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All Journal International Journal of Evaluation and Research in Education (IJERE) Prosiding Seminar Biologi Jurnal Pendidikan Sains Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Indonesian Journal of Islam and Muslim Societies Indonesian Journal of Urology Jurnal Bioterdidik: Wahana Ekspresi Ilmiah Bioedukasi: Jurnal Pendidikan Biologi Jurnal Pendidikan Biologi Indonesia Biology, Medicine, & Natural Product Chemistry Jurnal Florea UNEJ e-Proceeding Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan BIOEDUKASI Diklabio: Jurnal Pendidikan dan Pembelajaran Biologi Proceeding Biology Education Conference Berkala Penelitian Hayati Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) Ta'dib Jurnal Ilmu Hayat
Umie Lestari
Universitas Negeri Malang
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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Journal : UNEJ e-Proceeding

 1 
THE EFFECTS OF WATER FRACTION OF BITTER MELON (MOMORDICA CHARANTIA) LEAF EXTRACT IN MAMMARY GLAND DEVELOPMENT OF BALB/C MICE (MUS MUSCULUS) WITH HISTOLOGICAL AND MOLECULAR BIOLOGICAL ANALYSIS OF PROTEIN APPROACHES Nur Hayati; Afifah Nur Aini; Nafisatuzzamrudah Nafisatuzzamrudah; Umie Lestari
UNEJ e-Proceeding 2016: Proceeding The 1st International Basic Science Conference
Publisher : UPT Penerbitan Universitas Jember

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Abstract

Recently many breast-feeding mothers use chemical drugs to ease milk secretion, while the said drug could cause side effects if consumed in a long time. The problem could be solved by using natural medicine like bitter melon leaf because it contains charantin which is characteristically identical to phytosterol [6]. This study aimed to discover the potention of water fraction of bitter melon leaf extract to stimulate mammary gland development in Balb/c mice. The development of mammary gland was observed through histological approach by calculating the number of cells in mammary gland, and through molecular biological analysis of protein approach by using SDS-PAGE. The histology of mammary gland showed that the administration of the extract with concentration of 11,200 ppm had the highest number of cells, followed by 5,600 ppm; 22,400 ppm and 16,800 ppm. The result of SDS-PAGE on isolated mammary gland protein showed that the molecular weight of the proteins in the controlled treatment were 2, 5, 8, 10, 12, 19, 34, 40 and 49 kDa. In treatment with concentration of 5,600 ppm there were only 10, 12, 34, 40 and 49 kDa. In treatment with concentration of 11,200 ppm there were similar kinds of proteins with the controlled treatment, only without the 8 kDa protein. In treatment with concentration of 16,800 and 22,400 ppm, there were only 2, 5, 10, 12 kDa. The conclusion of this study was water fraction of bitter melon leaf extract could affect the development of mammary gland in Balb/c mice.
Co-Authors Abdul Gofur Abdul Gofur Abdul Gofur Abdul Gofur Abu Husen Abu Husen Afifah Nur Aini Alif Yanuar Zukmadini Aloysius Duran Corebima Amin, Ihya Fakhrurizal Anton Setia Budi Ardiyas Robi Saputra Basuki B Purnomo, Basuki B Beno Wahono Beno Wahono, Beno Betty Lukiati Cicilia Novi Primiani Cicilia Novi Primiani Cicilia Novi Primiani Cicilia Novi Primiani, Cicilia Desy Putri Rahmawati Dewi Murni Dina Maulina Dina Maulina Dwi Anggorowati Rahayu Endang Suarsini Endik Deni Nugroho Fahmi, Muhammad Najib Farizha Irmawati Farizha Irmawati, Farizha Fitri, Nurul Hadi Suwono Haqqi Anajili Setyanto Haqqi Anajili Setyanto Herawati Susilo Ihya Fakhrurizal Amin Ika Oktaviana Ika Oktaviana, Ika Istamar Syamsuri Istamar Syamsyuri Izza Rohman Kurniawan Setia Putra Listawati, Rizki Mei Misgiati, Misgiati Mochammad Ali Mashur Moh. Amin Mohamad Amin Mohamad Amin Mohamad Amin Mohamad Amin Mohamad Amin Mohamad Amin Mohamad Amin Mohamad Amin Mohamad Amin Mohamad Amin Mohammad Amin Mohammad Amin Mohammad Amin Mohammad Amin Monalisa PJ Taihuttu Muh. Nur Akbar Murni Sapta Sari Nafisatuzzamrudah Nafisatuzzamrudah Nanda Earlia Nandang Mufti Naning Wahyuni Nindya Ulfa Wardhani Nugrahaningsih Nugrahaningsih Nur Hayati Rahman Fadli Rahmawati D Rahmawati Darussyamsu Reni Istiningrum RENI ISTININGRUM Ridho, Muhammad Andi Ali Ristiana, Evi Ritia Rahmawati Ritia Rahmawati Rizka Elan Fadilah, Rizka Elan Rizki Mei Listawati Rizkia Suciati Rizkia Suciati Saparuddin Saparuddin Sembiring, Rinawati Siti Nur Arifah Siti Rahma Lestaluhu Sri Endah Indriwati Sri Rahayu Lestari Sulistyo Dwi Kartining Putro Sulistyo Dwi Kartining Putro Susriyati Mahanal Sutiman B Sumitro Sutiman B Sumitro, Sutiman Sutiman B. Sumitro Ulin Nuha Ulin Nuha Ulya Ruwaida Umi Fitriyati Urla Tri Wulanzani Urla Tri Wulanzani