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All Journal Jurnal Teknosains Majalah Obat Tradisional JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Kimia Riset Chemistry Indonesian Journal of Chemical Research Al-Khidmah JPSCR : Journal of Pharmaceutical Science and Clinical Research PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Acta Chimica Asiana Indonesian Journal of Pharmaceutical and Clinical Research Jurnal Insan Farmasi Indonesia Jurnal Farmasi Komunitas Media Farmasi Indonesia Jurnal Farmasi Sains dan Praktis Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Journal Pharmacy of Tanjungpura Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Bambang WIJIANTO
Universitas Tanjungpura
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Physics Public Health Social Sciences Other

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Optimization of Gel Cream Containing HAMIN™ and HPMC K100M as Bases for Topical Delivery of Diclofenac Sodium Winarti, Lina; Gazzali, Amirah Mohd; Mufidah, Fania Mufti; Faramayuda, Fahrauk; Ulfa, Evi Umayah; Nurahmanto, Dwi; Afthoni, Muhammad Hilmi; Pratiwi, Liza; Wijianto, Bambang
Borneo Journal of Pharmacy Vol. 9 No. 1 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i1.10417

Abstract

Diclofenac sodium, a widely used NSAID, has limited skin permeability, which reduces its topical efficacy; therefore, a gel-cream formulation combining the rapid absorption of gels with the emollient properties of creams is proposed to enhance drug penetration and patient comfort. To further improve delivery, HAMIN™, a novel natural palm oil–based base with excellent biocompatibility and lipid-enhancing properties, will be combined with HPMC K100M. This thickener stabilises viscosity and prolongs skin contact time, supporting better absorption. This study aimed to develop and optimise a topical gel cream for diclofenac sodium using HAMIN™ and HPMC K100M to achieve ideal physical properties and improved skin penetration. The formulation was statistically optimised using a Simplex Lattice Design (SLD), with HAMIN™ (X₁) and HPMC K100M (X₂) as independent variables, and pH (Y₁), spreadability (Y₂), viscosity (Y₃), extrudability (Y₄), release flux (Y₅), and permeation flux (Y₆) as dependent responses. Optimisation with Design Expert version 13 yielded the ideal composition of 16.84% HAMIN™ and 1.16% HPMC K100M, resulting in predicted values of pH 5.07, spreadability 7 cm, viscosity 4502.25 mPas, extrudability 78.98 N/s, release flux 70.61 µg/cm²√min, and permeation flux 0.4868 µg/cm²/min, with a desirability score of 0.829. Despite a slightly lower release flux, the optimised HAMIN™ and HPMC K100M-based gel cream demonstrated superior skin permeation compared to a commercial emulgel for up to 300 minutes. The incorporation of HAMIN™, a natural palm oil base, offers a novel and effective strategy to enhance the topical delivery of diclofenac sodium via a statistically optimised gel cream formulation.
Uji Toksisitas Akut Serbuk Instan Siput Onchidiid (Onchidium typhae) pada Tikus (Rattus norvegicus) Betina Wistar Wijianto, Bambang; IH, Hariyanto; Awlia, Salsa Nabila
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 10, No 2 (2025)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v10i2.79870

Abstract

Siput onchidiid (Onchidium typhae) mempunyai aktivitas antioksidan, antijamur, dan antibakteri, serta kandungan alkaloid, steroid, saponin, asam amino bebas, dan protein yang tinggi. Efek farmakologis dan gizi tersebut menjadikan siput onchidiid memiliki potensi untuk dijadikan minuman fungsional dalam bentuk serbuk instan. Namun, toksisitas akut serbuk instan siput onchidiid harus dipastikan terlebih dahulu sebelum dapat digunakan. Penelitian ini bertujuan untuk mengevaluasi toksisitas akut dari serbuk instan siput onchidiid secara oral pada hewan uji dengan menggunakan Pedoman OECD No. 425, Acute Oral Toxicity (AOT): Up-and-Down Procedure (UDP). Lima belas ekor tikus (Rattus norvegicus) betina dibagi menjadi tiga kelompok, yaitu kelompok Limit 2.000, kelompok Limit 5.000, dan kelompok kontrol normal. Parameter yang diukur adalah LD50, berat badan, dan indeks organ sebagai data kuantitatif serta perilaku dan aktivitas motorik sebagai data kualitatif. Hasil penelitian menunjukkan LD50 serbuk intan siput onchidiid lebih besar dari 5.000 mg/kgBB. Disamping itu, efek toksik tidak teramati pada berat badan, indeks organ, atau perilaku dan aktivitas motorik pada hewan uji. Hasil tersebut menunjukkan bahwa serbuk instan siput onchidiid memiliki LD50 dalam kategori sediaan tidak toksik dan tidak menimbulkan efek toksik pada hewan uji.
Co-Authors Agus Setyawan Agus Styawan Ajeng, Melia Ananda, Elcie Andhi FAHRURROJI Andhi Fahrurroji Andhi Fahrurroji Andhi FAHRURROJI Andhi Fahrurroji Andhi Fahrurroji Angellica, Grecya Annisa Larasati Nurhidayah Annisa Larasati Nurhidayah Arief, Ihsahnul Audrey Thendralie Awlia, Salsa Nabila Ayu Setyaningrum Azura, Dhea Nur Badaria, Lailatul Buannata, Jordi Budiarto, Dwi Damanik, Virna Helena Dimas Achmad Mu’arif Dwi Nurahmanto Emy OKTAVIANI Evi Umayah Ulfa Fahrauk Faramayuda, Fahrauk Fajar Nugraha Gazzali, Amirah Mohd Guci Intan Kemuning Guci Intan Kemuning Hadi Kurniawan Hafrizal Riza Hamzah, Hasyrul Hariyanto IH Harum Nadyanti Usman Ihsanul Arief Inggrid Aprilia Manullang Intan Yap Irawan, Dandi Isnindar Isnindar Lidya Hafidzah Putri Lina Winarti Liza Pratiwi Luliana, Sri Lurizma Putri Adinda Mohamad Andrie Mufidah, Fania Mufti Muhammad Akib Yuswar Nadine, Shahira Audia Nanda Paramita Nasution, Nuraini Pinondang Simaremare Pinondang Simaremare, Pinondang Putri, Alifa Rapaella Fadia Tito Rafika Sari Randi Mulyana Putra Risa Indriyani Riyadh Aqilsya Amaryl Dyas Riyadh Aqilsya Amaryl Dyas Ropiqa, Meri Shoma Rizkifani Tendianus, Tendianus Utami, Amanda Yanasari Virna Helena Damanik Wijianto, Bambang Wijianto Yanastya, Salsa Yoana Yohana, Vanesha Yuswar, Muhammad Akib Zikri, Tan Muhamad