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All Journal JURNAL FARMASIMED (JFM) Contagion: Scientific Periodical Journal of Public Health and Coastal Health Best Journal (Biology Education, Sains and Technology) Indonesian Journal of Pharmaceutical and Clinical Research Journal of Functional Food and Nutraceutical Jurnal Penelitian Farmasi dan Herbal Journal of Pharmaceutical and Health Research Journal of Multidisciplinary Applied Natural Science Jurnal Sains dan Teknologi Jurnal Pengabdian Masyarakat Bidang Sains dan Teknologi Nusantara Scientific Medical Research Journal PCJN Pharmaceutical and Clinical Journal of Nusantara Herbal Medicine Journal

Vera Estefania Kaban

Program Studi Farmasi, Sekolah Tinggi Ilmu Kesehatan (STIKes) Senior Medan

Author-ID : 4094083

Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Transportation Veterinary

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Aktivitas Antibakteri Ekstrak Etanol Daun Alpukat (Persea americana Mill) Terhadap Escherichia coli, Salmonella typhi, dan Pseudomonas aeruginosa Nasri Nasri; Vera Estefania Kaban; Hariyadi Dharmawan Syahputra; Denny Satria
Herbal Medicine Journal Vol 5 No 1 (2022): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Infectious disease is a serious health problem in the world of health. Escherichia coli causes diarrhea, Salmonella typhi causes typhoid fever, and Pseudomonas aeruginosa causes nosocomial infections which are Gram-negative pathogenic bacteria. Treatment with antibiotics is the therapy that is currently used, but other efforts in the use of herbal medicines are also being carried out in various studies. The purpose of this study was to analyze the antibacterial activity of the ethanolic extract of avocado leaves (Persea americana Mill.) against Escherichia coli, Salmonella typhi, and Pseudomonas aeruginosa. The method used is agar diffusion (Kirby-Bauer) with variations in the concentration of the test solution. The results showed that at a concentration of 500 mg/mL the three bacteria had an inhibition zone diameter of Escherichia coli with a value of 12.37±0.15 mm, Salmonella typhi with a value of 11.60±0.20 mm and Pseudomonas aeruginosa with a value of 10.87±0.15 mm. The ethanol extract of avocado leaves (Persea americana Mill.) showed antibacterial activity against three Gram-negative pathogenic bacteria.

Formulasi dan Uji Efektivitas Sabun Pencuci Tangan dari Ekstrak Daun Pandan (Pandanus amaryllifolius Roxb.) Terhadap Bakteri Salmonella sp. Vera Estefania Kaban; Nasri N; Hariyadi Dharmawan; Denny Satria
Herbal Medicine Journal Vol 5 No 1 (2022): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Pandan leaf (Pandanus amaryllifolius Roxb.) is a plant that grows wild, which belongs to the Pandanaceae tribe which is used as a natural medicine. The purpose of this study was to determine the antibacterial effectiveness of the handwashing soap formulation of pandan leaf extract against Salmonella sp bacteria and which concentration was the most effective. Extracts were made by maceration method using 96% ethanol as solvent. Formulation with mass 1 and mass 2. Testing of antibacterial effectiveness was carried out by diffusion method using disc paper. The results of the examination of the simplicia characterization of pandan leaves were determined to determine the water content of 0.1575%, the determination of the content of the water soluble extract was 0.1233%, the determination of the concentration of the soluble extract in ethanol was 0.0054%, the determination of the ash content of 0.1575%, the determination of the content of the acid insoluble extract. 0.0101%. Simplicia screening results contain alkaloids, flavonoids, tannins, saponins, and polyphenols. The yield of pandan leaf extraction is 90 g. The results of testing the effectiveness of Salmonella sp antibacterial on the diameter of the most effective inhibition zone was obtained at a concentration of 15% with a diameter of 22.70 mm. The results of the research, it can be concluded that the formulation of hand soap preparations with pandan leaf extract has antibacterial effectiveness against Salmonella sp.

Pengujian Potensi Aktivitas Antibakteri dari Daun Cep-cepan (Saurauia cauliflora DC.) dalam Formulasi Sediaan Gel Terhadap Propionibacterium acnes Hariyadi Dharmawan Syahputra; Nasri Nasri; Vera Estefania Kaban
Herbal Medicine Journal Vol 5 No 1 (2022): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

One of the causes of acne is due to a bacterial infection such as Propionibacterium acnes during adolescent puberty. Empirical studies of secondary metabolites contained in Cep-cepan leaves have potential as promising antimicrobials. The main objective of this study was to determine the antibacterial activity of the ethanolic extract of Cep-cepan leaves formulated into a gel preparation against the bacteria Propionibacterium acnes that causes acne. This research method was carried out experimentally where the ethanol extract of cep-cepan leaves was formulated into a gel preparation consisting of (F1) control blank; (F2) 0.5%, (F3) 1%, (F4) 1.5% and positive control (Mediklin). The results of the evaluation of gel preparations at concentrations of 0.5%, 1%, and 1.5% were physically stable during storage at room temperature, homogeneous, and pH. Based on the results of testing the antibacterial activity of gel preparations in inhibiting bacterial growth at a concentration of 0.5% with an average inhibition zone diameter of 11.33 mm, a concentration of 1% with a value of 15.66 mm, a concentration of 1.5% with a value of 19.5 mm. The conclusion of this study is that the ethanol extract of cep-cepan leaves has promising antibacterial activity in the form of a gel formulation.

Formulasi Sediaan Gel dari Ekstrak Metanol Biji Alpukat (Persea americana Mill.) Sebagai Penyembuh Luka Sayat Pada Tikus Jantan (Rattus norvegicus) Vera Estefania Kaban; Nasri Nasri; Hariyadi Dharmawan Syahputra; Raissa Fitri; Zulmai Rani; Muhammad Fauzan Lubis
Herbal Medicine Journal Vol 5 No 2 (2022): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

The avocado (Persea americana Mill.) is a fruit that is often found. This versatile fruit has many benefits for humans. The benefits of avocado are as anti-hyperlipidemic, analgesic, anti-inflammatory, anticonvulsant, hypoglycemic, hypercholesterolemic, wound healing and prevent cancer. The aims of this study was to make avocado seed methanol extract into a gel preparation and to determine the effect of avocado seed methanol extract gel and at what concentration the effective treatment for wounds in mice and its comparison with Star Ag gel as a positive control. The research was conducted using an experimental method. The manufacture of avocado seed methanol exstract was carried out by maceration method using methanol as a solvent. The result of the study were statistically analyzed using One Way Anova. The result of the data analysis at a concentration of 5% obtained a sig value <0,05. Based on One Way Anova analysis of the five treatments, the most effective was avocado seed methanol extract gel with a concentration of 5%.

Lip Cream Formulation from Miana Leaf Extract (Coleus scutellarioides L.) As A Natural Dye Vera Estefania Kaban; Nasri Nasri; Hariyadi Dharmawan Syahputra; Junius Gian Ginting
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 2 No. 02 (2023): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/nsmrj.v2i02.80

Abstrack The miana leaves (Coleus scutellarioides L.) contain flavonoids that can provide specific dyes. The purpose of the study was to formulate miana leaf extract in lip cream preparations as natural dyes. The use of natural lip cream dyes is a solution to overcome the problem of synthetic lip cream dyes. One of the plants such as the miana leaves contains secondary metabolites, one of which is flavonoids which can provide dyes. The natural colors found in miana leaves can be used as natural dyes in cosmetics. The purpose of the study was to determine at what concentration the miana leaves produced the most optimal physical quality of color in the preparation of lip cream. The method of the research includes the manufacture of ethanol extract of miana leaves (Coleus scutellarioides L.) by maceration for 5 days with 96% ethanol solvent and followed by remeseration with the same solvent. The extract formulas used were 5%, 10%, and 15%. The evaluations included organoleptic, homogeneity test, physical test, pH test, irritation test and color preference test. The results of the lip cream preparation, the results of the organoleptic examination were declared to have a semi-solid dosage form, a distinctive odor and varied colors F1, cream color, F2 salmon red, F3 brick red, homogeneity examination results were declared homogeneous, the results of observation of the preparation did not state that there was no change on the shape, color and odor of the preparation, the average pH test results were 4.1, the test results were declared non-irritating, the result of the color preference of the three formulas that the panelists preferred was a concentration of 15% because the color was clear and very soft. Miana leaf ethanol extract can be made as a colorant in lip cream preparations.

A Review on The Benefits of Probiotics as Fermented Food against Several Diseases Nasri, Nasri; Silalahi, Jansen; Kaban, Vera Estefania; Satria, Denny
Journal Akademik Universitas Swiss German Vol 5. No. 1 (Aug 2023)
Publisher : Swiss German University & Perhimpunan Penggiat Pangan Fungsional dan Nutrasetikal Indonesia (P3FNI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33555/jffn.v5i1.110

Fermentation is a natural process when microorganisms such as yeast and bacteria convert carbohydrates such as starch and sugar into alcohol or acid. Some fermented products from microorganisms can be processed into foods that can be consumed and provide good health effects for the body. Fermented foods such as kefir, tempeh, natto, and kimchi are foods that produce probiotic bacteria, which are good bacteria that have a beneficial effect on the host when consumed in sufficient quantities (about 108–1011 CFU/mL). If probiotics are consumed in combination with prebiotics, they will have a synergistic effect called "synbiotics" and will increase the benefits of probiotics. Several in vitro, in vivo, and clinical studies have shown that probiotics can help with diseases like diarrhea, high cholesterol, diabetes, colon cancer, and dyslipidemia

UJI AKTIVITAS KANDUNGAN ANTIOKSIDAN PADA DAUN BANGUN-BANGUN (PLECTRANTHUS AMBOINICUS) SECARA SPEKTROFOTOMETRI ULTRAVIOLET-VISIBLE Kaban, Vera Estefania; Yusmarlisa, Siti
Jurnal FARMASIMED (JFM) Vol 1 No 1 (2018): Jurnal FARMASIMED (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

The population explosion that occurred in Indonesia has a profound effect on the quality of life of the community, such as the decline in the level of public health. Therefore leaf plants can be used as medicines that can be useful as antioxidants. Antioxidants are compounds that can inhibit free radicals due to the presence of reactive oxygen, so as to prevent various degenerative diseases. The compounds in the leaves of the buildings include flavonoids, alkaloids and polyphenols. To determine the presence of antioxidant content in wake-up leaves and to determine differences in antioxidant concentrations in wake-up leaves with vitamin C. Samples of leaves of the buildings used were obtained from the Pematang Siantar area, North Sumatra. Sample preparation was carried out by making leaf extracts. The activity test of antioxidant content in the wake-up leaf extract using ultraviolet-visible spectrophotometry. The results showed that there was a decrease in the value of DPPH absorbance given by the wake-up leaf extract test sample with vitamin C. A decrease in the absorbance value indicates a greater DPPH damping activity. The highest DPPH damping activity by leaf extracts of buildings with IC50 values of 20,2842 ppm can be categorized as having very strong DPPH damping activity. There is an antioxidant content with the IC50 category which is very strong in the leaves of the wake-up plant (Plectranthus amboinicus) and the higher the concentration of a test sample of wake-up leaf extract (Plectranthus amboinicus) and BPFI of vitamin C, the absorbance value decreases, The percentage of damping is higher and IC50 is lower, the antioxidant activity is higher.

Formulasi Pembuatan Sediaan Eyeshadow dari Ekstrak Bunga Kecombrang (Etlingera elatior Jack) Barus, Bunga Rimta; Kaban, Vera Estefania
Jurnal FARMASIMED (JFM) Vol 1 No 2 (2019): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

One type of cosmetic or decorative cosmetic preparation is eyeshadow which contains a color pigment applied to the eyelid. The purpose of this study was to find out that kecombrang flower extract can be used as eyelid coloring. From the study to make eyeshadow preparations using dyes extracted from kecombrang flowers, to determine the stability of the eyeshadow by using kecombrang flower extract in storage at room temperature, and to find out whether eyeshadow preparations using extracts from kecombrang flowers cause irritation when used. Eyeshadow preparations from kecombrang flower extract (Etlingera elatior Jack) were made in various concentrations of 15%, 17.5%, 20%, 22.5%, 25% and blank preparations (without using kecombrang flower extract). Physical quality inspection of the preparation includes: color dispersion test (homogeneity), cracking test, and stock stability test. And for other tests carried out polishing tests (homogeneity) and irritation tests. Eyeshadow from kecombrang flower extract also does not cause irritation and is stable in room temperature storage for 30 days. Preparation of kecombrang flower extract with several good concentrations was used as eyeshadow preparations, stable eyeshadow preparations in storage at room temperature within 30 days, and the formulation of eyeshadow preparations using kecombrang flower extract as eyelid coloring did not cause irritation.

Formulation and Evaluation of Cream Turmeric Extract Preparations from Turmeric Rhizomes (Curcuma domestica Val.) Kaban Vera Estefania; Jansen Silalahi; Sumaiyah Sumaiyah; Denny Satria
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 5 No. 1 (2022): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v5i1.6479

The use of plants as a method of herbal treatment is a step that is currently being developed by many researchers to produce effective and minimal side effects. Turmeric is one of the most widely used cooking spices by the people of Indonesia. The main ingredients possessed by turmeric include curcumin (77%), demethoxy (17%) and bisdemethoxy (3%). One of the pharmaceutical preparations with a topical delivery system is a cream preparation which is a semi-solid dosage form, containing one or more drug ingredients dissolved or dispersed in an appropriate base material. Turmeric can be formulated in various preparations, one of which is a cream dosage form. The advantage of using cream preparations is that they are practical, easy to wash and clean. The purpose of this study was to formulate turmeric extract in a cream preparation. The results of the evaluation test showed that the formula produced a cream with a yellow-orange color, a characteristic odor of turmeric, and a preparation with a semisolid cream texture, had good homogeneity, good dispersing ability, the pH of the preparation was 5.84; 6.32; 6.24; 5,94;5,94 and the type of emulsion is O/W (Oil in Water).

Investigation of Potential Molecular Targets of Zanthoxylum acanthopodium in Ovarian Cancer Using Network Pharmacology Assessments Wijaya, Johanna Fransiska; Chiuman, Linda; Syahputra, Hariyadi Dharmawan; Kaban, Vera Estefania; Razoki, Razoki; Ginting, Chrismis Novalinda; Iksen, Iksen
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 2 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.268

Ovarian cancer is a serious disease that affects the ovaries, and its early detection is challenging due to vague symptoms often dismissed as minor ailments. Currently, natural sources have gained attention for their potential role in anticancer treatment. This study aimed to utilize network pharmacology to explore the potential targets and mechanisms of Zanthoxylum acanthopodium in the treatment of ovarian cancer. This study utilized the KNApSAcK and Swiss Target Prediction to identify active compounds and target genes. Additionally, ovarian cancer-specific target genes were sourced from the GEO database. To identify possible key target genes, the network interaction between protein-protein using the STRING database and visualized them in Cytoscape. Subsequent analysis using Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enabled us to focus on primary therapeutic targets. Our investigation into Zanthoxylum acanthopodium revealed 10 active compounds that pass Lipinski rule of five and oral bioavailability with acceptable pharmacokinetic profiles, 88 therapeutic targets, and identified 5 hub genes: SRC, CCNB2, MMP9, PTGS2, and PTPRC, which are strongly associated with ovarian cancer progression. Pathway enrichment analysis highlighted several pathways significantly related to the pathogenesis of ovarian cancer. This study elucidates the therapeutic potential and mechanisms of action of Z. acanthopodium as a promising candidate for ovarian cancer treatment. However, further research, including both in vitro and in vivo studies, is necessary to understand its molecular mechanisms comprehensively.

Co-Authors Bangar, Roy Indrianto Barus, Bunga Rimta Br Sembiring, Novitaria Chiuman, Linda Chyntia Glori Tania Chyntia Glori Tania Denny Satria Dian Ika Perbina Meliala Firdaus Fahdi Friska Raulina Situmorang Ginting, Chrismis Novalinda Ginting, Junius Gian Harahap, Daimah Wirdatus Sanaun Hariyadi Dharmawan Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Henni Cintya Herviani Sari Iksen, Iksen Jansen Silalahi Jessi Octavia Aritonang Kasta Gurning Lumban Gaol, Irma Yohana Mahatir Muhammad Muhammad Fauzan Lubis Muhammad Fauzan Lubis Nasri N Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri, Nasri Ningsih, Wulan Seppia Raissa Fitri Razoki, Razoki Sihotang, Nurhanifah Simanjuntak, Nerly Juli Pranita Siregar, Nurhakiki Sumaiyah Sumaiyah Syahputra, Hariyadi Dharmawan Wahyudi Wahyudi Waruwu, Loice Desy Krisna Yanti Wijaya, Johanna Fransiska Yulia Citra Hasibuan Yusmarlisa, Siti Zulmai Rani

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