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All Journal Jurnal Ilmiah Farmasi EKSAKTA: Journal of Sciences and Data Analysis JURNAL PHARMASCIENCE Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Sains dan Komunitas Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline Jurnal Ilmu Kefarmasian Indonesia JKPK (Jurnal Kimia dan Pendidikan Kimia) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Khazanah: Jurnal Mahasiswa JKKI : Jurnal Kedokteran dan Kesehatan Indonesia International Journal of Health and Pharmaceutical (IJHP) Jurnal Farmasi Sains dan Praktis Media Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian
Yandi Syukri
Department Of Pharmacy, Faculty Of Mathemathics And Natural Sciences, Universitas Islam Indonesia
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Nanotechnology-Based Formulations of Curcuma xanthorrhiza for Modern Herbal Therapy: A Narrative Literature Review: Formulasi Berbasis Nanoteknologi Curcuma xanthorrhiza Roxb. sebagai Terapi Herbal Modern: Tinjauan Literatur Naratif Fitriani, Hannie; Luthfiansyah Azhar, Hanif; Syukri, Yandi; Pramundita Ramadani, Arba
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 12 No. 1 (2026): (March 2026)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2026.v12.i1.17972

Abstract

Background: Curcuma xanthorrhiza Roxb. (temulawak) is an Indonesian medicinal plant with documented antibacterial, anti-inflammatory, antioxidant, hepatoprotective, and anticancer activities, yet its major active compounds, curcuminoids and xanthorrhizol, suffer from poor aqueous solubility, low stability, and very limited oral bioavailability. Objectives: This study aims to review nanotechnology-based formulation strategies developed to overcome the biopharmaceutical limitations of C. xanthorrhiza and to optimise its potential as a modern herbal therapy. Methods: A narrative literature review was conducted using national and international articles published mainly between 2015 and 2025 that were retrieved from PubMed, ScienceDirect, and Google Scholar with keywords related to Curcuma xanthorrhiza, nanoformulation, and drug delivery systems; data were qualitatively summarised according to type of nanoformulation, physicochemical characteristics, and in vitro or in vivo biological activities. Results: Various nanotechnology-based delivery systems were identified, including nanosuspensions, nanoemulsions, Solid Lipid Nanoparticles (SLN), Self-Nanoemulsifying Drug Delivery Systems (SNEDDS), Solid-SNEDDS, nanogels, polymeric nanoparticles, and green-synthesised metallic nanoparticles; these formulations consistently reduced particle size to the nanometre range, improved solubility and chemical stability, increased entrapment efficiency, and enhanced pharmacological effects such as anti-inflammatory, antioxidant, antimicrobial, and anticancer activities compared with conventional extracts. Conclusions: Nanotechnology-based formulations of Curcuma xanthorrhiza represent a promising strategy to improve the efficacy, safety, and practicality of temulawak as a modern herbal medicine, and further well-designed preclinical and clinical studies are required to confirm their therapeutic advantages.
Co-Authors Ade Herlin Aditya Sewanggara Amatyawangsa Wicaksana Aditya Sewanggara Amatyawangsa Wicaksana Agita Dyah Permatasari Agung Endro Nugroho Agung Endro Nugroho Aji Winanta Aldia Dwi Karina Ningrum Aldia Dwi Karina Ningrum Amalia Humairah Amelia Arum Prasetya Anik Ariyani Anisa Nur Fazzri Annisa Fitria Annisa Fitria Arba Pramundita Ramadani Arifa Caryn Dea Aris Perdana Kusuma, Aris Perdana Asih Lestari Asih Triastuti Asita, Nur Ayunanda, Nurul Putri Ramadhani Bambang Hernawan Nugroho Bambang Hernawan Nugroho, Bambang Hernawan Budy Wijiyanto Denox Asih Pertiwi Diny Rizayulianty Dwi Cahyani, Ervita Elfi Susanti V. H. Endang Lukitaningsih Endang Lukitaningsih Farida Ulfa Feris Firdaus Fernenda, Larysa Fissy Rizki Utami Fitriani, Hannie Galuh Annaba Maharani Hakim, Lukman Hakim, Sherina Nabila Putri Hannie Fitriani Hannie Fitriani Hayati, Farida Herianto Pandapotan Herianto Pandapotan, Herianto Iqmal Tahir Isna Qiftayati Isnatin Miladiyah Istanti Istanti Istanti Istanti, Istanti Joko Tri Wibowo Julio, Ivan Kartika Puspitasari Kholidah, Ziyyatul Larysa Fernenda Laryssa Fernenda Lelita Ayu Saputri Lisnawati Tiara Putri Lukman Hakim Lutfi Chabib, Lutfi Luthfiansyah Azhar, Hanif M. Hatta Wibowo Maulia Ulfa mega octavia Melinda Dewi M Mira Amaliasari Sitorus Muhammad Sulaiman Zubair Mulyanti, Eka Mulyanti, Eka Mutiara Herawati, Mutiara Nadia Hazami Nur Asita Nurul Ainah Octavia, Mega Pramundita Ramadani, Arba Prima Aulia Putra Primadara Damayanti Putri, Mutiara Sani Demira Ramadhani, Arba Pramundita Ratih Dyah Listianingrum Ratih Lestari Ratih Lestari Redjeki, Tri Rini Utami Rio Fandi Sholehuddin Ririk Purwati Rochmy Istikaharah Rochmy Istikharah Romdhonah Romdhonah Ronny Martien Ronny Martien Sabillah, Farhad Aulan Saepudin Saepudin Septiani Eka Cahyani Seran, Yuvina Sherina Nabila Putri Hakim Shinta Dewi Sista Werdyani Sista Werdyani Siti Zahliyatu Syafira Tri Nurmala Sari T. N. Saifullah Taher, Muhammad Tamhid, Hady Anshory Tasya Salsabila Tatang Shabur Julianto Tedjo Yuwono Tiara Putri, Lisnawati Utomo, Suryadi Budi Werdyani, Sista Wintari Taurina Yoga Febriana Yuni Darty Yuwono, Tedjo Ziyyatul Kholidah Zubair, Sulaiman