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Journal : Malacca Pharmaceutics

Investigating the Usage of Medicinal Plants and Herbal Products in Aceh to Address COVID-19 Symptoms: A Cross-Sectional Survey Suryawati, Suryawati; Rasydi, Ahmad; Puspita, Nanda Ayu; Hertiani, Triana
Malacca Pharmaceutics Vol. 1 No. 2 (2023): October 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v1i2.38

Abstract

Medicinal plants have been used worldwide as supportive therapy in reducing symptoms of various diseases, including COVID-19 symptoms. The objective of this study was to investigate the use of medicinal plants and herbal products in respondents who experienced symptoms of COVID-19 in Aceh, Indonesia. A cross-sectional study was conducted, involving 384 respondents from the age group over 18 years old residing in Aceh Province, Indonesia. Data was collected via an online questionnaire consisting of 4 structured questions to assess the types and names of medicinal plants, the time of use, and the purpose of using medicinal plants. The results showed that nearly half of the study population (181 respondents) consumed medicinal plants and commercial products, mainly for the reason to enhance their immunity (49.7%), followed by to overcome the COVID-19 symptoms (26.7%). Amongst all medicinal remedies mentioned in this study, Ginger (Zingiber officinale) and turmeric (Curcuma longa) are the most widely used, which were consumed by 65.5% of medicinal plant and herbal products users. The other medicinal plant chosen by the study population were lemon (Citrus lemon), Java Ginger/temulawak (Curcuma zanthorrhiza), and Habbatus sauda (Nigella sativa). Although the majority of the respondents had used the herbal remedies prior contracting COVID-19 symptoms (45.5%), a third of the respondents consumed traditional medicine during the symptomatic period only (less than two weeks). This study has demonstrated the characteristics of the consumption of medicinal plants and their commercial products in Aceh, during the occurrence of COVID-19 symptoms in the study population.
Probiotics and Their Role in Decreasing Diarrhea Prevalence in the Elderly Population: A Comprehensive Meta-Analysis Muliana, Devika; Mulia, Vera Dewi; Suardi, Hijra Novia; Puspita, Nanda Ayu; Suryawati, Suryawati
Malacca Pharmaceutics Vol. 2 No. 1 (2024): March 2024
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v2i1.143

Abstract

Diarrhea is an atypical state of the digestive system characterized by a soft or watery texture in bowel movements. Antibiotic-related diarrhea is common in the elderly due to extensive antibiotic use. Probiotics are vital microorganisms that support the intestinal flora and reduce bacterial colonization in the intestinal wall. This study aimed to assess the effectiveness, type, and dose of probiotics for diarrhea in the elderly. A systematic review with meta-analysis was conducted using PubMed, ScienceDirect, and Google Scholar. Seven records with a total of 2,087 participants were included. A quantitative analysis was carried out using Review Manager version 5 software. A meta-analysis was conducted to assess the frequency of diarrhea. The results showed that using probiotics significantly reduced the risk of antibiotic-related diarrhea 0.53 times compared to the placebo administration (OR 0.53; CI 95% 0.29 to 0.98; I2 = 70%). The type of probiotics frequently given was the genera of Lactobacillus, Bifidobacterium, and Streptococcus, with consumption durations varying from 3 days to a maximum of 4 weeks. The dose of probiotics ranged from a minimum of 1.0 × 10⁶ CFU to a maximum dose of 2 × 10¹⁰ CFU. To conclude, probiotic administration is more effective than placebo in reducing the risk of antibiotic-related diarrhea in the elderly.
Therapeutic Potential of Aceh's Syzygium polyanthum in Reducing Uric Acid in Rattus Norvegicus Nasrullah, Nasrullah; Siregar, Masra Lena; Suryawati, Suryawati
Malacca Pharmaceutics Vol. 2 No. 2 (2024): September 2024
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v2i2.210

Abstract

This research aims to evaluate the anti-hyperuricemic activity of Syzygium polyanthum ethanolic extract in hyperuricemic male rats (Rattus norvegicus) induced by liver juice.  A total of 25 animals were divided into five groups: a negative control group, a positive control group, and three treatment groups receiving S. polyanthum extract at doses of 150, 200, and 250 mg/kg body weight, respectively. The result showed that the dose of 250 mg/kg body weight resulted in the highest decrease of uric acid plasma, measuring 3.44 ± 2.03 mg/dL. This reduction is comparable to the effect of allopurinol, which showed a decrease of 3.70 ± 1.54 mg/dL. A minimum dose-dependent activity was observed. To conclude, the administration of ethanolic extract of S. polyanthum for 14 days significantly reduced uric acid levels. Further exploration of higher doses or a long-term treatment period to enhance its effectiveness is needed.
Bioactive Phytochemicals from Memecylon edule: Targeting Planktonic and Biofilm States of Pseudomonas aeruginosa Suryawati, Suryawati; Idroes, Rinaldi; Hertiani, Triana; Khairan, Khairan
Malacca Pharmaceutics Vol. 3 No. 1 (2025): March 2025
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v3i1.258

Abstract

The rise in antimicrobial resistance has prompted the search for potent antimicrobial agents, with plants from unique environments, such as geothermal areas, offering potential due to their diverse phytochemical profiles. This study evaluated the antiplanktonic and antibiofilm activity of M. edule fractions from the geothermal area, Jaboi, Sabang. Crude extracts of M. edule were sequentially fractionated using hexane, ethyl acetate, and ethanol. The resulting fractions were further analyzed for their phytochemical content and antiplanktonic and antibiofilm activities. The ethyl acetate fraction demonstrated superior antiplanktonic and antibiofilm activities compared to other fractions, inhibiting 50% of Pseudomonas aeruginosa planktonic and biofilm formation at a concentration of 10 mg/mL. The most potent fraction exhibited the phenolic content, 672.84 mg GAE/g extract, surpassing the other fractions. The GC-MS analysis shows the presence of pyrogallol, hexadecanoic acid, cedran-diol, and sitosterol. These findings highlight the potential of the ethyl acetate fraction of M. edule as a source of bioactive compounds with promising antiplanktonic and antibiofilm properties, laying the groundwork for future research into its therapeutic applications against biofilm-associated infections.