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All Journal AL KAUNIYAH El-Hayah : Jurnal Biologi CALYPTRA : Jurnal Ilmiah Mahasiswa Universitas Surabaya Indonesian Journal of Cancer Chemoprevention Jurnal Penelitian Pendidikan IPA (JPPIPA) IRJE (Indonesian Research Journal in Education) JURNAL PENDIDIKAN TAMBUSAI IKRA-ITH EKONOMIKA Jurnal Ekonomi dan Bisnis Dharma Andalas JURNAL ILMIAH ADVOKASI Mulawarman Law Review Coopetition : Jurnal Ilmiah Manajemen LEGAL BRIEF Jurnal Al Azhar Indonesia Seri Ilmu Sosial Medfarm: Jurnal Farmasi dan Kesehatan Pharmademica: Jurnal Kefarmasian dan Gizi JIPRO : Journal Of Intellectual Property Edu Society: Jurnal Pendidikan, Ilmu Sosial dan Pengabdian Kepada Masyarakat Journal of Tropical Food and Agroindustrial Technology JAPI: Jurnal Akses Pengabdian Indonesia Jambura Journal Civic Education Innovative: Journal Of Social Science Research Jurnal Informatika Ekonomi Bisnis Enrichment: Journal of Multidisciplinary Research and Development Indonesian Journal of Law and Justice Seminar Nasional Riset dan Teknologi (SEMNAS RISTEK) Yuriska : Jurnal Ilmiah Hukum Jurnal Info Kesehatan
Erna Susanti
Universitas Mulawarman
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : AL KAUNIYAH

 1 
Potential Combination of Cermai (Phyllanthus acidus) and Mulberry (Morus alba) Fruit Extract as a Candidate For Tyrosinase Inhibitor Susanti, Erna; AS, Nour Athiroh; Ramadhan, Majida; Mardhiyah, Mardhiyah; Noor, Mahanem Mat
Al-Kauniyah: Jurnal Biologi Vol 18, No 2 (2025): AL-KAUNIYAH JURNAL BIOLOGI
Publisher : Department of Biology, Faculty of Science and Technology, Syarif Hidayatullah State Islami

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/kauniyah.v18i2.42571

Abstract

Melanin, a pigment derived from UV radiation, is crucial in preventing skin damage and can cause aesthetic and dermatological problems such as hyperpigmentation or hypopigmentation. Melanogenesis is a complex process involving enzymes and cytokines, with UV being a primary contributor. Tyrosinase is a key enzyme in melanin synthesis. This study aims to test the potential of combining cermai fruit extract (CE) and mulberry fruit (ME) as a tyrosinase inhibitor. The tests included antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method, total phenolic content using the Folin Ciocalteu method, flavonoid content using the AlCl3 colorimetric method, and sun protection factor (SPF) value using UV-Vis spectrophotometric method. The results showed that the highest total phenolic content was observed in (CE), followed by the combination of ME: CE in the ratio of 1:3, 1:1, 3:1, and then ME. The same pattern was seen in the flavonoid content assay results. The antioxidant activity, as indicated by the IC50 values, followed the following order CE 418.30%; ME: CE (1:3) 400.49%; ME: CE (1:1) 367.73%; ME: CE (3:1) 358.04%; and ME 344.43%. The highest SPF value was observed in ME. It can be concluded that this study shows that the combination of CE and ME extracts has potential as a tyrosinase inhibitor and skin protective agent from hyperpigmentation due to UV exposure.
Potential Combination of Cermai (Phyllanthus acidus) and Mulberry (Morus alba) Fruit Extract as a Candidate For Tyrosinase Inhibitor Susanti, Erna; AS, Nour Athiroh; Ramadhan, Majida; Mardhiyah, Mardhiyah; Noor, Mahanem Mat
Al-Kauniyah: Jurnal Biologi Vol. 18 No. 2 (2025): AL-KAUNIYAH JURNAL BIOLOGI
Publisher : Department of Biology, Faculty of Science and Technology, Syarif Hidayatullah State Islami

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/kauniyah.v18i2.42571

Abstract

Melanin, a pigment derived from UV radiation, is crucial in preventing skin damage and can cause aesthetic and dermatological problems such as hyperpigmentation or hypopigmentation. Melanogenesis is a complex process involving enzymes and cytokines, with UV being a primary contributor. Tyrosinase is a key enzyme in melanin synthesis. This study aims to test the potential of combining cermai fruit extract (CE) and mulberry fruit (ME) as a tyrosinase inhibitor. The tests included antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method, total phenolic content using the Folin Ciocalteu method, flavonoid content using the AlCl3 colorimetric method, and sun protection factor (SPF) value using UV-Vis spectrophotometric method. The results showed that the highest total phenolic content was observed in (CE), followed by the combination of ME: CE in the ratio of 1:3, 1:1, 3:1, and then ME. The same pattern was seen in the flavonoid content assay results. The antioxidant activity, as indicated by the IC50 values, followed the following order CE 418.30%; ME: CE (1:3) 400.49%; ME: CE (1:1) 367.73%; ME: CE (3:1) 358.04%; and ME 344.43%. The highest SPF value was observed in ME. It can be concluded that this study shows that the combination of CE and ME extracts has potential as a tyrosinase inhibitor and skin protective agent from hyperpigmentation due to UV exposure.
Co-Authors Adhi Susano Aditya Hermawan, Aditya Alia Alusyanti Primawati Amelia, Deni Amukti, Enggal Triya Ananda, Muhammad Rizky Apriyanti , Nike Arifah, Salsabila Budi Ashoka, Izza Fauzia Aulya, Muhammad Choirida, Alma Damanik, Amsari Denada Futri Talia Dewi Kumala Sari Efendi, Muhammad Fauzan Eko Nursalim, Eko Emilda Kuspraningrum Endang Susilowati Fakhri, Arsyad Raziq Fauziyah, Tryana Hardani, Ika Harisriwijayanti , Harisriwijayanti Hediati, Febri Noor Huriadana, Asra Irwansyah Irwansyah Kacita, Sisillia Kartika, Avrillia Cindy Khairi, Awalul Khairunnisa, Ummul Kyrani, Velysha Rania lestari, winda Lingga Nico Pradana Mahanem Mat Noor, Mahanem Mat Mahendra, Yusril Mardhiyah, Mardhiyah Mardiyah Mardiyah Minggarwati, Trian Sidha Nour Athiroh Abdoes Sjakoer Nur Arifudin Parlina, Iin Perdana Oskar, Dimas Pianda, Didi Pratama, George Christian Pratiwi, Nurul Aziz Purwanto Purwanto Rahmayeni, Zulwida Ramadhan, Majida Ramadhani, Saskia Nadya Ravelby, Thesa Alif Ridianita, Cyntia Risma Aprinda Kristanti Roihatul Mutiah Sa'pang, Grecia Melisa Safitri, Adinda Hariana Safitri, Malikah Sanjaya, Infan Santi, Novi Sasmitha, Rahmat Mubaroh Mulya Setiadi, Antonius Adji Prayitno Setyadini, Ellyvına Simamora, Priskila Putri Sugiharto, Grisela Mawa Aqilah Suhery, Suhery Suryana, Rafdi Susilowati, Ervan Suwandhani, Deni Syukri Hidayatullah Syukriah Syukriah, Syukriah Tombi, Johan Tri Noval Hendrian Triana, Lily Triyana, Lily Wardana, Khristyawan Wisnu Wasilatul Murtafiah Wibowo, Yosi Irawati Wisnudari, Elly Dian Wulandari, Nur Azizah Yonita, Riza Yosua, Ricard Michail