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All Journal Jurnal Teknosains Majalah Obat Tradisional JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Kimia Riset Chemistry Indonesian Journal of Chemical Research Al-Khidmah PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Acta Chimica Asiana Indonesian Journal of Pharmaceutical and Clinical Research Jurnal Insan Farmasi Indonesia Jurnal Farmasi Komunitas Media Farmasi Indonesia Jurnal Farmasi Sains dan Praktis Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Journal Pharmacy of Tanjungpura Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Bambang WIJIANTO
Universitas Tanjungpura
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Physics Public Health Social Sciences Other

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Cosmetic Serum Loaded Arabica Coffee (Coffea arabica) Extract: Formulation and Antioxidant Study Harum Nadyanti Usman; Liza Pratiwi; Bambang Wijianto
Majalah Obat Tradisional Vol 28, No 2 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.83120

Abstract

Arabica coffee (Coffea arabica) is a natural antioxidant that can be used in the prevention of skin aging. This study was conducted to determine the comparison of variations in the composition of HPMC, CMC-Na, and Carbomer in the optimum formula of arabica coffee serum, then to determine the physical properties of the preparation, as well as the IC50 value ofarabica coffee extract and arabica coffee serum in the DPPH test. Arabica coffee extract was obtained by maceration method using 70% ethanol. Determination of the optimum formula of arabica coffee serum using the Simplex Lattice Design method. The optimum formula of arabica coffee serum was evaluated for physical properties including organoleptic test, homogeneity test, pH test, spreadability test, and adhesion test. The antioxidant activity of arabica coffee extract and the optimum formula of arabica coffee serum was tested using the DPPH method. Data analysis used SPSS One sample T-test statistics. The results showed that the composition variation of HPMC, CMC-Na, and Carbomer in the optimum formula of arabica coffee serum using the Simplex Lattice Design method was 0.1%:0.8%:0.1%. The resulting predicted values are a pH value of 4.88 and a spreadability value of 7.95 cm. The optimum formula of arabica coffee serum has the physical properties of the preparation, namely brown color, coffee aroma, light texture, a cool sensation when applied to the skin, homogeneous, has a spreadability of 7.93 cm, stickiness of 1 second, and pH value of 4.9. The IC50 value of arabica coffee extract and the optimum formula of arabica coffee serum are 8.13 ppm and 250 ppm. The results of the SPSS One sample T-test statistical analysis showed that there was no significant difference between the prediction response and the results of the optimum formula evaluation.
Edukasi Pencegahan Bullying kepada Siswa SDN 01 Rasau Jaya Kubu Raya: Bullying Prevention Education for Students at SDN 01 Rasau Jaya Kubu Raya Bambang Wijianto; Intan Yap; Risa Indriyani; Virna Helena Damanik; Inggrid Aprilia Manullang; Dimas Achmad Mu’arif
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 8 No. 5 (2023): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v8i5.4828

Abstract

Bullying in children can be classified as abnormal behavior that can affect the mental health of both the perpetrator and the victim. The village of Rasau Jaya I is a thriving transmigration area as a cultural, economic, and social center, including education with varied cultural, cultural, and social impacts. The Community Service Program (PKM) is designed to increase the knowledge of elementary students in grades 3 to 5 of SDN 01 Rasau Jaya in recognizing and preventing bullying in the school environment. This service program provides education using learning media such as posters and leaflets, lectures, question-and-answer discussions, and mini quizzes. The PKM program is conducted in groups, interactively and directly with students. Evaluation and monitoring activities were carried out using questionnaires (pre-test and post-test), which were analyzed descriptively and measured the ability of students to answer the questionnaire. The evaluation results show that there is an increase in the level of knowledge of students in recognizing and preventing bullying at school.
Characterization of Onchidiid Slug (Onchidium typhae) West Kalimantan Waters as Antibacterials and Antifungal Bambang Wijianto; Hasyrul Hamzah; Annisa Larasati Nurhidayah; Guci Intan Kemuning; Riyadh Aqilsya Amaryl Dyas
Borneo Journal of Pharmacy Vol. 5 No. 1 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i1.2936

Abstract

Onchidiid slug (Onchidium typhae) is a nudibranch that coastal communities in West Kalimantan have widely used as wounds. The study aims to characterize the West Kalimantan water O. typhae as antibacterial and antifungal. The study of O. typhae was carried out in several stages: preparation and optimization, extraction by Quinn method, characterization and identification of bioactive compounds, and antibacterial and antifungal assay using the microdilution method. The result of the proximate test showed that O. typhae powder contains high protein, namely 67.68%. Phytochemical screening results from methanol, ethyl acetate, and chloroform extracts contain alkaloids and amino acids. Methanol, chloroform, and ethyl acetate extract 1% of O. typhae showed inhibitory activity against Staphylococcus aureus, Escherichia coli, and Candida albicans. The most significant inhibition value was indicated by chloroform extract 1%, where the inhibition value against S. aureus, E. coli, and C. albicans was 82±0.01%; 85.8±0.01%; 85±0.01%, respectively. From these results, O. typhae powder can be developed as a wound medicine through its antibacterial and antifungal activity.
SERUM OF EXTRACT Onchidium Typhae USES HYDROXYETHYL CELLULOSE AND CARBOXYMETHYL CELLULOSE NATRIUM BASE AS ANTIOXIDANT Bambang Wijianto; Liza Pratiwi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1113

Abstract

Antioxidants can prevent premature aging (anti-aging) and various types of cancer and increase body immunity. Empirically, Onchidiid slugs have been used as natural antioxidants. This study aimed to determine the antioxidant potency of the serum of Onchidiid slug ethanolic extract. The Onchidiid slug extract was obtained by maceration and was prepared to create two effective serum formulations. Formula A involved hydroxyethyl cellulose (HEC), while Formula B employed sodium carboxymethyl cellulose (Na-CMC) as gelling agent. The second serum formula was rigorously evaluated and subjected to antioxidant activity testing by the diphenyl-2-picrylhydrazyl (DPPH) method. The serum preparation with the best physical properties and antioxidant activity was serum A at a concentration of 1%. Physical test results showed that serum A had a yellow color with a distinctive smell and was homogeneous with a soft texture. The test results for the spreadability and stickiness properties of serum A were 6 cm2 and 1'55'' second. The serum A antioxidant activity test results showed moderate free-radical scavenging activity, with an IC50 value of 277 ppm. Keywords: Anti-aging, 2,2-diphenyl-1-pikrilhidrazyl, Onchidium typhae, Antioxidant
UJI ANTIOKSIDAN EKSTRAK METANOL SIPUT ONCHIDIID (Onchidium typhae) DENGAN METODE DPPH Guci Intan Kemuning; Bambang Wijianto; Andhi Fahrurroji
Jurnal Ilmiah Kedokteran dan Kesehatan Vol 2 No 1 (2023): Januari : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1622.698 KB) | DOI: 10.55606/klinik.v2i1.794

Abstract

Siput Onchidid (Onchidium typhae) merupakan spesies dalam kelas gastropoda yang dapat ditemukan di daerah pesisir pulau Buton dan juga Madura dan Kalimantan Barat.. Siput onchidid diketahui memiliki kandungan metabolit sekunder berupa steroid yang dapat berpotensi sebagai antioksdian. Penelitian ini membahas tentang uji antioksidan di dalam siput onchidid dengan metode DPPH (1,1- diphenil-2-pikrilhirazil) dengan menggunakan pelarut methanol dan pengujian skrining senyawa metabolik ekstrak dengan uji fitokimia pada ekstrak yang meliputi uji steroid, alkaloid, dan steroid. Hasil pengujian didapat bahwa ekstrak metanol siput onchidid memiliki terdapat senyawa metabolik sekunder dari golongan alkaloid dan steroid yang ditandai dengan reaksi positif. Hasil uji antioksidan dengan metode DPPH dengan senyawa pembanding vitamin C. Penelitian menunjukkan besar aktivitas antioksidan ekstrak metanol siput onchidid yang dinyatakan dengan nilai IC50 sebesar 92,045 yang dikategorikan antioksidan kategori kuat.
Study of Anthocyanin Molecule Blocking as Anti-Hypertensive through the Pathway of the Renin-Angiotensin-Aldosterone System (RAAS) Budiarto, Dwi; Wijianto, Bambang; IH, Hariyanto
Indonesian Journal of Chemical Research Vol 11 No 1 (2023): Edition for May 2023
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598//ijcr.2023.11-bud

Abstract

Anthocyanins are flavonoid-derived compounds that can reduce blood pressure. This study aims to determine the affinity value of the compound to bind to Angiotensin Converting Enzyme (ACE) and bind to Angiotensin II type 1 Receptor (AT1R) and to determine the distance and shape of the bond that occurs. The results of anthocyanin-derived compounds Delphinidin, Petunidin, Malvidin, Cyanidin, Peonidin, and Pelargonidin have anti-hypertensive potential through the Renin Angiotensin Aldosterone (RAAS) pathway based on molecular docking calculations. The affinity value of each, against Angiotensin Converting Enzyme (ACE) -7.7; -7.8; -7.7; -7.7; -7.8, and -7.7, the best affinity value in anthocyanin-derived compounds is shown in the Malvidin test compound which has three types of hydrogen bonds at a distance of ± 2 Å (ASP377, TYR520, ASP415) and has 1 type of bond that is the same as the lisinopril control (TYR520). While the affinity value to Angiotensin Receptor (AT1R) is -7.7; -7.7; -7.8; -7.7; -7.8, and -7.6, respectively, the best affinity value is shown in the Malvidin test ligand compound of -7.8 kcal/mol which has four types of hydrogen bonds ± 2 Å distance (TYR92, SER105, ARG167, TRP84) and has one kind of bond in common with lisinopril control (TYR520).
STUDY MOLECULES DOCKING OF ALKALOIDS IN KRATOM ON SEROTONIN TRANSPORTER (SERT), NOREPINEPHRINE TRANSPORTER (NET), AND MONOAMINE OXIDASE (MAO) Irawan, Dandi; Wijianto, Bambang; IH, Hariyanto
Jurnal Kimia Riset Vol. 8 No. 2 (2023): December
Publisher : Universitas Airlangga, Campus C Mulyorejo, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkr.v8i2.50785

Abstract

Kratom (Mitragyna speciosa Korth) is a tropical plant originating from Southeast Asia that predominantly contains alkaloid compounds and can potentially maintain levels of monoamine compounds in the body to treat depression. The study aimed to examine the potential of 8 alkaloid compounds in kratom as antidepressants towards four target proteins: Serotonin Transporter (SERT), Dopamine Transporter (DOPAT), Leucine Transporter (LEUT), and Monoamine Oxidase (MAO) via molecular docking. The Pyrx program is used with exhaustiveness 106 as the protocol, and the grid is adapted to the active site of each receptor. The affinity values "‹"‹of the alkaloid compounds in kratom are mitragynine, 7-hydroxy mitragynine, speciociliatine, paynantheine, speciogynine, corynantheidine, mitraciliatine, and 9-hydroxycorynantheidine, for MAO were -7.1, -6.1, -5.7, -6.7, -5.7, -7.7, -5.7, and -5.7 kcal/ mole. All compounds bind to amino acid residues in the target protein through hydrogen and pi (Ï€) bonds. All the tested alkaloid compounds have the potential to be re-uptake inhibitors SERT, DOPAT, LEUT, and Monoamine Oxidase (MAO).
MOLECULAR DOCKING STUDY OF EPIGALLOCATECHIN GALLATE (EGCG) AS A THERAPY FOR TYPE 2 DIABETES MELLITUS Wijianto, Bambang; Arief, Ihsahnul; Yohana, Vanesha
Jurnal Kimia Riset Vol. 9 No. 1 (2024): June
Publisher : Universitas Airlangga, Campus C Mulyorejo, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkr.v9i1.56399

Abstract

Epigallocatechin gallate (EGCG) has an effect in reducing sugar levels in the blood by inhibiting α-glucosidase enzyme, which is connected explicitly by hydrogen bonds and modifies the secondary structure and micro-environment of the enzyme reversibly and non-competitive. This study looks at the activity and interaction of EGCG as α-glucosidase inhibitors in the form of binding affinity and compound bonding profiles with receptors, including toxicity predictions and drug-likeness results. The research was performed in silico with molecular docking on Autodock Vina that integrated through PyRx, then viewed the compound's binding profile with receptor using Discovery Studio 2021 Client, toxicity prediction using ProTox-II and determination of drug-likeness using SwissADME based on Lipinski's rule of five guidelines. The control drugs used were acarbose and miglitol. The molecular docking results obtained that the binding affinity of EGCG is -8.4 kcal/mol while acarbose and miglitol are -13.8 kcal/mol and -5.3 kcal/mol respectively. There are amino acid residues similar to the drug control with various interactions like electrostatic, hydrophobic, and hydrogen bonds; then it has an inactive target for each toxicity parameter and has a molecular weight of 458.37 g/mol; Log P value of 1.01; H-bond donor of 8; and H-bond acceptor of 11 in the determination of drug-likeness. Based on these results, EGCG has effectiveness as α-glucosidase inhibitors predicted to be non-toxic; however, there are violations in determining drug-likeness.
UJI ANTIOKSIDAN EKSTRAK METANOL SIPUT ONCHIDIID (Onchidium typhae) DENGAN METODE DPPH Guci Intan Kemuning; Bambang Wijianto; Andhi Fahrurroji
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 2 No. 3 (2022): NOVEMBER : Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v2i3.810

Abstract

Siput Onchidid (Onchidium typhae) merupakan spesies dalam kelas gastropoda yang dapat ditemukan di daerah pesisir pulau Buton dan juga Madura dan Kalimantan Barat.. Siput onchidid diketahui memiliki kandungan metabolit sekunder berupa steroid yang dapat berpotensi sebagai antioksdian. Penelitian ini membahas tentang uji antioksidan di dalam siput onchidid dengan metode DPPH (1,1- diphenil-2-pikrilhirazil) dengan menggunakan pelarut methanol dan pengujian skrining senyawa metabolik ekstrak dengan uji fitokimia pada ekstrak yang meliputi uji steroid, alkaloid, dan steroid. Hasil pengujian didapat bahwa ekstrak metanol siput onchidid memiliki terdapat senyawa metabolik sekunder dari golongan alkaloid dan steroid yang ditandai dengan reaksi positif. Hasil uji antioksidan dengan metode DPPH dengan senyawa pembanding vitamin C. Penelitian menunjukkan besar aktivitas antioksidan ekstrak metanol siput onchidid yang dinyatakan dengan nilai IC50 sebesar 92,045 yang dikategorikan antioksidan kategori kuat.
USE D-OPTIMAL MIXTURE DESIGN IN FORMULATION OF ONCHIDIID SLUG (ONCHIDIUM TYPHAE) INSTANT POWDER AS FUNCTIONAL FOODS Wijianto, Bambang; Tendianus, Tendianus; Pratiwi, Liza
Jurnal Farmasi Sains dan Praktis Vol 10 No 2 (May-August 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i2.11107

Abstract

Onchidiid slug (Onchidium typhae) is an animal with bioactive compounds with high nutritional value and the potential to be used as a functional food product. The study aimed to optimize the onchidiid slug instant powder formula, analyze its proximate content, and determine its hedonic level. The formula of instant powder was made with a comparison of the composition of maltodextrin and dextrose based on the run in the D-Optimal Mixture Design (DMD) program, namely run 1 (20%:10%), run 2 (10%:20%), run 3 (13.33%: 16.67%), run 4 (16.67%:13.33%), run 5 (15%:15%), run 6 (12.5%:17.5%), run 7 (10%: 20%), run 8 (20%:10%). The powder is tested for water content and dissolution time, and the optimal formula is analyzed using One Sample T-Test in SPSS. The results showed that the composition of maltodextrin and dextrose significantly affected the characteristics of instant powder. The optimal instant powder formula combines 18.690% maltodextrin and 11.310% dextrose with a water content of 4.892% and a soluble time of 118.052 seconds. The results of statistical analysis in verifying the optimal formula show a p-value > 0.05 (not significant). The results of the proximate content test were 8.21% water content, 0.42% ash content, 0.85% crude fiber, 3.54% protein, and 1.54%. They had a preference level in the like and acceptable in terms of color, taste, texture, and scent.
Co-Authors Agus Setyawan Agus Styawan Ajeng, Melia Ananda, Elcie Andhi Fahrurroji Andhi Fahrurroji Andhi FAHRURROJI Andhi Fahrurroji Andhi Fahrurroji Andhi FAHRURROJI Angellica, Grecya Annisa Larasati Nurhidayah Annisa Larasati Nurhidayah Arief, Ihsahnul Audrey Thendralie Ayu Setyaningrum Azura, Dhea Nur Badaria, Lailatul Buannata, Jordi Budiarto, Dwi Damanik, Virna Helena Dimas Achmad Mu’arif Emy OKTAVIANI Fajar Nugraha Guci Intan Kemuning Guci Intan Kemuning Hadi Kurniawan Hafrizal Riza Hamzah, Hasyrul Hariyanto IH Harum Nadyanti Usman Ihsanul Arief Inggrid Aprilia Manullang Intan Yap Irawan, Dandi Isnindar Isnindar Lidya Hafidzah Putri Liza Pratiwi Luliana, Sri Lurizma Putri Adinda Mohamad Andrie Muhammad Akib Yuswar Nadine, Shahira Audia Nanda Paramita Nasution, Nuraini Pinondang Simaremare Pinondang Simaremare, Pinondang Putri, Alifa Rapaella Fadia Tito Rafika Sari Randi Mulyana Putra Risa Indriyani Riyadh Aqilsya Amaryl Dyas Riyadh Aqilsya Amaryl Dyas Ropiqa, Meri Shoma Rizkifani Tendianus, Tendianus Utami, Amanda Yanasari Virna Helena Damanik Wijianto, Bambang Wijianto Yanastya, Salsa Yoana Yohana, Vanesha Yuswar, Muhammad Akib Zikri, Tan Muhamad