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All Journal JURNAL FARMASIMED (JFM) Contagion: Scientific Periodical Journal of Public Health and Coastal Health Best Journal (Biology Education, Sains and Technology) Indonesian Journal of Pharmaceutical and Clinical Research Journal of Functional Food and Nutraceutical Jurnal Penelitian Farmasi dan Herbal Journal of Pharmaceutical and Health Research Journal of Multidisciplinary Applied Natural Science Jurnal Sains dan Teknologi Jurnal Pengabdian Masyarakat Bidang Sains dan Teknologi Nusantara Scientific Medical Research Journal PCJN Pharmaceutical and Clinical Journal of Nusantara Herbal Medicine Journal Journal of Pharmaceutical and Sciences.
Vera Estefania Kaban
Program Studi Farmasi, Sekolah Tinggi Ilmu Kesehatan (STIKes) Senior Medan
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Transportation Veterinary

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Antioxidant Activity Test of The Aqueous Fraction of Tetanus Leaves (Leea aequata L.) Using The DPPH Method Siregar, Nurhakiki; Bangar, Roy Indrianto; Kaban, Vera Estefania; Simanjuntak, Nerly Juli Pranita
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 01 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i01.85

Abstract

Antioxidants play a crucial role in neutralizing free radicals, thereby helping to prevent cell damage and maintain overall health. This study aims to evaluate the antioxidant activity of the aqueous fraction of Tetanus (Leea aequata L.) leaf extract using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. The extraction process was carried out through maceration using ethanol as a solvent, followed by aqueous fractionation. Antioxidant activity was measured based on the extract’s ability to scavenge DPPH free radicals, expressed as the IC₅₀ value. The results showed that the aqueous fraction of Tetanus leaf extract exhibited high antioxidant activity, with an IC₅₀ value of 30.23 mg/L. The total phenolic and flavonoid contents in the aqueous fraction were 460.70 mg GAE/100g and 12,621.14 mg QE/100g, respectively. These findings align with pre vious studies indicating that the ethanolic extract of Leea angulata leaves also possesses strong antioxidant activity with a similar IC₅₀ value. Therefore, the aqueous fraction of Tetanus leaf extract has the potential to be an effective natural antioxidant source and can be further developed as a raw material for health supplements or pharmaceutical products.
Efficacy Test of Tetanus Leaf (Leea aequata L.) Ethanol Extract against Bacteria (Pseudomonas aeruginosa) Lumban Gaol, Irma Yohana; Bangar, Roy Indrianto; Kaban, Vera Estefania; Br Sembiring, Novitaria; Harahap, Daimah Wirdatus Sanaun
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 01 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i01.86

Abstract

Antibiotic-resistant nosocomial infections are caused by the opportunistic bacterium Pseudomonas aeruginosa. The purpose of this study is to use the disc diffusion method to assess the antibacterial efficacy of Tetanus (Leea aequata L.) leaf ethanol extract against Pseudomonas aeruginosa. The antibacterial activity was evaluated at 25%, 50%, and 75% concentrations after the leaves were extracted by maceration with 96% ethanol. The findings indicated that the antibacterial activity was depending on concentration, with respective minimum inhibition level measuring 12.97 mm, 16.7 mm, and 21.06 mm. The negative control (DMSO) displayed no inhibition zone, but the positive control (gentamicin) displayed KHM measuring 25.03 mm. The data distribution did not differ significantly, according to statistical analysis (p > 0.05). Bioactive substances that can harm bacterial cell structures, including flavonoids, alkaloids, tannins, and saponins, were thought to be responsible for this antibacterial action. According to these results, tetanus leaf extract may be used as a natural antibacterial agent and as a substitute for antibiotics in the treatment of Pseudomonas aeruginosa infections
Formulation and Evaluation of Tetanus Leaf (Leea aequata L.) Ethanol Extract on Tablet Preparation using Wet Granulation Method Ningsih, Wulan Seppia; Bangar, Roy Indrianto; Kaban, Vera Estefania; Harahap, Daimah Wirdatus Sanaun
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 01 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i01.87

Abstract

Degenerative diseases are currently widely suffered, especially in Indonesian society, as many as 30% of the population is detected with degenerative diseases. One alternative treatment that is widely consumed by Indonesian society is herbal or traditional medicine, one of the plants that is widely consumed by society, especially in Indonesia, namely Tetanus Leea Aequata L leaves. These leaves are often found, especially in the Karo area. The purpose of this study was to use ethanol extract of tetanus Leea Aequata leaves as tablets using the wet granulation method. The content contained in the leaves, such as Flavonoids, can be used as an alternative medicine to treat degenerative diseases by using a comparison of muchilago amyli used as a binder, namely f1 20%, f2 10% and F3 5% based on this study, a formula was obtained that can be used to make tablets, namely formula 1 20% muchilago amyli
Antioxidant Activity Test of The Ethyl Acetate Fraction of Tetanus Leaf (Leea aequata L.) Using The DPPH Method Waruwu, Loice Desy Krisna Yanti; Bangar, Roy Indrianto; Kaban, Vera Estefania; Br Sembiring, Novitaria
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 01 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i01.88

Abstract

Degenerative diseases, such as diabetes, stroke, and cancer, are increasingly common in modern society, with free radicals as one of the main causes. Both natural and artificial sources of antioxidants are available. However, natural antioxidants are a better choice due to concerns over the negative effects of synthetic antioxidants. This study aims to evaluate the antioxidant activity of ethanol extract from titanus (leea aequata L.) leaves using DPPH (2,2-diphenyl-1-picrylhydrazyl) method. titanus leaves are known to contain secondary metabolites that have potential as antioxidants, including flavonoids and phenols. This type of research is an experimental method. The extraction process was carried out by maceration method using 96% ethanol, followed by fractionation using solvents with different polarities to obtain ethyl acetate fraction. The results showed that the ethyl acetate fraction showed the ability as a free radical antidote with an IC50 value of 11.309 ppm, which indicates significant antioxidant activity. These results indicate that titanus leaf extract has the potential to be used as a source of natural antioxidants in the prevention of degenerative diseases.
Antioxidant Activity Test of Titanus (Leea aequata L) Leaf Extract with DPPH Method Sihotang, Nurhanifah; Bangar, Roy Indrianto; Kaban, Vera Estefania; Br Sembiring, Novitaria; Harahap, Daimah Wirdatus Sanaun
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 01 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i01.90

Abstract

Free radicals play an important role in oxidative stress, which can lead to a number of degenerative diseases, including heart disease, cancer and premature aging. Natural and artificial ingredients can be used to make antioxidants. The use of synthetic antioxidants is starting to be limited because excessive use can cause negative side effects, such as the accumulation of toxins in the body. This study aims to evaluate the antioxidant activity of tetanus (Leea aequata L.) leaf extract using DPPH method. Free radicals generated during metabolism can cause cell damage and contribute to various degenerative diseases. Therefore, it is important to find effective sources of antioxidants. In this study, Tetanus leaves were extracted using 96% ethanol solvent through maceration method. Antioxidant activity was evaluated by measuring the IC50 value against DPPH radical. The results showed that tetanus leaf extract had an IC50 value of 39.484 ppm, which indicated significant antioxidant activity. These results indicate that tetanus leaf extract can function as a free radical scavenging agent, which could potentially serve as a raw material in the development of herbal medicine to prevent oxidative stress-related diseases.
Computational Study of E-Compound from the Vitex Family as Novel Potential Anti-Alzheimer Agents: An in Silico Study Syahputra, Hariyadi Dharmawan; Nasri, Nasri; Kaban, Vera Estefania
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 3 No. 01 (2025): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/nsmrj.v3i01.93

Abstract

The degenerative disease of memory that most attacks the frontal lobe is Alzheimer's. Therapy for Alzheimer's is mostly done by targeting an increase in the amount of acetylcholinesterase in the synapse cleft by inhibiting the enzyme acetylcholinesterase. The purpose of this study is to conduct a comparative study of vitexifolin E compounds from the vitexium plant family with donepezil to obtain more precise and targeted drug candidates in Alzheimer's therapy. The results showed that donepezil compounds have a more active probability (0.53) of being carcinogenic compared to vitexifolin E with the web-based application Protox II. Tests with in silico studies found that the hydrogen bonding results of vitexifolin E had values close to those of donepezil drugs, as well as RMSD results with receptors between donepezil and vitexifolin E (1,781; 1,281) and free energy obtained (-6.9; -7.8). Based on these results, it can be concluded that vitexifolin E compounds can have good enough potential to be developed in implementing the treatment of Alzheimer's disease therapy.
Potensi Aktivitas Antioksidan dan Antibakteri Ekstrak Etanol Daun Kari (Murraya koenigii) terhadap Propionibacterium acnes Nasri, Nasri; Kaban, Vera Estefania; Rani, Zulmai; Suci, Nurul; Ferendina, Imelda; Tania, Chyntia Glori
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.881

Abstract

Indonesia is renowned for its rich natural resources, particularly medicinal plants with significant therapeutic potential. This study examined how the ethanolic extract of curry leaves (Murraya koenigii) can act as an antioxidant and antibacterial agent against Propionibacterium acnes, the primary cause of acne vulgaris. This study used phytochemical screening to identify secondary metabolites, such as alkaloids, flavonoids, tannins, saponins, and glycosides, which are associated with biological activities such as killing bacteria and protecting cells from damage. The DPPH method for testing antioxidants showed that the extract had an IC50 value of 45.88 mg/L, which is not significantly different from quercetin as a reference, at 23.7 mg/L. This result is still significant for the strong antioxidant category. We assessed antibacterial efficiency using a disc diffusion technique, which showed a zone of inhibition corresponding to the extract concentration. The widest zone of inhibition, measuring 17.77 ± 0.15 mm, was recorded at a concentration of 250 mg/mL, classifying its activity as strong by existing standards. These findings underscore the extract's promise as a natural acne therapy, addressing bacterial growth and oxidative stress. Furthermore, these results support the development of safe and efficacious pharmaceutical or cosmetic products derived from natural components. Future investigations should examine synergistic formulations and enhance bioavailability to optimize therapeutic outcomes.
Co-Authors Bangar, Roy Indrianto Barus, Bunga Rimta Br Sembiring, Novitaria Chiuman, Linda Chyntia Glori Tania Chyntia Glori Tania Denny Satria Dian Ika Perbina Meliala Ferendina, Imelda Firdaus Fahdi Friska Raulina Situmorang Ginting, Chrismis Novalinda Ginting, Junius Gian Harahap, Daimah Wirdatus Sanaun Hariyadi Dharmawan Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Henni Cintya Herviani Sari Iksen, Iksen Jansen Silalahi Jessi Octavia Aritonang Kasta Gurning Lumban Gaol, Irma Yohana Mahatir Muhammad Muhammad Fauzan Lubis Muhammad Fauzan Lubis Nasri N Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri, Nasri Ningsih, Wulan Seppia Raissa Fitri Razoki, Razoki Sihotang, Nurhanifah Simanjuntak, Nerly Juli Pranita Siregar, Nurhakiki Suci, Nurul Sumaiyah Sumaiyah Syahputra, Hariyadi Dharmawan Tania, Chyntia Glori Wahyudi Wahyudi Waruwu, Loice Desy Krisna Yanti Wijaya, Johanna Fransiska Yulia Citra Hasibuan Yusmarlisa, Siti Zulmai Rani