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All Journal Plumula : Berkala Ilmiah Agroteknologi Prosiding SNATIF saintis Agritrop : Jurnal Ilmu-Ilmu Pertanian (Journal of Agricultural Science) JURNAL PENDIDIKAN TAMBUSAI JPBIO (Jurnal Pendidikan Biologi) Justisia Ekonomika Bahtera Indonesia; Jurnal Penelitian Bahasa dan Sastra Indonesia Indonesian Journal of Advocacy and Legal Services Inovasi: Jurnal Diklat Keagamaan Jurnal Ilmiah Wahana Pendidikan International Journal of Multidisciplinary Research and Literature (IJOMRAL) Familia: Jurnal Hukum Keluarga Jurnal Pengabdian Masyarakat Bhinneka LoroNG Environmental and Agriculture Management Indonesian Journal of Advocacy and Legal Services Folia Medica Indonesiana
Mariyatul Qibtiyah
Fakultas Kesehatan Masyarakat, Universitas Airlangga
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Other

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Analysis of induction phase glucocorticoid use on adrenal suppression in pediatric patients with acute lymphoblastic leukemia Simbolon, Octaviana; Yulistiani, Yulistiani; Ugrasena, I DG; Qibtiyah, Mariyatul
Folia Medica Indonesiana Vol. 52, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

Glucocorticoids play an important role in the treatment of acute lymphoblastic leukemia (ALL). However, supraphysiological doses may cause suppression of the adrenal. Adrenal suppression resulting in reduced cortisol response may cause an inadequate host defence against infections, which remains a cause of morbidity and mortality in children with ALL. The occurrence of adrenal suppression before and after glucocorticoid therapy for childhood ALL is unclear. The aim of this study is to analysis the effect of glucocorticoid on cortisol levels during induction phase chemotherapy in children with acute lymphoblastic leukemia. A cross-sectional, observational prospective study was conducted to determine the effect of glucocorticoid on cortisol levels in children with acute lymphoblastic leukemia. Patients who met inclusion criteria were given dexamethasone or prednisone therapy for 49 days according to the 2013 Indonesian Chemotherapy ALL Protocol. Cortisol levels were measured on days 0, 14, 28, 42 and 56 of induction phase chemotherapy. There were 24 children, among 31 children recruited, who suffered from acute lymphoblastic leukemia. Before treatment, the means of cortisol levels were 228.95 ng/ml in standard risk group (prednisone) and 199.67 ng/ml in high risk group (dexamethasone). In standard risk group, the adrenal suppression occurs at about day 56. There was a significant decrement of cortisol levels in high risk group in days 14, 28, 42 against days 0 of induction phase (p=0.001). Both groups displayed different peak cortisol levels after 6 week of induction phase (p=0.028). Dexamethasone resulted in lower cortisol levels than prednisone during induction phase chemotherapy in children with acute lymphoblastic leukemia.
Analysis of High Dose and Long-Term Prednisone Therapy on Trap 5B Level Change in Children with Steroid Sensitive Nephrotic Syndrome Setyani, Dessy Surya; Qibtiyah, Mariyatul; Asmaningsih, Ninik; Yulistiani, Yulistiani
Folia Medica Indonesiana Vol. 54, No. 2
Publisher : Folia Medica Indonesiana

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Nephrotic syndrome is a condition which is characterized by protein leakage from the blood to the urine through glomeruli. It leads to hypoproteinemia and generalised oedema. Patients with nephrotic syndrome need high dose and long term glucocorticoid such as prednisone. High dose and long term glucocorticoid can increase bone resorption. Biological marker is a valuable tool to evaluate efficacy of therapy. TRAP 5B is a sensitive biological marker for bone resorption because it reflects the number of osteoclasts. TRAP 5B is not affected by renal dysfunction and food. It also has a low diurnal variation than other bone resorption marker. The aim of this study was to analyze the changes of TRAP 5B levels at induction and alternate phase in children with steroid sensitive nephrotic syndrome. This observational prospective study was conducted from May to October 2016. Venous blood samples obtained at 08.00-10.00 am. TRAP5B levels were measured before and after induction phase and after alternate phase using ELISA. Fifteen patients were included in this study (60% boys). Majority of their age was 6 - <12 years and 40% were dependent steroid NS. TRAP 5B serum levels in induction phase increased by 37.41%±56.22%. In alternate phase, TRAP 5B serum levels increased by 28.75%±66.55% compared to the induction phase. However, the level change of both phases were not significant. As a conclusion, TRAP 5B levels increased in induction and alternate phase after high dose and long-term prednisone treatment in nephrotic syndrome.
Co-Authors Ade Jamarudin Adistira Maulidi Hidayat, Muh Agus Sholeh Agustin, Almaidah Sela Ahmadi, Imam Ana Amiroh Anas Ahmadi Andriana, Fany Septi Arsita, Selly Asmaningsih, Ninik Astata, Naufal Ahmad Choirul Anam AM Diponegoro Dian Eka Kusumawati Dini, Widya Septian Dwiguna, Ratnanda Kresna Efendi, Muhammad Yusuf Eko Nurhadi Emmy Hamidah Hakim, M. Arief Rahman Hidayat, Moh. Masyrofi Imamah, Alfia Nur istiqomah istiqomah Istiqomah, Istiqomah Kusuma, Harun Indra Marasabessy, Rendy Mardhika, Dimas Ayu Melda Yunita Mia Ratwita Andarsini Muafifah, Siti Muafifah, Siti Novian Muriani R, Karina Nuriah Yuliati Nurwijayanti Octavia Indana, Della Ohiwal, Morgan Pramesty, Intan Budi Pudyartono, Pudyartono Rismayanti, Levana Setiawan, Ardhi Harry Setyani, Dessy Surya Simbolon, Octaviana Siti Hidayah Siti Muafifah SITI MUNTOMIMAH, SITI Sofyan, Misba Maulana Sukmawati Sukmawati Sunarto Sunarto Triningsih, Jessica Septina Ugrasena, I DG Uun Muhaji Wahyunengsih, Wahyunengsih Wicaksono, Fitra Wonnink, Riqbal Fauzi Salman Yasin, Mohammad Zeqi Yulistiani Yulistiani, Yulistiani