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Tenri Ayu Adri
Universitas Megarezky
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary

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The Comparison and Test of Antioxidant Activity of Ethanol Extracts of Pangi Leaves and Seeds (Pangium Edule Reinw.) Using the DPPH (1,1-Diphenyl-2-Picrylhydrazyl) Method Suleman, Abdul Wahid; Sari, Nurmala; Safaruddin, Safaruddin; Adri, Tenri Ayu; Siradjuddin, Mutmainnah; Prihandari, Ayu
CERATA Jurnal Ilmu Farmasi Vol 15 No 2 (2024): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v15i2.988

Abstract

The leaves and seeds of pangi (Pangium edule Reinw.) contain alkaloids, flavonoids, saponins, and tannins, which acts as antioxidants. Antioxidants are needed to protect the body and inhibit the negative impact of free radicals due to the oxidation reactions that occur. Antioxidants are compounds that inhibit oxidation reactions by binding free radicals and molecules. This research aims to determine the comparison of the antioxidants activity of pangi (Pangium edule Reinw.) leaves and seeds using the DPPH (1,1,-Diphenyl-2-Picrylhydrazyl) method. Reactive research method, experimentally, namely by carrying out serial dilutions of concentrations of 10, 20, 30, 40 and 50 ppm in each test solution, then adding the DPPH solution and measuring the antioxidants activity with a UV-Vis Spectrophotometer. After that, the IC50 (Inhibitor Concentration 50) value and the AAI (Antioxidant Activity Index) value are calculated, and the data were analyzed using ANOVA. The results of calculating the IC50 and AAI values are that the IC50 value of the pangi leaf ethanol extract is 49.6061 ppm (AAI=1.007), while the IC50 value of ethanol extract of pangi seeds is 50.2027 (AAI=0.9959). From the results of research and data analysis, it can be concluded that the ethanol extract of pangi leaves has higher antioxidant activity compared to the ethanol extract of pangi seeds.
SUBACUTE TOXICITY TEST OF BEACH CABBAGE [Scaevola taccada (Gaertn.) Roxb.] LEAF EXTRACT ON HISTOPATHOLOGICAL CHANGES IN THE LIVER AND KIDNEYS OF WHITE RATS Widati, Aritzah Dwi; Adri, Tenri Ayu; Kabo, Peter; Djabir, Yulia Yusrini
Jurnal Kedokteran Hewan Vol 16, No 2 (2022): June
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v16i2.19310

Abstract

The purpose of this study was to evaluate the toxic effects of beach cabbage leaves [Scaevola taccada (Gaertn.) Roxb.]by observing the histopathological changes in the livers and kidneys of male white rats. This study used 20 white rats which were divided into 4 groups: 1 control group and 3 groups receiving treatments in the form of Scaevola taccada leaf ethanolic extract (STLEE) in graded doses (200 mg/kg BW, 400 mg/kg BW, and 600 mg/kg BW). Toxicity test was performed by administering STLEE for 14 days. The results of daily observations showed that the experimental animals experienced diarrhea. Meanwhile, histopathological observations showed the occurrences of hydropic degeneration, fat degeneration, necrotic liver cells, and dilatation of Bowman's capsule in the animals kidney cells. It was concluded that STLEE at a dose of 200 mg/kg BW is safe to use, but is toxic at a dose of 600 mg/kg BW, both to the livers and kidneys.
Uji efek antiinflamasi dan analgetik ekstrak etanol daun jati putih (Gmelina Arborea Roxb) pada mencit jantan (Mus musculus) Adri, Tenri Ayu; Wulandari, Tri; Mansyur, Mansyur
Teknosains Vol 19 No 3 (2025): September-Desember
Publisher : Fakultas Sains dan Teknologi Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/teknosains.v19i3.60727

Abstract

Daun jati putih (Gmelina Arborea roxb) merupakan jenis tumbuhan dengan akar, kulit kayu, daun, bunga, dan buah yang biasa digunakan sebagai obat. Flavonoid adalah senyawa utama yang terkandung dalam daun jati putih yang memiliki aktivitas dalam menghambat jalur siklooksigenase 2 (COX 2) pada proses inflamasi. Tujuan penelitian ini untuk mengetahui pengaruh ekstrak daun jati putih (Gmelina arborea Roxb) terhadap aktivitas antiinflamasi dan analgetik pada mencit jantan (Mus musculus). Penggunaan mencit jantan dipilih karena hewan ini memiliki kemiripan biologis yang tinggi dengan manusia, termasuk kesamaan genetik sekitar 95% dan keserupaan mekanisme respons imun, seperti aktivasi makrofag serta produksi sitokin proinflamasi. Dalam penelitian ini, ekstrak daun jati putih diberikan pada tiga dosis, yaitu 10 mg, 15 mg, dan 20 mg sebagai kelompok perlakuan, sedangkan Natrium Diklofenak digunakan sebagai kontrol positif. Uji antiinflamasi dilakukan untuk mengevaluasi penurunan edema, dan uji analgetik digunakan untuk menilai pengurangan respons nyeri pada mencit. Hasil penelitian menunjukkan bahwa seluruh dosis ekstrak daun jati putih mampu menurunkan pembengkakan dibandingkan kelompok kontrol negatif, dengan penurunan edema paling besar ditunjukkan oleh dosis 20 mg. Pada uji analgetik, data menunjukkan bahwa dosis tertinggi ekstrak menghasilkan efek pengurangan nyeri paling signifikan dibandingkan kelompok kontrol negatif. Dengan demikian, ekstrak daun jati putih berpotensi memiliki aktivitas antiinflamasi dan analgetik yang sebanding dengan obat standar pada model mencit jantan.
Co-Authors Abdul Wahid Suleman Ade Irma Ade Irma Ade Irma Alief Ihram Fatany Andi Fitriani Andi Meinar Dwi Rantisari Arafah Nurfadillah Arafah Nurfadillah Arafah Nurfadillah Aritzah Dwi Widati Aritzah Dwi Widati Awaliah, Irma Nurul Djabir, Yulia Yusrini Hijral Aswad Irma Juniati Binti Lukman Luthfiyah Ambarpuri Ridwan Mansyur Mansyur Miladiarsi Miladiarsi Miladiarsi MUHAMMAD YUSUF Nadjamuddin, Mirfaidah Nur Insani Amir Nurmala Sari Peter Kabo Peter Kabo Peter Kabo Prayitno Setiawan Prihandari, Ayu RR. Ella Evrita Hestiandari Siradjuddin, Mutmainnah Syarif, Hardiyanti Tri Wulandari Ummu Syauqah Al Musyahadah W, Wahdaniar Wahdaniar Widati, Aritzah Dwi Yulia Yusrini Djabir