Article Per Year (5 Year)
p-Index From 2021 - 2026
2.978
P-Index
This Author published in this journals
All Journal PHARMACON Jurnal Ilmu Kefarmasian Indonesia The Studies of Social Sciences Jurnal Kesehatan Tambusai Jurnal Ilmiah Sains Grimsa Journal of Science Engineering and Technology Jurnal Lentera Farma
Paulina yamlean
Program Studi Farmasi, Universitas Sam Ratulangi
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Engineering Environmental Science Health Professions Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences

Published : 89 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 89 Documents
Search

 4   5   6   7   8 
ISOLASI DAN UJI ANTIBAKTERI DARI ISOLAT BAKTERI YANG BERASOSIASI DENGAN SPONS Callyspongia aerizusa SERTA IDENTIFIKASI SECARA BIOKIMIA Liempepas, Angelika; Lolo, Widya A.; Yamlean, Paulina V. Y.
PHARMACON Vol 8, No 2 (2019): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.8.2019.29304

Abstract

ABSTRACT               Sponge Callyspongia aerizusa contain potential bioactive compound that can be utilized in the health sector. Extract of sea sponge Callyspongia aerizusa, can hamper the growth of Salmonella typhi bacteria, Streptococcus pyogenes, Shigella and Staphylococcus epidermidis. The aim of this study was to test the antibacterial activity against Escherichia coli and Staphylococcus aureus bacteria and identify the type of symbionic bacteria of Callyspongia aerizusa sponge based on their physiological and biochemical characteristics. The method of testing the antibacterial activity was agar diffusion method (Kirby and Baurer diffusion disc). There were three bacterial isolates namely T1, T2, and T3 isolates. The result showed that T1, T2, and T3bacterial isolates had antibacterial activity against Escherichia coli and Staphylococcus aureus test bacteria. Based on the biochemical test, T2bacterial isolates were identified as Bronchothrix bacteria and T1and T3 bacterial identified as Desulfotomaculum. Keywords: Callyspongia aerizusa, Antibacterial activity, symbiont bacteria, Biochemical Identification   ABSTRAKSpons Callyspongia aerizusa memiliki kandungan senyawa bioaktif potensial yang dapat dimanfaatkan dibidang kesehatan. Ekstrak spons laut Callyspongia aerizusa dapat menghambat pertumbuhan bakteri Salmonella typhi, Streptococcus pyogenes, Shigella dan Staphylococcus epidermidis. Penelitian ini bertujuan untuk menguji aktivitas antibakteri dari bakteri simbion spons Callyspongia aerizusa terhadap bakteri Escherichia coli dan Staphylococcuc aureus dan mengidentifikasi jenis bakteri simbion spons Callyspongia aerizusa berdasarkan karakteristik fisiologis dan biokimianya. Metode pengujian aktivitas antibakteri yang digunakan yaitu metode difusi agar (disc diffusion Kirby and Baurer). Terdapat tiga isolat bakteri yaitu isolat T1, T2, dan T3. Hasil penelitian menunjukan bahwa isolat bakteri T1, T2, dan T3 memiliki aktivitas antibakteri terhadap bakteri uji Escherichia coli dan Staphylococcuc aureus. Berdasarkan uji biokima, isolat bakteri T2 diduga sebagai bakteri Brochothrix dan  isolat bakteri T1 dan T3 diduga sebagai bakteri Desulfotomaculum.Kata kunci: Callyspongia aerizusa, Aktivitas antibakteri, Bakteri simbion, Identifikasi Biokimia
PENGARUH PEMBUATAN SALEP EKSTRAK DAUN AFRIKA (Vernonia amygdalina) DENGAN BASIS HIDROKARBON DAN ABSORBSI TERHADAP PENYEMBUHAN LUKA BAKAR PADA KELINCI (Oryctolagus cuniculus) Lahagina, Juan C. G.; Yamlean, Paulina V. Y.; Supriati, Hamidah S
PHARMACON Vol 8, No 1 (2019): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.8.2019.29247

Abstract

ABSTRACTBurn wound is damaged tissue caused by contact with a heat source which causes infection, so needed some drug for this burn wound. Ointment is a pharmaceutical dosage form used on the skin which is intended for topical effect. In African leaves or Vernonia amygdalina  which has many chemical contents and useful effects. This study aimed to test the quality preparation of ointments made from African leaves ethanol extract with hydrocarbon and absorption and its effect on burn wound in rabbits in order to find out effective ointment base for burn wound. The procedures applied were to dry the samples and extract them by maceration. After that, the samples were soaked using ethanol and diaterbath to obtain their thick extract. Later, the base ointment was mixed with thick extract using hot mortar, and tested for its physical properties and effectiveness of burn wound. The results showed that the hydrocarbon and absorbtion ointment base has good quality except for absorption’s poor distribution capacity due to its small dispersive power. African leaves extract ointment with hydrocarbon base and absorption has good quality preparations except for the absorption base’ dispersion power for due to its small dispersive power. To conclude, this study proves that the African leaf extract ointment with hydrocarbon base is very effective for burn wound healing. Key Words: African Leaves, Burn Wound, Ointment. ABSTRAKLuka bakar merupakan rusaknya jaringan yang disebabkan kontak dengan sumber panas yang dapat menimbulkan infeksi, maka dari itu dibutuhkan sediaan yang dapat menangani luka bakar tersebut. Sediaan salep merupakan bentuk sediaan farmasi yang digunakan pada kulit yang dimaksudkan untuk efek topikal. Pada daun Afrika (Vernonia amygdalina) dapat ditemukan banyak kandungan kimia dan efek yang baik juga. Pada penelitian ini bertujuan untuk menguji salep ekstrak etanol daun Afrika dengan basis hidrokarbon dan absorbsi terhadap sediaan mutu dan juga terhadap luka bakar pada kelinci kemudian menemukan basis salep yang efektif untuk luka bakar. Sampel dikeringkan dan diekstraksi secara maserasi dan direndam menggunakan etanol dan diwaterbath untuk mendapatkan ekstrak kental, bahan basis salep dicampurkan dengan ekstrak kental menggunakan mortar panas, diuji sifat fisik dan efektifitas terhadap luka bakar. Basis hidrokarbon sangat efektif untuk luka bakar. Untuk basis hidrokarbon bersifat melunakkan lapisan kulit karena occlusive sehingga akan meningkatkan hidratasi kulit dengan menghambat penguapan air pada lapisan kulit, akibat hidratasi lapisan kulit, mungkin juga akan meningkatkan aktivitas obat. Absorbsi menunjukkan kemampuan basis dalam menyerap air, bukan kemampuan obat diabsorpsi oleh kulit. Salep ekstrak daun Afrika dengan basis hidrokarbon dan absorbsi memiliki sediaan mutu yang baik kecuali pada bagian daya sebar untuk basis absorbsi karena memiliki hasil daya sebar yang kecil, basis hidrokarbon salep ekstrak daun Afrika sangat efektif terhadap penyembuhan luka bakar. Kata Kunci: Daun Afrika, Luka Bakar, Salep.
UJI EFEK ANTIBAKTERI JAMUR ENDOFIT PADA TUMBUHAN KEMANGI (Ocimum bassilicum L.) PADA BAKTERI UJI Staphylococcus aureus DAN Escherichia coli Walewangko, Marfincy S.; Posangi, Jimmy; Yamlean, Paulina V. Y.
PHARMACON Vol 8, No 3 (2019): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.8.2019.29397

Abstract

ABSTRACT                                                                 Endophytic microbes are microbes that live in plant tissues. Endophytic fungi can produce various functional compounds in the form of anticancer compounds, antiviral, antibacterial, antifungal and plant growth hormones. Basil (Ocimum Sanctim L.) is the largest species both in fresh form or for the production of essential oils. Ethanol and methanol extracts, from Basil leaves is stated to have antibacterial activity. This study aimed to examine the presence or absence of antibacterial effects of endophytic fungi isolated from the stem and leaves of basil (Ocimum basilicum L.) against Escherichia coli and Staphylococcus aureus. The method used is an experimental laboratory by testing antibacterial activity. From the research carried out four endophytic fungi isolated from the stems and leaves of the Basil (Ocimum basilicum L.) plant. The four endophytic fungi have an antibacterial effect on the two test bacteria. Endophytic fungus from Basil stem 1.2 by 8mm which is categorized as medium and extract of Basil Stem 4.1 by 7mm which is categorized as medium and Basil Stem 1.1 by 17mm categorized as strong and Basil Leaf 2.1 by 22mm categorized as very strong. The conclusion is that endophytic fungi isolated from the Basil (Ocimum bassilicum L.) plant obtained from Lemoh Uner Village have antibacterial activity. Keywords: Antibacterial, Endophytic Fungi, Basil (Ocimum basilicum L.)  ABSTRAK Mikroba endofit merupakan mikroba yang hidup di dalam jaringan tumbuhan. Jamur endofit dapat menghasilkan berbagai senyawa fungsional berupa senyawa antikanker, antivirus, antibakteri, antifungi serta hormon pertumbuhan tanaman. Kemangi (Ocimum Sanctim L.) merupakan spesies terbesar baik dalam bentuk segar ataupun untuk produksi minyak esensial. Ekstrak etanol, metanol daun Kemangi dinyatakan memiliki aktivitas antibakteri. Penelitian ini bertujuan untuk menguji ada tidaknya efek antibakteri jamur endofit yang diisolasi dari batang dan daun tumbuhan Kemangi (Ocimum basilicum L.) terhadap Escherichia coli dan Staphylococcus aureus. Metode yang digunakan ialah eksperimental laboratorium dengan menguji aktivitas antibakteri. Dari penelitian yang dilakukan diperoleh empat jenis jamur endofit yang diisolasi dari batang dan daun tumbuhan Kemangi (Ocimum basilic um L.). Keempat jamur endofit memiliki efek sebagai antibakteri terhadap kedua bakteri uji. Jamur endofit dari Kemangi batang 1.2 sebesar 8mm yang dikategorikan sedang dan ekstrak Kemangi Batang 4.1 sebesar 7mm yang dikategorikan sedang dan Kemangi Batang 1.1 sebesar 17mm dikategorikan kuat dan Kemangi Daun 2.1 sebesar 22mm dikategorikan sangat kuat. Kesimpulanya jamur endofit yang diisolasi dari tumbuhan Kemangi (Ocimum bassilicum L.) yang diperoleh dari Desa Lemoh Uner memiliki aktivitas antibakteri. Kata kunci :  Antibakteri, Jamur Endofit, Kemangi (Ocimum basilicum L.)
ANALISIS EFEKTIVITAS BIAYA PADA PASIEN INFEKSI SALURAN KEMIH (ISK) RAWAT INAP DI RUMAH SAKIT BHAYANGKARA MANADO Sukandi, Gabrilia P. C.; Citraningtyas, Gayatri; Yamlean, Paulina V. Y.
PHARMACON Vol 8, No 1 (2019): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.8.2019.29258

Abstract

ABSTRACT Urinary tract infections are a clinical condition due to the presence of microorganisms in the urine and the potential for invasion of the upper urinary tract, invading the renal pelvic mucosa and extending into the interstitial tissues of the kidneys. Urinary tract infections treated with antibiotics are one of the significant cost categories in the pharmaceutical budget in hospitals. The purpose of this study was to determine a more cost effective therapy between the use of Ceftriaxone and Ciprofloxacin in UTI patients hospitalized at Bhayangkara Hospital, Manado. This study uses a descriptive research method with retrospective data collection. The sample in this study were 36 patients including 15 patients using Ceftriaxone and 21 patients using Ciprofloxacin. The results showed that the most cost-effective  antibiotic was Ceftriaxone with an ACER value of IDR 781,890 and ICER value of IDR 551,255. Keywords: Cost Effectiveness Analysis, Urinary Tract Infections, Ceftriaxone, Ciprofloxacin. ABSTRAK Infeksi saluran kemih adalah keadaan klinis akibat adanya mikroorganisme dalam urin dan berpotensi untuk invasi ke saluran kemih bagian atas, menginvasi mukosa pelvis ginjal dan meluas ke dalam jaringan interstisial ginjal. Infeksi saluran kemih diobati dengan antibiotik yang menjadi salah satu kategori biaya yang signifikan dalam anggaran farmasi di rumah sakit. Tujuan penelitian ini untuk menentukan terapi yang lebih cost effective antara penggunaan Seftriakson dan Siprofloksasin pada pasien ISK rawat inap di RS Bhayangkara Manado. Penelitian ini menggunakan metode penelitian deskriptif dengan pengambilan data secara retrospektif. Sampel pada penelitian ini sebanyak 36 pasien diantaranya15 pasien menggunakan Seftriakson dan 21 pasien menggunakan Siprofloksasin. Hasil penelitian menunjukan, antibiotik yang paling cost-effective adalah Seftriakson dengan nilai ACER sebesar Rp. 781.890 dan nilai ICER sebesar Rp. 551.255. Kata Kunci : Analisis Efektivitas Biaya, Infeksi Saluran Kemih, Seftriakson, Siprofloksasin
FORMULASI DAN UJI AKTIVITAS ANTIJAMUR SEDIAAN KRIM EKSTRAK METANOL KETEPENG CINA (Cassia alata L.) TERHADAP JAMUR Candida albicans Rumayar, Ricky C.; Yamlean, Paulina V. Y.; Siampa, Jainer P.
PHARMACON Vol 9, No 3 (2020): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.9.2020.30020

Abstract

ABSTRACTCandle tree is widely used traditionally as an antiparasitic and antifungal. Candle tree leaves have important ingredients such as alkaloids, saponins, tannins, steroids, anthraquinones, flavonoids. This study aims to formulate, evaluate, and test the antifungal effectiveness of cream preparations with M / A cream types of methanol extract of Candle tree (cassia alata L.) leaves at a concentration of 3.5%; 5.5% and 7.5%. Antifungal effectiveness tests were performed using the diffusion method for creams with the largest antifungal activity. Then the results of testing the effectiveness of the largest antifungal cream was obtained at a concentration of 7.5% with a 9.5 mm diameter of inhibition zone. Physical evaluation of the preparation includes organoleptic test, homogeneity test, pH test, dispersion test, adhesion test, and cycling test. All tests are carried out before and after cyling test. The results of the cream preparation study met the physical evaluation requirements before the cycling test and after the cyling test. Antifungal cream showed organoleptic, homogeneity, pH 8, spreadability test 6.67 cm and adhesion test 27.41 seconds after storage did not change. In conclusions from the study of 3.5% concentration cream; 5.5% and 7.5% methanol extract of Candle tree leaves can be formulated as a cream preparation because it is physically stable and has strong antifungal activity. Keywords: Candle tree (cassia alata L.), Cream, Candida albicans, Antifungal  ABSTRAK Ketepeng cina banyak dimanfaatkan secara tradisional, antara lain adalah sebagai antiparasit dan antijamur Daun ketepeng cina memiliki kandungan penting seperti alkaloid, saponin, tannin, steroid, antrakuinon, flavonoid. Penelitian ini bertujuan untuk memformulasi, mengevaluasi, serta menguji efektivitas antijamur sediaan krim dengan tipe krim M/A daun ekstrak metanol ketepeng cina (cassia alata L.) pada konsentrasi 3,5%; 5,5% dan 7,5%. Uji efektivitas antijamur dilakukan dengan metode difusi untuk krim dengan aktivitas antijamur terbesar. Kemudian dilakukan hasil pengujian efektivitas krim antijamur terbesar diperoleh pada konsentrasi 7,5% dengan diameter zona hambat 9,5 mm. evaluasi fisik sediaan meliputi uji organoleptic, uji homogenitas, uji pH, uji daya sebar, uji daya lekat, dan uji cycling test semua pengujian dilakukan sebelum dan sesudah cyling test. Hasil  penelitian sediaan krim memenuhi persyaratan evaluasi fisik sebelum uji cycling test dan setelah cyling test. Krim antijamur memperlihatkan organoleptic, homogenitas, pH 8, uji daya sebar 6,67 cm dan uji daya lekat 27,41 detik setelah penyimpanan tidak terjadi perubahan. Kesimpulan dari penelitan pada krim konsentrasi 3,5%; 5,5% dan 7,5% ekstrak metanol daun ketepeng cina dapat diformulasi sebagai sediaan krim karena stabil secara fisik dan memiliki aktivitas antijamur yang kuat. Kata kunci : Ketepeng cina (cassia alata L.), Krim, Candida albicans, Antijamur
FORMULASI KRIM EKSTRAK ETANOL DAUN LAMUN (Syringodium isoetifolium) Juwita, Anisa Puspa; Yamlean, Paulina V.Y; Edy, Hosea Jaya
PHARMACON Vol 2, No 2 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.1414

Abstract

Seagrass (Syringodium isoetifolium) is a plant that lives submerged at sea, this floweringplant, leaves, and stems that are plugged into a powerful in water. The chemical content ofthe leaves of the Seagrass is a flavonoid, phenol, hydroquinone, and antioxidants.This studyaims to determine the quality of the cream of seagrass leaf extracts using a concentration of5%, 10%, 20% dan 40%. on organoleptic testing conducted cream, homogeneity test, testdispersive power, pH and absorbance test. results obtained in the organoleptic seen from thecolor green, semi-solid dosage forms and distinctive smell seagrass cream. homogeneity test.homogeneity test cream seagrass leaf extract with a concentration of 5% 10% 20% and 40%did not experience any clumping or phase separation dispersive power test creams rangedfrom 2.5 cm - 3.5 cm. pH ranged from 4.93 - 5.96 and test absorption ranged from 3.7 ml - 5ml. seagrass leaf extract cream with type W/O creams that meet the test of homogeneity testquality, dispersive power test, test and test pH absorptionKeyword : Syringodium isoetifolium, Seagrass Leaves, Cream W/O
FORMULASI SEDIAAN SABUN CAIR KOMBINASI EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura L.) DAN DAUN KEMANGI (Ocymum basilicum L.) DAN UJI TERHADAP BAKTERI Staphylococcus aureus Nau'e, Dwi A.K.; Yamlean, Paulina V. Y.; Mpila, Deby A.
PHARMACON Vol 9, No 3 (2020): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.9.2020.30025

Abstract

ABSTRACTKersen leaves (Muntingia Calabura L.) and Basil leaves (Ocymum basilicum L.) are plants that contain flavonoid compounds, saponin and tannin which acts as antibacterial. The aims of this study is formulate liquid soap in combination of ethanol extract of Kersen leaves and basil leaves and to test the antibacterial effectiveness and evaluate the physical preparates of liquid soap in combination of ethanol extract of Kersen leaves and Kemangi leaves. This research uses a laboratorium experimental method. Based on the results of the study showed physical evaluations such as organoleptics which are dark green and dark brown, Soap pH above 8, measurement height of foam 60-88 mm, calculation of water content was 46%, free alkali content was 0,05-0,06 g/ml, and specific gravity was 1,01-1,09 g/ml. Liquid soap combination of Kersen and Basil leaves extract has antibacterial effectiveness of average diameter for FI 10 mm, F2 10,33 mm, F3 11 mm, F4 11,5 mm, and F5 10,67 mm. In conclusion, the combination of Kersen and Basil leaves extract can be formulated into liquid soap, liquid soap preparations in physical evaluation testing had met the standards set by SNI. Liquid soap preparation has antibacterial effectiveness which is included in the strong category.Keywords: Antibacterial, Liquid Soap, Kersen, Basil.ABSTRAK Daun Kersen (Muntingia Calabura L.) dan Daun Kemangi (Ocymum basilicum L.) merupakan tanaman yang memiliki kandungan senyawa flavonoid, saponin dan tannin yang bersifat sebagai antibakteri. Penelitian ini bertujuan untuk memformulasikan sabun cair kombinasi ekstrak etanol daun Kersen dan daun Kemangi serta menguji efektivitas antibakteri dan mengevaluasi sediaan fisik dari sabun cair kombinasi ekstrak etanol daun Kersen dan daun Kemangi. Penelitian ini menggunakan metode ekperimental laboratorium. Berdasarkan hasil penelitian menunjukkan evaluasi fisik seperti organoleptik berwarna hijau tua dan cokelat tua, pH sabun diatas 8, pengukuran tinggi busa 60-88 mm, perhitungan kadar air yaitu 46%, kadar alkali bebas yaitu 0,05-0,06 g/ml, dan bobot jenis yaitu 1,01-1,09 g/ml. Sediaan sabun cair kombinasi ekstrak daun Kersen dan daun Kemangi memiliki efektifitas antibakteri diameter rata-rata untuk FI 10 mm, F2 10,33 mm, F3 11 mm, F4 11,5 mm, dan F5 10,67 mm. Kesimpulannya kombinasi ekstrak daun Kersen dan daun Kemangi dapat diformulasikan menjadi sabun cair, sediaan sabun cair dalam pengujian evaluasi fisik telah memenuhi standar yang ditetapkan oleh SNI. Sediaan sabun cair memiliki efektifitas antibakteri yang termasuk kategori kuat. Kata Kunci: Antibakteri, Sabun Cair, Kersen, Kemangi.
ISOLASI DAN IDENTIFIKASI SENYAWA FLAVANOID PADA DAUN ADAM HAWA (Rhoe discolor) Sitorus, Risma Meidy Hardina; Wullur, Adeanne; Yamlean, Paulina
PHARMACON Vol 1, No 1 (2012)
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.1.2012.446

Abstract

One of the plants can be used as a drug crop is Adam Hawa (Rhoe discolor) are thought to containflavanoid compounds, it is seen from the purple on the leaf. This study aims to determine the presenceor absence of flavonoids and other types of flavanoid compounds are contained in the leaf AdamHawa (Rhoe discolor). Isolation of flavonoids is done by maceration. Flavanoid compoundidentification is done by preparative Thin Layer Chromatography (KLTP) using the eluent n-butanol:acetic acid: water (BAA) with a ratio of 4:1:5. Identification of flavanoid compounds made with UVVisspectrophotometer. The results showed the leaf extract of Adam Hawa (Rhoe discolor) containsflavanoid compounds. Seen from the results of preparative thin layer chromatography to yield threespots with Rf value of 0.09; 0.36, and 0.71. Based on the analysis of UV-Vis spectrophotometer, threeisolates with Rf value of 0.71 has a maximum wavelength of 275 nm.Keyword : Adam Eve leaf (Rhoe discolor), Flavanoid, Preparative Thin Layer Chromatography(KLTP), UV-Vis spectrophotometer.
PENGUJIAN EFEK DIURETIK SARI WORTEL (Daucus carota L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus) Sinaga, Mery A R; Bodhi, Widdhi; Yamlean, Paulina V Y
PHARMACON Vol 1, No 2 (2012)
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.1.2012.484

Abstract

Carrot (Daucus carota L.) is a plant which used as traditional medicine and one of its benefits isas diuretic. The research was aimed to find out diuretic effect of Carrot juice and relationship ofthe increases of Carrot juice (Daucus carota L.) concentration on white male mice strain Wistar(Rattus norvegicus). Fifteen mices were divided into five group of treatment, namely negativecontrol group (CMC 1% suspension), positive control group (furosemid suspension), 15%suspension of carrot juice group, 30% suspension of carrot juice group and 60% suspension ofCarrot juice group.The test of diuretic effect were conducted by calculate volume of excretedurine during 24 hours treatment. Data were analyzed using spss ver.19. The differences betweentreatments were analyzed using one way ANOVA.The result shows that suspension of Carrotjuice treatment increase urine volume. The increases of juice concentration shows better effect.Based on result, it can be concluded that Carrot juice possess diuretic effect (p<0,05), and thereare correlation between concentrations of Carrot juice to the increasing of urinevolume.Keywords : Carrot juice, diuretic effect, Rattus norvegicus
Formulasi Granul Effervescent Ekstrak Daun Leilem (Clerodendrum minahassae L) Palobo, Fabiola N; Yamlean, Paulina V. Y.; Yudistira, Adithya
PHARMACON Vol 1, No 2 (2012)
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.1.2012.488

Abstract

Leilem Leaves had a bitter taste, but it is believed as antioxidant. This research aims to find way formaking a formulation of effervescent granules from Leilem leaves extract wich is demand thestandards for effervescent granules. The extracts resulted from soxhletasi method with 95% ethanol(1:5), and the formula based from 7% extract, citric acid 16.2%, 25.2% tartaric acid, lemon essence2%, 0.5% CMC, and food coloring. Effervescent granules from Leilem leaves are prepared by drygranulation method. Results of manufacturing effervescent granules was tested by physical stuff, andthen compared with the literature, the test results showed effervescent granules have a regularlyshape, with orange-scented, had a 4.35% value of LOD, the pour volume is 150g/183mL with 1.09%volume of shrinkage, the test flow capacity is 30.650, and able to complete the test of dispersion timefor 1 minute 9 seconds. Based on these results it can be concluded that the extract of Leilem leavescan be made an effervescent granules by dry granulation method, and has a good quality because itwas demand the standards test of good granules.Key word: Clerodendrum minahassae L, Ekstract, Formulation, Effervescent
Co-Authors Aaltje Manampiring Abdullah, Surya S. Abdullah, Surya Sumantri Abubakar, Poetry M.S. Abubakar, Poetry Melinda Adeanne Wullur Adithya Yudistira Amanda Putri Pratikto Anisa Puspa Juwita Antasionasti, Irma Apriliani Margaret Marista Lourina Rarung Ariem, Feiby Ba'u, Defrikson Billy Kepel Christania A. E. Pakasi Clements, Garry Daimunon, Regita Defrikson Ba'u Dewa G Katja Dewa Gede Katja Edi Suryanto Edwin de Queljoe Edwin De Queljoe Ekawati Tallei, Trina Elly Suoth Ering, Mariando N. Fabiola N Palobo Fadillah Djafar Falugah, Fathia Fatimawali . Fona Budiarso Frendsiane Pangalinan Gayatri Citraningtyas Grace Riani Pongsipulung Gratia, Berta Gusti Ayu Wulandari Hamdiyah Hamzah Hamidah Sri Supriati Hosea Jaya Edy Hutauruk, Hamido Immanuela Irene Mandias Inriani MarlinMareyke Rumayar Jainer P. Siampa Jainer Pasca Siampa Jainer Siampa Jayanto, Imam Jeane Mongi Jimmy Posangi Jonly Piere Uneputty Julianri Sari Lebang, Julianri Sari Kalalo, Tekla Karlah L. R. Mansauda Korompis, Freisy C.C Lahagina, Juan Lahagina, Juan C. G. Lakoro, Julia Elsa Lebang, Julianri S. Legoh, Dina Imorina Lempoy, Sela S Liempepas, Angelika Lisma Burhan Lolowang, Sheren N. Lomboan, Evander Roliand Majid, Nurul Majid, Nurul S Manarisip, Thesya Marhaba, Fera Anelia Maureen Regina Satolom Max R. J. Runtuwene Max R.J Runtuwene Max R.J. Runtuwene Merry Senewe Mery A R Sinaga Moilati, Veronica O. Monibala, Tiarma Mopangga, Elisticia Nau'e, Dwi A.K. Nelwan, Sabine A. Niswah Paju Novel Kojong Olivia H Naibaho, Omega Agral Pakasi, Christania A. E. Pakpahan, Kevin Yosua Pangemanan, David Albert Pingkan, Aprilia Pogaga, Eklesia Poluan, Omega A Pratasik, Meyla Pratasik, Meyla C. M. Purwoko, Agus Ratte, Titah Amelia Ravael Kurnia Kolibu Risma Meidy Hardina Sitorus Rompis, Ferrna Rumayar, Ricky C. Rundengan, Gerald Runtuwene, Kristianus Siampa, Jainer Pasca Singal, Ausich Sukandi, Gabrilia Sukandi, Gabrilia P. C. Suru, Eunike Surya S. Abdullah Surya Sumantri Abdullah Surya Sumantri Abdullah Tasya Mangkey Tiarma Tiarma TRINA EKAWATI TALLEI Umboh, Defritsevani Umboh, Defritsevani Y. Vanda S Kamu Vanda S Kamu Veren Naftalia Mamangkey Violeta Gavelentri Melga Tambingon Virginia lasut Walewangko, Marfincy Walewangko, Marfincy S. Weny I Wiyono Weny Wiyono Widdhi Bodhi Widdhi Bodhi Widya Astuty Lolo, Widya Astuty Yos Banne Yuni Arista N Kumesan