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All Journal HAYATI Journal of Biosciences Indonesian Journal of Pharmaceutical Science and Technology Indonesian Journal of Biotechnology Warta IHP (Warta Industri Hasil Pertanian) Indonesian Journal of Chemistry JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Locus Penelitian dan Pengabdian Journal of Applied Agricultural Science and Technology Pharmaceutical Sciences and Research (PSR) Eduvest - Journal of Universal Studies Ezra Science Bulletin Jurnal Kefarmasian Indonesia
Herman Suryadi
Department Of Pharmacy, Faculty Of Pharmacy, Universitas Indonesia, Jakarta, Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Electrical & Electronics Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Antibacterial Potential of Cinnamomum culilaban Bark Ethanolic Extract Prepared by Ultrasound-Assisted Extraction against Oral Pathogens Kurniatri, Arifayu Addiena; Elya, Berna; Suryadi, Herman
Jurnal Kefarmasian Indonesia VOLUME 14, NUMBER 2, AUGUST 2024
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Cinnamomum culilaban is one of the native Indonesian plants that has been used as medicinal plant. The local community on Seram Island uses the stem bark to treat toothaches. Eugenol, a chemical compound found in Cinnamomum culilaban, is used in dental practice and has antibacterial activity. Research on Cinnamomum culilaban is very limited, its activity against bacteria that cause oral infections has not been reported. This study aims to investigate the antibacterial activity of Cinnamomum culilaban bark extract against oral pathogens Porphyromonas gingivalis, Streptpcoccus mutans, and Enterococcus faecalis. The extraction was carried out using 96% ethanol with ultrasound-assisted extraction method. Disc diffusion assay was conducted to investigate the antibacterial activity. The concentration of extract used were 50%, 25%, and 12.5% (b/v) in DMSO. Eugenol (50% v/v in DMSO) was used as positive control. The phytochemicals screening was carried out to investigate the chemical compounds contained in Cinnamomum culilaban bark extract. Extraction of Cinnamomum culilaban bark using 96% ethanol with the ultrasound-assisted extraction method obtained a yield of 23.36±0.49%. The extract contains alkaloids, flavonoids, tannins, saponins, phenolics, and steroids/terpenoids. The ethanolic extract of Cinnamomum culilaban bark has inhibitory activity against Streptpcoccus mutans and Enterococcus faecalis. Cinnamomum culilaban bark has the potential as an antibacterial agent.
A Preliminary Study of Formulations of Transfersomes for Improved Transdermal Peptide Delivery Hutabarat, Rahmi; Bahtiar, Anton; Suryadi, Herman; Surini, Silvia
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.55269

Abstract

Peptide-containing dosage forms are often administered through invasive injection. However, due to their great ultra-mobility, transfersomes offer a promising alternative for non-invasive and non-allergenic transdermal peptide delivery. Therefore, this study aimed to conduct preliminary investigations into the formulations of transfersomes for transdermal peptide delivery. Transfersomes were prepared using the thin-layer hydration method with Tweenâ 80 as an edge activator and Phospholiponâ 90G as vesicle formers. Four formulations: F1, F2, F3, and F4 were optimized with various ratios of the two components, including 90:10, 85:15, 80:20, and 75:25. Particle size, zeta potential, deformability index, polydispersity index (PDI), and vesicle morphology were used to assess transfersomes. As a result, the zeta potential was -37.2 ± 2.19, the deformability index was 1.78 ± 0.03 and the smallest vesicle size (147 ± 1.93), PDI value of 0.105 ± 0.01 and spherical were all found in the optimal formula, F3, with an 80:20 ratio. These results suggest significant potential for the further development of transfersomes using Tweenâ 80 and Phospholiponâ 90G as effective transdermal peptide delivery systems.
Synthesis and Evaluation of Mannich Base Derivatives of Hexyl Ferulate as Antibacterial and Antioxidant Agents Kadek Devi Arum Savitri; Hayun Hayun; Herman Suryadi
Eduvest - Journal of Universal Studies Vol. 6 No. 5 (2026): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v6i5.52642

Abstract

Antimicrobial resistance (AMR) constitutes a serious global health issue, with its impact being especially pronounced in developing countries like Indonesia. Developing new antibacterial and antioxidant agents through structural modification offers a promising strategy to address AMR. Ferulic acid, a natural phenolic compound with known biological activity, has limited bioavailability. To enhance its potency, structural modification into hexyl ester and Mannich base derivatives was performed. Ferulic acid (1) was synthesized via solvent-free Knoevenagel condensation, converted to hexyl ferulate (2) through esterification with hexyl bromide, and further modified with dimethylamine (3a), diethylamine (3b), morpholine (3c), and 2,6-dimethylmorpholine (3d). The antioxidant assays (DPPH and FRAP) showed that 3a–d had IC₅₀ values of 1.89–22.67 µM and EC₅₀ values of 0.34–4.08 µM. Compounds 3b (EC₅₀ 0.34±0.00 µM) and 3d (IC₅₀ 1.89±0.00 µM) exhibited strongest antioxidant activity, exceeding the activity of ascorbic acid. Antibacterial testing showed 3d produced the largest inhibition zones, up to 26.90 mm at 3 mg/mL against S. aureus. MBC testing confirmed that 3b was the most active (0.75–3.00 mg/mL). The enhanced activities correlated with increased lipophilicity (logP 3.32–4.25). Overall, Mannich base substitution of hexyl ferulate significantly improved antioxidant and antibacterial properties, suggesting its potential as a lead scaffold for developing agents against resistant pathogens.
Co-Authors -, Harmita . Azizahwati . Azizahwati . Harmita Abdul Mun'ím Agus Firmansyah Ambarsari, Christy Andi Utama ANDI UTAMA Andiri Niza Syarifah Anja Tamabri Anton Bahtiar Arif Arrahman Arif Arrahman Arif Arrahman, Arif Arifayu Addiena Kurniatri Arifianti, Ayun Erwina Arry Yanuar Berna Elya Callista Andinie Mulyadi Chairunissa, Ananda Hanny Dessy Ariyanti Dessy Ariyanti Esti Mumpuni Forestrania, Roshamur Cahyan Fready SIP Fuad, Asrul Muhammad Hayun . Hayun Hayun Hayun Hayun Hendri, Rifki Anshory Heria Oktavia Heria Oktavia, Heria Irianti, Marina Ika Jantan, Ibrahim Junaidi, Lukman Kadek Devi Arum Savitri Kamaruzzaman, Mohd Amir Larosa, Febri LS Lina Elfita Lina Elfita Luh Putu Ratna Sundari Makau, Juliann Nzembi Maksum Radji Maksum Radji Maksum Radji MARIA BINTANG Maryati Kurniadi Maryati Kurniadi Melanie, Yuanki Nafi’ah, Nadya Ismi Nani Dharmasetiawani Ofa Suzanti Betha Partomuan Simanjuntak Prasetio, Nisrina Putri PUSPITA LISDIYANTI Putri Mulia, Ocha Rahmadi, Agus Rahmasari, Ratika Rahmi Hutabarat Sembiring, Enny Rimita Septiarini, Tri Hastuti Shanti Ratnakomala SHANTI RATNAKOMALA Silvia Surini Siswa Setyahadi Siswa Setyahadi Sri Wardatun Subagja ., Subagja Sunarsih Sunarsih Susandra Jaya Vicha Vicha Yahdiana Harahap Yodifta Astiningrum Yodifta Astriningrum Yodifta Astriningrum, Yodifta