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All Journal HAYATI Journal of Biosciences Jurnal Ilmiah Farmasi Media Eksakta Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Biocelebes KOVALEN: Jurnal Riset Kimia Journal of Islamic Pharmacy Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Indonesian Journal of Chemistry GHIDZA: Jurnal Gizi dan Kesehatan Jurnal Ilmu Kefarmasian Indonesia Jurnal Mandala Pengabdian Masyarakat Jurnal DiMas (Jurnal Pengabdian Kepada Masyarakat) Pharmaceutical Reports Jurnal Pengabdian Farmasi dan Sains Jurnal Dedikatif Kesehatan Masyarakat Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Poltekita: Jurnal Pengabdian Masyarakat
Agustinus Widodo
Jurusan Farmasi, Fakultas MIPA, Universitas Tadulako, Palu, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Earth & Planetary Sciences Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Vitamin A Ikan Sidat (Anguilla Bicolor) Asal Danau Poso Sulawesi Tengah Nur Pita Sari; Jamaluddin Jamaluddin; Agustinus Widodo
Ghidza: Jurnal Gizi dan Kesehatan Vol 3 No 2 (2019): December
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/ghidza.v3i2.24

Abstract

Ikan sidat (Anguilla bicolor) memiliki nilai gizi yang sangat tinggi antara lain vitamin larut air (B dan C) dan larut lemak A, D, E, dan K. Vitamin A merupakan salah satu vitamin yang diperlukan oleh tubuh untuk membantu pembentukan jaringan tubuh, tulang, meningkatkan penglihatan dan ketajaman mata, memelihara kesehatan kulit dan rambut, meningkatkan kekebalan tubuh, anti kanker dan katarak. Penelitian ini bertujuan untuk mengetahui perbandingan kandungan vitamin A pada fase glass eel, yellow eel dan silver eel asal Danau Poso Sulawesi Tengah. Penelitian ini dilakukan di Laboratorium dengan pengambilan sampel menggunakan teknik Purposive sampling berdasarkan kriteria seperti jenis (Anguilla bicolor) umur (4,5 – 10 tahun) dan panjang (55 mm – 30 cm ) asal Danau Poso Sulawesi Tengah. Pengujian vitamin A dilakukan dengan menggunakan metode KCKT (Kromatografi Cair Kinerja Tinggi). Kadar vitamin A ikan sidat fase Glass eel sebanyak 24,36 mcg/100g, Yellow eel 204,53 mcg/100g, dan Silver eel 59,92 mcg/100g. Hasil statistik uji anova menunjukkan bahwa kadar vitamin A ikan sidat Anguilla bicolor fase Glass eel, Yellow eel, dan Silver eel berbeda signifikan (P=0,000). Ikan sidat (Anguilla bicolor) fase Glass eel, Yellow eel dan Silver eel asal Danau Poso Sulawesi Tengah dapat dijadikan sumber vitamin A baik dalam bentuk olahan makanan maupun produk
Studi Perbandingan Kandungan Vitamin B Ikan Sidat (Anguilla marmorata (Q.) Gaimard) Fase Yellow Eel dan Silver Eel Asal Sungai Palu Sulawesi Tengah Jamaluddin Jamaluddin; Agustinus Widodo; Natasha Setiawan
Ghidza: Jurnal Gizi dan Kesehatan Vol 4 No 2 (2020): December
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/ghidza.v4i2.36

Abstract

Ikan sidat (Anguilla marmorata (Q.) Gaimard) memiliki keunggulan gizi atau nutrisi yang tinggi seperti protein, asam lemak, dan vitamin. Penelitian ini bertujuan untuk membandingkan kadar vitamin B (B1, B2, B3, B5, B6, B7, B9, dan B12) pada ikan sidat fase yellow eel dan silver eel asal Sungai Palu Sulawesi Tengah. Metode yang digunakan yaitu purposive sampling berdasarkan pada tempat, ukuran, dan fase ikan. Hasil pengujian vitamin B (B1, B2, B3, B5, B6, dan B9) menggunakan Kromatografi Cair Kinerja Ultra menunjukkan bahwa vitamin B2 fase yellow eel sebesar 0,07 mg/100 g; silver eel sebesar 0,05 mg/100 g; vitamin B3 fase yellow eel sebesar 0,3 mg/100 g; silver eel sebesar 1,16 mg/100 g; dan untuk vitamin B1, B5, B6, dan B9 tidak terdeteksi kadarnya. Sedangkan pengujian vitamin B7 dan B12 menggunakan Kromatografi Cair-Spektrometri Massa menunjukkan bahwa vitamin B7 fase yellow eel sebesar 58,35 µg/100 g; silver eel sebesar 10,61 µg/100 g; vitamin B12 fase yellow eel sebesar 0,52 µg/100 g; dan silver eel sebesar 0,27 µg/100 g. Kesimpulan yaitu vitamin B7 dengan menggunakan Kromatografi Cair-Spektrometri Massa memiliki kadar vitamin tertinggi sebesar 58,35 µg/100 g pada fase yellow eel dan untuk vitamin B3 (Nicotinamide) menggunakan Kromatografi Cair Kinerja Ultra memiliki kadar vitamin terendah sebesar 0,3 mg/100 g pada fase yellow eel.
Kadar Albumin Pada Ikan Sidat Anguilla marmorata Q Gaimard dan Anguilla bicolor Asal Sungai Palu dan Danau Poso Jamaluddin Jamaluddin; Gugun Gunawan; Siti Nurhafsah; Padhlun A Jerni; Dytha Okvhyanitha; Ade Fazliana Mantika; Jessica Jessica; Asty Ivon Samaliwu; Yusriadi Yusriadi; Agustinus Widodo
Ghidza: Jurnal Gizi dan Kesehatan Vol 4 No 1 (2020): July
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/ghidza.v4i1.37

Abstract

Ikan sidat termasuk ikan yang memiliki kandungan gizi yang tinggi seperti vitamin A, vitamin B, DHA(Docosahexaenoic acid), EPA(Eicosapentaeonic acid), dan protein albumin. Albumin memiliki peranan penting sebagai sarana pada proses transportasi dalam darah, pembentukan jaringan tubuh yang baru pada masa pertumbuhan, senyawa proteksi hati dan juga bermanfaat dalam proses penyembuhan luka pada pasien pasca operasi. Penelitian ini bertujuan untuk mengetahui perbandingan kadar albumin ikan sidat Anguilla marmorata dan Anguilla bicolor pada fase glass eel, elver, yellow eel dan silver eel asal Sungai Palu dan Danau Poso. Sampel diambil menggunakan metode purposive sampling berdasarkan pada jenis, berat, ukuran, dan lokasi pengambilan. Pengujian kadar albumin ditentukan dengan menggunakan metode Bromocresol green dengan alat fotometer dan hasil penelitian menunjukkan bahwa kadar albumin tertinggi terdapat pada fase silver eel, yakni sebanyak 1,62 gram / 100 gram pada Anguilla marmorata asal Danau Poso dan kadar paling rendah terdapat pada fase elver sebanyak 0,24 gram / 100 gram pada Anguilla bicolor asal Danau Poso. Hal ini menunjukkan bahwa spesies Anguilla marmorata memiliki kadar albumin yang lebih tingi dari Anguilla bicolor.
Profil Proliferasi Sel Limfosit Benalu Batu (Begonia medicinalis) Asal Kabupaten Morowali UTARA Provinsi Sulawesi Tengah Akhmad Khumaidi; Agustinus Widodo; Arsa Wahyu Nugrahani; Ediati Sasmito; Nanang Fakhrudin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 1 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (634.931 KB) | DOI: 10.35814/jifi.v18i1.785

Abstract

The plant of Benalu Batu (Begonia medicinalis) from the North Morowali regency has been used empirically and is known to have anticancer activity. The study aims to determine the profile of the activity of lymphocytes cell proliferation of extracts and fractions of Benalu Batu in vitro as well to measure the correlation of total flavonoid content against the stimulating index of lymphocytes cell proliferation. The extraction of simplicia by using the maceration method with methanol solvent. The liquid-liquid partition method is used in the fractionation of methanol extracts with hexane, ethyl acetate, and water solvents, sequentially. Test of lymphocytes cell proliferation using MTT reduction (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) method with concentration series 10, 20, 50, and 100 μg/mL. The total of flavonoids content of extracts and fractions were determined by using colorimetric method. The stimulation index (IS) is used in measuring the activity of lymphocytes cell proliferation. The test results showed that the methanol extracts, hexane fraction, ethyl acetate, and water may increase the proliferation of lymphocytes in the entire test concentration. The concentration of test influences on increasing the stimulation of the proliferation of lymphocytes cells. A test concentration of 100 μg/mL has the highest stimulation index on each test sample and its stimulant index value of hexane fraction, ethyl acetate fraction, methanol fraction and water fraction were 10.12, 6.56, 4.82, and 4.17, respectively. Total flavonoids content and stimulation indices have very low correlation (r = 0,082) and concentrations of 10 μg/mL have the highest correlation coefficient (r2 = 0.18). The results showed that the hexane and ethyl acetate fractions can be developed as immunostimulant materials for the anticancer supportive therapeutic agents despite having a very low correlation to the flavonoid levels.
COMPARATIVE STUDY OF MINERAL CONTENT OF SIDAT FISH MEAT (ANGUILLA MARMORATA QUOY GAIMARD) ON YELLOW EEL PHASE FROM PALU RIVER AND LAKE POSO Jamaluddin Jamaluddin; Widodo Agustinus
Journal of Islamic Pharmacy Vol 3, No 1 (2018): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v3i1.4992

Abstract

Eel fish (Anguilla marmorata Quoy Gaimard) is one of the strategic commodities to be developed because it has high nutritional value such as protein, fatty acid, vitamins and minerals. Minerals are one of the nutrients the body needs for the body's physiological processes. This study aims to determine the amount and mineral content of eel meat Anguilla marmorata Quoy Gaimard) originating from the river Palu and lake Poso. Sampling was done by Purposive sampling method based on type, weight 35-40 gram, size 300-450 mm and location of taking. Mineral testing on eel meat using laboratory experimental with Inductively Coupled Plasma Mass Spectrometry (ICP-MS). The results showed that the mineral content contained in yellow eel fish from Palu river contains potassium 1,519 mg/kg, magnesium 203 mg/kg, zinc 11,2 mg/kg, and mercury 0,129 mg/kg; and from the  Poso lake contains potassium 1,360 mg/kg, magnesium 179 mg/kg, and strontium 1.32 mg/kg. Based on this study  can be concluded that there is influence the location against the amount of mineral content.
Comparative Study of Nutritional Content and Amino Acid Profile on Rono Poso Fish (Adrianichthys oophorus) and Rono Lindu Fish (Oryzias sarasinorum) Endemic of Central Sulawesi Jamaluddin Jamaluddin; Meita Meita; Syariful Anam; Agustinus Widodo; Pitriani Pitriani
Pharmaceutical Reports Vol 1, No 1 (2022): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (483.147 KB) | DOI: 10.33096/pharm rep.v1i1.152

Abstract

Rono Poso fish (Adrianichthys oophorus) originating from Lake Poso and  Rono Lindu fish (Oryzias sarasinorum) from Lake Lindu, is central Sulawesi endemic fish that consumed the communities around the lake, but it is not known nutritional content. This study aims to determine the nutrient content and amino acid profile in Rono Poso and Rono fish Lindu. Ash content analysis testing using the dry ashing method, testing the moisture content using the oven method, using soxhlet fat, and protein content using the method and the testing Kjeldhal amino acid profile using Chromatography Hight Performance Liquid (HPLC). The results showed that several nutrients and amino acid profiles differ between the two samples. In Rono Poso fish containing ash 11:00%, water 6:11%, 58.88% protein,  fat, and carbohydrates 22.68% 1:33%. In Rono Lindu containing ash 18.84%, water 9.77%, 58.97% protein, fat, and carbohydrate 10:35% 2:07%.
STUDI TUMBUHAN BERKHASIAT OBAT PADA SUKU DONDO DI KECAMATAN OGODEIDE, KABUPATEN TOLITOLI, PROVINSI SULAWESI : Study of Drug Effective Plants on The Dondo Tribe in Ogodeide District, Tolitoli Regency, Central Sulawesi Province Syariful Anam; Agustinus Widodo; Muhamad Rinaldhi Tandah
Biocelebes Vol. 16 No. 2 (2022)
Publisher : Biology Department, Mathematics and natural science, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/bioceb.v16i2.16063

Abstract

The Dondo Tribe is an indigenous tribe in Ogodeide District. The Dondo Tribe still uses traditional medicine to treat various diseases. The high trust of the Dondo people towards the use of traditional medicine makes people prefer to use traditional medicine. This study aimed to determine the types, parts, and methods of use of plants that have been used as traditional medicine by the bolrians of the Dondo tribe, Ogodeide District, Tolitoli Regency, Central Sulawesi Province. This type of research was descriptive qualitative and the sampling technique was purposive sampling, with structured interview techniques on 11 informants by filling out questionnaires with supporting documentation. The results of the study found that as many as 40 species of plants used as traditional medicine by the bolrians of the Dondo tribe in Ogodeide District which are still preserved today. The percentages of the most widely used plant parts were leaves 55%, stems 11%, rhizomes 11%, roots 5%, fruit 5%, herbs 5%, bark 2%, twigs 2%, tubers 2% and flowers 2%. The percentage of how to use plants as traditional medicine is 65% taken, 26% affixed, 3% seen, 3% washing and 3% smeared.
Phytochemical Analysis and Cytotoxic Activities of Hantap Leaves (Sterculia coccinea Jack) Extract Yuliet Yuliet; Agustinus Widodo; Khildah Khaerati; Joni Tandi
Indonesian Journal of Chemistry Vol 23, No 3 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.79362

Abstract

Hantap (Sterculia coccinea Jack) has been used traditionally for various health issues, including cancer treatment. The therapeutic effects of natural ingredients are often attributed to their chemical constituents. This study aimed to analyze the phytochemical contents and cytotoxic activities of S. coccinea leaves on HeLa and MCF-7 cancer cell lines. The quantitative phytochemical analysis was carried out following standard laboratory procedures. Phytochemical compounds were identified using LC-MS/MS QTOF. The MTT assay PrestoBlue™ Cell Viability Reagent test method was used to test cytotoxic activity in the cell culture. Extraction was carried out by the maceration method using 96% ethanol as solvent. The quantitative analysis revealed that tannins were the major phytochemical constituent in the highest percentage of 72.16%, followed by alkaloids, flavonoids, and steroids, with values of 30.80, 28.66, and 2.85%, respectively. Saponins were present in the lowest percentage of 1.15%. The ethanolic extract exhibited moderate cytotoxicity on HeLa and MCF-7 cells with IC50 values of 591.00 and 578.10 µg/mL, respectively. Identification using LC-MS/MS showed the suspected compounds 5,7-dihydroxy-3-(4'-hydroxybenzyl)chromone as homoisoflavanones and kaempferide-3-O-α-L-rhamnosyl-7-O-α-L-rhamnoside from flavonol triglycosides. These results may contribute to the study on the use of leaves extract of S. coccinea for developing a chemoprevention agent.
Isolation of Endophytic Fungi from Rui (Harrisonia perforata (Blanco) Merr.) and Determining Their Antibacterial, Antioxidant, and Cytotoxic Activity Anam, Syariful; Syamsidi, Armini; Tunreng, Muh. Fadil Usman; Djaleha, Helena Fransisca; Arisca, Windhy Nur; Syaputra, Gunawan; Iklima; Indriani, Meri Feki; Widodo, Agustinus; Pratiwi, Ritha; Yuliet; Razak, Abd. Rahman
HAYATI Journal of Biosciences Vol. 31 No. 3 (2024): May 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.3.443-456

Abstract

Endophytic fungi produce bioactive metabolites that exhibit antibacterial, antioxidant, and anti-cancer activity. Rui (Harrisonia perforata (Blanco) Merr.) is a traditional medicinal plant proven to be an antibacterial and anticancer. Endophytic fungi live in plant tissues without damaging or producing chemicals that infect the host cell. Endophytes produce the same and similar compound as an original plant. This study aimed to isolate the endophytic fungi from Rui and determine their antibacterial, antioxidant, and cytotoxic activity. 13 fungal isolates were successfully isolated using PDA for seven days at 30°C. Molecular identification using the ITS1 and ITS4 DNA sequences only revealed six species: Diaporthe sp., Phomopsis sp., Aspergillus tubingensis, Aspergillus viridinutans, Pseudofusicoccum sp., and Daldinia eschscholtz. Seven isolates showed antibacterial activity based on plate assay. Aspergillus tubingensis and RA-1 exhibited antibacterial activity against Staphylococcus aureus and Salmonella typhi, with the MIC and MBC starting from 24 to 32 mg/ml. The DPPH assay showed the most increased antioxidant activity in Daldinia eschscholtzii with an IC50 of 98.14±2.39 µg/ml. The Brine Shrimp Lethality Test (BSLT) showed the highest potential cytotoxic activity, as shown by Aspergillus tubingensis and Phomopsis sp. with LC50 of 7.78±7.48 and 30.83±0.39 µg/ml. In conclusion, our study demonstrates that the fungal extract from Rui could be a source of antibacterial, antioxidant, and cytotoxic agents.
Pemberdayaan Masyarakat Petani Aren: Nira Aren Sebagai Bahan Baku Etanol Untuk Pencegahan Covid-19 Wa Ode Sitti Musnina; Jamaluddin Jamaluddin; Adrianton Adrianton; Agustinus Widodo
Jurnal Dedikatif Kesehatan Masyarakat Vol 2 No 1 (2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/dedikatifkesmas.v2i1.394

Abstract

Handsanitizer berbahan dasar alkohol (etanol) sampai saat ini masih sangat dibutuhkan dalam pelaksanaan protokol kesehatan pada masa pandemi Covid-19. Kebutuhan akan handsanitizer berbanding lurus dengan kebutuhan alkohol. Salah satu sumber bahan penghasil alkohol yang dapat dimanfaatkan guna memenuhi kebutuhan alkohol adalah nira yang berasal dari pohon enau melalui proses fermentasi dan destilasi. Tujuan program pengabdian ini adalah melakukan transfer teknologi ke kelompok tani mitra tentang cara memrproduksi etanol berkadar tinggi melalui proses penyulingan dengan bahan dasar nira aren serta mampu membuat Hand sanitizer dengan cara yang tepat dan benar menggunakan etanol hasil penyulingan Nira. Metode yang digunakan pada kegiatan pengabdian ini yakni penyuluhan (koordinasi dan penyadaran), praktek penerapan teknologi pengolahan nira aren menjadi alkohol teknis berkonsentrasi tinggi serta praktek pembuatan Handsanitizer. Berdasarkan hasil kegiatan pengabdian yang telah dilakukan diperoleh data sebanyak 7 orang petani terdiri dari 3 petani laki-laki dan 4 petani perempuan. Dari ketujuh petani, terdapat satu petani yang memelihara dan mengolah pohon aren. Produk yang dihasilkan adalah tuak “cap tikus”. Sedang keenam petani lainnya memiliki pohon aren yang tumbuh liar dan tidak diolah sama sekali. Rata-rata petani yang tidak mengolah pohon arennya memiliki >4 pohon aren. Berdasarkan hal tersebut, maka kegiatan pengabdian yang dilakukan terhadap kelompok mitra tepat sasaran, sehingga dengan adanya kegiatan ini dapat meningkatkan pengetahuan dan kemampuan petani dalam menghasilkan produk olahan aren yang bermanfaat dan dapat meningktakan pendapatan petani
Co-Authors A. Lasongke, Putri Faradila Abd. Rahman Razak Ade Fazliana Mantika Adrianton Adrianton Akhmad Khumaidi Amelia, Putri Anita Purwantari Anita Tri Damayanti Anugraini, Annisa Putri Arisca, Windhy Nur Armini Syamsidi Asty Ivon Samaliwu Bella Melinda Djaleha, Helena Fransisca Dytha Okvhyanitha Ediati Sasmito Erdy Prasetyo Fenti Fenti Gugun Gunawan Iklima Indriani, Meri Feki Jamaluddin Jamaluddin Jamaluddin Jamaluddin Jamaluddin Jamaluddin Jamaluddin Jessica Jessica Joni Tandi Joni Tandi, Joni Khildah Khaerati Ma'rifah Ma'rifah Maskur, Risda Meita Meita Muhamad Rinaldhi Tandah Muhammad Sulaiman Zubair Musyahidah Musyahidah Nanang Fakhrudin, Nanang Natasha Setiawan Nur Pita Sari Nurlina Ibrahim Nurul Ambianti Nurul Mufliha Padhlun A Jerni Pitriani Purnamasari Zainal, Amalia Rasida Risna Yanti Ritha Pratiwi Satriani Siti Nurhafsah Syaputra, Gunawan Syariful Anam Syariful Anam Tien Wahyu Handayani Tunreng, Muh. Fadil Usman Wa Ode Sitti Musnina Wa Ode Sitti Musnina Yonelian Yuyun Yuliet Yuliet Yusriadi Yusriadi Zainal, Amalia Purnama Zubair, M. Sulaiman Zulfaidah