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Theopilus W Watuguly
Program Pendidikan Biologi, Jurusan PMIPA FKIP Dan Program Pendidikan Dokter Universitas Pattimura Ambon, Jl. Dr. Tamaela, Kampus Universitas Pattimura Ambon
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Other

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Aplikasi Ekstrak Kulit Buah Naga Merah (Hylocereus polyrhizus) Pada Nata De Coco Dalam Menurunkan Kadar Kolesterol Total, LDL, Dan Meningkatkan HDL Pada Mencit (Mus musculus) Theopilus Wilhelmus Watuguly; Anik Uniarti; Maria Nindatu
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 13, No 1 (2019): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (232.29 KB) | DOI: 10.33533/jpm.v13i1.691

Abstract

Hypercholesterolemic sufferers generally consume conventional drugs using hypolipidemic drugs to reduce cholesterol levels. But this type of drug also has side effects. In addition to consuming hypolipidemic drugs, increased cholesterol levels can be suppressed by regulating dietary patterns by controlling nutrient intake in a balanced manner as needed. Red dragon fruit skin extract (Hylocereus polyrhizus) applied to nata de coco is believed to reduce cholesterol levels because both contain fiber which can be used for dietary needs, and improve the digestive process. The purpose of this study was to determine the application and determine the dose of red dragon fruit skin extract (Hylocereus polyrhizus) in nata de coco in reducing total cholesterol, LDL and increasing HDL in mice (Mus musculus). The type of research used is experimental research using the Pre-Post Test Only Control Group Design research design that uses 18 mices with different doses of 1: 1 and 1: 2 doses. ANOVA statistical test on the results of the study showed that effective treatment in reducing total cholesterol, LDL, and increasing HDL was treated with extracts of red dragon fruit skin (Hylocereus polyrhizus) in a 1: 2 nata de coco. Thus it can be concluded that the higher the dosage given to mice tested it showed a significant reduction in cholesterol levels.
Effectiveness of Chinese Ketepeng Infusion on Streptozotocin-Induced Mice Watuguly, Theopilus Wilhelmus; Pattiasina, Eifan Boyke
Jurnal Kesehatan Masyarakat Vol 19, No 2 (2023)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v19i2.42825

Abstract

Blood sugar is a metabolic disorder disease that occurs due to insufficiency of insulin hormone production or due to insulin insensitivity resulting in typical clinical manifestations in the form of increased glucose levels in the blood (hyperglycemia). This study aims to determine the effect of Chinese ketepeng leaf decoction on blood glucose levels in hyperglycemic mice. This research was carried out in the Zoology laboratory, Faculty of Mathematics and Natural Sciences, Pattimura University, Ambon. This research is an experimental laboratory with a pre and post-test research design with a control group design. This study wanted to prove whether there was an effect of giving Chinese ketepeng leaf decoction to decreasing blood sugar levels in male Balb/C mice using Chinese ketepeng leaf decoction at a dose of 3.64 mg/kg, 7.28 mg/kg, 10.92 mg/kg. The results showed that the usage of Chinese ketepeng leaves (Cassia alata L) can reduce blood sugar levels in mice (Mus musculus). The most effective dose to lower blood sugar levels is a dose of 10.92 mg/kg BW.
IDENTIFICATION OF MEDICINAL PLANTS AND BENEFITS IN THE VILLAGE OF NEGERI LIMA, MALUKU DISTRICT Nusaly, Windy Natalia; Watuguly, Theopilus Wilhelmus; Pattiasina, Eifan Boyke; Wael, Syahran
BIOPENDIX: Jurnal Biologi, Pendidikan dan Terapan Vol 10 No 1 (2023): Biopendix: Jurnal Biologi, Pendidikan & Terapan
Publisher : Program Studi Pendidikan Biologi FKIP Unpatti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biopendixvol10issue1page156-170

Abstract

Backgraound: Medicinal plants are the biodiversity that exists around us, both those that grow wild and those that are deliberately cultivated. For generations, plants have been used as medicinal plants. The largest part of medicinal raw materials derived from plants is still not cultivated, while opportunities for agribusiness have the potential to increase the opportunities and possibilities open for medicinal products. Methods: The aim of the research is to find out the types of medicinal plants and find out how the community perceives the benefits of medicinal plants in the village of Negeri Lima. Maluku. The material used in this research is a questionnaire or questionnaire. The research uses the Guttman scale by distributing questionnaires to respondents which are used to find scores, percent scores, total scores, and percent ideal scores, the results of which are converted into score interpretation criteria. Results: The research results showed that the criteria distributed to respondents were very good with the highest total score being 90% and the lowest being 10%. Conclusion: As a result of the identification carried out, 20 types of medicinal plants were identified which were spread across Negeri Lima Village, Central Maluku. Analysis of questionnaires distributed to the public to measure public perceptions by distributing questionnaires used the Guttman scale from question no. 1 - 5, it is known that the highest percentage is 90% and the lowest percentage is 10%. Meanwhile, the results of the analysis of attitude question items to measure public perception from question no. 6 - 10 has the highest percentage, namely 80% and the lowest percentage, namely 20%.
ANALYSIS OF POTASSIUM (K) AND IRON (Fe) ON ORIGINAL HONEY OF WETAR ISLAND ILPUTI VILLAGE, SOUTHWEST MALUKU Lestari, Hana Ayu; Watuguly, Theopilus Wilhelmus
RUMPHIUS Vol 3 No 2 (2021): RUMPHIUS Pattimura Biological Journal
Publisher : Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/rumphiusv3i2p051-055

Abstract

Efek Antidiabetes Yoghurt Pala Terhadap Penurunan Kadar Glukosa Darah Tikus Model Diabetes Melitus Tipe 2 Unitly, Adrien Jems Akiles; Baszary, Chomsa Dintasari Umi; Moniharapon, Debby D.; Watuguly, Theopilus W.; Moniharapon, Mechiavel; Eddy, La; Lesbatta, Kezia Josawel; Sillehu, Eka Safitri; Sikafir, Beatrix Belina; Sopacua, Gracia N.
Kalwedo Sains (KASA) Vol 5 No 2 (2024): Kalwedo Sains (KASA), September 2024
Publisher : Program Studi Di Luar Kampus Utama Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/kasav5i2p91-98

Abstract

Diabetes Melitus tipe 2 adalah penyakit gangguan metabolik yang di tandai oleh kenaikan gula darah akibat penurunan sekresi insulin oleh sel beta pankreas atau gangguan fungsi insulin (resistensi insulin). Potensi yoghurt dalam menurunkan kadar glukosa darah berhubungan dengan kemampuan bakteri asam laktat dalam yoghurt menurunkan kadar kolesterol dan plasma lipid, sehingga meningkatkan sensitivitas insulin pankreas. Buah pala mengandung senyawa kimia yang dapat menunjukkan sifat antioksidan dan antibakteri. Tujuan penelitian ini untuk mengetahui efek terapi yoghurt pala terhadap penurunan kadar glukosa darah tikus model diabetes melitus tipe 2. Penelitian ini menggunakan rancangan acak lengkap (RAL). Penelitian ini menggunakan rancangan acak lengkap (RAL) yang terdiri dari lima perlakuan dan tiga kali ulangan, yaitu K(-): Kelompok kontrol negatif yaitu kelompok tikus yang diberi STZ, K(+): Kelompok kontrol positif yaitu kelompok tikus yang diberi STZ 45 mg/ekor/hari kemudian diberikan obat glibenklamid selama 14 hari, 1.25: Kelompok tikus yang diberi STZ 45 mg /ekor/hari kemudian diberi ekstrak yoghurt pala 1.25 ml /ekor/hari selama 14 hari, 2.5: Kelompok tikus yang diberi STZ 45 mg /ekor/hari kemudian diberi ekstrak yoghurt pala 2.5 ml/ekor/hari selama 14 hari dan 5.0: Kelompok tikus yang diberi STZ 45 mg /ekor/hari kemudian diberi ekstrak yoghurt pala 5 ml/ekor/hari selama 14 hari. Hasil penelitian menunjukkan pemberian yoghurt pala terbukti memiliki efek antioksidan dalam menurunkan kadar glukosa darah dimana dosis yoghurt pala yang efektif adalah 5.0 ml.
ANALISIS KADAR SERAT PADA NUGGET BATANG LENGKUAS MUDA (Alpinia galanga L) SEBAGAI PENUNJANG SUMBER BELAJAR MATA KULIAH ETNOBOTANI Titdoy, Nia Rusfita; Watuguly, Theopilus W; Tuapattinaya, Prelly M.J
BIOPENDIX: Jurnal Biologi, Pendidikan dan Terapan Vol 7 No 2 (2021): Biopendix: Jurnal Biologi, Pendidikan & Terapan
Publisher : Program Studi Pendidikan Biologi FKIP Unpatti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biopendixvol7issue2page89-94

Abstract

Background: Indonesia is a country rich in various types of plants, including spices. One of them is galangal [Alpinia galanga (L.) Swartz.] Which is often used by Indonesians as a cooking spice. This plant of the Zingiberaceae family has active substances that function to treat digestive disorders, relieve colic, as an antidote to poisoning, anti convulsions and has anti-arthritis activity. Galangal rhizome extract also has anticancer and anti-tuberculosis activity. Methods: The location for crude fiber testing was carried out at the Ambon Industrial Research and Standardization Center (Baristand). Young galangal stems are taken at Jl. Mount Malintang, Batu Merah, Sirimau, Ambon City Maluku. This research is a descriptive study with a qualitative approach. Results: The results showed that crude fiber content in young galangal stem nuggets in P3 with a ratio of 2: 1 resulted in crude fiber content of 2.62% higher than young galangal stem nuggets at P2 with a ratio of 1: 2 resulting in crude fiber content of 0 , 52% and young galangal stem nuggets at P1 with a ratio of 1: 1 resulted in crude fiber content of 1.46%. Conclusion: Crude fiber content with different ratios obtained P1 (1.46%), P2 (O, 52%), P3 (2.62%).
ANALISIS KADAR VITAMIN C PADA MINUMAN PROBIOTIK BUAH BLIGO (Benincasa hispida) Patty, Rezza Julian; Watuguly, Theopilus W; Tuapattinaya, Prelly M
BIOPENDIX: Jurnal Biologi, Pendidikan dan Terapan Vol 7 No 2 (2021): Biopendix: Jurnal Biologi, Pendidikan & Terapan
Publisher : Program Studi Pendidikan Biologi FKIP Unpatti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biopendixvol7issue2page160-166

Abstract

Background: Bligo (Benincasa hispida) is a Creeper plant, wooden trunk, soft, hairy and green. Bligo (Benincasahispida) contains water, protein, vegetable fats, carbohydrates, fiber, minerals and vitamins. Probiotic drinks are lacticacid fermented drinks that contain lactic acid bacteria and can provide health effects when consumed. Vitamin C isknown as ascorbic acid (C6H8O6), it is one of the vitamins needed by the body and its functions to increase the body'simmune system. The Measurement of vitamin C in probiotic drinks used spectrophotometric tool.Methods: This study used a qualitative descriptive research and the aim to determine the amount of vitamin C levelsin a probiotic drink made from Bligo (Benincasa hispida).Results: Based on the results of conducting this research, probiotic drinks containing Vitamin C in sample 1 with avitamin C in the level of 0.00790 and samples 2 and 3 with a vitamin C in the level of 0.00869%.Conclusion : Probiotic drink contains vitamin C in samples 2 and 3 with a Vitamin C level of 0.00869%. So Bligo(Benincasa hispida) can be used as a probiotic drink because it contains vitamin C.
ETHANOL EXTRACT OF RED DRAGONS (Hylocereus polyrhizus) IN PREVENTING DAMAGE OF THE ALVEOLUS OF MICE (Mus Musculus) EXPOSURE TO KRETEK SMOKE Rumangun, Febi Stevano; Watuguly, Theopillus; Arini, Ine
BIOPENDIX: Jurnal Biologi, Pendidikan dan Terapan Vol 8 No 2 (2022): Biopendix: Jurnal Biologi, Pendidikan & Terapan
Publisher : Program Studi Pendidikan Biologi FKIP Unpatti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biopendixvol8issue2page71-79

Abstract

Background: The main toxins in tobacco such as tar, nicotine, and carbon monoxide can trigger the formation of free radicals. Red dragon fruit (Hylocereus polyrhizus) is one of the plants that can be used as a source of protein antioxidants in red dragon fruit that can increase body metabolism and maintain heart health, can lose weight, and vitamin C is able to maintain healthy skin. Based on the description above, it is necessary to conduct research to determine the benefits of red dragon fruit as a source of antioxidants to prevent the formation of free radicals against the risk of oxidative damage in the body by looking at the number of alveolar macrophages. Methods: This research is an experimental laboratory using a qualitative descriptive method. The data obtained from this study will be analyzed using a qualitative descriptive method by observing the histopathology of the alveoli in the lungs of mice. Results: The results showed that the reduction of alveolar damage in mice at each treatment dose (250 mg/g BW, 500 mg/g BW and 750 mg/g BW) ethanol extract of dragon fruit before being exposed to kretek cigarette smoke for 30 days. This is because free radicals contained in kretek cigarette smoke are inhibited by flavonoids from dragon fruit which play a role in stopping chain reactions due to exposure to cigarette smoke, so that neutrophil activity can be balanced by antiproteases. Conclusion: Red dragon fruit has antioxidant potential that plays a role in preventing damage to the alveoli of mice (Mus musculus) exposed to kretek cigarette smoke. Administration of red dragon fruit ethanol extract at a dose of 750 mg/g BW gave a more effective effect in preventing alveolus damage in mice caused by free radicals from kretek cigarette smoke compared to a dose of 250 mg/g BB.
ANALISIS PENGGUNAAN MODEL PEMBELAJARAN HYPOTHETICAL – DEDUCTIVE LEARNING CYCLES UNTUK MENINGKATKAN HASIL BELAJAR IPA-BIOLOGI SISWA SMP Lopulalan, Silvia E; Watuguly, Theopilus W; Liline, Sintje
BIOPENDIX: Jurnal Biologi, Pendidikan dan Terapan Vol 9 No 1 (2022): Biopendix: Jurnal Biologi, Pendidikan & Terapan
Publisher : Program Studi Pendidikan Biologi FKIP Unpatti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biopendixvol9issue1page76-81

Abstract

Background: Student learning outcomes of SMP Negeri 22 Ambon on the subject of additive biology learning have not yet fully reached the KKM because the learning process only prioritizes the completeness of the material and the learning strategies applied by the teacher still tend to use the lecture method. The Hypothetical-Deductive Learning Cycles (HDLC) learning model provides opportunities for students to construct their own knowledge and act like scientists. This study aims to determine the improvement of science-biology learning outcomes for junior high school students using the hypothetical-deductive learning cycles model of additive material in class VIII SMP Negeri 22 Ambon. Methods: The type of research used is descriptive research which is used to determine the improvement of student learning outcomes. Results: The results of the study illustrate that the learning outcomes of Biology Sciences for junior high school students before the application of the hypothetical - deductive learning cycles learning model were under the KKM, but after the application of the hypothetical - deductive learning cycles model, the SMP students' learning outcomes of Biology turned out to be increased and fulfilled the KKM. Conclusion: Based on the results of research and discussions that have been carried out, it can be concluded that the final score (NA) obtained by each student shows that using the hypothetical-deductive learning cycles model can help students improve learning outcomes.
POTENSI EKSTRAK DAUN BANDOTAN (Ageratum conyzoides L) SEBAGAI OBAT DIABETES MELITUS Pay, Chrismenda; Watuguly, Theopilus W; Wael, Syahran
BIOPENDIX: Jurnal Biologi, Pendidikan dan Terapan Vol 9 No 1 (2022): Biopendix: Jurnal Biologi, Pendidikan & Terapan
Publisher : Program Studi Pendidikan Biologi FKIP Unpatti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biopendixvol9issue1page89-99

Abstract

Background: Diabetes mellitus is a chronic disease due to insulin deficiency from pancreatic cells so that blood sugar increases (hyperglycemia) and leads to complications. Bandotan plant (Ageratum Conyzoides L) is an alternative medicine that is safe, affordable and effective because it contains many phytochemicals, especially accumulated in the leaves such as alkaloids and flavonoid compounds that act as antioxidants to ward off free radicals and regenerate pancreatic cells. Methods: This research is a laboratory experiment to determine the antidiabetic activity test of bandotan leaf extract with doses of 75 mg/kg BW, 100 mg/kg BW and 150 mg/kg BW through blood sugar level tests and histopathological observations of Langerhans islet cells in induced diabetic mice. Alloxan monohydrate as much as 150 mg/kg BW intraperitoneally divided into 4 groups, namely 1 control group and 3 treatment groups according to dose. Results: The results showed bandotan leaf extract doses of 75 mg/kg BW, 100 mg/kg BW and 150 mg/kg BW reduced blood sugar levels by an average of 54 mg/dL and there was an improvement in damage as well as regeneration in islet cells. Langernas as the dose increases. With the best results there is a dose of 150 mg/kg BW. Conclusion: It is concluded that bandotan leaf extract can reduce blood sugar levels and repair damage to cells of the islets of Langerhans with the best results at a dose of 150 mg/kg BW, which is 78 mg/kg BW.
Co-Authors Adrien Jems Akiles Unitly Aknes Tahya Alfia Sabban Amos Killay Anggraeni, Andi Sri Dewi Anik Uniarti ARINI, INE Bare, Yohanes Baszary, Chomsa Dintasari Umi Beatrixs Rupilu Didik Wahyudi Dominggus Rumahlatu Edi Dharmana Eldo Dandirwalu F Leiwakabessy Fredy Leiwakabessy H Sinay Hanna Kalorbobir Harfalien Tehubijuluw Haslina Kole Icak Darling Rahakbauw Indahsari, Lilin Ika Nur Indranila KS Jecklyn A Lekal Johanis Fritzgal Rehena Kakisina, Alter Glen La Eddy La Sitiman, Hediaty Lesbatta, Kezia Josawel Lesiela, Laidonirka O. S. Lesirolo, Medlin Lestari, Hana Ayu Liline, Sintje Lopulalan, Silvia E M Kaihena Maria Nindatu Martha Kaihena Moniharapon, Debby D. Moniharapon, Mechiavel Mose, Windi Nindatu, Maria Nindatu, Maria Nurmila Nurmila Nusaly, Windy Natalia Pamella Mercy Papilaya Pattiasina, Eifan Boyke Patty, Rezza Julian Pay, Chrismenda Prelly M.J Tuapattinaya Prelly Tuapattinaya R Malawat Rumangun, Febi Stevano Sari, Dewi Ratih Tirto Sikafir, Beatrix Belina Silahooy, Veince Benjamin Sillehu, Eka Safitri Sopacua, Gracia N. Sriyanti Imelda Aksamina Salmanu Syahran Wael Syahran Wael Syahran Wael Titdoy, Nia Rusfita Tjahjono Tjahjono Tuapattinaya, Prelly M Tuapattinaya, Prelly M.J Uniarti, Anik Viesta Sampe Yosep Matruty Yulviany Latuihamallo