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All Journal Jurnal Bios Logos Jurnal Pendidikan Biologi Undiksha JSME MIPA UNIMA Jurnal Bioedukatika Jurnal Biologi Tropis JURNAL PENDIDIKAN TAMBUSAI Jambura Edu Biosfer Journal Jurnal Pembelajaran dan Biologi Nukleus Sciening : Science Learning Journal BIOCHEPHY: Journal of Science Education Indonesian Biodiversity Journal Molekul: Jurnal Ilmiah Kimia West Science Social and Humanities Studies Jurnal Pengabdian Masyarakat dan Riset Pendidikan EJHEAA Indonesian Biodiversity Journal Pentagon: Jurnal Matematika dan Ilmu Pengetahuan Alam Polygon: Jurnal Ilmu Komputer dan Ilmu Pengetahuan Alam Jurnal Cendekia Ilmiah Jurnal Pendidikan Progresif Jurnal Pendidikan Kimia, Fisika dan Biologi Jurnal Cakrawala Pendidikan dan Biologi (jucapenbi) Journal of Higher Education and Academic Advancement Advances in Tropical Biodiversity and Environmental Sciences Riset : Jurnal Ilmiah Multidisiplin Ilmu
Herry Maurits Sumampouw
Universitas Negeri Manado
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Public Health Social Sciences Veterinary Other

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Multifunctional Bioactivities of Apis dorsata Binghami Nest Extract-Fortified Tea: Antioxidant, Cytotoxic, and α-Glucosidase Inhibitory Potential Yermia Semuel Mokosuli; Alva Sahiri Supit; Herry Maurits Sumampouw
Molekul Vol 21 No 2 (2026)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2026.21.2.18327

Abstract

ABSTRACT. Bee-derived products are increasingly acknowledged as valuable functional ingredients because of their abundant phenolic and flavonoid content; yet, the biological potential of honeycomb or nest extracts is still inadequately investigated. The current research examined the bioactive characteristics and multifunctional properties of a tea formulation enhanced with Apis dorsata Binghami nest extract. The total phenolic and flavonoid concentrations were measured with Folin–Ciocalteu and AlCl₃ colorimetric tests, respectively, with results reported as equivalents of gallic acid and quercetin. The antioxidant capacity was examined by DPPH radical scavenging, anticancer activity was determined by cytotoxicity against human breast adenocarcinoma (MCF-7) cells through the Presto Blue™ assay, and antidiabetic potential was investigated via α-glucosidase inhibition. The formulation demonstrated significant quantities of phenolic and flavonoid compounds, which were associated with pronounced free radical scavenging activity. Cytotoxicity experiments demonstrated a concentration-dependent decrease in MCF-7 viability, with IC₅₀ values reflecting moderate potency relative to cisplatin, although above the potency of crude extracts noted in previous investigations. The extract exhibited notable α-glucosidase inhibitory actions, indicating its promise in glycemic management. Collectively, our data underscore the potential synergistic interaction of tea polyphenols and nest-derived bioactives in augmenting antioxidant, anticancer, and antidiabetic effects. This is, to our knowledge, the inaugural integrated study assessing the multifunctional bioactivities of Apis dorsata Binghami nest extract prepared as tea. The findings highlight its promise as an innovative functional beverage and nutraceutical option, offering scientific validation for the enhancement of underutilized bee resources in combating oxidative stress–related ailments. Keywords: Apis dorsata Binghami, anticancer, antidiabetic, antioxidant, Multifunctional Bioactivities, phenolic content
Development of a PjBL-Based Science Project Teaching Module on the Material of Living Things and Their Environment to Improve Students' Scientific Literacy State Vocational School 1 Modoinding Yunita Meylan Kumajas; Anatje Lihiang; Jovialine Albertine Rungkat; Herry Sumampouw
Riset : Jurnal Ilmiah Multidisiplin Ilmu Volume 1, Nomor 4 Juni 2026
Publisher : PT. AHLAL PUBLISHER NUSANTARA

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Abstract

This study aims to develop a Project Based Learning (PjBL) based Science Project module on the subject of living things and their environment that meets the criteria of validity, practicality, and effectiveness and is able to improve students' scientific literacy. This study is a research and development (R&D) using the ADDIE model which includes the stages of Analysis, Design, Development, Implementation, and Evaluation. The study was conducted at SMK Negeri 1 Modoinding. The results of the study indicate that the PjBL-based Science Project module developed meets the criteria of very validity based on the assessment of material experts and media experts. The module also received positive responses from teachers and students so that it is included in the category of very practical for use in learning. In addition, the application of the module is able to support the implementation of project-based learning well and contribute to improving students' scientific literacy. In conclusion, the PjBL-based Science Project module on the subject of living things and their environment developed through the ADDIE model is suitable for use in learning because it meets the criteria of validity, practicality, and effectiveness and can improve students' scientific literacy. Keywords: PjBL, Science Project Module, Living Things and Their Environment, Science Literacy.
Co-Authors Adinda Givinia Rintang Akulina Kelitubun Alaratu, Sri Kevin S. Alva Sahiri Alexander Supit Anatje Lihiang Anita Constanci Christine Tengker Anita Costanci Christine Tengker Arrijani - Aser Yalindua Bellatrix H.Ch Kaliboto Britney Meissy Pandoh Carolin Manuahe Christny Ferdina Evie Rompas Crescentia Mishi Juniorita Ngangi Danny Christian Posumah Decky D. W. Kamagi Dewa Nyoman Oka Dino Rahardiyan Dintje Pendong Emma M Moko Febiola Najoan Ferny M. Tumbel Friska Mery Montolalu Gladys Sisca Pusung Gurumanis, Ahebron Helen Joan Lawalata Hendra Pratama Maliangkay Jantje Ngangi Jemmy Sumakul Jimmy Langi Jovialine Albertine Rungkat Kaliboto, Bellatrix H.Ch Kasim, Yuriko Livana Dethris Rawung Luntungan, Geraldo M. Marchelle Nhatanael Walangitan Mariana Rengkuan Marsanda Tandiapa Masje Wurarah Masye Wurarah Meity Nelltje Tanor Melany Piri Melti Arista Mokosuli Yermia Samuel Muli, Efel J. R. Muliati, Muliati Ngantung, Carolina Ni Nyoman Serma Adi Nova L.I.M Ogi Orbanus Naharia Pusung, Gladys Sisca Rengkung, Prisilia Marlin Revolson Mege Salunusa, Kandita Juliet Sasauw, Dien A. Simarmata, Iyusnita Sari Sri Kevin S. Alaratu Sukmarayu P. Gedoan Taghulihi, Nick B. Talu, Olfi Taulu, Stella M. L. Tuegeh, Reinny Silvana Tumanduk, Yahya Y.R. Tumbel, Ferny M. Utari Satiman Wiesye Nangoy Yunita Meylan Kumajas