, Efilia Muhammad Arif nisa, Annisa Nurul Maharani Noveri Rahmawati Novtafia Endri Nurbaiti Nurdin, Khazanah Nurain Nurdina Putri Nursyafni Rahma Cintya Faiza Rahma Dona Rahmi Amini Rustini Rustini Sari Rahmadhani Siti Niqmatun Jannah Tri Nova Lovena Ummul Khairiah Yasinda Oktariza Yasinda Oktariza Yufri Aldi