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All Journal Jurnal Teknosains Majalah Obat Tradisional JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Kimia Riset Chemistry Indonesian Journal of Chemical Research Al-Khidmah PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Acta Chimica Asiana Indonesian Journal of Pharmaceutical and Clinical Research Jurnal Insan Farmasi Indonesia Jurnal Farmasi Komunitas Media Farmasi Indonesia Jurnal Farmasi Sains dan Praktis Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Journal Pharmacy of Tanjungpura Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Bambang WIJIANTO
Universitas Tanjungpura
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Physics Public Health Social Sciences Other

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Analisis Efektivitas dan Rasionalitas Penggunaan Digoxin pada Pasien Gagal Jantung Kongestif di Instalasi ICCU RSUD DR.Soedarso Pontianak Ajeng, Melia; Rizkifani, Shoma; Wijianto, Bambang
Jurnal Farmasi Komunitas Vol. 12 No. 2 (2025): JURNAL FARMASI KOMUNITAS
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfk.v12i2.48438

Abstract

Terapi glikosida jantung yaitu obat digoksin dapat digunakan untuk mengatasi gagal jantung kongestif. Namun, digoksin merupakan obat dengan indeks terapeutik sempit yang memungkinkan terjadinya keracunan digitalis. Sehubungan dengan penggunaan digoksin, perhatian harus diberikan untuk memastikan bahwa golongan obat ini digunakan secara rasional dan efektif.  Tujuan dari penelitian ini adalah untuk menganalisis efektivitas dan rasionalitas penggunaan digoksin pada pasien gagal jantung. Penelitian ini dilakukan dengan menganalisis ketepatan obat, indikasi, dosis, dan frekuensi serta efektivitas digoksin terhadap pasien gagal jantung kongestif. Hasil penelitian ini terdapat 19 pasien yang menerima digoksin, 19 (100%) pasien tepat obat, 7 (36,8%) pasien menerima digoksin sesuai indikasi, 19 (100%) pasien mendapatkan dosis yang sesuai dan 19 (100%) pasien diberikan frekuensi pemberian yang tepat. Efektivitas digoksin ditunjukan berdasarkan tanda vital pasien dengan rata-rata HR normal 88,2x/menit, RR normal 20x/menit, SPO2 normal 97,5% dan TD pasien 105/66 mmHg. Kesimpulan penelitian ini bahwa evaluasi ketepatan obat pasien rata-rata sesuai dan tanda-tanda vital pada pasien gagal jantung kongestif berada dalam rentang normal.
Optimization of Gel Cream Containing HAMIN™ and HPMC K100M as Bases for Topical Delivery of Diclofenac Sodium Winarti, Lina; Gazzali, Amirah Mohd; Mufidah, Fania Mufti; Faramayuda, Fahrauk; Ulfa, Evi Umayah; Nurahmanto, Dwi; Afthoni, Muhammad Hilmi; Pratiwi, Liza; Wijianto, Bambang
Borneo Journal of Pharmacy Vol. 9 No. 1 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i1.10417

Abstract

Diclofenac sodium, a widely used NSAID, has limited skin permeability, which reduces its topical efficacy; therefore, a gel-cream formulation combining the rapid absorption of gels with the emollient properties of creams is proposed to enhance drug penetration and patient comfort. To further improve delivery, HAMIN™, a novel natural palm oil–based base with excellent biocompatibility and lipid-enhancing properties, will be combined with HPMC K100M. This thickener stabilises viscosity and prolongs skin contact time, supporting better absorption. This study aimed to develop and optimise a topical gel cream for diclofenac sodium using HAMIN™ and HPMC K100M to achieve ideal physical properties and improved skin penetration. The formulation was statistically optimised using a Simplex Lattice Design (SLD), with HAMIN™ (X₁) and HPMC K100M (X₂) as independent variables, and pH (Y₁), spreadability (Y₂), viscosity (Y₃), extrudability (Y₄), release flux (Y₅), and permeation flux (Y₆) as dependent responses. Optimisation with Design Expert version 13 yielded the ideal composition of 16.84% HAMIN™ and 1.16% HPMC K100M, resulting in predicted values of pH 5.07, spreadability 7 cm, viscosity 4502.25 mPas, extrudability 78.98 N/s, release flux 70.61 µg/cm²√min, and permeation flux 0.4868 µg/cm²/min, with a desirability score of 0.829. Despite a slightly lower release flux, the optimised HAMIN™ and HPMC K100M-based gel cream demonstrated superior skin permeation compared to a commercial emulgel for up to 300 minutes. The incorporation of HAMIN™, a natural palm oil base, offers a novel and effective strategy to enhance the topical delivery of diclofenac sodium via a statistically optimised gel cream formulation.
Co-Authors Agus Setyawan Agus Styawan Ajeng, Melia Ananda, Elcie Andhi FAHRURROJI Andhi Fahrurroji Andhi Fahrurroji Andhi FAHRURROJI Andhi Fahrurroji Andhi Fahrurroji Angellica, Grecya Annisa Larasati Nurhidayah Annisa Larasati Nurhidayah Arief, Ihsahnul Audrey Thendralie Ayu Setyaningrum Azura, Dhea Nur Badaria, Lailatul Buannata, Jordi Budiarto, Dwi Damanik, Virna Helena Dimas Achmad Mu’arif Dwi Nurahmanto Emy OKTAVIANI Evi Umayah Ulfa Fahrauk Faramayuda, Fahrauk Fajar Nugraha Gazzali, Amirah Mohd Guci Intan Kemuning Guci Intan Kemuning Hadi Kurniawan Hafrizal Riza Hamzah, Hasyrul Hariyanto IH Harum Nadyanti Usman Ihsanul Arief Inggrid Aprilia Manullang Intan Yap Irawan, Dandi Isnindar Isnindar Lidya Hafidzah Putri Lina Winarti Liza Pratiwi Luliana, Sri Lurizma Putri Adinda Mohamad Andrie Mufidah, Fania Mufti Muhammad Akib Yuswar Nadine, Shahira Audia Nanda Paramita Nasution, Nuraini Pinondang Simaremare Pinondang Simaremare, Pinondang Putri, Alifa Rapaella Fadia Tito Rafika Sari Randi Mulyana Putra Risa Indriyani Riyadh Aqilsya Amaryl Dyas Riyadh Aqilsya Amaryl Dyas Ropiqa, Meri Shoma Rizkifani Tendianus, Tendianus Utami, Amanda Yanasari Virna Helena Damanik Wijianto, Bambang Wijianto Yanastya, Salsa Yoana Yohana, Vanesha Yuswar, Muhammad Akib Zikri, Tan Muhamad