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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Biocelebes JURNAL PHOTON Collaborative Medical Journal (CMJ) Nommensen Journal of Medicine Jurnal Abdidas Indonesian Journal of Pharmaceutical Education Jurnal Pengabdian Masyarakat : Pemberdayaan, Inovasi dan Perubahan Jurnal Pengabdian Inovasi dan Teknologi Kepada Masyarakat E-Amal: Jurnal Pengabdian Kepada Masyarakat
Marwan, Deinike Wanita
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AKTIVITAS PEMBERIAN MADU ASAL BASERAH KUANTAN SINGINGI TERHADAP PERTUMBUHAN STAPHYLOCOCCUS AUREUS Eliya Mursyida; Deinike Wanita Marwan
Collaborative Medical Journal Vol 2 No 2 (2019): Mei
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (172.084 KB)

Abstract

Madu merupakan cairan kental yang dihasilkan oleh lebah dan memiliki aktivitas sebagai antimikroba. Staphylococcus aureus (S. aureus) adalah bakteri Gram positif penyebab infeksi nosokomial, keracunan makanan, dan sindroma syok toksik. Penelitian ini bertujuan untuk menganalisis aktivitas pemberian madu terhadap pertumbuhan bakteri S. aureus. Metode pada penelitian ini adalah eksperimental dengan post only with control group menggunakan difusi kertas cakram. Hasil penelitian menunjukkan bahwa madu memiliki aktivitas dalam menghambat pertumbuhan bakteri S. aureus dengan zona hambat tertinggi yaitu 5,33mm pada konsentrasi 100% dan terrendah pada konsentrasi 25% dengan zona hambat yaitu 3,00mm.
ISOLATION OF LACTIC ACID BACTERIA FROM TEMPOYAK AND ITS ANTIMICROBIAL ACTIVITY ON THE Escherichia coli Eliya Mursyida; Fifi Candita; Muhammad Faisal; Deinike Wanita Marwan
Biocelebes Vol. 16 No. 1 (2022)
Publisher : Biology Department, Mathematics and natural science, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/bioceb.v16i1.15833

Abstract

Diarrhea is a potential extraordinary event that can cause death. The most common microbes that cause diarrhea in developing countries are Rotavirus and Escherichia coli. One of the treatment of diarrhea is by giving antibiotics. However, the use of antibiotics is known to disrupt the balance of normal gastrointestinal flora, thereby changing the composition of the microbiota. Probiotics can be given to balance the normal flora during or after treatment with antibiotics. Lactic acid bacteria (LAB) is one of the probiotics that can inhibit the growth of pathogenic microbes and is commonly found in fermented foods. This study aimed to isolate LAB from tempoyak made from kampar durian, Riau Province, Indonesia and test its antimicrobial activity against Escherichia coli. The study was initiated by isolating LAB from tempoyak using the multilevel dilution method, followed by characterizing LAB by colony and cell morphology, and testing its antimicrobial activity against Escherichia coli using the agar well diffusion method. The antimicrobial activity test results were analyzed using one-way ANOVA and Bonferroni follow-up test. The results of LAB characterization showed that four LAB isolates had different colony morphology, including spherical Gram-positive bacteria and catalase-negative bacteria. The results of the antimicrobial activity test showed that LAB1 isolates had the highest ability to inhibit Escherichia coli with an average inhibition zone diameter of 15.21 mm and the lowest inhibition zone was found in LAB 4 isolates, which was 10.80 mm. The results of the one way ANOVA test showed a significant difference between the four LAB isolates in inhibiting Escherichia coli with P value <0.05. In the Bonferroni test, there were significant differences between LAB 1 and LAB 4 isolates. It can be concluded that LAB isolated from tempoyak has the potential to be a source of probiotics.
Sosialisasi Pelaksanaan Posyandu Melalui Transformasi Digital Kesehatan Menggunakan Aplikasi Mobile Posyandu Q Ira Puspita Sari; Debi Setiawan; Deinike Wanita Marwan
Jurnal Abdidas Vol. 3 No. 5 (2022): October Pages 785 - 943
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/abdidas.v3i5.691

Abstract

Untuk meningkatkan pelayanan kesehatan pada warga masyarakat di Desa Pulau Gadang XIII Koto Kampar, maka posyandu setempat memiliki beberapa permasalahan yang dihadapi yaitu: 1) Minimnya minat masyarakat sekita untuk dating membawa batita dan balita ke posyandu terutama pada ibu muda. 2) Tidak jalannya Posyandu setelah masa pandemic Covid-19. 3) Belum tersedianya IPTEK pada Posyandu. Berdasarkan permasalahan yang dihadapi mitra maka solusi dari permasalahan tersebut yaitu: 1) Sosialisasi dengan transformasi digital Kesehatan menggunakan smartphone pada ibu muda umur 25-30. 2) Pelatihan ke kader Posyandu tentang peraturan pelaksanaan kegiatan yang ada di Posyandu. 3) Implementasi aplikasi PosyanduQ di Desa Pulau Gadang XIII Koto Kampar. Metode pelaksanaan kegiatan adalah analisis dan perancangan, pendampingan dan pelatihan, implementasi dan pengawasan, serta mentoring dan evaluasi kegiatan. Kegiatan pengabdian ini bertujuan untuk meningkatkan pengetahuan masyarakat melalui transformasi digital dengan memanfaatkan media smartphone.
Antibacterial Activity of Papaya Seeds (Carica papaya L.) Ethanol Extract Against Escherichia coli Eliya Mursyida; Fitria Dina Sella; Deinike Wanita Marwan
Sistem Informasi Vol 13 No 1 (2022): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v13i1.3699

Abstract

Escherichia coli is a normal flora found in the large intestine of humans and is opportunistic. Acute diarrhea is the discharge of watery or loose stools in larger amounts than normal, lasting less than 14 days. Acute diarrhea is caused by several microbes, one of which is Escherichia coli. Treatment of acute diarrhea caused by bacteria can be given antibiotics, but the relatively high use of antibiotics can lead to resistance. One of the natural ingredients known to treat acute diarrhea is papaya seeds (Carica papaya L.). Papaya seeds are known to have antibacterial activity because they contain flavonoids (quercetin), alkaloids, saponins, and tannins. This study aims to determine and analyze the antibacterial activity of the ethanol extract of papaya seeds on the growth of Escherichia coli. This research is an experimental study with a post-test only with a control group research design using papaya seeds (Carica papaya L.). The test bacteria used in this study were Escherichia coli with the dilution method to determine the Minimum Inhibitory Concentration (MIC) and the spread plate to determine the Minimum Bactericidal Concentration (MBC). The results showed that MIC was present at a concentration of 2%, while MBC was at a concentration of 5%. It was concluded that the ethanol extract of papaya seeds (Carica papaya L.) had antibacterial activity against Escherichia coli.
Efektivitas Ekstrak Spirulina platensis terhadap Jumlah Fibroblas pada Tikus yang Dilakukan Insisi pada Kulitnya Riski dwi utami; olvaria misfa; Bimby Irenesia; deinike wanita marwan
Indonesian Journal of Pharmaceutical Education Vol 3, No 2 (2023): Mei-Agustus 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i2.19268

Abstract

Fibroblasts play a role in the wound healing process. The active compound content of Spirulina sp. has fibroblastic activity. The use of extracts from S. platensis can play a role in the wound healing process. To analyze the effectiveness of Spirulina platensis extract on the number of fibroblasts in rats that were incised in their skin. This study used a randomized post test only control group design. Forty-eight male Wistar rats were skin incised and infected with S.aureus divided into 4 groups, namely the group given S.platensis extract at a dose of 500 mg/kgBW/day, a dose of 750 mg/kgBW/day, the negative control group was given saline solution and positive control group with diclofenac 20 mg/kgBW orally. The number of fibroblasts was counted on histopathological examination of the wound tissue on the 7th and 14th days covering 5 visual fields. Data analysis was carried out with a one way ANOVA test and continued with the LSD Post Hoc Test. The mean number of fibroblasts on the 7th day in the 500 mg/kgBW/day group, 750 mg/kgBW/day, positive control and negative control was 13.33 ± 3.615; 117.42±3.980; 9.58±2.417; and 4.00 ± 1.761 with p 0.001. The number of fibroblasts on the 14th day in the 500 mg/kgBW/day, 750 mg/kgBW/day group, positive control and negative control was 16.17 ± 3.251; 19.67±1.633; 12.17±2.137; and 8.33 ± 2.317 with p 0.001. The post hoc test found that the number of fibroblasts on day 7 significantly increased in the 500 mg/kgBB/day S. platensis group compared to the positive and negative control groups. While at a dose of 750 mg/kg/day, the number of fibroblasts was higher than the positive and negative control groups after 14 days of treatment.Administration of Spirulina platensis extract at doses of 500 and 750 mg/kg/day significantly increased the number of fibroblasts in the incision wounds of Wistar rats.
PENINGKATAN KUALITAS PELAYANAN KESEHATAN DENGAN SOSIALISASI PELAKSANAAN POSYANDU PADA MASA PANDEMI COVID 19 DAN PENERAPAN APLIKASI MOBILE POSYANDU-Q Ramalia Noratama Putri; Debi Setiawan; Deinike Wanita Marwan; Yenny Desnelita; Gustientiedina Gustientiedina; Irwan Irwan
E-Amal: Jurnal Pengabdian Kepada Masyarakat Vol 1 No 3: September 2021
Publisher : LP2M STP Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47492/eamal.v1i3.894

Abstract

Untuk meningkatkan Pelayanan Kesehatan pada Keluarahan Sialang Munggu maka posyandu sri mersing memiliki beberapa permasalahan yang dihadapi yaitu : 1) Minimnya minat masyarakat pada RW 18 untuk datang membawa batita dan balita ke posyandu terutatama pada ibu muda. 2) Tidak jalannya Posyandu pada masa pandemic covid-19. 3) Belum tersedianya IPTEK pada posyandu. 4) Posyandu lansia dan pengendalian PTM belum dijalankan sepenuhnya. Berdasarkan permasalahan yang dihadapi mitra maka solusi dari permasalahan tersebut yaitu: 1) sosialiasasi dengan tranformasi digital kesehatan menggunakan smartphone pada ibu muda umur 25-30. 2) pelatihan ke kader posyandu tentang tentang peraturan pelaksanaan kegiatan posyandu pada masa pandemic covid 19. 3) Implementasi aplikasi PosyanduQ Sri Mersing 4) Sosialisasi panduan pelaksanaan posyandu lansia dan cek kesehatan PTM. Metode pelakasanaan kegiatan adalah perancangan, pelatihan, dan implementasi. Setelah kegiatan dilakasanakan maka tahapan evaluasi dilakukan dengan cara menyebarkan kuesioner kepada kader dan masyarakat RW 18..
Effect of Eurycoma longifolia Jack Root Extract on Sperm pH and Morphology in Nicotine-Exposed Rats Irenesia, Bimby; Afri Yati, Umaimah; Utami, Riski Dwi; Marwan, Deinike Wanita
Indonesian Journal of Pharmaceutical Education Vol 5, No 1 (2025): January–April 2025
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v5i1.30157

Abstract

Infertility is the inability of couples of childbearing age (PUS) to conceive offspring. Male infertility can be caused by several trigger factors, one of which is smoking. One of the ingredients contained in cigarettes is nicotine which can cause free radicals. As a result of free radicals, there is damage to spermatozoa DNA. The sterol and isoprenoid content in pasak bumi can prevent infertility in men. both of these ingredients are necessary for the synthesis of steroid hormones. Steroid hormones play a critical role in spermatozoa development. The objective of this study to determine the effect of administering pasak bumi root extract on the pH and sperm morphology of male Wistar rats exposed to nicotine. This research is experimental with a posttest-only control design. The research was carried out for 51 days and the analysis used was the one way anova test. In the results of the spermatozoa pH examination, there was no influence in the treatment group or control group, whereas in the morphology examination there was an influence or difference at doses of 50, 100, and 200 100 mg/kgBW with (p-value 0.05). Pasak bumi root extract (Eurycoma longifolia Jack) on the morphology of spermatozoa in male Wistar rats exposed to nicotine. In research, the pH of pasak bumi root extract (Eurycoma longifolia Jack) had no effect on the pH of spermatozoa exposed to nicotine.
Analysis of The Effectiveness Combination Allium Ascalonicum L. And Zingiber Officinale Var. Rubrum Extracts On Uric Acid Levels In Hyperuricemic Rattus Norvegicus Marwan, Deinike Wanita; Irenesia, Bimby; Eryta, Evy; Sartika, Wiwi; Aflah, Randhy
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 13 No. 1 (2025): JAMBI MEDICAL JOURNAL: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v13i1.41457

Abstract

BackgroundHyperuricemia is an increase in uric acid levels caused by increased uric acid metabolism (overproduction), decreased uric acid excretion through urine (underexcretion), or a combination of both. In Indonesia, the average age of occurrence is younger compared to Western countries, with approximately 32% of hyperuricemia cases occurring under the age of 34. The long-term and excessive use of medication can lead to toxic side effects. Previous studies have indicated that certain plants have effects in lowering uric acid levels, such as shallots (Allium ascalonicum L.) and red ginger (Zingiber officinale var. rubrum). Objective :To analyze the effectiveness of the combined extract of Allium ascalonicum L. and Zingiber officinale var. rubrum in reducing uric acid levels in male white rats induced with potassium oxonate. Method : An experimental study using a Pre-Post Test Control Group Design with a combination of shallot and red ginger extracts. The samples were divided into five groups. Result : Based on the One-Way ANOVA test conducted before and after the treatment, a p-value of <0.05 was obtained, indicating that the combination of shallot and red ginger extracts was effective in reducing uric acid levels in hyperuricemic rats. The combination of 450 mg red ginger extract and 150 mg shallot extract showed the most effective and significant reduction in uric acid levels. Conclusion : The combination of shallot and red ginger extracts is effective in reducing uric acid levels in hyperuricemic rats. Keywords : hyperuricemia, red ginger, shallots, uric acid levels
Efektivitas Ekstrak Spirulina platensis sebagai Antiinflamasi terhadap Jumlah Neutrofil dan Makrofag pada Luka yang Diinfeksi Staphylococcus aureus pada Tikus Wistar Misfa, Olvaria; Utami, Riski Dwi; Irenesia, Bimby; Marwan, Deinike Wanita
Nommensen Journal of Medicine Vol 8 No 1 (2022): Nommensen Journal of Medicine: Edisi Agustus
Publisher : Universitas HKBP Nommensen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36655/njm.v8i1.735

Abstract

ABSTRAK Latar belakang: Kandungan senyawa aktif dari Spirulina sp. memiliki aktivitas antiinflamasi dan antibakteri. Penggunaan senyawa tersebut berperan dalam proses inflamasi pada luka yang terinfeksi. Tujuan: Menganalisis efektifitas pemberian ekstrak Spirulina platensis terhadap jumlah neutrofil dan makrofag pada luka insisi tikus wistar yang diinfeksikan S. aureus. Metode: Penelitian ini menggunakan randomized post test only control group design. Dua puluh empat ekor tikus wistar jantan diinsisi kulitnya dan diinfeksikan S.aureus dibagi menjadi 4 kelompok, yaitu kelompok yang diberi ekstrak S.platensis dosis 500 mg/kgBB/hari, dosis 750 mg/kgBB/hari, kelompok kontrol negatif diberi larutan salin serta kelompok kontrol positif dengan pemberian amoksisilin 150 mg/kgBB peroral. Jumlah neutrofil dan makrofag dihitung pada pemeriksaan histopatologis dari jaringan luka pada hari ke-14 yang mencakup 5 lapang pandang. Analisis data dilakukan dengan uji one way ANOVA dan dilanjutkan dengan Post Hoc Test LSD. Hasil: Rerata jumlah neutrofil hari ke-14 pada kelompok dosis 500 mg/kgBB/hari, 750 mg/kgBB/hari, kontrol positif dan kontrol negatif adalah 17,83; 12,17; 5,17; dan 8,83 dengan p < 0,001. Jumlah makrofag hari ke-14 pada kelompok dosis 500 mg/kgBB/hari, 750 mg/kgBB/hari, kontrol positif dan kontrol negatif adalah 7,17; 10,83; 16,83; 15,83 dengan p < 0,002. Uji Post Hoc menemukan jumlah neutrofil pada kelompok dosis 500 mg/kgBB/hari secara signifikan lebih tinggi dibandingkan kelompok lainnya. Sementara, uji Post Hoc untuk jumlah makrofag menemukan perbedaan signifikan hanya pada kelompok dosis 500 mg/kgBB/hari terhadap kelompok kontrol positif dan kontrol negatif. Simpulan: Pemberian ekstrak Spirulina platensis dosis 500mg/kgBB/hari secara signifikan meningkatan jumlah neutrofil dan menurunkan jumlah makrofag pada luka insisi tikus wistar yang diinfeksikan Staphylococcus aureus . Kata kunci: luka, makrofag, neutrofil, Spirulina platensis ABSTRACT Background: The active compound of Spirulina sp. has anti-inflammatory and antibacterial property. The use of these contents plays a role in the inflammatory process in infected wounds. Objective: To analyse the effectiveness of Spirulina platensis extract on the number of neutrophils and macrophages in the incision wound of Wistar rats infected by S. aureus. Methods: This study used a randomized posttest-only control group design. Twenty-four male Wistar rats had their skin incised and infected with S. aureus were divided into 4 groups. The group was given with the extract of S. platensis at a dose of 500 mg/kgBW/day (1), a dose of 750 mg/kgBW/day (2), the negative control group was given saline solution(3), and the positive control group was given amoxicillin 150 mg/kg body weight orally (4). The number of neutrophils and macrophages was counted on histopathological examination of the wound tissue on day 14 which included 5 visual fields. Data analysis was carried out by one way ANOVA test and followed by LSD Post Hoc Test . This study used a randomized posttest-only control group design. Twenty-four male wistar rats were divided into 4 groups, the groups were given S. platensis extract 500 mg/kgBW/day and 750 mg/kgBW/day, the positive control group was given amoxicillin 150 mg/kgBW orally and the negative control group was given saline solution. The skin of the mice was incised and infected with S. aureus. Histopathological examination of wound tissue was performed on day 14 to assess the number of neutrophils and macrophages. Data analysis was carried out with the oneway ANOVA test. Results: The mean numbers of neutrophils on the 14th day in the group of a dose of 500 mg/kgBW/day, 750 mg/kgBW/day, positive control, and negative control were 17.83; 12.17; 5.17; and 8.83 with p < 0.001, respectively. The numbers of macrophages on the 14th day in the group of a dose of 500 mg/kgBW/day, 750 mg/kgBW/day, positive control, and negative control were 7.17; 10.83; 16.83; 15.83 with p < 0.002, respectively. The Post Hoc test exhibited that the neutrophil count in the group of 500 mg/kgBW/day was significantly higher than the other groups. Meanwhile, the Post Hoc test for the number of macrophages found a significant difference, only in the group of a dose of 500 mg/kgBW/day against the positive and negative control groups. Conclusion: There was a significant decrease in the number of macrophages in the group of wistar rats that were incised and infected with Staphylococcus aureus and given Spirulina platensis extract at a dose of 500mg/kgBW/day. Keywords: wound, macrophages, neutrophils, Spirulina platensis
Edukasi dan Pemberian Face Massage For Anti Aging Untuk Memberikan Pemahaman Bagi Siswa Tentang Fisioterapi Integument Serta Membantu Pengarahan Pada Minat Dan Bakat Setelah Lulus SMA Ismaningsih, Ismaningsih; Zein, Renni Hidayati; Marlita, Lora; Marwan, Deinike Wanita
Jurnal Pengabdian Masyarakat: Pemberdayaan, Inovasi dan Perubahan Vol 4, No 6 (2024): JPM: Pemberdayaan, Inovasi dan Perubahan
Publisher : Penerbit Widina, Widina Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59818/jpm.v4i6.896

Abstract

This service aims to provide education about face massage as an anti-aging technique to high school students, as well as introducing the basics of integument physiotherapy. This activity is expected to increase students' understanding of the benefits and techniques of facial massage as well as the field of physiotherapy, which is a branch of health science that focuses on skin and soft tissue care. Apart from that, this program also plays a role in helping students identify their interests and talents, as well as providing career guidance after graduating from high school, especially in the health and beauty fields. The methods used include counseling, demonstrations of facial massage practice, and interactive discussions. The results of the activity showed an increase in students' understanding of integument physiotherapy and a significant interest in careers in the health and beauty sector.ABSTRAKPengabdian ini bertujuan untuk memberikan edukasi mengenai face massage sebagai teknik anti-aging kepada siswa SMA, sekaligus memperkenalkan dasar- dasar fisioterapi integument. Kegiatan ini diharapkan dapat meningkatkan pemahaman siswa tentang manfaat dan teknik face massage serta bidang fisioterapi, yang merupakan cabang ilmu kesehatan yang berfokus pada perawatan kulit dan jaringan lunak. Selain itu, program ini juga berperan dalam membantu siswa mengidentifikasi minat dan bakat mereka, serta memberikan pengarahan karir setelah lulus SMA, khususnya dalam bidang kesehatan dan kecantikan. Metode yang digunakan meliputi penyuluhan, demonstrasi praktik face massage, dan diskusi interaktif. Hasil kegiatan menunjukkan peningkatan pemahaman siswa tentang fisioterapi integument dan adanya minat yang signifikan terhadap karir di bidang kesehatan dan kecantikan.
Co-Authors Aflah, Randhy Afri Yati, Umaimah Ari Diansyah Ayuningtiyas, Ratih Bimby Irenesia Debi Setiawan Debi Setiawan Desnelita, Yenny Eliya Mursyida Eliya Mursyida Elly Anggreny Elvina Zuhir Eryta, Evy Eva Oktariani Evy Eryta Evy Eryta Faisal Faisal Fakhrun Nisya Zain Fifi Candita Fitria Dina Sella Gustientiedina Ira Puspita Sari Irenesia, Bimby Irwan Irwan ismaningsih, ismaningsih Jusman, Yessi Marlita, Lora Marsela Br Sirait Muhammad Faisal Nasution, Azlaini Yus Nurjamilah Nurjamilah Nurlaila Nurlaila Olvaria Misfa Ramalia Noratama Putri Ratih Ayuningtiyas Riski dwi utami Risnandar Risnandar Ruswaldi Munir Shania Mili Utami, Riski Dwi Valzon, May Wahyu Ramadhan Wiwi Sartika Yusmaharani, Yusmaharani Zein, Renni Hidayati