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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Journal of Food and Pharmaceutical Science Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Sains dan Komunitas Jurnal Biodjati Majalah Farmaseutik JFIOnline Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Pharmaceutical Sciences and Research (PSR) Journal of Food and Pharmaceutical Sciences
Nunung Yuniarti
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy Universitas Gadjah Mada Yogyakarta
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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The Development of Alternative Dosage Form for Creatine Monohydrate: A Floating Tablet Nur Hidayah, Arifatu; Ardiana Wati, Anas; Yuniarti, Nunung; Laksitorini, Marlyn Dian
Journal of Food and Pharmaceutical Sciences Vol 11, No 3 (2023): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.8284

Abstract

Creatine monohydrate has been developed as a neuroprotective agent and can penetrate in vitro model of the blood-brain barrier. However, its delivery is hampered by its limited capacity of creatine transporter. The floating system is known to increase the residence time of drugs in the stomach; thus, the active substances can be absorbed more optimally. Therefore, this study is aimed to develop creatine monohydrate floating tablets by optimizing the proportion of HPMC K100M and NaHCO2 and evaluating the quality of floating tablets. The formula was designed Simplex Lattice Design method. Tablets were prepared by the wet granulation method and evaluated for granule and tablet parameters. The results showed that HPMC K100M significantly increased flow time, absorption rate, hardness, floating time, swelling index; decreased index tap, fragility, and floating lag time. Meanwhile, an increase in NaHCO2 significantly affects an increase in floating lag time. The optimum formula obtained was 18.87% HPMC K100M and 21.12% NaHCO2. Verification of the optimum formula showed that tablet parameters were not significantly different from the predicted formula. The studies suggest that this prototype can be developed to increase creatine residence time in the stomach.
Antioxidant Activity and Pancreatic Lipase Inhibition of Curcuma aeruginosa Roxb Rhizome Fractions Suharsanti, Ririn; Wahyuono, Subagus; Yuniarti, Nunung; Astuti, Puji
Jurnal Biodjati Vol 9 No 2 (2024): November
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v9i2.33900

Abstract

Antiobesity with a lipase inhibitor mechanism will block the hydrolysis of triglycerides into fatty acids and glycerol, while antioxidant compounds are very useful in conditions of obesity to prevent excess damage from degenerative diseases. Curcuma aeruginosa Roxb extract has been proven to have the effect of inhibiting pancreatic lipase so further effects will be seen at the fraction level. The purpose of this research is to investigate the phytochemical components ,antioxidant activity and pancreatic lipase inhibition of Curcuma aeruginosa Roxb fractions. Ethanolic extract of the Curcuma aeruginosa Roxb rhizome was separated using the solid-liquid chromatography with 3 different solvents (n-hexane, ethyl acetate, ethanol) to give n-hexane (HF), ethyl acetate (EAF), and ethanol (EF), and the insoluble (IF) fractions. Each fraction detected phenolics, flavonoids, alkaloids, tannins, saponins, triterpenoids/steroids. EF has the highest total flavonoid and phenolic content. Antioxidant activity of all fractions were measured using DPPH reduction, ABTS, and FRAP methods. The best antioxidant activity of all fractions using the DPPH method was EF with IC50 21.93 ± 3.39µg/mL, ABTS method was HF with IC50 24.56±1,03 µg/mL and FRAP method was IF with IC50 20.79±1,03 µg/mL. Totals of phenolics and flavonoids in EF strongly support the antioxidant activity of the DPPH method. The highest inhibition of pancreatic lipase was found in EAF at 35.16±0.24 % (100 µg/ml). There was significant difference between EAF and xenical (orlistat) (p
OPTIMASI FASE GERAK PADA KLT DAN IDENTIFIKASI METABOLIT SEKUNDER Ipomoea pes-caprae Hidayat, Lalu Husnul; Murti, Yosi Bayu; Yuniarti, Nunung; Riski, Akhmad
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2995

Abstract

Ipomoea pes-caprae (L.) R.Br traditionally used to treat pain, skin infections, inflammation, and rheumatic disorders. In vitro studies also reported antioxidant, anti-inflammatory, and antimicrobial potential activities obtained from secondary metabolites such as flavonoids, tannins, terpenoids, steroids, saponins, and alkaloids contained in Ipomoea pes-caprae. The purpose of this study is to optimize the mobile phase and identify secondary metabolite compounds of Ipomoea pes-caprae. The analysis used thin layer chromatography (TLC) in identifying compounds responsible for providing antioxidant activity with a spray reagent in the form of DPPH. The results showed the ideal of mobile phase, namely Chloroform: Ethyl Acetate: Methanol: Formic Acid (2: 7: 0.5: 0.5). Ethanol extract of 96% leaves has antioxidant activity with a DPPH spray reaction than ethyl acetate and N-hexane extracts. The metabolite profiles in samples with various specific reagents include the group of polyphenols, alkaloids and flavonoid compounds. Based on the results of the descriptive analysis, it was shown that the most dominant group of flavonoid compounds from ethanol extract was 96% of Ipomoea pes-caprae leaves, so it had a strong correlation with antioxidant activity.
Comparison of Thin Layer Hydration and Dispersion Method of Transfersome Formulation Containing Hyaluronic Acid and Glutathione as Antioxidant Dian Ermawati; Adhyatmika; Yuniarti, Nunung; Teuku Nanda Saifullah Sulaiman
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 11 No. 1 (2026)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v11i1.44450

Abstract

Glutathione is a tripeptide (L-ᵞ-glutamyl-L-cysteinyl-glycine) that serves as an antioxidant in the body and can be coupled with hyaluronic acid for anti-aging purposes. Glutathione, being hydrophilic, encounters challenges in penetrating the stratum corneum barrier to access the deeper epidermal layers; thus, a transfersome delivery mechanism is requisite. This study aimed to examine the synthesis of transfersome containing glutathione and hyaluronic acid using the thin layer hydration method and the dispersion method. The characteristics measured included organoleptic properties, particle size, zeta potential, polydispersity index (PDI), entrapment efficiency, and antioxidant activity assessed via the DPPH method. Particle size and PDI were found to be 124.5 ± 14.11 nm, 0.367± 0.07 for thin layer hydration method and 583.03 ± 32.41 nm, 0.595 ± 0.03 for dispersion method respectively. Entrapment efficiency showed that the thin layer hydration method was greater at 35.65% ± 3.54 compared to the dispersion method at 19.10 % ± 1.13. Antioxidant activity showed the inhibition in thin layer hydration and dispersion method was 42.48% ± 0.84 and 41.23% ± 2.09 respectively. In conclusion, the thin layer hydration method gives more optimal results than the dispersion method.
Comparative Physicochemical Characterization of Porcine, Fish, and Bovine Gelatin in Gummy Candies: Toward Halal Nutraceutical Development Laksitorini, Marlyn Dian; Darsih, Cici; Yuniarti, Nunung; Rumiyati, Rumiyati; Abidin, Mohammad Zainal
Pharmaceutical Sciences and Research Vol. 12, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Gummy candies have emerged as one of the most popular dosage forms for multivitamins and nutraceutical supplements, including those for brain health. Gelatin is the primary gelling agent used to achieve the gummy texture; however, the influence of different gelatin sources on the physicochemical properties of gummies has not been systematically examined. This study investigated the physicochemical characteristics of gummies prepared with porcine, bovine, and fish gelatin. The gummies were evaluated for mechanical properties (gumminess, hardness, cohesiveness, springiness, adhesiveness, and stringiness), color, water activity, antioxidant activity, and protein content. Additionally, the effects of intentional adulteration—specifically the addition of porcine gelatin to fish or bovine gelatin—were assessed. The results showed that gumminess, hardness, cohesiveness, and springiness were comparable across different gelatin sources, whereas adhesiveness and stringiness were highly sensitive to source variation. Notably, adulteration with porcine gelatin significantly altered those two parameters. These findings underscored the importance of verifying gelatin origin in gummy formulations, as source-related variations and gelatin adulteration could have a direct impact on product quality and performance.
Co-Authors Adhyatmika Ardiana Wati, Anas Ardiningtyas, Bondan Arko Jatmiko Wicaksono, Arko Jatmiko Azizah, Ulfah Laily Cici Darsih Devi, Dwitya Devi Nurlistyo Dian Ermawati Hidayat, Lalu Husnul Ika Puspitasari Ilham Perdana Marlyn Dian Laksitorini, Marlyn Dian Mohammad Zainal Abidin Nur Hidayah, Arifatu Puji Astuti Retno Murwanti Rina Nur Maulawati, Rina Nur Ririn Suharsanti, Ririn Riski, Akhmad Rumiyati, Rumiyati Subagus Wahyuono Sudibyo Martono Supardjan A.M., Supardjan SUWIJIYO PRAMONO Teuku Nanda Saifullah Sulaiman Wulandari, Febri Yance Anas Yosi Bayu Murti