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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Kedokteran Brawijaya Dentika Dental Journal Jurnal Kesehatan Andalas Jurnal Sains dan Teknologi Farmasi Journal of Agromedicine and Medical Sciences Majalah Kesehatan Pharmamedika Jurnal Ners Pharmaceutical Sciences and Research (PSR)
Yanwirasti Yanwirasti
Faculty of Medicine Universitas Andalas, Padang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health

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Serum Prolactine Levels and Prolactine Receptor Expression in Premenopausal Breast Cancer: A Potential Predictive Biomarker? Tripriadi, Effif Syofra; Maulanisa, Sinta Chaira; Lipoeto, Nur Indrawati; Yanwirasti, Yanwirasti; Oenzil, Fadil; Harahap, Wirsma Arif; Utami, Tania Nugrah; Mardhiyah, Farah
Jurnal Ners Vol. 10 No. 1 (2026)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.52299

Abstract

Introduction: Premenopausal breast cancer (PBC) is often more aggressive than postmenopausal cases, with prolactin playing a key role in tumor development. This study examines the relationship between serum prolactin levels, prolactin receptor (PRLR) expression, and clinicopathological features in PBC patients. Methods: This cross-sectional study was conducted from 2021 - 2022 at multiple hospitals in Pekanbaru, Indonesia. Thirty-five PBC patients and 35 healthy controls were included. Serum prolactin levels were measured using ELISA, and PRLR expression was assessed via IHC. Statistical analysis was performed using independent t-tests and correlation analysis (p < 0.05). Results: PBC patients had higher prolactin levels (51.96±80.40 ng/mL) than controls (20.83±15.74 ng/mL, p = 0.031). PRLR expression was detected in over 90% of tumors, with a significant correlation between prolactin levels and cancer stage (p = 0.035). Discussion: These findings suggest prolactin contributes to PBC progression, with higher levels linked to advanced stages, possibly through JAK2/STAT5 signaling. Conclusion: Serum prolactin levels and PRLR expression are associated with cancer stage, supporting their potential as biomarkers for early detection and disease progression. Further studies are needed for validation.
Co-Authors Adriani Susanty Akhmad Yogi Pramatirta, Akhmad Yogi Akmal Djamaan Alimin, Nur Arni Amir Basyir, Vaulinne Ben, Elfi Sahlan Dachriyanus Dedi Afandi Dewi, Citra Kartika Dian Handayani Djamaludin, Heder Efa Ismardianita, Efa Effif Syofra Tripriadi, Effif Syofra Elita Rafni, Elita Ellyza Nasrul Eriyati Darwin, Eriyati Eti Yerizel Fadil Oenzil Fatma Sri Wahyuni Hillbertina, Noza Ismawati Ismawati Johanes C. Mose Magdazaleni, Magdazaleni Mardhiyah, Farah Maulanisa, Sinta C. Mieke Hemiawati, Mieke Mohammad Tegar Indrayana Muh Ade Artasasta Noza Hilbertina, Noza Nur Indrawati Lipoeto Nuzulia Irawati Prima Nanda Fauziah Rahmi Nofita Rasmi Rikmasari Rika Susanti S Siswanto Sekar, Andisyah Putri Selfi Renita Rusjdi Sofia, Sri Esky Syahputra, Roni Eka Taher, Muhammad Utami, Tania Nugrah Wirsma Arif Harahap Yufri Aldi