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All Journal HAYATI Journal of Biosciences Indonesian Journal of Pharmaceutical Science and Technology Indonesian Journal of Biotechnology Warta IHP (Warta Industri Hasil Pertanian) JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Science and Technology Indonesia Indonesian Journal of Chemistry JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Locus Penelitian dan Pengabdian Journal of Applied Agricultural Science and Technology Pharmaceutical Sciences and Research (PSR) Eduvest - Journal of Universal Studies Ezra Science Bulletin Jurnal Kefarmasian Indonesia Biodiversitas Journal of Biological Diversity
Herman Suryadi
Department Of Pharmacy, Faculty Of Pharmacy, Universitas Indonesia, Jakarta, Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Review: Sintesis Senyawa Turunan Dari ?-Amino Alkohol Yang Memiliki Potensi Aktivitas Antibakteri Nafi’ah, Nadya Ismi; Hayun, Hayun; Suryadi, Herman
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 9 (2025): : JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i9.4767

Abstract

?-Amino alkohol merupakan senyawa organik yang mengandung gugus amino dan hidroksil pada posisi ? terhadap satu sama lain, dan diketahui memiliki potensi sebagai agen antibakteri. Permasalahan utama dalam penelitian ini adalah terbatasnya informasi sistematis mengenai hubungan struktur-aktivitas senyawa turunan ?-amino alkohol dan metode sintesis optimal untuk menghasilkan senyawa dengan aktivitas antibakteri yang tinggi. Tujuan kajian ini adalah untuk menganalisis berbagai metode sintesis turunan ?-amino alkohol, mengevaluasi potensi aktivitas antibakteri berdasarkan parameter zona hambat dan konsentrasi hambat minimum (KHM), serta mengidentifikasi hubungan struktur-aktivitas untuk pengembangan kandidat antibakteri baru. Metode penelitian menggunakan systematic review dengan pendekatan PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) melalui pencarian literatur pada basis data Perpustakaan Online Universitas Indonesia, Google Scholar, ScienceDirect, Scopus, PubMed, Wiley Journal, dan The Royal Society of Chemistry menggunakan kata kunci "synthesis of ?-amino alcohol", "?-amino alcohol", "antimicrobial", "antibacterial", dan "?-amino alcohol derivatives". Dari 244 artikel yang ditemukan, 4 artikel memenuhi kriteria inklusi dan mengevaluasi aktivitas antibakteri senyawa hasil sintesis. Hasil kajian menunjukkan bahwa sintesis turunan ?-amino alkohol dapat dilakukan melalui berbagai metode seperti pembukaan cincin epoksida, reaksi Mannich, pembentukan basa Schiff, dan reduksi asimetris dengan yield berkisar 68-96%. Senyawa dengan substituen seperti fenil piperazin, imidazol, serta gugus aromatik menunjukkan aktivitas signifikan terhadap bakteri Gram positif (S. aureus, B. subtilis) dan Gram negatif (E. coli, P. aeruginosa) dengan nilai KHM terendah 15,6 µg/mL pada senyawa 1-fenil-2-[(1-fenilpropil)amino]propan-1-ol terhadap Klebsiella pneumoniae. Implikasi penelitian ini menunjukkan bahwa desain struktur kimia yang tepat, terutama keberadaan sistem aromatik dan gugus donor elektron yang kuat, dapat meningkatkan potensi antibakteri senyawa turunan ?-amino alkohol dan mendukung pengembangan lebih lanjut sebagai kandidat antibakteri baru untuk mengatasi resistensi antimikroba.
Antibacterial Synergy Detection of Lignin Extract from Oil Palm Empty Fruit Bunches (Opefb) Combined with Amoxicillin Against Staphylococcus Aureus Using The Azdast Method Hendri, Rifki Anshory; Suryadi, Herman; Hayun, Hayun
Journal of Applied Agricultural Science and Technology Vol. 8 No. 1 (2024): Journal of Applied Agricultural Science and Technology
Publisher : Green Engineering Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55043/jaast.v8i1.191

Abstract

Oil palm empty fruit bunches (OPEFB) are waste generated by the palm oil industry and are generally considered an environmental problem due to their large quantity and difficult recyclability. This study's objective was to examine the potential of OPEFB lignin extract combined with amoxicillin in inhibiting the growth of Staphylococcus aureus bacteria. The Synergism Test of the OPEFB lignin extract-antibiotic combination was conducted using the AZDAST method (Ameri Ziaei Double Antibiotic Synergism Test). The lignin extraction process was a steam process using a 4% oxalic acid solution under optimal conditions. Then, Calcium ions precipitate 4% oxalate by adding Ca(OH)2 to the extract. The Lignin content was determined by UV-Vis spectrophotometry at 280 nm, and then the lignin extract was combined with antibiotics for antibacterial assay. The results showed a lignin content of 1.06 %. The AZDAST test results revealed clear zones from the combination of OPEFB lignin extract and amoxicillin with a diameter of 20.23 mm for the extract containing oxalate and 15.83 mm for the oxalate-free extract. Meanwhile, on average, the clear zone of single amoxicillin was only 14.13 mm. Based on these results, the combination of OPEFB lignin extract with amoxicillin was stronger than amoxicillin alone in inhibiting the growth of S. aureus, but it was not significantly different (p-value> 0.05). In conclusion, the potential of OPEFB lignin extract synergistically worked with the antibiotic amoxicillin in inhibiting the growth of S. aureus.
Antibacterial Potential of Cinnamomum culilaban Bark Ethanolic Extract Prepared by Ultrasound-Assisted Extraction against Oral Pathogens Kurniatri, Arifayu Addiena; Elya, Berna; Suryadi, Herman
Jurnal Kefarmasian Indonesia VOLUME 14, NUMBER 2, AUGUST 2024
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Cinnamomum culilaban is one of the native Indonesian plants that has been used as medicinal plant. The local community on Seram Island uses the stem bark to treat toothaches. Eugenol, a chemical compound found in Cinnamomum culilaban, is used in dental practice and has antibacterial activity. Research on Cinnamomum culilaban is very limited, its activity against bacteria that cause oral infections has not been reported. This study aims to investigate the antibacterial activity of Cinnamomum culilaban bark extract against oral pathogens Porphyromonas gingivalis, Streptpcoccus mutans, and Enterococcus faecalis. The extraction was carried out using 96% ethanol with ultrasound-assisted extraction method. Disc diffusion assay was conducted to investigate the antibacterial activity. The concentration of extract used were 50%, 25%, and 12.5% (b/v) in DMSO. Eugenol (50% v/v in DMSO) was used as positive control. The phytochemicals screening was carried out to investigate the chemical compounds contained in Cinnamomum culilaban bark extract. Extraction of Cinnamomum culilaban bark using 96% ethanol with the ultrasound-assisted extraction method obtained a yield of 23.36±0.49%. The extract contains alkaloids, flavonoids, tannins, saponins, phenolics, and steroids/terpenoids. The ethanolic extract of Cinnamomum culilaban bark has inhibitory activity against Streptpcoccus mutans and Enterococcus faecalis. Cinnamomum culilaban bark has the potential as an antibacterial agent.
A Preliminary Study of Formulations of Transfersomes for Improved Transdermal Peptide Delivery Hutabarat, Rahmi; Bahtiar, Anton; Suryadi, Herman; Surini, Silvia
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.55269

Abstract

Peptide-containing dosage forms are often administered through invasive injection. However, due to their great ultra-mobility, transfersomes offer a promising alternative for non-invasive and non-allergenic transdermal peptide delivery. Therefore, this study aimed to conduct preliminary investigations into the formulations of transfersomes for transdermal peptide delivery. Transfersomes were prepared using the thin-layer hydration method with Tweenâ 80 as an edge activator and Phospholiponâ 90G as vesicle formers. Four formulations: F1, F2, F3, and F4 were optimized with various ratios of the two components, including 90:10, 85:15, 80:20, and 75:25. Particle size, zeta potential, deformability index, polydispersity index (PDI), and vesicle morphology were used to assess transfersomes. As a result, the zeta potential was -37.2 ± 2.19, the deformability index was 1.78 ± 0.03 and the smallest vesicle size (147 ± 1.93), PDI value of 0.105 ± 0.01 and spherical were all found in the optimal formula, F3, with an 80:20 ratio. These results suggest significant potential for the further development of transfersomes using Tweenâ 80 and Phospholiponâ 90G as effective transdermal peptide delivery systems.
A Review on Mannich Base Derivatives Some of Natural Compounds: Antimicrobial Activities Eva Siburian; Hayun Hayun; Herman Suryadi
Eduvest - Journal of Universal Studies Vol. 5 No. 3 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i3.50917

Abstract

This review explores the synthesis and antimicrobial potential of Mannich base derivatives derived from various natural compounds. The Mannich reaction, a versatile method in organic synthesis, enables structural modification of bioactive compounds to enhance their pharmacological properties, particularly antimicrobial activities. This study systematically reviews recent literature on the design, synthesis, and biological evaluation of these derivatives against bacterial and fungal pathogens. The findings demonstrate that Mannich base derivatives exhibit improved efficacy through multiple mechanisms of action, such as inhibition of cell wall synthesis, protein synthesis, and membrane disruption. The review highlights the relevance of Mannich-based structural optimization as a promising strategy in the development of novel antimicrobial agents.
Synthesis and Evaluation of Mannich Base Derivatives of Hexyl Ferulate as Antibacterial and Antioxidant Agents Kadek Devi Arum Savitri; Hayun Hayun; Herman Suryadi
Eduvest - Journal of Universal Studies Vol. 6 No. 5 (2026): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v6i5.52642

Abstract

Antimicrobial resistance (AMR) constitutes a serious global health issue, with its impact being especially pronounced in developing countries like Indonesia. Developing new antibacterial and antioxidant agents through structural modification offers a promising strategy to address AMR. Ferulic acid, a natural phenolic compound with known biological activity, has limited bioavailability. To enhance its potency, structural modification into hexyl ester and Mannich base derivatives was performed. Ferulic acid (1) was synthesized via solvent-free Knoevenagel condensation, converted to hexyl ferulate (2) through esterification with hexyl bromide, and further modified with dimethylamine (3a), diethylamine (3b), morpholine (3c), and 2,6-dimethylmorpholine (3d). The antioxidant assays (DPPH and FRAP) showed that 3a–d had IC₅₀ values of 1.89–22.67 µM and EC₅₀ values of 0.34–4.08 µM. Compounds 3b (EC₅₀ 0.34±0.00 µM) and 3d (IC₅₀ 1.89±0.00 µM) exhibited strongest antioxidant activity, exceeding the activity of ascorbic acid. Antibacterial testing showed 3d produced the largest inhibition zones, up to 26.90 mm at 3 mg/mL against S. aureus. MBC testing confirmed that 3b was the most active (0.75–3.00 mg/mL). The enhanced activities correlated with increased lipophilicity (logP 3.32–4.25). Overall, Mannich base substitution of hexyl ferulate significantly improved antioxidant and antibacterial properties, suggesting its potential as a lead scaffold for developing agents against resistant pathogens.
Production of cellulase from Aspergillus niger and Trichoderma reesei mixed culture in carboxymethylcellulose medium as sole carbon Dia Septiani; HERMAN SURYADI; Abdul Mun'im; WIBOWO MANGUNWARDOYO
Biodiversitas Journal of Biological Diversity Vol. 20 No. 12 (2019)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d201211

Abstract

Abstract. Septiani D, Suryadi H, Mun’im A, Mangunwardoyo W. 2019. Production of cellulase from Aspergillus niger and Trichoderma reesei mixed culture in carboxymethylcellulose medium as sole carbon. Biodiversitas 20: 3539-3544. Cellulase is one of hydrolytic enzymes that breakdown cellulose into glucose. Cellulases are promising to be applied in natural products which may improve the yield of bioactive in plant extract through cellulose depolymerization. Cellulases from mixed culture of Aspergillus niger and Trichoderma reesei can produce a high cellulase activity because of the synergism activity among endoglucanase, exoglucanase, and also ?-glucoside. Cellulase production and partial purification of monoculture and mixed culture (1:1) of these fungi on carboxymethylcellulose media were investigated in this study. Total cellulase activity was measured by filter paper assay followed by protein estimation with Bradford method. The crude extract of Aspergillus niger monoculture has the highest cellulase activity (0.131 U/mL, P<005) followed by mixed culture (0.109 U/mL) and Trichoderma reesei (0.106 U/mL). The cellulase activity of partially purified cellulase from mixed culture significantly increased (0.335, 0.348, 0.374 U/mL, P<0.05) compared to crude extract along with stepwise addition of ammonium sulfate. Cellulase activity of mixed culture at 80% ammonium sulfate increase up to 2.238-fold and showed highest value (P<0.05) compared to monocultures. In conclusion, combination of Aspergillus niger and Trichoderma reesei fungi in carboxymethyl cellulose media followed by 80% ammonium sulfate precipitation can be a promising cellulase production with high cellulase activity.
Co-Authors -, Harmita . Azizahwati . Azizahwati . Harmita . Hayun Abdul Mun'ím Abdul Mun'im Agus Firmansyah Ambarsari, Christy ANDI UTAMA Andi Utama Andiri Niza Syarifah Anja Tamabri Anton Bahtiar Arif Arrahman Arifayu Addiena Kurniatri Arry Yanuar Ayun Erwina Arifianti Berna Elya Callista Andinie Mulyadi Chairunissa, Ananda Hanny Dessy Ariyanti Dessy Ariyanti Dia Septiani Esti Mumpuni Eva Siburian Forestrania, Roshamur Cahyan Fready SIP Fuad, Asrul Muhammad Hayun Hayun Hendri, Rifki Anshory Heria Oktavia Heria Oktavia, Heria Jantan, Ibrahim Junaidi, Lukman Kadek Devi Arum Savitri Kamaruzzaman, Mohd Amir Khairul Basyar Larosa, Febri LS Lina Elfita Lina Elfita Luh Putu Ratna Sundari Makau, Juliann Nzembi Maksum Radji Maksum Radji Maksum Radji MARIA BINTANG Marina Ika Irianti Maryati Kurniadi Maryati Kurniadi Melanie, Yuanki Mi'rajunnisa Nafi’ah, Nadya Ismi Nani Dharmasetiawani Nisa Yulianti Suprahman Ofa Suzanti Betha Partomuan Simanjuntak Prasetio, Nisrina Putri PUSPITA LISDIYANTI Putri Mulia, Ocha Rahmadi Agus Rahmasari, Ratika Rahmi Hutabarat Sembiring, Enny Rimita Septiarini, Tri Hastuti SHANTI RATNAKOMALA Shanti Ratnakomala Silvia Surini Siswa Setyahadi Siswa Setyahadi Sri Wardatun Subagja ., Subagja Sunarsih Sunarsih Susandra Jaya Sutriyo Vicha Vicha WIBOWO MANGUNWARDOYO Yahdiana Harahap Yodifta Astiningrum Yodifta Astriningrum Yodifta Astriningrum, Yodifta Yulianita Pratiwi Indah Lestari