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Journal : Jurnal Sains dan Kesehatan

Senyawa Metabolite Sekunder dan Aktifitas Afrodisiak Ekstrak Etanol Cabe Jawa (Piper retrofractum Vahl) Secara In silico: Secondary Metabolite Compounds and Aphrodisiac Activity of Ethanol Extract of Cabe Jawa (Piper retrofractum Vahl) With In silico Methode Taufikurrahman, Taufikurrahman; Widyowati, Retno; Sukardiman, Sukardiman
Jurnal Sains dan Kesehatan Vol. 6 No. 5 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i5.2391

Abstract

Erectile dysfunction is one of the most common sexual problems in men. Drugs available on the market can be used to treat this problem, but the use of these drugs often causes unwanted side effects, the use of natural ingredients as an alternative treatment is increasingly popular, one of which is a herb made from chili jamu (Piper retrofractum Vahl). Metabolite profiling of the chili jamu plant turns out to be different depending on the location of growth, it is thought to result in differences in natural conditions and circumstances which result in differences in aphrodisiac activity. Cabe Jawa extracted with 96% ethanol was analyzed using LC / MS, detected as many as ten secondary metabolites namely, Salsolinol, Quercetin, Caffeoyl putrescin, Diferuloyl putrescine, Feruloyl tyramine, Hydroxychloroquine, Tetrahydropapaveroline, Piperine, N-Oleyl-Leucine, Capsaicin. From the results of in silico tests, it is known that piperine has activity as a phosphodiesterase type 5 (PDE5) inhibitor with binding energy and inhibition constant values of -8.62 kcal/mol and 0.485 uM. Keywords:          Piper retrofractum Vahl, Secondary metabolite, Aphrodisiac   Abstrak Disfungsi ereksi merupakan salah satu masalah seksual yang paling umum terjadi pada pria. Obat yang tersedia di pasaran dapat digunakan untuk mengatasi masalah ini, tetapi penggunaan obat tersebut seringkali menimbulkan efek samping yang tidak diinginkan., penggunaan bahan alami sebagai alternatif pengobatan semakin populer, salah satunya yaitu ramuan berbahan cabe jamu (Piper retrofractum Vahl). Metabolit profiling dari tanaman cabe jamu ternyata berbeda-beda tergantung dari lokasi tumbuhnya, hal tersebut diduga mengakibatkan perbedaan kondisi dan keadaan alam yang berakibat pada perbedaan aktivitas afrodisiak. Cabe jamu yang diekstrak dengan etanol 96% di analisa dengan menggunakan LC/MS, terdeteksi sebanyak sepuluh metabolite sekunder yaitu, Salsolinol, Quercetin, Caffeoyl putrescin, Diferuloyl putrescine, Feruloyl tyramine, Hydroxychloroquine, Tetrahydropapaveroline, Piperine, N-Oleyl-Leucine, Capsaicin. Dari hasil uji in silico diketahui bahwa piperine memiliki aktifitas sebagai penghambat phosphodiesterase type 5 (PDE5) dengan nilai energi ikat dan konstanta inhibisi sebesar -8,62 kkal/mol dan 0,485 uM. Kata Kunci:         Piper retrofractum Vahl, Metabolite sekunder, Afrodisiak
Co-Authors Abdul Wakhid Agustian Putra, Ilham Ahmad Barizi Ahmad Junaidi Aji Saputra, Muhamad Akhmad Fathir Ali Efendi, M Sabilal Alief Putriana Rahman Amorita Azzahra Annizham, Rizqi Aprilina, Della Ardi Saputri, Amelia Oktavia Ardiyana, I Gede Aris Munandar Ayu Rahmawati, Diya Ayu, Nabila Sukma Baihaqi Yusuf, Ahmad Riki Berlian, Rizky Beth Nasarani, Eunike Elisa Bintari, Padang Fitria Cendrawati, Vinda Chairun Nisa Chatarina Umbul Wahyuni Dahri, Ahmad Dary, Dary David Chandra Dewi Sasmita, Retna Dian Rahmatika, Ajeng Dieva, Diknastiya Putri Diva Nabilah, Larissa Dzurriyah, Afifatudz Eka Prakarsa Mandyartha Eliza, Nidya Fadila Aprilia, Farah Fajrin, Megawati Fatimatuzzahro, Ucik Febriari Rahmawati, Ernesta Gita Kharisma Effendhi Hakim, Ichsanul Hamidah, Nazala Zalfa Hardiansyah, Putra Bima Hasanah, Muidatul Hayu Pinasthi, Driyaningrum Hidayanti, Wulandari Hisyam, Ali Ida Syamsu Roidah, Ida Syamsu Imam M, Alfiandi Indra Gunawan Irmawati, Eka Febrianti Fera Istibsyaroh Ar Ruhimat*, Imroati Kamila, Shaffa Cahya Karimah, Nabilatul Kholifah, Ni'matul Kurniasari, Dian Nova Kusmiarto, Kusmiarto Kusuma Wardani, Renata Dian Kusuma, Septian Agung Putra Kusumawati, Nabila Dhea Laksmana Putra, Setyo Febri Lubis, Daffa Ghifari M Mansur, M Maslikhatun Aliyah, Siti Maulana, M. Reza Maylani Amelia Putri Meiyantika, Alodiya Sifa Mochammad Imron Awalludin Muhammad Banda Selamat Munib Munib, Munib Muslimah, Izzah Asyanti Nabila Pramana, Tasya Nabilah, Larissa Diva Nafisah Nurulrahmatiah Niken Amalia Rusmedi Ninik Nihayatul Wahibah Nisrina, Adinda Yumna Novitasari, Dwi Sukma Nur Fadillah, Ayu Nur, Muhammad Ilham Fauzi Nurbaiti Nurbaiti Nurrahmah Nurrahmah, Nurrahmah Oka Warmana, Gde Oktavia, Ade Ririn Pradila, Faiq Pranata, Hanif Ardhi Pratama, Muhammad Alif Pratiwi, Vira Puspita, Eka Amelia Putra, Muhammad Rassya Putri Nur Azizah, Putri Nur Putri, Fatma Jumaita Rahma Krisna, Nabilah Rahman, Fathin Rahmayanti, Silvia Ramadhan, Ike Ramadhani, Putri Oktavia Retno Widyowati REZA FAHLEVI Riandi, M. Inas Riswan, Mokhamad Romli Romli, Romli Sabilal Ali Efendi, M Sabitha, Alifa Sadrai, Maharani Putri Salsabilla, Dalfinta Nadya Saputra, Farta Ade Setianti, Ikko Ukumi Putri Setiawan, Winda Putri Setiawati, Putri Shivam Vivekananda, Gipih Siti Saliyah, Fildha Hibatur Rahma Soeliyono, Firda Fitri Sri Wibawani, Sri Subhanulfikri, Muhammad Faiz Sugeng Prasetyo Sukardiman Sundari, Ella Supriadi - Surya Murti, Deva Suryana, Didi Sutrisno, Alifia Iga Syafei, Syafei Syamsul Rizal Syarifudin Syarifudin Syarivah, Ulvatus Tahsin, Akhmad Fatih Nabil Tri Aidhaningtyas, Fera Triputra, Yuli Asmara Umbara, Leony Ayu Puteri Umi Sumbulah Wahyu Hidayat wahyuni wahyuni Wardani, Renata Dian Kusuma Widya Pramesti, Arin Wijaya, Aditya Satria Wiyono, Ahmad Y., Rizky Brillian Y. Yaqutun Nafis, Attin Zulfi, Adetya Nindra