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All Journal Jurnal Gizi dan Pangan Jurnal Gizi Jurnal Kesehatan Masyarakat Indonesia MEDIA MEDIKA INDONESIANA Journal of Nutrition and Health JURNAL GIZI INDONESIA Journal of Nutrition College Indonesian Journal of Cancer Chemoprevention Sari Pediatri Universa Medicina Health Notions Jurnal Ilmu Kefarmasian Indonesia Medica Hospitalia World Nutrition Journal Medica Arteriana (Med-Art) IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN) Berita Kedokteran Masyarakat
Hertanto Wahyu Subagio
Clinical Nutrition Department, Medical Faculty, Diponegoro University
Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Effect of Astaxanthin Supplementation in Preventing Anemia in Head and Neck Cancer Patients Receiving Cisplatin Chemotherapy Aminullah, Yusuf; Subagio, Hertanto Wahyu; Santosa, Damai; Naftali, Zulfikar
Indonesian Journal of Cancer Chemoprevention Vol 14, No 2 (2023)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev14iss2pp72-82

Abstract

The incidence of anemia due to reactive oxygen species (ROS) in patients with head and neck cancer (HNC) can be caused by a side effect of cisplatin chemotherapy, namely myelosuppression. In the presence of ROS, external antioxidants are needed, including astaxanthin as an antioxidant to neutralize and fight ROS in preventing anemia. This study aims to prove and analyze the antioxidant effect of astaxanthin in preventing anemia in HNC patients due to cisplatin chemotherapy for 3 weeks. The study design was a randomized controlled trial pre-post test design, involving 42 research subjects who were randomly divided into two groups, then 3 cc of blood was taken I to check the hemoglobin level and the number of erythrocytes. The treatment group was given astaxanthin 2x4 mg and the control group was given a combination of vitamin C 1x500 mg and vitamin E 1x250 IU for 3 weeks then 3 cc of blood was taken II to check hemoglobin levels and erythrocyte counts. The independent variable is intake of astaxanthin, the dependent variable is hemoglobin level and the number of erythrocytes and the confounding variables are age, sex, type of HNC, stage of HNC, ECOG and BMI. Data analysis was performed by the Descriptive test, Levene test, Shapiro Wilks, Wilcoxon test, and Mann-Whitney test. The significance of the hypothesis test was obtained with p<0.05. The 42 research subjects met the inclusion criteria, most aged between 41-50 years, male and female ratio 2:1, The most HNC were Nasopharyngeal Cancer, the most HNC stage was stage IV, the most HNC performance status was ECOG I and the most HNC patients had normal BMI. There was a significant difference in hemoglobin levels p=0.012 (p<0.05) and the number of erythrocytes, p=0.04 (p<0.05) between the treatment and control groups. There was a significant difference in hemoglobin levels after therapy in the treatment and control groups p=0.012 (p<0.05) and the number of erythrocytes p=0.04 (p<0.05) between the treatment and control groups. Astaxanthin can prevent anemia in the form of decreased hemoglobin levels and the number of erythrocytes in HNC patients who receive cisplatin chemotherapy.Keywords: astaxanthin, anemia, HNC, cisplatin, ROS.
POLA ASUH DAN STATUS GIZI BALITA DI KECAMATAN LAPE, KABUPATEN SUMBAWA, NUSA TENGGARA BARAT Apriyanto, Denny; Subagio, Hertanto Wahyu; Sawitri, Dian Ratna
Jurnal Gizi dan Pangan Vol. 11 No. 2 (2016)
Publisher : The Food and Nutrition Society of Indonesia in collaboration with the Department of Community Nutrition, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (343.926 KB) | DOI: 10.25182/jgp.2016.11.2.%p

Abstract

The purpose of this study was to investigate the relationship between caregiving behavior and nutritional status of under five children. This research used the quantitative cross-sectional design. The number of samples were 70 mothers taken by a multistage random sampling. The data was gained through in-depth interview and observation. Nutritional status was obtained by anthropometric measurement based on the z-score weight-for-age index. Caregiving behaviors that consist of attention to the mothers and feeding practices were poor, while home health practices were adequate. Most of the nutritional status of children under five was good (57.1%). Correlation analysis showed that attention to the mothers (r=0.321; p<0.05), feeding practices (r=0.252; p<0.05) and home health practices (r=0.358; p<0.05) were related positively to nutritional status. The study showed that caregiving behavior that affects nutritional status was attention to the mothers, feeding practices and home health practices.
Hubungan Asupan Protein dan Lama Menjalani Hemodialisis dengan Body Cell Mass pada Pasien Hemodialisis Esti Widiasih; Hertanto Wahyu Subagio; Lestariningsih Lestariningsih
Medica Arteriana (Med-Art) Vol 8, No 1 (2026): Juni 2026
Publisher : University of Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/medart.8.1.2026.44-50

Abstract

Latar Belakang: Pasien hemodialisis berisiko mengalami penurunan massa sel tubuh akibat asupan yang tidak memadai dan proses katabolik. Body Cell Mass menggambarkan jaringan metabolik aktif, tetapi hubungannya dengan asupan protein dan lama menjalani hemodialisis belum banyak dikaji. Penelitian ini bertujuan menganalisis hubungan asupan protein dan lama menjalani hemodialisis dengan Body Cell Mass pada pasien hemodialisis.Metode: Penelitian observasional analitik dengan pendekatan cross-sectional ini menggunakan data awal 35 pasien yang dipilih secara purposive di sebuah Klinik Ginjal dan Hemodialisis di Kota Semarang, pada Juni-Agustus 2023. Asupan protein satu bulan terakhir dinilai menggunakan semi-quantitative food frequency questionnaire, lama hemodialisis diperoleh dari rekam medis, dan Body Cell Mass diukur menggunakan multifrequency bioelectrical impedance analyzer 30 menit setelah hemodialisis. Hubungan antarvariabel dianalisis menggunakan korelasi Pearson atau Spearman sesuai distribusi data.Hasil: Sebanyak 65,7% responden adalah perempuan dan rerata usia 52,38±4,54 tahun. Rerata asupan protein adalah 39,26±6,51 gram per hari, median lama hemodialisis 2,0 (1,5-3,0) tahun, dan rerata Body Cell Mass 28,85±4,99 kilogram. Asupan protein berhubungan positif dengan Body Cell Mass dengan kekuatan sedang (koefisien korelasi=0,413; nilai p=0,014). Lama menjalani hemodialisis tidak menunjukkan hubungan bermakna dengan Body Cell Mass (koefisien korelasi peringkat=-0,010; nilai p=0,954).Kesimpulan: Asupan protein yang lebih tinggi berkaitan dengan Body Cell Mass yang lebih besar, sedangkan lama menjalani hemodialisis tidak menunjukkan hubungan yang bermakna. Pemantauan asupan protein dan komposisi tubuh diperlukan dalam pelayanan gizi pasien hemodialisis
Co-Authors Adriyan Pramono Ag Soemantri Agustinus Soemantri Ali Manfaluthi Ahmad Amalia Sukmadianti Amalia Sukmadianti Amin Samiasih Aminullah, Yusuf Annisa Fauziah, Annisa Annta Kern Annta Kern Nugrohowati Annta Kern Nugrohowati Apoina Kartini Apoina Kartini Apriyanto, Denny Aryu Candra Bagoes Widjanarko Banundari Rachmawati Besari Adi Pramono Binar Panunggal Budi Santoso Camelia Bomaztika Sari Darmono SS Darmono SS Dewi, Clara Rashinta Dian Ratna Sawitri EDI DHARMANA Edi Dharmana Enny Probosari Enny Probosari Esti Widiasih Etisa Adi Murbawani Eunika Lusiana Febe Christianto Febe Christianto Febriana Rahmawati Hardhono Susanto Hardono Susanto, Hardono Hartanti Sandi Wijayanti Henna Rya Sunomo Heri Nugroho Jennifer Setiawan Joriandhita Ramadhan Lestariningsih Lestariningsih Lisyani Suromo Luciana Sutanto M Herumuryawan M Mexitalia M Sakundarno MARTHA ARDIARIA Martha Irene Kartasurya Mexitalia Mexitalia Minidian Fasitasari Mohammad Zen Rahfiludin MR Arientasari Himawan MS Anam Muchlis Achsan Udji Muchlis Ahsan Udji Sofro Muhammad Heru Muryawan Muhammad Sulchan Muji Mulyati Nanan Sekarwana Nathalia Safitri Niken Puruhita Noor Pramono Nugrahaningsih Nugrahaningsih Nurrohmiati, Siti Nurul Ratna Mutu Manikam Nuryanto Nuryanto Nyoman Suci Widyastiti Phitra Sekar Dianggra Pusaka, Semerdanta Retnaningsih - Rimahardika, Rosita Riwanto Rosa Kristiansen Roziana Roziana, Roziana RRJ. Sri Djokomoeljanto Santi Rahayu Santosa, Damai SARJADI SARJADI SITI MASITHA DEWI - A01111079 Sofyan Harahap Sri Djokomoeljanto suhartono - Suhartono Suhartono Suhartono, Suhartono Suharyo Hadisaputro Suharyo Hadisaputro Suratman Suratman Susilani, Amalina Tri Taufik Hilmansyah Tri Indah Winarni Ulfa, Viny Rosaliana Wendiranti, Catra Ibriza Widya Budiarni Wijayanto Wijayanto Wiwid Widiyatni Wiwid Widiyatni, Wiwid Yuliyani, Ni Nyoman Sri Zulfikar Naftali, Zulfikar