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Journal : Jurnal Farmasi Sains dan Praktis

SAGO STARCH AND SODIUM ALGINATE AS NATURAL CROSSLINKING FOR CAPSULE ALTERNATIVES Harimurti, Sabtanti; Mulyanti, Amelia Nur'afni; Kusnindyasita, Anisa; Widada, Hari; Febriansah, Rifki; Suwanda, Totok; Muhtadi, Muhtadi
Jurnal Farmasi Sains dan Praktis Vol 9 No 3 (September-December 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i3.8856

Abstract

Capsule shells are generally made from gelatin. The gelatin that is spread in the world is commonly derived from pigs. This animal is forbidden to be consumed by Muslims. This issue is due to the halal aspect. Sago starch and sodium alginate are halal materials that are capable of gelatinizing. This property made it able to be molded as a capsule. This research aims to determine the formula of sago and sodium alginate as a capsule and the evaluation. Three formulas were made with the ratio of sago and sodium alginate 100%: 0% (formula 1), 50%: 50% (formula 2), and 0%: 100% (formula 3). The capsule was manually molded using a food-grade stainless steel capsule mold. The size of the capsule, weight uniformity, swelling, and disintegration time were determined for a physical evaluation. SLD was used to determine the best formula, and the validation was done using One-sample T-test. The evaluations of the capsule shell were found ranged as follows: the size specifications were 21-22 mm, the body diameter was 6.1-7.2 mm, the cap diameter was 13.6-13.8 mm, weight uniformity was 0.10-0.26 gram, the swelling test was 433-1583%, and the disintegration time was 10.20-14.43 minutes. The best formula based on the SLD of the experiment was formula 3, which are two parameters that met the requirements, i.e., swelling and disintegration time. The sago and sodium alginate were crosslinked, and the capsule was made. However, the performance dislike of gelatin capsules. Continued research shall be done to find the optimum formula and its characteristics for alternative material on halal capsules.
Co-Authors Adi Nugroho Adi Purnama Adi, Rahmad Kuncoro Aditya Kurniawan Aditya Kurniawan Ady Ryan Romadhan Agung Astuti Ahmad Janan Febrianto Ahmad Muslim Aji Wijayanto, Nur Ardiyansyah, Nur Arifin Arifin Aris Widyo Nugroho Asmara, Muhammad Rafi Astuti, Agung Azhar, Chusnul Azizah, Aulia Fitri Nur Azmi, Azhim Asyratul Bambang Riyanta, Bambang Bayu Satriya Wardhana Budiantoro, Cahyo Budiyantoro, Cahyo Cahyani, Isma Afdwi Deny Fajrur Ramdani, Deny Fajrur Diharjo, Kuncoro Dwi Saputra, Muhammad Rifai Dwi Saputra, Muhammad Rifai Febriansyah, Albyan Windra Fitroh Anugrah Kusuma Yudha Hadi Prayitno, Hadi Hakim, Moh. Hari Widada, Hari Ikhsan, Subkhan Nur Imam Crespo Padilah Imbaraga, M. Rafiudin Iswanto Iswanto Jannah, Meyriska Julianto, Achmad Zamhari krisdiyanto, krisdiyanto Krisdiyanto, Krisdiyanto Kuncoro Diharjo Kuncoro Diharjo Kusnindyasita, Anisa Muh Budi Nur Rahman, Muh Budi Nur Muhajir Muhajir, Muhajir Muhammad Budi Nur Rahman Muhammad Budi Nur Rahman, Muhammad Budi Muhammad, Bagja Restu Muhammad, Bagja Restu Muhtadi Muhtadi Mujiyana Mujiyana Mulyanti, Amelia Nur'afni Muniib, Abdin Nugroho, Ahmad Restian Adi Nur Ardiyansyah Nyeleker, Kerkulah P Pradana, Benanta Ogi Prasetyo, Satria Iman Puspitasari, Alfina Dwi Rahman, Khukuh Aulia Rahman, Muh Budi Nur Rahman, Muhammad Budi Nur Rahman, Muhammad Budi Nur Rahman, Reza Taufikur Ramdani, Deny Fajrur Ramdhan, Gilang Joy Habib Reza Taufikur Rahman Rifki Febriansah Riza, Eduar Iqbal Romadhan, Ady Ryan Romi Wilza S. Sudarisman Sabtanti Harimurti, Sabtanti Santosa, Tito Hadji Agung Septian Aldo Serena Serena, Septian Aldo Sigit Hidayat Nuri Sigit Hidayat Nuri, Sigit Hidayat Sosiati, Harini Subkhan Nur Ikhsan Suminto, Joko Sunardi, Sunardi Syahputra, Koko Nusyi Syaifudin, Eko TH Adi Nugroho Tri Yulianto Trisnani, Wenny Nur Wahyudi, Wahyudi Wilza, Romi Yudha, Fitroh Anugrah Kusuma