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All Journal Jurnal Veteriner Majalah Kedokteran Bandung Althea Medical Journal Jurnal Kesehatan Andalas Global Medical and Health Communication Jurnal Kebidanan The Indonesian Biomedical Journal Universa Medicina JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA Indonesian Journal of Obstetrics & Gynecology Science PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Lintas Keperawatan Folia Medica Indonesiana
Vita Murniati Tarawan
Faculty Of Medicine, Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Journal : Jurnal Veteriner

 1 
Ethionamide Modulates of Thyroid Stimulating Hormone, Thyroxine, and Triiodothyronine Levels in White Ratstimulating Hormone (TSH), Thyroxine (T4), and Triiodothyronine (T3) Serum are potentially modulated Level by Ethionamide in Rats ronny lesmana; Fani Rahma Yenita; Prayudi Santoso; Hanna Goenawan; Arto Yuwono Soeroto; Yuni Susanti Pratiwi; Nova Sylviana; Iwan Setiawan; Vita Murniati Tarawan; Unang Supratman
Jurnal Veteriner Vol 21 No 3 (2020)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (141.585 KB)

Abstract

Multidrug-Resistant Tuberculosis (MDR-TB) infection is not solely caused serious impact for patient and cause long recovery process. Multidrug-Resistant Tuberculosis needs specific treatment approach using second-line TB drugs. Ethionamide as one of medication used in MDR-TB are known to cause greater side effects compared to the first-line drugs. One of side effect like hypothyroidism is remain unclear. There is limited study about role of ethionamide cause hypothyroidism. In this present study, 24 male, wistar rats were divided into three groups: ethionamide group; positive control positive (propylthiouracil) and negative control group (received distilled water only) and treated accordingly for 12 week. Under ketamine and xylazine anesthesia, blood sample were collected from retroorbital vein at 8 and 12 week, put in EDTA tube and stored -20Ë%C until use. After last sampling, rat were sacrificed using CO2 chamber. Our data showed that thyroid stimulating hormone (TSH) levels in ethionamide group is increased from 8 weeks to 12 weeks significantly, but there is no significant changes in control groups. Thyroxine (T4) levels is trend decreased from 8 weeks to 12 weeks compared to control groups. There is no change of Triiodothyronine (T3) levels. Effect of ethionamide on thyroid hormone (T3 and T4) levels was not prominent and there were no significant changes observed. Interestingly, we observed an increase of TSH level after ethionamide treatment. Taken together, 12 week treatment of ethionamide tablet might potentially modulate thyroid hormone (T3 and T4) levels that is reflected from an increase of TSH levels in the plasmas feed back negative mechanism.
Effect of Specific Formulated Feed to Alter the Glucose, Triglycerides and Total Cholesterol Level in Rat (EFEK FORMULASI PAKAN TIKUS TERHADAP PERUBAHAN KADAR GLUKOSA, TRIGLISERIDA DAN KOLESTEROL TOTAL) Jihan Mudrika Rahmi; Ronny Lesmana; Hana Goenawan; Setiawan Setiawan; Vita Murniati Tarawan; Okta Wismandanu; Unang Supratman
Jurnal Veteriner Vol 20 No 2 (2019)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (997.945 KB) | DOI: 10.19087/jveteriner.2019.20.2.179

Abstract

Understanding the molecular mechanism of type 2 diabetes mellitus using human sample is very difficult, therefore utilization of animal model can be the solution for studying diabetes mellitus. However, there is still limited option of the animal model that can describe the process of type 2 diabetes mellitus. The aim of this study is to develop a formulated feed with increased glucose, triglycerides, and total cholesterol as characteristics of type 2 diabetes mellitus. This study was done using a descriptive method and experimental study design for 8 weeks. Total 9 male and 12 female Wistar rats were randomly divided into 3 groups: 1 control group and 2 treatment group (formula 1: high carbohydrate, formula 2: high fat). The increase of delta mean body weight was higher in the group given formula 1 for both male and female rats (f: 52g, m: 71.67g). The glucose level was increase from 4th- 8th week in both gender of rats and higher in the group given formula 1 of female rats (4W: 221.13 mg/dl; 8W: 249.83 mg/dl). The triglycerides level was increased from 4th to 8th week and higher in group given formula 2 either male (4W: 37.42 mg/dl; 8W: 58.92 mg/dl) but not in female rats (4W: 76.78 mg/dl; 8W: 71.22 mg/dl). The cholesterol total level also increased in male (4W: 93.05 mg/dl; 8W: 282.5 mg/dl) and female (4W: 101.58 mg/dl; 8W: 227.17 mg/dl) rats and higher in the group given formula 1. In conclussio, either high carbohydrate or high fat pellet showed potential capability to increase the glucose, triglyceride and total cholesterol level especially in female rats.
Co-Authors Akhmad Yogi Pramatirta, Akhmad Yogi Arto Yuwono Soeroto Astrid Feinisa Khairani Astrid, Stephanie Atika Andianti Aziis Mardanarian Rosdianto Benny Hasan Purwara Benny Muliawan Daba, Mariel Dany Hilmanto Decky Gunawan, Decky Diah Dhianawaty Diah Dhianawaty Diana Krisanti Jasaputra Dimpuulina Erna Mariati Dwi Prasetyo Edhyana Sahiratmadja Fani Rahma Yenita Fernandez, Veronica Fitria Fitria Gunadi, Julia Windi Hana Goenawan Hanna Goenawan Hardisiswo Soedjana Hendarsyah Suryadinata Irma Ruslina Defi Iwan Setiawan Iwan Setiawan Jatnika, Danti Dja Jihan Mudrika Rahmi Julia Windi Gunadi Kastella, Faysal Krisnadi, Sofie Riyani Leonardo Lubis Lisa Hasibuan Mariel Daba Nelly Amalia Risan, Nelly Amalia Nova Sylviana Nurul Husna Okta Wismandanu Prasetyo, Wibowo Budi Prayudi Santoso Putra Haqiqie Adnantama Lubis Qiantori, Adziqa Ammara Rachmawati, Anita Radhiyanti, Putri Teesa Rahdiyanti, Putri Teesa Ramadhanti, Julia Ray, Hamidie Ronald Daniel Rokhimawaty, Afita Ronny Lesmana Rosdianto, Aziis Mardanarian Ruswana Anwar Setiawan Setiawan Shelly Iskandar Siti Sakinah Siti Sakinah, Siti Sofiyanti, Santi Sunarjati Sudigdoadi Susiarno, Hadi Syahida, Jihan Alifa Teresa Lucretia, Teresa Tiodora Arimenda Br. Subekti Titing Nurhayati Unang Supratman Wahyu Widowati Widiyanti, Alvira Yuni Susanti Pratiwi Yuni Susanti Pratiwi, Yuni Susanti