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Journal : Manuju : Malahayati Nursing Journal

 1 
Efek Minyak Nigella Sativa dan Vitamin D terhadap Kadar Il-5 dan Ifn-Γ Serum pada Alergi Studi Eksperimental pada Mencit Balb/C yang Diinduksi Ovalbumin Rahmawati, Fany Dyah; Suprihati, Suprihati; Lestari, Rinna Dwi
Malahayati Nursing Journal Vol 7, No 11 (2025): Volume 7 Nomor 11 (2025)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v7i11.23108

Abstract

ABSTRACT Allergy is a hypersensitivity reaction associated with specific IgE, which, upon re-exposure to the same allergen, results in the release of histamine and other mediators, causing allergic symptoms. In allergic reactions, IgE levels increase, and IL-5 plays a significant role. Nigella sativa (NS) has an anti-inflammatory role thru its thymoquinone content, which can inhibit the formation of oxidants and reduce inflammatory mediators. Vitamin D in atopic diseases reduces the Th2 lymphocyte immune response in the airways. To determine the effect of NS and vitamin D on the reduction of serum IFN-γ and IL-5 levels in Ovalbumin-induced Balb/c mice. Methods: This study is a true experiment with a post-test only control group design, using 30 Balb/c mice as research subjects divided into 5 groups: 1) negative control, 2) positive control (allergy), 3) NS treatment group, 4) vitamin D treatment, 5) NS + vitamin D treatment (combination). Serum IL-5 and IFN-γ levels were compared for each group. There were significant differences in IL-5 levels between the negative control group and the positive control group (p= 0.007), the positive control group and NS (p= 0.020), and the positive control group and the NS+vitamin D combination (p= 0.033). There were significant differences in IFN-γ levels between the positive control group and NS (p=0.01), NS and vitamin D (p= 0.006), and NS and the NS+vitamin D combination (p= 0.013). Nigella Sativa significantly reduced IL-5 levels and increased IFN-γ levels, while Vitamin D had no effect on IL5 and IFN-γ levels. Keywords: Nigella Sativa, Vitamin D, IL-5, IFN-γ, OVA Sensitization.  ABSTRAK Latar Belakang: Alergi adalah suatu reaksi hipersensitivitas yang berhubungan dengan IgE spesifik yang jika terpapar ulang alergen yang sama mengakibatkan penglepasan histamin dan mediator lainnya menimbulkan gejala alergi. Pada reaksi alergi meningkatnya kadar IgE, IL-5 yang berperan penting dalam reaksi alergi. Nigella sativa (NS) memiliki peran anti inflamasi melalui kandungan thymoquinone yang dapat menghambat terbentuknya oksidan dan penurunan mediator inflamasi. Vitamin D pada penyakit atopi, menurunkan respon imun limfosit Th2 pada jalan nafas. Tujuan: Mengetahui pengaruh NS dan vitamin D terhadap penurunan kadar IFN- γ, dan IL-5 serum pada mencit Balb/c yang diinduksi Ovalbumin. Metode: Penelitian ini suatu true experiment with post-test only control group design menggunakan 30 ekor mencit Balb/c sebagai subjek penelitian yang dibagi dalam 5 kelompok: 1) kontrol negatif, 2) kontrol positif (alergi), 3) kelompok perlakuan NS, 4) perlakuan vitamin D, 5) perlakuan NS + vitamin D (kombinasi).  Kadar IL-5 dan IFN- γ serum setiap kelompok dibandingkan. Hasil: Terdapat perbedaan bermakna kadar IL-5 antara kelompok kontrol negatif dengan kontrol positif (p= 0.007), kelompok kontrol positif dengan NS (p= 0.020), kelompok kontrol positif dengan kombinasi NS+vitamin D (p= 0.033). Perbedaan bermakna kadar IFN-γ antara kelompok kontrol positif dengan NS (p=0.01), kelompok NS dengan vitamin D (p= 0.006), dan kelompok NS dengan kombinasi NS+vitamin D (p= 0.013). Simpulan: Nigella Sativa menurunkan kadar IL-5 dan meningkatkan kadar IFN-γ secara bermakna, sedangkan Vitamin D tidak berpengaruh terhadap kadar IL5 dan kadar IFN-γ. Kata Kunci: Nigella Sativa, Vitamin D, IL-5, IFN- γ, Sensitisasi OVA.
Co-Authors Adi Koesoema Aman, Adi Koesoema Agus Marimin, Agus Ahmad Sidiq Ananda, Raditya Se'o Anastasia Ediyati Anastasya, Diana Ayu Andriani, Helen Antono, Dwi Aprilia Aprilia, Aprilia Ardella, Yuga Ray Ari Budi Himawan Bambang S. R Utomo Budiarti, Rery Budiyono Budiyono Dahlan Lubis, M. Nadjib Dahlan Lubis, Muhammad Nadjib Darmanto Darmanto Darmanto Dewi Muliasari Dina Rotua Valentina Banjarnahor Efendi, Tino Feri Esti Setiawati Farida, Ilya Farokah, Farokah Fathurrahman, Abdullah Febriani, Nur Leni Budi Frediyanto, Muhammad Sigit Gintu, Agung Rimayanto Hadi Samanto, Hadi Hendri Setyawan Iin Emy Prastiwi, Iin Emy Indra Lila Kusuma, Indra Lila Istiqomah, Layli Nur Jaya, Surachman Koesoema, Adi Kusulistyo, Farryanto LMS Kristiyanti, LMS LMS. Kristiyanti M. Sholeh Kosim Ma'ruf, Muhammad Hasan Maulani, Rifatun Muliasari, Dewi Muqorobin, Muqorobin Muyassaroh Muyassaroh Nursalam . Octavianingrum, Putri Eka Pameling, Marselinus Teduh Pardana Wati, Sri Laksmi Pinaraswati, Sandra Oktaviana Prabowo, Desnardo Ivan Pratiwi, Desy Nur Pujo Widodo, Pujo Putri, Latifah Eka Rahmawati, Fany Dyah Rahmawati, Rahmawati Rengganis, Yacinta Rini Handayani Rinna Dwi Lestari Rita Noviani, Rita Rochmatullah ., Rochmatullah Rukmini Rukmini Sabila, Attina Surya Sarah Rum Handayani Sarah, Diah Ayu Siti Sekti, Wahyu Cahyani Simanjuntak, Bistok H Siti Arifah Siti Nurlaela Sri Laksmi Pardanawati, Sri Laksmi Sri Mulyani Sri Susilowati Subarkah, Johny Suharyo Hadisaputro Suhestiningsih, Suhestiningsih SUMADI SUMADI Sumartini Sumartini Tho'in, Muhammad Tri nani, Lusia Ria Widodo, Eko Widyanto Wikan Budi Utami Willy Yusmawan, Willy Yuwita Ariessa Pravasanti, Yuwita Ariessa Zachreini, Indra Zachreini, Indra Zulfikar Naftali, Zulfikar